PMC:7417114 / 63028-64153
Annnotations
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T305 | 0-8 | Body_part | denotes | Cytokine | http://purl.org/sig/ont/fma/fma84050 |
| T306 | 168-176 | Body_part | denotes | platelet | http://purl.org/sig/ont/fma/fma62851 |
| T307 | 257-265 | Body_part | denotes | tyrosine | http://purl.org/sig/ont/fma/fma82768 |
| T308 | 295-299 | Body_part | denotes | gene | http://purl.org/sig/ont/fma/fma74402 |
| T309 | 480-488 | Body_part | denotes | cytokine | http://purl.org/sig/ont/fma/fma84050 |
| T310 | 665-670 | Body_part | denotes | liver | http://purl.org/sig/ont/fma/fma7197 |
| T311 | 825-835 | Body_part | denotes | mast cells | http://purl.org/sig/ont/fma/fma66784 |
| T312 | 830-835 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T313 | 837-847 | Body_part | denotes | macrophage | http://purl.org/sig/ont/fma/fma63261 |
| T314 | 881-890 | Body_part | denotes | cytokines | http://purl.org/sig/ont/fma/fma84050 |
| T315 | 1043-1052 | Body_part | denotes | cytokines | http://purl.org/sig/ont/fma/fma84050 |
| T316 | 1061-1065 | Body_part | denotes | IL-1 | http://purl.org/sig/ont/fma/fma86583 |
| T317 | 1061-1063 | Body_part | denotes | IL | http://purl.org/sig/ont/fma/fma86578 |
| T318 | 1070-1072 | Body_part | denotes | IL | http://purl.org/sig/ont/fma/fma86578 |
LitCovid-PD-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T100 | 665-670 | Body_part | denotes | liver | http://purl.obolibrary.org/obo/UBERON_0002107 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T562 | 115-123 | Disease | denotes | leukemia | http://purl.obolibrary.org/obo/MONDO_0005059 |
| T563 | 307-319 | Disease | denotes | Rous sarcoma | http://purl.obolibrary.org/obo/MONDO_0025382 |
| T564 | 312-319 | Disease | denotes | sarcoma | http://purl.obolibrary.org/obo/MONDO_0005089 |
| T565 | 366-374 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T566 | 391-399 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T567 | 444-447 | Disease | denotes | ABL | http://purl.obolibrary.org/obo/MONDO_0008692 |
| T568 | 533-542 | Disease | denotes | influenza | http://purl.obolibrary.org/obo/MONDO_0005812 |
| T569 | 609-624 | Disease | denotes | acute hepatitis | http://purl.obolibrary.org/obo/MONDO_0002251 |
| T570 | 665-683 | Disease | denotes | liver inflammation | http://purl.obolibrary.org/obo/MONDO_0002251 |
| T571 | 671-683 | Disease | denotes | inflammation | http://purl.obolibrary.org/obo/MONDO_0021166 |
| T572 | 747-767 | Disease | denotes | rheumatoid arthritis | http://purl.obolibrary.org/obo/MONDO_0008383 |
| T573 | 758-767 | Disease | denotes | arthritis | http://purl.obolibrary.org/obo/MONDO_0005578 |
| T574 | 945-963 | Disease | denotes | pulmonary fibrosis | http://purl.obolibrary.org/obo/MONDO_0002771 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T687 | 59-67 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activity |
| T688 | 161-165 | http://purl.obolibrary.org/obo/CLO_0053407 | denotes | ABL2 |
| T689 | 213-216 | http://purl.obolibrary.org/obo/CLO_0009132 | denotes | SRC |
| T690 | 242-243 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T691 | 291-294 | http://purl.obolibrary.org/obo/CLO_0009132 | denotes | Src |
| T692 | 295-299 | http://purl.obolibrary.org/obo/OGG_0000000002 | denotes | gene |
| T693 | 320-325 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T694 | 510-511 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T695 | 665-670 | http://purl.obolibrary.org/obo/UBERON_0002107 | denotes | liver |
