PMC:7417114 / 27304-27501 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T138","span":{"begin":35,"end":39},"obj":"Body_part"},{"id":"T139","span":{"begin":40,"end":44},"obj":"Body_part"},{"id":"T140","span":{"begin":140,"end":148},"obj":"Body_part"}],"attributes":[{"id":"A138","pred":"fma_id","subj":"T138","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A139","pred":"fma_id","subj":"T139","obj":"http://purl.org/sig/ont/fma/fma7195"},{"id":"A140","pred":"fma_id","subj":"T140","obj":"http://purl.org/sig/ont/fma/fma84050"}],"text":"Osimertinib (Tagrisso)’\n(non-small cell lung cancer; EGFR) EGFR\n(60)** AZ5104, active metabolite of osimertinib, downregulates Th17-related cytokine production via inhibition of SRC-ERK-STAT3\n(127)"}

{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T32","span":{"begin":40,"end":44},"obj":"Body_part"}],"attributes":[{"id":"A32","pred":"uberon_id","subj":"T32","obj":"http://purl.obolibrary.org/obo/UBERON_0002048"}],"text":"Osimertinib (Tagrisso)’\n(non-small cell lung cancer; EGFR) EGFR\n(60)** AZ5104, active metabolite of osimertinib, downregulates Th17-related cytokine production via inhibition of SRC-ERK-STAT3\n(127)"}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T275","span":{"begin":25,"end":51},"obj":"Disease"},{"id":"T276","span":{"begin":29,"end":51},"obj":"Disease"},{"id":"T277","span":{"begin":40,"end":51},"obj":"Disease"},{"id":"T278","span":{"begin":45,"end":51},"obj":"Disease"}],"attributes":[{"id":"A275","pred":"mondo_id","subj":"T275","obj":"http://purl.obolibrary.org/obo/MONDO_0005233"},{"id":"A276","pred":"mondo_id","subj":"T276","obj":"http://purl.obolibrary.org/obo/MONDO_0008433"},{"id":"A277","pred":"mondo_id","subj":"T277","obj":"http://purl.obolibrary.org/obo/MONDO_0008903"},{"id":"A278","pred":"mondo_id","subj":"T278","obj":"http://purl.obolibrary.org/obo/MONDO_0004992"}],"text":"Osimertinib (Tagrisso)’\n(non-small cell lung cancer; EGFR) EGFR\n(60)** AZ5104, active metabolite of osimertinib, downregulates Th17-related cytokine production via inhibition of SRC-ERK-STAT3\n(127)"}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T324","span":{"begin":35,"end":39},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T325","span":{"begin":40,"end":44},"obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"id":"T326","span":{"begin":40,"end":44},"obj":"http://www.ebi.ac.uk/efo/EFO_0000934"},{"id":"T327","span":{"begin":79,"end":85},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T328","span":{"begin":178,"end":181},"obj":"http://purl.obolibrary.org/obo/CLO_0009132"}],"text":"Osimertinib (Tagrisso)’\n(non-small cell lung cancer; EGFR) EGFR\n(60)** AZ5104, active metabolite of osimertinib, downregulates Th17-related cytokine production via inhibition of SRC-ERK-STAT3\n(127)"}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T234","span":{"begin":13,"end":21},"obj":"Chemical"},{"id":"T235","span":{"begin":86,"end":96},"obj":"Chemical"},{"id":"T236","span":{"begin":100,"end":111},"obj":"Chemical"}],"attributes":[{"id":"A234","pred":"chebi_id","subj":"T234","obj":"http://purl.obolibrary.org/obo/CHEBI_90948"},{"id":"A235","pred":"chebi_id","subj":"T235","obj":"http://purl.obolibrary.org/obo/CHEBI_25212"},{"id":"A236","pred":"chebi_id","subj":"T236","obj":"http://purl.obolibrary.org/obo/CHEBI_90943"}],"text":"Osimertinib (Tagrisso)’\n(non-small cell lung cancer; EGFR) EGFR\n(60)** AZ5104, active metabolite of osimertinib, downregulates Th17-related cytokine production via inhibition of SRC-ERK-STAT3\n(127)"}

