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PMC:7417114 / 68709-69500 JSONTXT

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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T366 211-215 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T367 383-387 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T109 211-215 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T110 383-387 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T614 95-103 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T615 114-136 Disease denotes respiratory infections http://purl.obolibrary.org/obo/MONDO_0024355
T616 166-174 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T617 198-223 Disease denotes interstitial lung disease http://purl.obolibrary.org/obo/MONDO_0015925
T618 211-223 Disease denotes lung disease http://purl.obolibrary.org/obo/MONDO_0005275

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T767 37-46 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T768 188-189 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T769 211-215 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T770 211-215 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T771 266-275 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T772 322-325 http://purl.obolibrary.org/obo/CLO_0001046 denotes 116
T773 351-360 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T774 383-387 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T775 383-387 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T776 487-496 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T777 677-678 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T778 679-684 http://purl.obolibrary.org/obo/CLO_0007836 denotes mouse
T779 758-759 http://purl.obolibrary.org/obo/CLO_0001020 denotes a

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T193 249-252 Chemical denotes EGF http://purl.obolibrary.org/obo/CHEBI_140739
T40825 261-265 Chemical denotes beta http://purl.obolibrary.org/obo/CHEBI_10545
T92367 647-656 Chemical denotes bleomycin http://purl.obolibrary.org/obo/CHEBI_22907
T93517 702-711 Chemical denotes erlotinib http://purl.obolibrary.org/obo/CHEBI_114785

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
1993 32-36 Gene denotes EGFR Gene:1956
1994 177-181 Gene denotes EGFR Gene:1956
1995 257-265 Gene denotes TFG-beta Gene:7039
1996 346-350 Gene denotes EGFR Gene:1956
1997 482-486 Gene denotes EGFR Gene:1956
1998 587-596 Gene denotes TGF-beta1 Gene:21803
1999 249-252 Gene denotes EGF Gene:1950
2000 95-103 Species denotes SARS-CoV Tax:694009
2001 679-684 Species denotes mouse Tax:10090
2002 567-576 Chemical denotes Gefitinib MESH:D000077156
2003 647-656 Chemical denotes bleomycin MESH:D001761
2004 702-711 Chemical denotes erlotinib MESH:D000069347
2005 114-136 Disease denotes respiratory infections MESH:D012141
2006 166-174 Disease denotes COVID-19 MESH:C000657245
2007 211-223 Disease denotes lung disease MESH:D008171
2008 312-320 Disease denotes fibrosis MESH:D005355
2009 383-396 Disease denotes lung fibrosis MESH:D005355
2010 552-560 Disease denotes fibrosis MESH:D005355
2011 610-618 Disease denotes fibrosis MESH:D005355
2012 665-673 Disease denotes fibrosis MESH:D005355
2013 734-742 Disease denotes fibrosis MESH:D005355

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T201 114-136 Phenotype denotes respiratory infections http://purl.obolibrary.org/obo/HP_0011947
T202 198-223 Phenotype denotes interstitial lung disease http://purl.obolibrary.org/obo/HP_0006530

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T201 32-36 http://purl.obolibrary.org/obo/GO_0005006 denotes EGFR
T202 37-46 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T203 177-181 http://purl.obolibrary.org/obo/GO_0005006 denotes EGFR
T204 266-275 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T205 346-350 http://purl.obolibrary.org/obo/GO_0005006 denotes EGFR
T206 351-360 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T207 482-486 http://purl.obolibrary.org/obo/GO_0005006 denotes EGFR
T208 487-496 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T536 0-176 Sentence denotes Studies suggest that inhibiting EGFR signaling might prevent an excessive fibrotic response to SARS-CoV and other respiratory infections (like that characteristic of COVID-19).
T537 177-333 Sentence denotes EGFR plays a role in interstitial lung disease, and interaction between EGF and TFG-beta signaling is believed to drive development of fibrosis (116) (117).
T538 334-566 Sentence denotes The role of EGFR signaling in the development of lung fibrosis is complex, though, with data suggesting both profibrotic and antifibrotic roles for EGFR signaling, at least in part seeming to depend on the trigger for fibrosis (13).
T539 567-791 Sentence denotes Gefitinib inhibited TGF-beta1 induction of fibrosis in vivo (118) and inhibited bleomycin-induced fibrosis in a mouse model (119), and erlotinib was reported to block fibrosis development in a variety of in vivo models (13).

2_test

Id Subject Object Predicate Lexical cue
32778962-19306296-84130798 328-331 19306296 denotes 117
32778962-23086930-84130799 628-631 23086930 denotes 118
32778962-16741154-84130800 692-695 16741154 denotes 119