PMC:7408073 / 97540-98031 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7408073","sourcedb":"PMC","sourceid":"7408073","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7408073","text":"Here, I have focused my attention on inhibitors of human ACE2 pathway that were consistently administered in vivo. Making use of published reports in which human/rodent ACE2 pathway inhibitors were administered in vivo, I have hypothesized a possible therapeutic pharmacological intervention through an inhibition strategy of the RAS pathways for COVID-19 in patients experiencing both mild and critical, advanced and untreatable stages of the disease (the most problematic cases to manage).","tracks":[{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T194","span":{"begin":330,"end":333},"obj":"Body_part"}],"attributes":[{"id":"A194","pred":"uberon_id","subj":"T194","obj":"http://purl.obolibrary.org/obo/UBERON_0018229"},{"subj":"T194","pred":"source","obj":"LitCovid-PD-UBERON"}]},{"project":"LitCovid-PubTator","denotations":[{"id":"3416","span":{"begin":57,"end":61},"obj":"Gene"},{"id":"3417","span":{"begin":169,"end":173},"obj":"Gene"},{"id":"3418","span":{"begin":51,"end":56},"obj":"Species"},{"id":"3419","span":{"begin":156,"end":161},"obj":"Species"},{"id":"3420","span":{"begin":359,"end":367},"obj":"Species"},{"id":"3421","span":{"begin":347,"end":355},"obj":"Disease"}],"attributes":[{"id":"A3416","pred":"tao:has_database_id","subj":"3416","obj":"Gene:59272"},{"id":"A3417","pred":"tao:has_database_id","subj":"3417","obj":"Gene:59272"},{"id":"A3418","pred":"tao:has_database_id","subj":"3418","obj":"Tax:9606"},{"id":"A3419","pred":"tao:has_database_id","subj":"3419","obj":"Tax:9606"},{"id":"A3420","pred":"tao:has_database_id","subj":"3420","obj":"Tax:9606"},{"id":"A3421","pred":"tao:has_database_id","subj":"3421","obj":"MESH:C000657245"},{"subj":"3416","pred":"source","obj":"LitCovid-PubTator"},{"subj":"3417","pred":"source","obj":"LitCovid-PubTator"},{"subj":"3418","pred":"source","obj":"LitCovid-PubTator"},{"subj":"3419","pred":"source","obj":"LitCovid-PubTator"},{"subj":"3420","pred":"source","obj":"LitCovid-PubTator"},{"subj":"3421","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]},{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T547","span":{"begin":347,"end":355},"obj":"Disease"}],"attributes":[{"id":"A547","pred":"mondo_id","subj":"T547","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"subj":"T547","pred":"source","obj":"LitCovid-PD-MONDO"}]},{"project":"LitCovid-PD-CLO","denotations":[{"id":"T1194","span":{"begin":13,"end":20},"obj":"http://purl.obolibrary.org/obo/CLO_0009985"},{"id":"T1195","span":{"begin":21,"end":23},"obj":"http://purl.obolibrary.org/obo/CLO_0050475"},{"id":"T1196","span":{"begin":51,"end":56},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9606"},{"id":"T1197","span":{"begin":156,"end":161},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9606"},{"id":"T1198","span":{"begin":240,"end":241},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"}],"attributes":[{"subj":"T1194","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T1195","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T1196","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T1197","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T1198","pred":"source","obj":"LitCovid-PD-CLO"}]},{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T25711","span":{"begin":37,"end":47},"obj":"Chemical"},{"id":"T33721","span":{"begin":174,"end":192},"obj":"Chemical"},{"id":"T20781","span":{"begin":182,"end":192},"obj":"Chemical"},{"id":"T88121","span":{"begin":330,"end":333},"obj":"Chemical"}],"attributes":[{"id":"A22589","pred":"chebi_id","subj":"T25711","obj":"http://purl.obolibrary.org/obo/CHEBI_35222"},{"id":"A99301","pred":"chebi_id","subj":"T33721","obj":"http://purl.obolibrary.org/obo/CHEBI_76932"},{"id":"A25906","pred":"chebi_id","subj":"T20781","obj":"http://purl.obolibrary.org/obo/CHEBI_35222"},{"id":"A84684","pred":"chebi_id","subj":"T88121","obj":"http://purl.obolibrary.org/obo/CHEBI_63620"},{"subj":"T25711","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T33721","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T20781","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T88121","pred":"source","obj":"LitCovid-PD-CHEBI"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T473","span":{"begin":0,"end":114},"obj":"Sentence"},{"id":"T474","span":{"begin":115,"end":491},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T473","pred":"source","obj":"LitCovid-sentences"},{"subj":"T474","pred":"source","obj":"LitCovid-sentences"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-PD-UBERON","color":"#ecdc93","default":true},{"id":"LitCovid-PubTator","color":"#c293ec"},{"id":"LitCovid-PD-MONDO","color":"#93eca8"},{"id":"LitCovid-PD-CLO","color":"#ec9397"},{"id":"LitCovid-PD-CHEBI","color":"#93b1ec"},{"id":"LitCovid-sentences","color":"#ccec93"}]}]}}