{"project":"LitCovid-PubTator","denotations":[{"id":"900","span":{"begin":53,"end":57},"obj":"Gene"},{"id":"901","span":{"begin":59,"end":63},"obj":"Gene"},{"id":"902","span":{"begin":182,"end":185},"obj":"Gene"}],"attributes":[{"id":"A900","pred":"tao:has_database_id","subj":"900","obj":"Gene:1956"},{"id":"A901","pred":"tao:has_database_id","subj":"901","obj":"Gene:1956"},{"id":"A902","pred":"tao:has_database_id","subj":"902","obj":"Gene:5594"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Osimertinib (Tagrisso)’\n(non-small cell lung cancer; EGFR) EGFR\n(60)** AZ5104, active metabolite of osimertinib, downregulates Th17-related cytokine production via inhibition of SRC-ERK-STAT3\n(127)"}

{"project":"LitCovid-PD-HP","denotations":[{"id":"T57","span":{"begin":25,"end":51},"obj":"Phenotype"}],"attributes":[{"id":"A57","pred":"hp_id","subj":"T57","obj":"http://purl.obolibrary.org/obo/HP_0030358"}],"text":"Osimertinib (Tagrisso)’\n(non-small cell lung cancer; EGFR) EGFR\n(60)** AZ5104, active metabolite of osimertinib, downregulates Th17-related cytokine production via inhibition of SRC-ERK-STAT3\n(127)"}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T81","span":{"begin":53,"end":57},"obj":"http://purl.obolibrary.org/obo/GO_0005006"},{"id":"T82","span":{"begin":59,"end":63},"obj":"http://purl.obolibrary.org/obo/GO_0005006"},{"id":"T83","span":{"begin":140,"end":159},"obj":"http://purl.obolibrary.org/obo/GO_0001816"}],"text":"Osimertinib (Tagrisso)’\n(non-small cell lung cancer; EGFR) EGFR\n(60)** AZ5104, active metabolite of osimertinib, downregulates Th17-related cytokine production via inhibition of SRC-ERK-STAT3\n(127)"}

{"project":"LitCovid-sentences","denotations":[{"id":"T188","span":{"begin":0,"end":23},"obj":"Sentence"},{"id":"T189","span":{"begin":24,"end":63},"obj":"Sentence"},{"id":"T190","span":{"begin":64,"end":191},"obj":"Sentence"},{"id":"T191","span":{"begin":192,"end":197},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Osimertinib (Tagrisso)’\n(non-small cell lung cancer; EGFR) EGFR\n(60)** AZ5104, active metabolite of osimertinib, downregulates Th17-related cytokine production via inhibition of SRC-ERK-STAT3\n(127)"}

{"project":"2_test","denotations":[{"id":"32778962-24893891-84130629","span":{"begin":65,"end":67},"obj":"24893891"}],"text":"Osimertinib (Tagrisso)’\n(non-small cell lung cancer; EGFR) EGFR\n(60)** AZ5104, active metabolite of osimertinib, downregulates Th17-related cytokine production via inhibition of SRC-ERK-STAT3\n(127)"}

{"project":"LitCovid-PMC-OGER-BB","denotations":[{"id":"T635","span":{"begin":40,"end":44},"obj":"UBERON:0002048"},{"id":"T636","span":{"begin":86,"end":96},"obj":"CHEBI:25212;CHEBI:25212"},{"id":"T637","span":{"begin":100,"end":111},"obj":"CHEBI:25675;CHEBI:25675"},{"id":"T638","span":{"begin":178,"end":181},"obj":"PR:000027234"},{"id":"T639","span":{"begin":186,"end":191},"obj":"PR:000002089"}],"text":"Osimertinib (Tagrisso)’\n(non-small cell lung cancer; EGFR) EGFR\n(60)** AZ5104, active metabolite of osimertinib, downregulates Th17-related cytokine production via inhibition of SRC-ERK-STAT3\n(127)"}