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PMC:7408073 / 98033-103319 JSONTXT

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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T1 2091-2106 Body_part denotes digestive tract http://purl.org/sig/ont/fma/fma317863
T2 2135-2140 Body_part denotes bowel http://purl.org/sig/ont/fma/fma7199
T3 2596-2601 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670
T4 2652-2660 Body_part denotes capsules http://purl.org/sig/ont/fma/fma85272
T5 2796-2804 Body_part denotes capsules http://purl.org/sig/ont/fma/fma85272
T6 3029-3033 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T7 3190-3194 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T8 3262-3279 Body_part denotes respiratory tract http://purl.org/sig/ont/fma/fma265130
T9 4285-4289 Body_part denotes face http://purl.org/sig/ont/fma/fma24728
T10 4323-4327 Body_part denotes hand http://purl.org/sig/ont/fma/fma9712
T11 4707-4712 Body_part denotes heart http://purl.org/sig/ont/fma/fma7088
T12 4713-4717 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T13 4718-4723 Body_part denotes liver http://purl.org/sig/ont/fma/fma7197
T14 4724-4733 Body_part denotes intestine http://purl.org/sig/ont/fma/fma7199
T15 4734-4740 Body_part denotes kidney http://purl.org/sig/ont/fma/fma7203
T16 4741-4754 Body_part denotes immune system http://purl.org/sig/ont/fma/fma9825
T17 4755-4760 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670
T18 4902-4907 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670
T19 4998-5004 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T20 5149-5153 Body_part denotes face http://purl.org/sig/ont/fma/fma24728
T512 413-418 Body_part denotes lungs http://purl.org/sig/ont/fma/fma68877
T513 562-570 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T514 1497-1504 Body_part denotes insulin http://purl.org/sig/ont/fma/fma83365

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T195 2091-2106 Body_part denotes digestive tract http://purl.obolibrary.org/obo/UBERON_0001555
T196 2596-2601 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T197 3029-3033 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T198 3190-3194 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T199 3262-3279 Body_part denotes respiratory tract http://purl.obolibrary.org/obo/UBERON_0000065
T200 3792-3795 Body_part denotes RAS http://purl.obolibrary.org/obo/UBERON_0018229
T201 4285-4289 Body_part denotes face http://purl.obolibrary.org/obo/UBERON_0001456
T202 4323-4327 Body_part denotes hand http://purl.obolibrary.org/obo/UBERON_0002398
T203 4707-4712 Body_part denotes heart http://purl.obolibrary.org/obo/UBERON_0000948
T204 4713-4717 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T205 4718-4723 Body_part denotes liver http://purl.obolibrary.org/obo/UBERON_0002107
T206 4724-4733 Body_part denotes intestine http://purl.obolibrary.org/obo/UBERON_0000160
T207 4734-4740 Body_part denotes kidney http://purl.obolibrary.org/obo/UBERON_0002113
T208 4741-4754 Body_part denotes immune system http://purl.obolibrary.org/obo/UBERON_0002405
T209 4755-4760 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T210 4902-4907 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T211 5149-5153 Body_part denotes face http://purl.obolibrary.org/obo/UBERON_0001456

