PMC:7417114 / 24462-24673 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T114","span":{"begin":185,"end":193},"obj":"Body_part"}],"attributes":[{"id":"A114","pred":"fma_id","subj":"T114","obj":"http://purl.org/sig/ont/fma/fma84050"}],"text":"Lestaurtinib\n(orphan drug status, acute myeloid leukemia; multi-targeted; FLT3, JAK2, TrkA, TrkB, TrkC) AAK1, AXL, FYN, GAK, JAK1, JAK2, JAK3, RET\nKd KIT (150nM)* Anti-inflammatory and cytokine suppression (107)"}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T194","span":{"begin":34,"end":56},"obj":"Disease"},{"id":"T196","span":{"begin":40,"end":56},"obj":"Disease"},{"id":"T197","span":{"begin":48,"end":56},"obj":"Disease"}],"attributes":[{"id":"A194","pred":"mondo_id","subj":"T194","obj":"http://purl.obolibrary.org/obo/MONDO_0015667"},{"id":"A195","pred":"mondo_id","subj":"T194","obj":"http://purl.obolibrary.org/obo/MONDO_0018874"},{"id":"A196","pred":"mondo_id","subj":"T196","obj":"http://purl.obolibrary.org/obo/MONDO_0004643"},{"id":"A197","pred":"mondo_id","subj":"T197","obj":"http://purl.obolibrary.org/obo/MONDO_0005059"}],"text":"Lestaurtinib\n(orphan drug status, acute myeloid leukemia; multi-targeted; FLT3, JAK2, TrkA, TrkB, TrkC) AAK1, AXL, FYN, GAK, JAK1, JAK2, JAK3, RET\nKd KIT (150nM)* Anti-inflammatory and cytokine suppression (107)"}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T281","span":{"begin":74,"end":78},"obj":"http://purl.obolibrary.org/obo/PR_000002001"},{"id":"T282","span":{"begin":120,"end":123},"obj":"http://purl.obolibrary.org/obo/CLO_0037126"}],"text":"Lestaurtinib\n(orphan drug status, acute myeloid leukemia; multi-targeted; FLT3, JAK2, TrkA, TrkB, TrkC) AAK1, AXL, FYN, GAK, JAK1, JAK2, JAK3, RET\nKd KIT (150nM)* Anti-inflammatory and cytokine suppression (107)"}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T210","span":{"begin":14,"end":25},"obj":"Chemical"},{"id":"T211","span":{"begin":21,"end":25},"obj":"Chemical"}],"attributes":[{"id":"A210","pred":"chebi_id","subj":"T210","obj":"http://purl.obolibrary.org/obo/CHEBI_71031"},{"id":"A211","pred":"chebi_id","subj":"T211","obj":"http://purl.obolibrary.org/obo/CHEBI_23888"}],"text":"Lestaurtinib\n(orphan drug status, acute myeloid leukemia; multi-targeted; FLT3, JAK2, TrkA, TrkB, TrkC) AAK1, AXL, FYN, GAK, JAK1, JAK2, JAK3, RET\nKd KIT (150nM)* Anti-inflammatory and cytokine suppression (107)"}

