PMC:7417114 / 5493-6087 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T29","span":{"begin":101,"end":106},"obj":"Body_part"},{"id":"T30","span":{"begin":138,"end":143},"obj":"Body_part"},{"id":"T31","span":{"begin":246,"end":250},"obj":"Body_part"},{"id":"T32","span":{"begin":264,"end":273},"obj":"Body_part"},{"id":"T33","span":{"begin":275,"end":281},"obj":"Body_part"},{"id":"T34","span":{"begin":286,"end":293},"obj":"Body_part"},{"id":"T35","span":{"begin":488,"end":493},"obj":"Body_part"},{"id":"T36","span":{"begin":494,"end":500},"obj":"Body_part"},{"id":"T37","span":{"begin":548,"end":553},"obj":"Body_part"}],"attributes":[{"id":"A29","pred":"fma_id","subj":"T29","obj":"http://purl.org/sig/ont/fma/fma7088"},{"id":"A30","pred":"fma_id","subj":"T30","obj":"http://purl.org/sig/ont/fma/fma7088"},{"id":"A31","pred":"fma_id","subj":"T31","obj":"http://purl.org/sig/ont/fma/fma256135"},{"id":"A32","pred":"fma_id","subj":"T32","obj":"http://purl.org/sig/ont/fma/fma7131"},{"id":"A33","pred":"fma_id","subj":"T33","obj":"http://purl.org/sig/ont/fma/fma7203"},{"id":"A34","pred":"fma_id","subj":"T34","obj":"http://purl.org/sig/ont/fma/fma15900"},{"id":"A35","pred":"fma_id","subj":"T35","obj":"http://purl.org/sig/ont/fma/fma50801"},{"id":"A36","pred":"fma_id","subj":"T36","obj":"http://purl.org/sig/ont/fma/fma9637"},{"id":"A37","pred":"fma_id","subj":"T37","obj":"http://purl.org/sig/ont/fma/fma50801"}],"text":"The point of entry for SARS-CoV-2, angiotensin-converting enzyme 2 (ACE2) is highly expressed in the heart and upregulated in the failing heart (10), and ACE2 receptor levels have been found to be significantly expressed in various organs in the body, such as the esophagus, kidney and bladder (11). These are potential target organs for SARS-CoV-2 and could explain the observed systemic inflammation beyond respiratory issues. In addition, there is evidence for the presence of ACE2 in brain tissue (12), which could explain some of the observed brain manifestations associated with COVID-19."}

{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T14","span":{"begin":101,"end":106},"obj":"Body_part"},{"id":"T15","span":{"begin":138,"end":143},"obj":"Body_part"},{"id":"T16","span":{"begin":232,"end":238},"obj":"Body_part"},{"id":"T17","span":{"begin":264,"end":273},"obj":"Body_part"},{"id":"T18","span":{"begin":275,"end":281},"obj":"Body_part"},{"id":"T19","span":{"begin":286,"end":293},"obj":"Body_part"},{"id":"T20","span":{"begin":327,"end":333},"obj":"Body_part"},{"id":"T21","span":{"begin":488,"end":493},"obj":"Body_part"},{"id":"T22","span":{"begin":494,"end":500},"obj":"Body_part"},{"id":"T23","span":{"begin":548,"end":553},"obj":"Body_part"}],"attributes":[{"id":"A14","pred":"uberon_id","subj":"T14","obj":"http://purl.obolibrary.org/obo/UBERON_0000948"},{"id":"A15","pred":"uberon_id","subj":"T15","obj":"http://purl.obolibrary.org/obo/UBERON_0000948"},{"id":"A16","pred":"uberon_id","subj":"T16","obj":"http://purl.obolibrary.org/obo/UBERON_0000062"},{"id":"A17","pred":"uberon_id","subj":"T17","obj":"http://purl.obolibrary.org/obo/UBERON_0001043"},{"id":"A18","pred":"uberon_id","subj":"T18","obj":"http://purl.obolibrary.org/obo/UBERON_0002113"},{"id":"A19","pred":"uberon_id","subj":"T19","obj":"http://purl.obolibrary.org/obo/UBERON_0001255"},{"id":"A20","pred":"uberon_id","subj":"T20","obj":"http://purl.obolibrary.org/obo/UBERON_0000062"},{"id":"A21","pred":"uberon_id","subj":"T21","obj":"http://purl.obolibrary.org/obo/UBERON_0000955"},{"id":"A22","pred":"uberon_id","subj":"T22","obj":"http://purl.obolibrary.org/obo/UBERON_0000479"},{"id":"A23","pred":"uberon_id","subj":"T23","obj":"http://purl.obolibrary.org/obo/UBERON_0000955"}],"text":"The point of entry for SARS-CoV-2, angiotensin-converting enzyme 2 (ACE2) is highly expressed in the heart and upregulated in the failing heart (10), and ACE2 receptor levels have been found to be significantly expressed in various organs in the body, such as the esophagus, kidney and bladder (11). These are potential target organs for SARS-CoV-2 and could explain the observed systemic inflammation beyond respiratory issues. In addition, there is evidence for the presence of ACE2 in brain tissue (12), which could explain some of the observed brain manifestations associated with COVID-19."