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
3424 19-23 Gene denotes ACE2 Gene:59272
3425 25-28 Gene denotes MLN Gene:4295
3437 306-310 Gene denotes ACE2 Gene:59272
3438 452-456 Gene denotes ACE2 Gene:59272
3439 542-546 Gene denotes ACE2 Gene:59272
3440 624-628 Gene denotes ACE2 Gene:59272
3441 649-653 Gene denotes ACE2 Gene:59272
3442 556-561 Gene denotes spike Gene:43740568
3443 431-439 Species denotes patients Tax:9606
3444 446-451 Species denotes human Tax:9606
3445 665-675 Species denotes SARS-CoV-2 Tax:2697049
3446 379-390 Disease denotes hypercapnia MESH:D006935
3447 422-430 Disease denotes COVID-19 MESH:C000657245
3451 826-830 Gene denotes ACE2 Gene:59272
3452 930-934 Gene denotes ACE2 Gene:59272
3453 1034-1040 Species denotes humans Tax:9606
3457 1288-1292 Gene denotes ACE2 Gene:59272
3458 1497-1504 Gene denotes insulin Gene:3630
3459 1398-1403 Chemical denotes water MESH:D014867
3466 1658-1662 Gene denotes ACE2 Gene:59272
3467 1621-1634 Chemical denotes disodium salt
3468 1822-1852 Chemical denotes 2-hydroxypropyl-β-cyclodextrin MESH:D000073738
3469 1854-1859 Chemical denotes HPBDC
3470 1865-1868 Chemical denotes H2O
3471 1897-1903 Chemical denotes GL1001 MESH:C486469
3477 2216-2220 Gene denotes ACE2 Gene:59272
3478 1992-1995 Gene denotes MLN Gene:4295
3479 1970-1976 Species denotes humans Tax:9606
3480 2122-2148 Disease denotes Inflammatory bowel disease MESH:D015212
3481 2150-2171 Disease denotes gastritis and colitis MESH:D005756
3490 3170-3174 Gene denotes ACE2 Gene:59272
3491 3395-3398 Gene denotes MLN Gene:4295
3492 2942-2945 Gene denotes MLN Gene:69563
3493 3043-3047 Species denotes mice Tax:10090
3494 3051-3062 Species denotes Pseudomonas Tax:287
3495 3029-3042 Disease denotes lung-infected MESH:D012141
3496 3190-3207 Disease denotes lung inflammation MESH:D011014
3497 3382-3390 Disease denotes toxicity MESH:D064420
3499 1186-1192 Species denotes humans Tax:9606
3504 181-185 Gene denotes ACE2 Gene:59272
3505 162-165 Gene denotes MLN Gene:4295
3506 88-96 Species denotes patients Tax:9606
3507 79-87 Disease denotes COVID-19 MESH:C000657245
3528 3876-3879 Gene denotes ACE Gene:59272
3529 3880-3884 Gene denotes ACE2 Gene:59272
3530 3904-3907 Gene denotes ACE Gene:59272
3531 3966-3970 Gene denotes ACE2 Gene:59272
3532 4650-4654 Gene denotes ACE2 Gene:59272
3533 4815-4819 Gene denotes ACE2 Gene:59272
3534 5060-5064 Gene denotes ACE2 Gene:59272
3535 4458-4461 Gene denotes MLN Gene:4295
3536 4146-4149 Gene denotes MLN Gene:4295
3537 3475-3478 Gene denotes MLN Gene:4295
3538 3659-3667 Species denotes patients Tax:9606
3539 4084-4092 Species denotes patients Tax:9606
3540 4621-4629 Species denotes patients Tax:9606
3541 4880-4888 Species denotes patients Tax:9606
3542 4992-4997 Species denotes human Tax:9606
3543 5101-5109 Species denotes patients Tax:9606
3544 5268-5275 Species denotes patient Tax:9606
3545 3755-3773 Disease denotes hypoxic conditions MESH:D000071069
3546 4075-4083 Disease denotes COVID-19 MESH:C000657245
3547 4871-4879 Disease denotes COVID-19 MESH:C000657245