| T696 | 665-670 | http://www.ebi.ac.uk/efo/EFO_0000887 | denotes | liver |
| T697 | 721-730 | http://purl.obolibrary.org/obo/SO_0000418 | denotes | signaling |
| T698 | 790-799 | http://purl.obolibrary.org/obo/SO_0000418 | denotes | signaling |
| T699 | 830-835 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T700 | 848-851 | http://purl.obolibrary.org/obo/PR_000002062 | denotes | FMS |
| T701 | 852-862 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activation |
| T702 | 928-936 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activity |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T82091 | 86-96 | Chemical | denotes | inhibitors | http://purl.obolibrary.org/obo/CHEBI_35222 |
| T81682 | 257-265 | Chemical | denotes | tyrosine | http://purl.obolibrary.org/obo/CHEBI_18186 |
| T77589 | 444-457 | Chemical | denotes | ABL inhibitor | http://purl.obolibrary.org/obo/CHEBI_76617 |
| T58634 | 444-447 | Chemical | denotes | ABL | http://purl.obolibrary.org/obo/CHEBI_30805 |
| T48824 | 448-457 | Chemical | denotes | inhibitor | http://purl.obolibrary.org/obo/CHEBI_35222 |
| T20304 | 459-468 | Chemical | denotes | ponatinib | http://purl.obolibrary.org/obo/CHEBI_78543 |
| T37057 | 572-577 | Chemical | denotes | alpha | http://purl.obolibrary.org/obo/CHEBI_30216 |
| T54819 | 643-648 | Chemical | denotes | alpha | http://purl.obolibrary.org/obo/CHEBI_30216 |
| T48876 | 808-813 | Chemical | denotes | alpha | http://purl.obolibrary.org/obo/CHEBI_30216 |
| T87267 | 911-920 | Chemical | denotes | bosutinib | http://purl.obolibrary.org/obo/CHEBI_39112 |
| T86067 | 1061-1063 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
| T59460 | 1070-1072 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 1737 | 100-153 | Gene | denotes | Abelson murine leukemia viral oncogene homolog 1 or 2 | |
| 1738 | 155-159 | Gene | denotes | ABL1 | Gene:11350 |
| 1739 | 161-165 | Gene | denotes | ABL2 | Gene:11352 |
| 1740 | 185-207 | Gene | denotes | growth factor receptor | Gene:20187 |
| 1741 | 444-447 | Gene | denotes | ABL | Gene:25 |
| 1742 | 568-577 | Gene | denotes | TNF-alpha | Gene:21926 |
| 1743 | 639-648 | Gene | denotes | TNF-alpha | Gene:7124 |
| 1744 | 777-780 | Gene | denotes | KIT | Gene:3815 |
| 1745 | 804-813 | Gene | denotes | TNF-alpha | Gene:7124 |
| 1746 | 1061-1065 | Gene | denotes | IL-1 | Gene:3552 |
| 1747 | 1070-1074 | Gene | denotes | IL-6 | Gene:3569 |
| 1748 | 307-325 | Species | denotes | Rous sarcoma virus | Tax:11886 |
| 1749 | 366-374 | Species | denotes | SARS-CoV | Tax:694009 |
| 1750 | 377-385 | Species | denotes | MERS-CoV | Tax:1335626 |
| 1751 | 411-419 | Species | denotes | patients | Tax:9606 |
| 1752 | 592-598 | Species | denotes | murine | Tax:10090 |
| 1753 | 533-542 | Species | denotes | influenza | Tax:11320 |
| 1754 | 459-468 | Chemical | denotes | ponatinib | MESH:C545373 |
| 1755 | 549-557 | Chemical | denotes | Imatinib | MESH:D000068877 |
| 1756 | 897-906 | Chemical | denotes | Nilotinib | MESH:C498826 |
| 1757 | 911-920 | Chemical | denotes | bosutinib | MESH:C471992 |
| 1758 | 391-410 | Disease | denotes | SARS-CoV-2-infected | MESH:C000657245 |
| 1759 | 609-624 | Disease | denotes | acute hepatitis | MESH:D017114 |
| 1760 | 659-683 | Disease | denotes | acute liver inflammation | MESH:D017114 |
| 1761 | 747-767 | Disease | denotes | rheumatoid arthritis | MESH:D001172 |
| 1762 | 945-963 | Disease | denotes | pulmonary fibrosis | MESH:D011658 |
| 1763 | 984-992 | Disease | denotes | fibrosis | MESH:D005355 |
