PMC:7417114 / 46886-47620 JSONTXT

{"target":"http://pubannotation.org/docs/sourcedb/PMC/sourceid/7417114","sourcedb":"PMC","sourceid":"7417114","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7417114","text":"Gefitinib (Iressa)\n(AstraZeneca/Tiva) Bioavailability not affected by food;\nslowly absorbed following oral administration; mean bioavailability=60%. Peak plasma levels 3-7 h following dosing;\nVd= 1400 L (IV administration) Metabolized mainly by hepatic CYP3A4 250 mg orally once daily;\n90% binding (AAG, HSA) Associated with increased incidence of interstitial lung disease, which often acts as a precursor to pulmonary fibrosis; approximately 1 percent of patients treated with gefitinib develop pulmonary toxicity, within the first few months of treatment; gefitinib-related interstitial lung disease is generally uncommon (212) (213) (140) (214); shown to exacerbate bleomycin-induced pulmonary fibrosis in preclinical models 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