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T548 79-87 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T549 422-430 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T550 665-673 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T551 665-669 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T552 1259-1262 Disease denotes DLM http://purl.obolibrary.org/obo/MONDO_0016745
T553 1440-1447 Disease denotes sterile http://purl.obolibrary.org/obo/MONDO_0005047
T554 1612-1615 Disease denotes DLM http://purl.obolibrary.org/obo/MONDO_0016745
T555 2107-2120 Disease denotes inflammations http://purl.obolibrary.org/obo/MONDO_0021166
T556 2122-2148 Disease denotes Inflammatory bowel disease http://purl.obolibrary.org/obo/MONDO_0005265
T557 2150-2159 Disease denotes gastritis http://purl.obolibrary.org/obo/MONDO_0004966
T558 2164-2171 Disease denotes colitis http://purl.obolibrary.org/obo/MONDO_0005292
T559 3195-3207 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T560 3286-3290 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T561 4075-4083 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T562 4871-4879 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T1 1970-1976 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes humans
T2 2026-2032 http://purl.obolibrary.org/obo/UBERON_0000473 denotes tested
T3 2091-2106 http://purl.obolibrary.org/obo/UBERON_0001555 denotes digestive tract
T4 2225-2226 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T5 2244-2251 http://purl.obolibrary.org/obo/UBERON_0000473 denotes testing
T6 2596-2601 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T7 2596-2601 http://www.ebi.ac.uk/efo/EFO_0000296 denotes blood
T8 2778-2784 http://purl.obolibrary.org/obo/CLO_0001658 denotes active
T9 2818-2819 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T10 3029-3033 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T11 3029-3033 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T12 3063-3071 http://purl.obolibrary.org/obo/NCBITaxon_2 denotes bacteria
T13 3190-3194 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T14 3190-3194 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T15 3671-3672 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T16 3780-3784 http://www.ebi.ac.uk/efo/EFO_0001410 denotes arms
T17 3827-3828 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T18 3981-3989 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T19 4260-4268 http://purl.obolibrary.org/obo/CLO_0001658 denotes actively
T20 4285-4289 http://purl.obolibrary.org/obo/UBERON_0001456 denotes face
T21 4405-4407 http://purl.obolibrary.org/obo/CLO_0050475 denotes my
T22 4639-4640 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T23 4707-4712 http://purl.obolibrary.org/obo/UBERON_0000948 denotes heart
T24 4707-4712 http://purl.obolibrary.org/obo/UBERON_0007100 denotes heart
T25 4707-4712 http://purl.obolibrary.org/obo/UBERON_0015228 denotes heart
T26 4707-4712 http://www.ebi.ac.uk/efo/EFO_0000815 denotes heart
T27 4713-4717 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T28 4713-4717 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T29 4718-4723 http://purl.obolibrary.org/obo/UBERON_0002107 denotes liver
T30 4718-4723 http://www.ebi.ac.uk/efo/EFO_0000887 denotes liver
T31 4724-4733 http://purl.obolibrary.org/obo/UBERON_0000160 denotes intestine
T32 4724-4733 http://www.ebi.ac.uk/efo/EFO_0000834 denotes intestine
T33 4734-4740 http://purl.obolibrary.org/obo/UBERON_0002113 denotes kidney
T34 4734-4740 http://www.ebi.ac.uk/efo/EFO_0000927 denotes kidney
T35 4734-4740 http://www.ebi.ac.uk/efo/EFO_0000929 denotes kidney
T36 4741-4754 http://purl.obolibrary.org/obo/UBERON_0002405 denotes immune system
T37 4755-4760 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T38 4755-4760 http://www.ebi.ac.uk/efo/EFO_0000296 denotes blood
T39 4902-4907 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T40 4902-4907 http://www.ebi.ac.uk/efo/EFO_0000296 denotes blood
T41 4933-4941 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T42 4980-4988 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T43 4992-4997 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T44 4998-5004 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T45 5043-5046 http://purl.obolibrary.org/obo/CLO_0001046 denotes 116
T46 5065-5075 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T47 5130-5138 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T48 5149-5153 http://purl.obolibrary.org/obo/UBERON_0001456 denotes face
T49 5197-5198 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T1199 211-214 http://purl.obolibrary.org/obo/CLO_0002096 denotes C16
T1200 275-278 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T1201 321-329 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T1202 413-418 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lungs
T1203 446-451 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T1204 457-465 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T1205 629-637 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T1206 692-694 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T1207 831-841 http://purl.obolibrary.org/obo/CLO_0001658 denotes activators
T1208 866-876 http://purl.obolibrary.org/obo/CLO_0001658 denotes activating
T1209 935-943 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T1210 1006-1007 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T1211 1034-1040 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes humans
T1212 1186-1192 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes humans
T1213 1209-1210 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T1214 1254-1258 http://purl.obolibrary.org/obo/CLO_0002096 denotes C-16
T1215 1293-1303 http://purl.obolibrary.org/obo/CLO_0001658 denotes activating
T1216 1367-1368 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T1217 1408-1409 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T1218 1459-1460 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T1219 1488-1489 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T1220 1497-1504 http://purl.obolibrary.org/obo/PR_000009054 denotes insulin
T1221 1546-1547 http://purl.obolibrary.org/obo/CLO_0001021 denotes b
T1222 1663-1673 http://purl.obolibrary.org/obo/CLO_0001658 denotes activating
T1223 1750-1751 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T1224 1777-1778 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T1225 1798-1799 http://purl.obolibrary.org/obo/CLO_0001020 denotes a

