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PMC:7417114 / 17404-18941 JSONTXT

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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T85 445-454 Body_part denotes endosomal http://purl.org/sig/ont/fma/fma67180
T86 790-794 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T87 884-888 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T88 1050-1054 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T89 1133-1137 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T141 4-7 Disease denotes ABL http://purl.obolibrary.org/obo/MONDO_0008692
T142 94-102 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T143 182-190 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T144 259-267 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T145 576-584 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T146 746-754 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T147 1309-1317 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T148 1411-1419 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T187 63-64 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T188 202-204 http://purl.obolibrary.org/obo/CLO_0050509 denotes 27
T189 328-333 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T190 455-463 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T191 528-532 http://purl.obolibrary.org/obo/CLO_0053407 denotes ABL2
T192 790-794 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T193 884-894 http://purl.obolibrary.org/obo/CLO_0000031 denotes cell lines
T194 929-936 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T195 938-940 http://purl.obolibrary.org/obo/CLO_0050509 denotes 27
T196 965-972 http://purl.obolibrary.org/obo/UBERON_0000473 denotes testing
T197 1050-1054 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T198 1094-1099 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T199 1121-1129 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T200 1133-1142 http://purl.obolibrary.org/obo/CL_0000000 denotes cell-type
T201 1203-1208 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T202 1266-1267 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T203 1467-1475 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T146 4-18 Chemical denotes ABL inhibitors http://purl.obolibrary.org/obo/CHEBI_76617
T147 4-7 Chemical denotes ABL http://purl.obolibrary.org/obo/CHEBI_30805
T148 8-18 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T149 20-28 Chemical denotes imatinib http://purl.obolibrary.org/obo/CHEBI_45783
T150 33-42 Chemical denotes dasatinib http://purl.obolibrary.org/obo/CHEBI_49375|http://purl.obolibrary.org/obo/CHEBI_70839
T152 75-85 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T153 133-142 Chemical denotes nilotinib http://purl.obolibrary.org/obo/CHEBI_52172
T154 164-173 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T155 242-250 Chemical denotes imatinib http://purl.obolibrary.org/obo/CHEBI_45783
T156 703-711 Chemical denotes imatinib http://purl.obolibrary.org/obo/CHEBI_45783
T157 716-725 Chemical denotes dasatinib http://purl.obolibrary.org/obo/CHEBI_49375|http://purl.obolibrary.org/obo/CHEBI_70839
T159 861-865 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T160 1078-1082 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T161 1111-1120 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T162 1291-1299 Chemical denotes imatinib http://purl.obolibrary.org/obo/CHEBI_45783
T163 1358-1363 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T164 1457-1466 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
461 4-7 Gene denotes ABL Gene:25
462 528-532 Gene denotes ABL2 Gene:27
463 546-550 Gene denotes ABL1 Gene:25
464 94-102 Species denotes SARS-CoV Tax:694009
465 107-115 Species denotes MERS-CoV Tax:1335626
466 182-190 Species denotes SARS-CoV Tax:694009
467 259-267 Species denotes SARS-CoV Tax:694009
468 272-280 Species denotes MERS-CoV Tax:1335626
469 417-428 Species denotes coronavirus Tax:694448
470 576-584 Species denotes SARS-CoV Tax:694009
471 589-597 Species denotes MERS-CoV Tax:1335626
472 746-754 Species denotes SARS-CoV Tax:694009
473 759-767 Species denotes MERS-CoV Tax:1335626
474 1309-1319 Species denotes SARS-CoV-2 Tax:2697049
475 1411-1419 Species denotes SARS-CoV Tax:694009
476 1424-1432 Species denotes MERS-CoV Tax:1335626
477 20-28 Chemical denotes imatinib MESH:D000068877
478 33-42 Chemical denotes dasatinib MESH:D000069439
479 133-142 Chemical denotes nilotinib MESH:C498826
480 242-250 Chemical denotes imatinib MESH:D000068877
481 703-711 Chemical denotes imatinib MESH:D000068877
482 716-725 Chemical denotes dasatinib MESH:D000069439
483 1291-1299 Chemical denotes imatinib MESH:D000068877

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T27 861-876 Phenotype denotes drug resistance http://purl.obolibrary.org/obo/HP_0020174

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T50 350-381 http://purl.obolibrary.org/obo/GO_1903901 denotes inhibition of viral replication
T51 364-381 http://purl.obolibrary.org/obo/GO_0019079 denotes viral replication
T52 364-381 http://purl.obolibrary.org/obo/GO_0019058 denotes viral replication
T53 861-876 http://purl.obolibrary.org/obo/GO_0042493 denotes drug resistance