LitCovid-PD-HP
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T173 | 115-123 | Phenotype | denotes | leukemia | http://purl.obolibrary.org/obo/HP_0001909 |
| T174 | 312-319 | Phenotype | denotes | sarcoma | http://purl.obolibrary.org/obo/HP_0100242 |
| T175 | 480-494 | Phenotype | denotes | cytokine storm | http://purl.obolibrary.org/obo/HP_0033041 |
| T176 | 609-624 | Phenotype | denotes | acute hepatitis | http://purl.obolibrary.org/obo/HP_0200119 |
| T177 | 659-683 | Phenotype | denotes | acute liver inflammation | http://purl.obolibrary.org/obo/HP_0200119 |
| T178 | 747-767 | Phenotype | denotes | rheumatoid arthritis | http://purl.obolibrary.org/obo/HP_0001370 |
| T179 | 945-963 | Phenotype | denotes | pulmonary fibrosis | http://purl.obolibrary.org/obo/HP_0002206 |
LitCovid-PD-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T182 | 185-191 | http://purl.obolibrary.org/obo/GO_0040007 | denotes | growth |
| T183 | 568-588 | http://purl.obolibrary.org/obo/GO_0032640 | denotes | TNF-alpha production |
| T184 | 671-683 | http://purl.obolibrary.org/obo/GO_0006954 | denotes | inflammation |
| T185 | 721-730 | http://purl.obolibrary.org/obo/GO_0023052 | denotes | signaling |
| T186 | 790-799 | http://purl.obolibrary.org/obo/GO_0023052 | denotes | signaling |
| T187 | 1002-1012 | http://purl.obolibrary.org/obo/GO_0065007 | denotes | regulation |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T511 | 0-425 | Sentence | denotes | Cytokine inhibition and anti-inflammatory and antifibrotic activity displayed by some inhibitors of Abelson murine leukemia viral oncogene homolog 1 or 2 (ABL1, ABL2), platelet-derived growth factor receptor, and SRC (proto-oncogene encoding a non-receptor tyrosine kinase, similar to the v-Src gene of the Rous sarcoma virus), could potentially provide benefit for SARS-CoV-, MERS-CoV-, or SARS-CoV-2-infected patients (77). |
| T512 | 426-548 | Sentence | denotes | For instance, the ABL inhibitor, ponatinib, exhibited cytokine storm suppression in a preclinical model of influenza (78). |
| T513 | 549-896 | Sentence | denotes | Imatinib inhibited TNF-alpha production in murine models of acute hepatitis and prevented TNF-alpha-dependent acute liver inflammation in these models (77), and attenuated signaling associated with rheumatoid arthritis, such as KIT-mediated signaling and TNF-alpha release by mast cells, macrophage FMS activation and production of cytokines (79). |
| T514 | 897-1125 | Sentence | denotes | Nilotinib and bosutinib showed activity against pulmonary fibrosis and other models of fibrosis, through regulation of levels of pro-inflammatory cytokines such as IL-1 and IL-6 (80) (81) (82) (83) (84) (85) (86) (87) (88) (89). |
2_test
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| 32778962-17504122-84130760 | 421-423 | 17504122 | denotes | 77 |
| 32778962-31293574-84130761 | 544-546 | 31293574 | denotes | 78 |
| 32778962-17504122-84130762 | 701-703 | 17504122 | denotes | 77 |
| 32778962-16981009-84130763 | 892-894 | 16981009 | denotes | 79 |
| 32778962-21659722-84130764 | 1076-1078 | 21659722 | denotes | 80 |
| 32778962-21251937-84130765 | 1081-1083 | 21251937 | denotes | 81 |
| 32778962-32089708-84130766 | 1086-1088 | 32089708 | denotes | 82 |
| 32778962-26053624-84130767 | 1091-1093 | 26053624 | denotes | 83 |
| 32778962-28584790-84130768 | 1096-1098 | 28584790 | denotes | 84 |
| 32778962-31396972-84130769 | 1101-1103 | 31396972 | denotes | 85 |
| 32778962-29718973-84130770 | 1116-1118 | 29718973 | denotes | 88 |