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T445 153-161 Chemical denotes molecule http://purl.obolibrary.org/obo/CHEBI_25367
T21827 181-195 Chemical denotes ACE2 inhibitor http://purl.obolibrary.org/obo/CHEBI_147289
T447 186-195 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T82941 211-214 Chemical denotes C16 http://purl.obolibrary.org/obo/CHEBI_15756
T449 562-570 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T63759 1398-1403 Chemical denotes water http://purl.obolibrary.org/obo/CHEBI_15377
T53319 1410-1418 Chemical denotes solution http://purl.obolibrary.org/obo/CHEBI_75958
T52282 1461-1469 Chemical denotes solution http://purl.obolibrary.org/obo/CHEBI_75958
T57829 1497-1504 Chemical denotes insulin http://purl.obolibrary.org/obo/CHEBI_145810
T12810 1630-1634 Chemical denotes salt http://purl.obolibrary.org/obo/CHEBI_24866|http://purl.obolibrary.org/obo/CHEBI_26710
T39693 1808-1816 Chemical denotes solution http://purl.obolibrary.org/obo/CHEBI_75958
T31089 1840-1852 Chemical denotes cyclodextrin http://purl.obolibrary.org/obo/CHEBI_23456
T9 1865-1868 Chemical denotes H2O http://purl.obolibrary.org/obo/CHEBI_15377
T3495 2057-2071 Chemical denotes pharmaceutical http://purl.obolibrary.org/obo/CHEBI_52217
T11 2317-2321 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T72202 2785-2789 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T58611 3159-3168 Chemical denotes molecules http://purl.obolibrary.org/obo/CHEBI_25367
T57445 3792-3795 Chemical denotes RAS http://purl.obolibrary.org/obo/CHEBI_63620
T42648 4250-4258 Chemical denotes molecule http://purl.obolibrary.org/obo/CHEBI_25367
T66997 4333-4337 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T55490 5032-5041 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T1 2107-2120 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammations
T2 3195-3207 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T3 4755-4772 http://purl.obolibrary.org/obo/GO_0007596 denotes blood/coagulation
T4 4761-4772 http://purl.obolibrary.org/obo/GO_0050817 denotes coagulation

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T475 0-4 Sentence denotes 8.1.
T476 5-33 Sentence denotes Inhibition of ACE2: MLN-4760
T477 34-705 Sentence denotes Briefly, one of the best candidates to treat COVID-19 patients, but not to prevent viral entry, is the small synthetic molecule MLN-4760 (specific ACE2 inhibitor, also known as C16, GL1001 or ORE1001, [113]) for the following reasons:(1) It has been shown to bind/inhibit ACE2 enzymatic activity even at low/acidic pH (pH 6.5, [115]) typical of hypercapnia (as it might occur in lungs of COVID-19 patients) when human ACE2 activity is maximal [79]; nevertheless, it retains its inhibitory effects on soluble ACE2 bound to spike proteins [24], indicating that it is able to bind and inhibit ACE2 activity regardless ACE2 binding to SARS-CoV-2 particles or to S1 fragments.
T478 706-1110 Sentence denotes (2) No significant adverse effects were described upon its chronic administration neither alone nor in combination with ACE2 activators (while inhibiting their activating effects) nor after inducing functional impairment of ACE2 activity in rodent experiments in vivo [52,117,118,122,183,184] nor in a clinical Phase I trial in humans (http://oreholdings.com/wp-content/uploads/2013/06/09.10.09-425.pdf);
T479 1111-1193 Sentence denotes (3) Its administration by different route is well described in rodents and humans.
T480 1194-1544 Sentence denotes In particular:(a) Chronic administration (about 4 weeks) of C-16/DLM-4760 in combination with ACE2 activating treatments was performed by daily intraperitoneal injection at a dose of 25mg/kg in distilled water (as a solution of 42 mg/mL) or 0.9% sterile saline (as a solution of 84 mg/mL using a 0.5-mL insulin syringe) freshly prepared [52,183,184].
T481 1545-1876 Sentence denotes (b) Alternatively, chronic administration (about 8 days) of GL1001/DLM-4760 disodium salt in combination with an ACE2 activating treatment was performed by subcutaneous injection (5mL/kg) containing up to a dose of 300 mg/kg, twice a day, formulated in a vehicle solution [15% 2-hydroxypropyl-β-cyclodextrin (HPBDC)/85% H2O] [122].
T482 1877-1962 Sentence denotes Subchronic doses of GL1001 indicate no adverse effects up to 1,000 mg/kg (see [122]).
T483 1963-2052 Sentence denotes (c) In humans ORE1001/GL1001/MLN-4760 was already proposed and tested in clinical trials.
T484 2053-2221 Sentence denotes Its pharmaceutical indication was for digestive tract inflammations (Inflammatory bowel disease, gastritis and colitis) that are correlated with overexpression of ACE2.
T485 2222-2298 Sentence denotes In a Phase I clinical testing up 14 days dosing, ORE1001 was well tolerated.
T486 2299-2383 Sentence denotes Subjects received drug (dosing up to 2100 mg) with no side adverse effects reported.
T487 2384-2521 Sentence denotes In particular, 47 subjects received single-dose from 2.1 to 2100 mg and 24 subjects received 14 day multiple doses from 50 mg to 1800 mg.
T488 2522-2611 Sentence denotes All doses were well tolerated, with no significant side effects including blood pressure.
T489 2612-2769 Sentence denotes Pharmacokinetics of orally administered capsules was consistent with once-daily dosing. (http://oreholdings.com/wp-content/uploads/2013/06/09.10.09-425.pdf).
T490 2770-2928 Sentence denotes 300 mg (active drug) oral capsules were used in a Phase Ib/IIa clinical trial that was, however, abandoned. (https://clinicaltrials.gov/ct2/show/NCT01039597).
T491 2929-3078 Sentence denotes (d) Finally, MLN-4760 was also administered (2.5 mg/kg per day) by nasal inhalation for 2–3 days in lung-infected mice by Pseudomonas bacteria [185].
T492 3079-3220 Sentence denotes Interestingly, the report underscores the role played by local concentration of molecules (ACE2) in modulating lung inflammation and disease.
T493 3221-3454 Sentence denotes For these reasons, in diseases involving respiratory tract, like SARS, inhalation treatment is preferable, even for the lower concentration (and hopefully lower toxicity) of MLN-4760 needed for this route of treatment administration.
T494 3455-3570 Sentence denotes Different routes of MLN-4760 treatment administration can be pursued depending on the hospital condition/expertise.
T495 3571-3733 Sentence denotes In this exceptionally critical situation, it could be delivered to critical untreatable patients as a controlled “compassionate use”, in particular by inhalation.
T496 3734-3933 Sentence denotes However, when, under hypoxic conditions, both arms of the RAS are upregulated, it might have a limited action and, by shifting the balance of ACE/ACE2 ratio in favour of ACE, might be even dangerous.
T497 3934-4145 Sentence denotes Instead, specific inhibition of ACE2 enzymatic activity might effectively work in preventing the establishment of positive feedback loops in COVID-19 patients who are suffering from mild symptoms of the disease.
T498 4146-4309 Sentence denotes MLN-4760 is sold by different companies, that, in case it works, could be encouraged to manufacture the molecule, actively contributing to face this global threat.
T499 4310-4457 Sentence denotes On the other hand, the drug could be also synthesized in University chemistry labs because, to my knowledge, is no longer under patent restriction.
T500 4458-4889 Sentence denotes MLN-4760, whose clinical development was abandoned after phase I trials (clinical name, ORE1001), is actually an interesting compound that could be useful for all patients in which a specific ACE2 upregulation is proven and associated to different (heart/lung/liver/intestine/kidney/immune system/blood/coagulation, etc.) pathological conditions related to ACE2 pathway downstream events, as it seems to occur in COVID-19 patients.
T501 4890-5286 Sentence denotes Although in blood of normal subjects sACE2 activity is undetectable because its catalytic activity in human plasma is masked by an endogenous inhibitor [116] and chronic ACE2 activation may be deleterious, some patients might need of sACE2 activity to better face an acute pathological condition, therefore a careful monitoring of clinical parameters should be performed during patient treatment.