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T106 0-206 Sentence denotes The ABL inhibitors, imatinib and dasatinib, were identified in a screen as inhibitors of both SARS-CoV and MERS-CoV replication, and nilotinib was identified as an inhibitor of only SARS-CoV, in vitro (27).
T107 207-474 Sentence denotes Investigation of the mechanism for imatinib against SARS-CoV and MERS-CoV revealed inhibition of the early stages of the virus life cycle, and inhibition of viral replication through blocking the fusion of the coronavirus virion with the endosomal membrane (28) (29).
T108 475-630 Sentence denotes Importantly, authors show that targeted knockdown of ABL2, however not ABL1, significantly inhibited SARS-CoV and MERS-CoV replication/entry in vitro (29).
T109 631-1017 Sentence denotes The relatively high, albeit minimally toxic, μM range concentrations of imatinib and dasatinib required to inhibit SARS-CoV and MERS-CoV in the aforementioned cell-based studies may be attributable to experimental factors such as drug resistance of the cell lines used as tools for propagating the viruses (27) (29), and thus in vivo testing would be needed to determine optimal dosing.
T110 1018-1224 Sentence denotes It is worth noting that in many cell-based assays measuring drug effects on virus titer, the antiviral activity is cell-type dependent, and there is also variability depending on which virus strain is used.
T111 1225-1537 Sentence denotes Recent, unpublished results, reported as a preprint, suggest that imatinib inhibits SARS-CoV-2 in vitro, among 17 other FDA-approved drugs with IC50 values similar to those observed for SARS-CoV and MERS-CoV; concentrations showing antiviral activity were not cytotoxic (BioRxiv, 2020, 10.1101/2020.03.25.008482)

2_test

Id Subject Object Predicate Lexical cue
32778962-24841273-84130550 202-204 24841273 denotes 27
32778962-29557770-84130551 465-467 29557770 denotes 28
32778962-27466418-84130552 470-472 27466418 denotes 29
32778962-27466418-84130553 626-628 27466418 denotes 29
32778962-24841273-84130554 938-940 24841273 denotes 27
32778962-27466418-84130555 943-945 27466418 denotes 29

LitCovid-PMC-OGER-BB

Id Subject Object Predicate Lexical cue
T369 8-18 CHEBI:35222;CHEBI:35222 denotes inhibitors
T370 20-28 CHEBI:45783;CHEBI:45783 denotes imatinib
T371 33-42 CHEBI:5291;CHEBI:5291 denotes dasatinib
T372 75-85 CHEBI:35222;CHEBI:35222 denotes inhibitors
T373 94-102 SP_10 denotes SARS-CoV
T374 107-115 SP_9 denotes MERS-CoV
T375 116-127 GO:0006260 denotes replication
T376 164-173 CHEBI:35222;CHEBI:35222 denotes inhibitor
T377 182-190 SP_10 denotes SARS-CoV
T378 242-250 CHEBI:14434;CHEBI:14434 denotes imatinib
T379 259-267 SP_10 denotes SARS-CoV
T380 272-280 SP_9 denotes MERS-CoV
T381 328-333 NCBITaxon:10239 denotes virus
T382 334-338 UBERON:0000104 denotes life
T383 364-369 NCBITaxon:10239 denotes viral
T384 370-381 GO:0006260 denotes replication
T385 403-412 GO:0061025 denotes fusion of
T386 417-428 NCBITaxon:11118 denotes coronavirus
T387 445-463 GO:0010008 denotes endosomal membrane
T388 528-532 PR:000003583 denotes ABL2
T389 546-550 PR:000003582 denotes ABL1
T390 576-584 SP_10 denotes SARS-CoV
T391 589-597 SP_9 denotes MERS-CoV
T392 598-609 GO:0006260 denotes replication
T393 703-711 CHEBI:45783;CHEBI:45783 denotes imatinib
T394 716-725 CHEBI:5291;CHEBI:5291 denotes dasatinib
T395 746-754 SP_10 denotes SARS-CoV
T396 759-767 SP_9 denotes MERS-CoV
T397 861-865 CHEBI:23888;CHEBI:23888 denotes drug
T398 929-936 NCBITaxon:10239 denotes viruses
T399 1078-1082 CHEBI:23888;CHEBI:23888 denotes drug
T400 1094-1099 NCBITaxon:10239 denotes virus
T401 1203-1208 NCBITaxon:10239 denotes virus
T402 1291-1299 CHEBI:45783;CHEBI:45783 denotes imatinib
T403 1309-1319 SP_7 denotes SARS-CoV-2
T404 1358-1363 CHEBI:23888;CHEBI:23888 denotes drugs
T405 1411-1419 SP_10 denotes SARS-CoV
T406 1424-1432 SP_9 denotes MERS-CoV