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T63","span":{"begin":23,"end":31},"obj":"Disease"},{"id":"T64","span":{"begin":338,"end":346},"obj":"Disease"},{"id":"T65","span":{"begin":389,"end":401},"obj":"Disease"},{"id":"T66","span":{"begin":585,"end":593},"obj":"Disease"}],"attributes":[{"id":"A63","pred":"mondo_id","subj":"T63","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A64","pred":"mondo_id","subj":"T64","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A65","pred":"mondo_id","subj":"T65","obj":"http://purl.obolibrary.org/obo/MONDO_0021166"},{"id":"A66","pred":"mondo_id","subj":"T66","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"}],"text":"The point of entry for SARS-CoV-2, angiotensin-converting enzyme 2 (ACE2) is highly expressed in the heart and upregulated in the failing heart (10), and ACE2 receptor levels have been found to be significantly expressed in various organs in the body, such as the esophagus, kidney and bladder (11). These are potential target organs for SARS-CoV-2 and could explain the observed systemic inflammation beyond respiratory issues. In addition, there is evidence for the presence of ACE2 in brain tissue (12), which could explain some of the observed brain manifestations associated with COVID-19."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T48","span":{"begin":101,"end":106},"obj":"http://purl.obolibrary.org/obo/UBERON_0000948"},{"id":"T49","span":{"begin":101,"end":106},"obj":"http://purl.obolibrary.org/obo/UBERON_0007100"},{"id":"T50","span":{"begin":101,"end":106},"obj":"http://purl.obolibrary.org/obo/UBERON_0015228"},{"id":"T51","span":{"begin":101,"end":106},"obj":"http://www.ebi.ac.uk/efo/EFO_0000815"},{"id":"T52","span":{"begin":138,"end":143},"obj":"http://purl.obolibrary.org/obo/UBERON_0000948"},{"id":"T53","span":{"begin":138,"end":143},"obj":"http://purl.obolibrary.org/obo/UBERON_0007100"},{"id":"T54","span":{"begin":138,"end":143},"obj":"http://purl.obolibrary.org/obo/UBERON_0015228"},{"id":"T55","span":{"begin":138,"end":143},"obj":"http://www.ebi.ac.uk/efo/EFO_0000815"},{"id":"T56","span":{"begin":232,"end":241},"obj":"http://purl.obolibrary.org/obo/UBERON_0003103"},{"id":"T57","span":{"begin":264,"end":273},"obj":"http://purl.obolibrary.org/obo/UBERON_0001043"},{"id":"T58","span":{"begin":275,"end":281},"obj":"http://purl.obolibrary.org/obo/UBERON_0002113"},{"id":"T59","span":{"begin":275,"end":281},"obj":"http://www.ebi.ac.uk/efo/EFO_0000927"},{"id":"T60","span":{"begin":275,"end":281},"obj":"http://www.ebi.ac.uk/efo/EFO_0000929"},{"id":"T61","span":{"begin":295,"end":297},"obj":"http://purl.obolibrary.org/obo/CLO_0053733"},{"id":"T62","span":{"begin":327,"end":333},"obj":"http://purl.obolibrary.org/obo/UBERON_0003103"},{"id":"T63","span":{"begin":488,"end":493},"obj":"http://purl.obolibrary.org/obo/UBERON_0000955"},{"id":"T64","span":{"begin":488,"end":493},"obj":"http://www.ebi.ac.uk/efo/EFO_0000302"},{"id":"T65","span":{"begin":548,"end":553},"obj":"http://purl.obolibrary.org/obo/UBERON_0000955"},{"id":"T66","span":{"begin":548,"end":553},"obj":"http://www.ebi.ac.uk/efo/EFO_0000302"}],"text":"The point of entry for SARS-CoV-2, angiotensin-converting enzyme 2 (ACE2) is highly expressed in the heart and upregulated in the failing heart (10), and ACE2 receptor levels have been found to be significantly expressed in various organs in the body, such as the esophagus, kidney and bladder (11). These are potential target organs for SARS-CoV-2 and could explain the observed systemic inflammation beyond respiratory issues. In addition, there is evidence for the presence of ACE2 in brain tissue (12), which could explain some of the observed brain manifestations associated with COVID-19."