{"project":"LitCovid-PubTator","denotations":[{"id":"813","span":{"begin":74,"end":78},"obj":"Gene"},{"id":"814","span":{"begin":80,"end":84},"obj":"Gene"},{"id":"815","span":{"begin":86,"end":90},"obj":"Gene"},{"id":"816","span":{"begin":92,"end":96},"obj":"Gene"},{"id":"817","span":{"begin":98,"end":102},"obj":"Gene"},{"id":"818","span":{"begin":104,"end":108},"obj":"Gene"},{"id":"819","span":{"begin":110,"end":113},"obj":"Gene"},{"id":"820","span":{"begin":115,"end":118},"obj":"Gene"},{"id":"821","span":{"begin":120,"end":123},"obj":"Gene"},{"id":"822","span":{"begin":125,"end":129},"obj":"Gene"},{"id":"823","span":{"begin":131,"end":135},"obj":"Gene"},{"id":"824","span":{"begin":137,"end":141},"obj":"Gene"},{"id":"825","span":{"begin":150,"end":153},"obj":"Gene"}],"attributes":[{"id":"A813","pred":"tao:has_database_id","subj":"813","obj":"Gene:2322"},{"id":"A814","pred":"tao:has_database_id","subj":"814","obj":"Gene:3717"},{"id":"A815","pred":"tao:has_database_id","subj":"815","obj":"Gene:4914"},{"id":"A816","pred":"tao:has_database_id","subj":"816","obj":"Gene:4915"},{"id":"A817","pred":"tao:has_database_id","subj":"817","obj":"Gene:4916"},{"id":"A818","pred":"tao:has_database_id","subj":"818","obj":"Gene:22848"},{"id":"A819","pred":"tao:has_database_id","subj":"819","obj":"Gene:558"},{"id":"A820","pred":"tao:has_database_id","subj":"820","obj":"Gene:2534"},{"id":"A821","pred":"tao:has_database_id","subj":"821","obj":"Gene:2580"},{"id":"A822","pred":"tao:has_database_id","subj":"822","obj":"Gene:3716"},{"id":"A823","pred":"tao:has_database_id","subj":"823","obj":"Gene:3717"},{"id":"A824","pred":"tao:has_database_id","subj":"824","obj":"Gene:3718"},{"id":"A825","pred":"tao:has_database_id","subj":"825","obj":"Gene:3815"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Lestaurtinib\n(orphan drug status, acute myeloid leukemia; multi-targeted; FLT3, JAK2, TrkA, TrkB, TrkC) AAK1, AXL, FYN, GAK, JAK1, JAK2, JAK3, RET\nKd KIT (150nM)* Anti-inflammatory and cytokine suppression (107)"}

{"project":"LitCovid-PD-HP","denotations":[{"id":"T31","span":{"begin":34,"end":56},"obj":"Phenotype"}],"attributes":[{"id":"A31","pred":"hp_id","subj":"T31","obj":"http://purl.obolibrary.org/obo/HP_0004808"}],"text":"Lestaurtinib\n(orphan drug status, acute myeloid leukemia; multi-targeted; FLT3, JAK2, TrkA, TrkB, TrkC) AAK1, AXL, FYN, GAK, JAK1, JAK2, JAK3, RET\nKd KIT (150nM)* Anti-inflammatory and cytokine suppression (107)"}

{"project":"LitCovid-sentences","denotations":[{"id":"T148","span":{"begin":0,"end":12},"obj":"Sentence"},{"id":"T149","span":{"begin":13,"end":146},"obj":"Sentence"},{"id":"T150","span":{"begin":147,"end":211},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Lestaurtinib\n(orphan drug status, acute myeloid leukemia; multi-targeted; FLT3, JAK2, TrkA, TrkB, TrkC) AAK1, AXL, FYN, GAK, JAK1, JAK2, JAK3, RET\nKd KIT (150nM)* Anti-inflammatory and cytokine suppression (107)"}

{"project":"LitCovid-PMC-OGER-BB","denotations":[{"id":"T552","span":{"begin":14,"end":20},"obj":"SO:0000910"},{"id":"T553","span":{"begin":21,"end":25},"obj":"CHEBI:71031;CHEBI:71031"},{"id":"T554","span":{"begin":40,"end":47},"obj":"CL:0000763"},{"id":"T555","span":{"begin":74,"end":78},"obj":"PR:000002001"},{"id":"T556","span":{"begin":80,"end":84},"obj":"PR:000009197"},{"id":"T557","span":{"begin":86,"end":90},"obj":"PR:000024112"},{"id":"T558","span":{"begin":92,"end":96},"obj":"PR:000011470"},{"id":"T559","span":{"begin":98,"end":102},"obj":"PR:000011471"},{"id":"T560","span":{"begin":104,"end":108},"obj":"PR:000003526"},{"id":"T561","span":{"begin":120,"end":123},"obj":"PR:000007805"},{"id":"T562","span":{"begin":125,"end":129},"obj":"PR:000009196"},{"id":"T563","span":{"begin":131,"end":135},"obj":"PR:000009197"},{"id":"T564","span":{"begin":137,"end":141},"obj":"PR:000009198"}],"text":"Lestaurtinib\n(orphan drug status, acute myeloid leukemia; multi-targeted; FLT3, JAK2, TrkA, TrkB, TrkC) AAK1, AXL, FYN, GAK, JAK1, JAK2, JAK3, RET\nKd KIT (150nM)* Anti-inflammatory and cytokine suppression (107)"}