PMC:7408073 / 94193-94523 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T503","span":{"begin":20,"end":26},"obj":"Body_part"}],"attributes":[{"id":"A503","pred":"fma_id","subj":"T503","obj":"http://purl.org/sig/ont/fma/fma62970"}],"text":"Indeed, analysis of plasma samples (from a healthy subjects), treated ex vivo with recombinant renin, showed an increase of Ang I, Ang II, Ang (1–7) and Ang (1–5), but not Ang (1–9) [115,179,181], further suggesting both the ACE2 specific activity in producing Ang (1–9) and an activation of both arms of the RAS in ARDS patients."}

{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T188","span":{"begin":309,"end":312},"obj":"Body_part"}],"attributes":[{"id":"A188","pred":"uberon_id","subj":"T188","obj":"http://purl.obolibrary.org/obo/UBERON_0018229"}],"text":"Indeed, analysis of plasma samples (from a healthy subjects), treated ex vivo with recombinant renin, showed an increase of Ang I, Ang II, Ang (1–7) and Ang (1–5), but not Ang (1–9) [115,179,181], further suggesting both the ACE2 specific activity in producing Ang (1–9) and an activation of both arms of the RAS in ARDS patients."}

{"project":"LitCovid-PubTator","denotations":[{"id":"3245","span":{"begin":95,"end":100},"obj":"Gene"},{"id":"3246","span":{"begin":172,"end":180},"obj":"Gene"},{"id":"3247","span":{"begin":225,"end":229},"obj":"Gene"},{"id":"3248","span":{"begin":261,"end":269},"obj":"Gene"},{"id":"3259","span":{"begin":153,"end":161},"obj":"Gene"},{"id":"3260","span":{"begin":139,"end":147},"obj":"Gene"},{"id":"3289","span":{"begin":321,"end":329},"obj":"Species"},{"id":"3298","span":{"begin":131,"end":137},"obj":"Gene"},{"id":"3322","span":{"begin":316,"end":320},"obj":"Disease"}],"attributes":[{"id":"A3245","pred":"tao:has_database_id","subj":"3245","obj":"Gene:5972"},{"id":"A3246","pred":"tao:has_database_id","subj":"3246","obj":"Gene:284"},{"id":"A3247","pred":"tao:has_database_id","subj":"3247","obj":"Gene:59272"},{"id":"A3248","pred":"tao:has_database_id","subj":"3248","obj":"Gene:284"},{"id":"A3259","pred":"tao:has_database_id","subj":"3259","obj":"Gene:284"},{"id":"A3260","pred":"tao:has_database_id","subj":"3260","obj":"Gene:284"},{"id":"A3289","pred":"tao:has_database_id","subj":"3289","obj":"Tax:9606"},{"id":"A3298","pred":"tao:has_database_id","subj":"3298","obj":"Gene:24179"},{"id":"A3322","pred":"tao:has_database_id","subj":"3322","obj":"MESH:D012128"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Indeed, analysis of plasma samples (from a healthy subjects), treated ex vivo with recombinant renin, showed an increase of Ang I, Ang II, Ang (1–7) and Ang (1–5), but not Ang (1–9) [115,179,181], further suggesting both the ACE2 specific activity in producing Ang (1–9) and an activation of both arms of the RAS in ARDS patients."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T533","span":{"begin":316,"end":320},"obj":"Disease"}],"attributes":[{"id":"A533","pred":"mondo_id","subj":"T533","obj":"http://purl.obolibrary.org/obo/MONDO_0006502"}],"text":"Indeed, analysis of plasma samples (from a healthy subjects), treated ex vivo with recombinant renin, showed an increase of Ang I, Ang II, Ang (1–7) and Ang (1–5), but not Ang (1–9) [115,179,181], further suggesting both the ACE2 specific activity in producing Ang (1–9) and an activation of both arms of the RAS in ARDS patients."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T1143","span":{"begin":20,"end":26},"obj":"http://purl.obolibrary.org/obo/UBERON_0001969"},{"id":"T1144","span":{"begin":41,"end":42},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T1145","span":{"begin":239,"end":247},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T1146","span":{"begin":278,"end":288},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T1147","span":{"begin":297,"end":301},"obj":"http://www.ebi.ac.uk/efo/EFO_0001410"}],"text":"Indeed, analysis of plasma samples (from a healthy subjects), treated ex vivo with recombinant renin, showed an increase of Ang I, Ang II, Ang (1–7) and Ang (1–5), but not Ang (1–9) [115,179,181], further suggesting both the ACE2 specific activity in producing Ang (1–9) and an activation of both arms of the RAS in ARDS patients."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T412","span":{"begin":135,"end":137},"obj":"Chemical"},{"id":"T44343","span":{"begin":309,"end":312},"obj":"Chemical"}],"attributes":[{"id":"A23606","pred":"chebi_id","subj":"T412","obj":"http://purl.obolibrary.org/obo/CHEBI_74067"},{"id":"A57940","pred":"chebi_id","subj":"T44343","obj":"http://purl.obolibrary.org/obo/CHEBI_63620"}],"text":"Indeed, analysis of plasma samples (from a healthy subjects), treated ex vivo with recombinant renin, showed an increase of Ang I, Ang II, Ang (1–7) and Ang (1–5), but not Ang (1–9) [115,179,181], further suggesting both the ACE2 specific activity in producing Ang (1–9) and an activation of both arms of the RAS in ARDS patients."}

{"project":"LitCovid-sentences","denotations":[{"id":"T456","span":{"begin":0,"end":330},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Indeed, analysis of plasma samples (from a healthy subjects), treated ex vivo with recombinant renin, showed an increase of Ang I, Ang II, Ang (1–7) and Ang (1–5), but not Ang (1–9) [115,179,181], further suggesting both the ACE2 specific activity in producing Ang (1–9) and an activation of both arms of the RAS in ARDS patients."}

{"project":"2_test","denotations":[{"id":"32708755-22777933-20679010","span":{"begin":183,"end":186},"obj":"22777933"},{"id":"32708755-25107336-20679011","span":{"begin":187,"end":190},"obj":"25107336"},{"id":"32708755-22518284-20679012","span":{"begin":191,"end":194},"obj":"22518284"}],"text":"Indeed, analysis of plasma samples (from a healthy subjects), treated ex vivo with recombinant renin, showed an increase of Ang I, Ang II, Ang (1–7) and Ang (1–5), but not Ang (1–9) [115,179,181], further suggesting both the ACE2 specific activity in producing Ang (1–9) and an activation of both arms of the RAS in ARDS patients."}