PMC:7408073 / 98242-98592 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T512","span":{"begin":204,"end":209},"obj":"Body_part"}],"attributes":[{"id":"A512","pred":"fma_id","subj":"T512","obj":"http://purl.org/sig/ont/fma/fma68877"}],"text":"s C16, GL1001 or ORE1001, [113]) for the following reasons:(1) It has been shown to bind/inhibit ACE2 enzymatic activity even at low/acidic pH (pH 6.5, [115]) typical of hypercapnia (as it might occur in lungs of COVID-19 patients) when human ACE2 activity is maximal [79]; nevertheless, it retains its inhibitory effects on soluble ACE2 bound to spi"}

{"project":"LitCovid-PubTator","denotations":[{"id":"3437","span":{"begin":97,"end":101},"obj":"Gene"},{"id":"3438","span":{"begin":243,"end":247},"obj":"Gene"},{"id":"3439","span":{"begin":333,"end":337},"obj":"Gene"},{"id":"3443","span":{"begin":222,"end":230},"obj":"Species"},{"id":"3444","span":{"begin":237,"end":242},"obj":"Species"},{"id":"3446","span":{"begin":170,"end":181},"obj":"Disease"},{"id":"3447","span":{"begin":213,"end":221},"obj":"Disease"}],"attributes":[{"id":"A3437","pred":"tao:has_database_id","subj":"3437","obj":"Gene:59272"},{"id":"A3438","pred":"tao:has_database_id","subj":"3438","obj":"Gene:59272"},{"id":"A3439","pred":"tao:has_database_id","subj":"3439","obj":"Gene:59272"},{"id":"A3443","pred":"tao:has_database_id","subj":"3443","obj":"Tax:9606"},{"id":"A3444","pred":"tao:has_database_id","subj":"3444","obj":"Tax:9606"},{"id":"A3446","pred":"tao:has_database_id","subj":"3446","obj":"MESH:D006935"},{"id":"A3447","pred":"tao:has_database_id","subj":"3447","obj":"MESH:C000657245"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"s C16, GL1001 or ORE1001, [113]) for the following reasons:(1) It has been shown to bind/inhibit ACE2 enzymatic activity even at low/acidic pH (pH 6.5, [115]) typical of hypercapnia (as it might occur in lungs of COVID-19 patients) when human ACE2 activity is maximal [79]; nevertheless, it retains its inhibitory effects on soluble ACE2 bound to spi"}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T549","span":{"begin":213,"end":221},"obj":"Disease"}],"attributes":[{"id":"A549","pred":"mondo_id","subj":"T549","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"}],"text":"s C16, GL1001 or ORE1001, [113]) for the following reasons:(1) It has been shown to bind/inhibit ACE2 enzymatic activity even at low/acidic pH (pH 6.5, [115]) typical of hypercapnia (as it might occur in lungs of COVID-19 patients) when human ACE2 activity is maximal [79]; nevertheless, it retains its inhibitory effects on soluble ACE2 bound to spi"}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T1199","span":{"begin":2,"end":5},"obj":"http://purl.obolibrary.org/obo/CLO_0002096"},{"id":"T1200","span":{"begin":66,"end":69},"obj":"http://purl.obolibrary.org/obo/CLO_0051582"},{"id":"T1201","span":{"begin":112,"end":120},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T1202","span":{"begin":204,"end":209},"obj":"http://www.ebi.ac.uk/efo/EFO_0000934"},{"id":"T1203","span":{"begin":237,"end":242},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9606"},{"id":"T1204","span":{"begin":248,"end":256},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"}],"text":"s C16, GL1001 or ORE1001, [113]) for the following reasons:(1) It has been shown to bind/inhibit ACE2 enzymatic activity even at low/acidic pH (pH 6.5, [115]) typical of hypercapnia (as it might occur in lungs of COVID-19 patients) when human ACE2 activity is maximal [79]; nevertheless, it retains its inhibitory effects on soluble ACE2 bound to spi"}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T82941","span":{"begin":2,"end":5},"obj":"Chemical"}],"attributes":[{"id":"A7128","pred":"chebi_id","subj":"T82941","obj":"http://purl.obolibrary.org/obo/CHEBI_15756"}],"text":"s C16, GL1001 or ORE1001, [113]) for the following reasons:(1) It has been shown to bind/inhibit ACE2 enzymatic activity even at low/acidic pH (pH 6.5, [115]) typical of hypercapnia (as it might occur in lungs of COVID-19 patients) when human ACE2 activity is maximal [79]; nevertheless, it retains its inhibitory effects on soluble ACE2 bound to spi"}

{"project":"LitCovid-PD-HP","denotations":[{"id":"T161","span":{"begin":170,"end":181},"obj":"Phenotype"}],"attributes":[{"id":"A161","pred":"hp_id","subj":"T161","obj":"http://purl.obolibrary.org/obo/HP_0012416"}],"text":"s C16, GL1001 or ORE1001, [113]) for the following reasons:(1) It has been shown to bind/inhibit ACE2 enzymatic activity even at low/acidic pH (pH 6.5, [115]) typical of hypercapnia (as it might occur in lungs of COVID-19 patients) when human ACE2 activity is maximal [79]; nevertheless, it retains its inhibitory effects on soluble ACE2 bound to spi"}

{"project":"2_test","denotations":[{"id":"32708755-12358520-20679021","span":{"begin":27,"end":30},"obj":"12358520"},{"id":"32708755-22777933-20679022","span":{"begin":153,"end":156},"obj":"22777933"}],"text":"s C16, GL1001 or ORE1001, [113]) for the following reasons:(1) It has been shown to bind/inhibit ACE2 enzymatic activity even at low/acidic pH (pH 6.5, [115]) typical of hypercapnia (as it might occur in lungs of COVID-19 patients) when human ACE2 activity is maximal [79]; nevertheless, it retains its inhibitory effects on soluble ACE2 bound to spi"}