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PMC:7408073 / 95934-96642 JSONTXT

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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T510 417-421 Body_part denotes axis http://purl.org/sig/ont/fma/fma12520

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
3347 55-59 Gene denotes ACE2 Gene:59272
3348 173-177 Gene denotes ACE2 Gene:59272
3349 326-330 Gene denotes ACE2 Gene:59272
3350 397-401 Gene denotes ACE2 Gene:59272
3351 431-435 Gene denotes ACE2 Gene:59272
3352 456-459 Gene denotes ACE Gene:59272
3353 460-464 Gene denotes ACE2 Gene:59272
3354 613-617 Gene denotes ACE2 Gene:59272
3355 644-648 Gene denotes MasR Gene:116511
3356 668-673 Gene denotes renin Gene:5972
3357 412-416 Gene denotes MasR Gene:116511
3358 101-109 Species denotes patients Tax:9606
3359 283-293 Species denotes SARS-CoV-2 Tax:2697049
3360 402-410 Gene denotes Ang (1–7 Gene:27329
3361 692-697 Chemical denotes metal MESH:D008670
3362 92-100 Disease denotes COVID-19 MESH:C000657245
3363 539-546 Disease denotes hypoxia MESH:D000860

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T543 92-100 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T544 283-291 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T545 283-287 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T1169 143-144 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T1170 229-235 http://purl.obolibrary.org/obo/CLO_0001658 denotes active
T1171 245-247 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T22916 618-636 Chemical denotes pathway inhibitors http://purl.obolibrary.org/obo/CHEBI_76932
T430 626-636 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T28021 649-660 Chemical denotes antagonists http://purl.obolibrary.org/obo/CHEBI_48706
T432 674-684 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T48464 698-707 Chemical denotes chelators http://purl.obolibrary.org/obo/CHEBI_38161

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T465 0-110 Sentence denotes Based on the above described hypothesis, inhibition of ACE2 pathway might be beneficial for COVID-19 patients.
T466 111-371 Sentence denotes Indeed, the clinical picture as a whole is consistent with an ACE2 gain of function (possibly due to both circulating active forms of S1-sACE2 complexes and local forms of SARS-CoV-2-sACE2 complexes) rather than an ACE2 loss of function, as initially supposed.
T467 372-566 Sentence denotes Therefore, inhibition of ACE2/Ang (1–7)/MasR axis or other ACE2 pathways to restore ACE/ACE2 balance might be needed, at least in the first phases of the disease when hypoxia is not yet induced.
T468 567-708 Sentence denotes Different strategies could be pursued through ACE2 pathway inhibitors and/or MasR antagonists and/or renin inhibitors and/or metal chelators.

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T159 539-546 Phenotype denotes hypoxia http://purl.obolibrary.org/obo/HP_0012418