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T161 379-390 Phenotype denotes hypercapnia http://purl.obolibrary.org/obo/HP_0012416
T162 2122-2148 Phenotype denotes Inflammatory bowel disease http://purl.obolibrary.org/obo/HP_0002037
T163 2150-2159 Phenotype denotes gastritis http://purl.obolibrary.org/obo/HP_0005263
T164 2164-2171 Phenotype denotes colitis http://purl.obolibrary.org/obo/HP_0002583

2_test

Id Subject Object Predicate Lexical cue
32708755-12358520-20679021 236-239 12358520 denotes 113
32708755-22777933-20679022 362-365 22777933 denotes 115
32708755-15791205-20679023 572-574 15791205 denotes 24
32708755-20797602-20679024 975-977 20797602 denotes 52
32708755-18235039-20679025 978-981 18235039 denotes 117
32708755-20300067-20679026 982-985 20300067 denotes 118
32708755-19517214-20679027 986-989 19517214 denotes 122
32708755-23370913-20679028 990-993 23370913 denotes 183
32708755-31982938-20679029 994-997 31982938 denotes 184
32708755-20797602-20679030 1532-1534 20797602 denotes 52
32708755-23370913-20679031 1535-1538 23370913 denotes 183
32708755-31982938-20679032 1539-1542 31982938 denotes 184
32708755-19517214-20679033 1871-1874 19517214 denotes 122
32708755-19517214-20679034 1956-1959 19517214 denotes 122
32708755-31645418-20679035 3073-3076 31645418 denotes 185
32708755-18223027-20679036 5043-5046 18223027 denotes 116