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T29","span":{"begin":35,"end":46},"obj":"Chemical"}],"attributes":[{"id":"A29","pred":"chebi_id","subj":"T29","obj":"http://purl.obolibrary.org/obo/CHEBI_48433"}],"text":"The point of entry for SARS-CoV-2, angiotensin-converting enzyme 2 (ACE2) is highly expressed in the heart and upregulated in the failing heart (10), and ACE2 receptor levels have been found to be significantly expressed in various organs in the body, such as the esophagus, kidney and bladder (11). These are potential target organs for SARS-CoV-2 and could explain the observed systemic inflammation beyond respiratory issues. In addition, there is evidence for the presence of ACE2 in brain tissue (12), which could explain some of the observed brain manifestations associated with COVID-19."}

{"project":"LitCovid-PubTator","denotations":[{"id":"184","span":{"begin":35,"end":66},"obj":"Gene"},{"id":"185","span":{"begin":68,"end":72},"obj":"Gene"},{"id":"186","span":{"begin":154,"end":158},"obj":"Gene"},{"id":"187","span":{"begin":480,"end":484},"obj":"Gene"},{"id":"188","span":{"begin":23,"end":33},"obj":"Species"},{"id":"189","span":{"begin":338,"end":348},"obj":"Species"},{"id":"190","span":{"begin":389,"end":401},"obj":"Disease"},{"id":"191","span":{"begin":585,"end":593},"obj":"Disease"}],"attributes":[{"id":"A184","pred":"tao:has_database_id","subj":"184","obj":"Gene:59272"},{"id":"A185","pred":"tao:has_database_id","subj":"185","obj":"Gene:59272"},{"id":"A186","pred":"tao:has_database_id","subj":"186","obj":"Gene:59272"},{"id":"A187","pred":"tao:has_database_id","subj":"187","obj":"Gene:59272"},{"id":"A188","pred":"tao:has_database_id","subj":"188","obj":"Tax:2697049"},{"id":"A189","pred":"tao:has_database_id","subj":"189","obj":"Tax:2697049"},{"id":"A190","pred":"tao:has_database_id","subj":"190","obj":"MESH:D007249"},{"id":"A191","pred":"tao:has_database_id","subj":"191","obj":"MESH:C000657245"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"The point of entry for SARS-CoV-2, angiotensin-converting enzyme 2 (ACE2) is highly expressed in the heart and upregulated in the failing heart (10), and ACE2 receptor levels have been found to be significantly expressed in various organs in the body, such as the esophagus, kidney and bladder (11). These are potential target organs for SARS-CoV-2 and could explain the observed systemic inflammation beyond respiratory issues. In addition, there is evidence for the presence of ACE2 in brain tissue (12), which could explain some of the observed brain manifestations associated with COVID-19."}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T17","span":{"begin":389,"end":401},"obj":"http://purl.obolibrary.org/obo/GO_0006954"}],"text":"The point of entry for SARS-CoV-2, angiotensin-converting enzyme 2 (ACE2) is highly expressed in the heart and upregulated in the failing heart (10), and ACE2 receptor levels have been found to be significantly expressed in various organs in the body, such as the esophagus, kidney and bladder (11). These are potential target organs for SARS-CoV-2 and could explain the observed systemic inflammation beyond respiratory issues. In addition, there is evidence for the presence of ACE2 in brain tissue (12), which could explain some of the observed brain manifestations associated with COVID-19."}

