PMC:7417114 / 58440-59175
Annnotations
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T284 | 362-368 | Body_part | denotes | tissue | http://purl.org/sig/ont/fma/fma9637 |
LitCovid-PD-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T91 | 362-368 | Body_part | denotes | tissue | http://purl.obolibrary.org/obo/UBERON_0000479 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T546 | 596-599 | Disease | denotes | HSA | http://purl.obolibrary.org/obo/MONDO_0011848 |
| T547 | 713-722 | Disease | denotes | pneumonia | http://purl.obolibrary.org/obo/MONDO_0005249 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T648 | 396-397 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T649 | 596-599 | http://purl.obolibrary.org/obo/PR_000001932 | denotes | HSA |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T59107 | 12-16 | Chemical | denotes | Ofev | http://purl.obolibrary.org/obo/CHEBI_85170 |
| T90014 | 316-318 | Chemical | denotes | IV | http://purl.obolibrary.org/obo/CHEBI_74327 |
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 1537 | 241-245 | Gene | denotes | P-gp | Gene:5243 |
| 1538 | 383-389 | Gene | denotes | CYP3A4 | Gene:1576 |
| 1587 | 152-160 | Species | denotes | patients | Tax:9606 |
| 1588 | 177-185 | Species | denotes | patients | Tax:9606 |
| 1589 | 542-550 | Species | denotes | patients | Tax:9606 |
LitCovid-PD-HP
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T167 | 713-722 | Phenotype | denotes | pneumonia | http://purl.obolibrary.org/obo/HP_0002090 |
LitCovid-PD-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T174 | 286-296 | http://purl.obolibrary.org/obo/GO_0008152 | denotes | metabolism |
| T175 | 428-438 | http://purl.obolibrary.org/obo/GO_0008152 | denotes | metabolism |
| T176 | 475-485 | http://purl.obolibrary.org/obo/GO_0008152 | denotes | metabolism |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T484 | 0-30 | Sentence | denotes | Nintedanib (Ofev and Vargatef) |
| T485 | 31-99 | Sentence | denotes | (Boehringer Ingelheim) Fatty meal increased Cmax 15% and AUC by 20%; |
| T486 | 100-186 | Sentence | denotes | following oral dosing, Tmax after 2 hours in fasted patients, 4 hours in fed patients; |
| T487 | 187-303 | Sentence | denotes | absolute bioavailability is low (4.7%), likely due to P-gp transporters and significant first-pass metabolism (241); |
| T488 | 304-512 | Sentence | denotes | Vd= 1050 L (IV administration) (suggests potentially high tissue distribution) CYP3A4 plays a minor role, accounting for 5% metabolism; esterase cleavage accounts for 25% metabolism 150 mg orally twice daily; |
| T489 | 513-580 | Sentence | denotes | 100 mg orally twice daily in patients with mild hepatic impairment; |
| T490 | 581-735 | Sentence | denotes | 97.8% binding (HSA) In placebo-controlled INPULSIS® trials, among adverse events leading to permanent treatment discontinuation was pneumonia (0.9%) (242) |
2_test
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| 32778962-31016670-84130758 | 298-301 | 31016670 | denotes | 241 |
| 32778962-26400368-84130759 | 731-734 | 26400368 | denotes | 242 |