{"project":"LitCovid-sentences","denotations":[{"id":"T33","span":{"begin":0,"end":299},"obj":"Sentence"},{"id":"T34","span":{"begin":300,"end":428},"obj":"Sentence"},{"id":"T35","span":{"begin":429,"end":594},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"The point of entry for SARS-CoV-2, angiotensin-converting enzyme 2 (ACE2) is highly expressed in the heart and upregulated in the failing heart (10), and ACE2 receptor levels have been found to be significantly expressed in various organs in the body, such as the esophagus, kidney and bladder (11). These are potential target organs for SARS-CoV-2 and could explain the observed systemic inflammation beyond respiratory issues. In addition, there is evidence for the presence of ACE2 in brain tissue (12), which could explain some of the observed brain manifestations associated with COVID-19."}

{"project":"2_test","denotations":[{"id":"32778962-15151696-84130505","span":{"begin":145,"end":147},"obj":"15151696"},{"id":"32778962-19014390-84130506","span":{"begin":502,"end":504},"obj":"19014390"}],"text":"The point of entry for SARS-CoV-2, angiotensin-converting enzyme 2 (ACE2) is highly expressed in the heart and upregulated in the failing heart (10), and ACE2 receptor levels have been found to be significantly expressed in various organs in the body, such as the esophagus, kidney and bladder (11). These are potential target organs for SARS-CoV-2 and could explain the observed systemic inflammation beyond respiratory issues. In addition, there is evidence for the presence of ACE2 in brain tissue (12), which could explain some of the observed brain manifestations associated with COVID-19."}

{"project":"LitCovid-PMC-OGER-BB","denotations":[{"id":"T115","span":{"begin":23,"end":33},"obj":"SP_7"},{"id":"T116","span":{"begin":35,"end":66},"obj":"PG_10;PR:000003622"},{"id":"T117","span":{"begin":68,"end":72},"obj":"G_3;PG_10;PR:000003622"},{"id":"T118","span":{"begin":84,"end":93},"obj":"GO:0010467"},{"id":"T119","span":{"begin":101,"end":106},"obj":"UBERON:0000948"},{"id":"T120","span":{"begin":138,"end":143},"obj":"UBERON:0000948"},{"id":"T121","span":{"begin":154,"end":158},"obj":"G_3;PG_10;PR:000003622"},{"id":"T122","span":{"begin":211,"end":220},"obj":"GO:0010467"},{"id":"T123","span":{"begin":232,"end":238},"obj":"UBERON:0000062"},{"id":"T124","span":{"begin":264,"end":273},"obj":"UBERON:0001043"},{"id":"T125","span":{"begin":275,"end":281},"obj":"UBERON:0002113"},{"id":"T126","span":{"begin":286,"end":293},"obj":"UBERON:0018707"},{"id":"T127","span":{"begin":327,"end":333},"obj":"UBERON:0000062"},{"id":"T128","span":{"begin":338,"end":348},"obj":"SP_7"},{"id":"T129","span":{"begin":409,"end":420},"obj":"UBERON:0001004"},{"id":"T130","span":{"begin":480,"end":484},"obj":"G_3;PG_10;PR:000003622"},{"id":"T131","span":{"begin":488,"end":493},"obj":"UBERON:0000955"},{"id":"T132","span":{"begin":494,"end":500},"obj":"UBERON:0000479"},{"id":"T133","span":{"begin":548,"end":553},"obj":"UBERON:0000955"},{"id":"T134","span":{"begin":585,"end":593},"obj":"SP_7"}],"text":"The point of entry for SARS-CoV-2, angiotensin-converting enzyme 2 (ACE2) is highly expressed in the heart and upregulated in the failing heart (10), and ACE2 receptor levels have been found to be significantly expressed in various organs in the body, such as the esophagus, kidney and bladder (11). These are potential target organs for SARS-CoV-2 and could explain the observed systemic inflammation beyond respiratory issues. In addition, there is evidence for the presence of ACE2 in brain tissue (12), which could explain some of the observed brain manifestations associated with COVID-19."}