PMC:7408073 / 8702-9113 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7408073","sourcedb":"PMC","sourceid":"7408073","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7408073","text":"The subsequent binding of ACE2 receptor to the spike glycoprotein triggers both the ADAM17-mediated ACE2 shedding and dissociation of S1 fragments by exogenous (furin-related or other) proteases from the spike trimer, which leads on one hand to one S1-ACE2 complex and two S1 free fragments, and on the other hand to fusion of S2 viral trimers and cellular membrane structures, finally producing cell infection.","tracks":[{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T54","span":{"begin":53,"end":65},"obj":"Body_part"},{"id":"T55","span":{"begin":237,"end":241},"obj":"Body_part"},{"id":"T56","span":{"begin":309,"end":313},"obj":"Body_part"},{"id":"T57","span":{"begin":348,"end":365},"obj":"Body_part"},{"id":"T58","span":{"begin":396,"end":400},"obj":"Body_part"}],"attributes":[{"id":"A54","pred":"fma_id","subj":"T54","obj":"http://purl.org/sig/ont/fma/fma62925"},{"id":"A55","pred":"fma_id","subj":"T55","obj":"http://purl.org/sig/ont/fma/fma9712"},{"id":"A56","pred":"fma_id","subj":"T56","obj":"http://purl.org/sig/ont/fma/fma9712"},{"id":"A57","pred":"fma_id","subj":"T57","obj":"http://purl.org/sig/ont/fma/fma63841"},{"id":"A58","pred":"fma_id","subj":"T58","obj":"http://purl.org/sig/ont/fma/fma68646"},{"subj":"T54","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T55","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T56","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T57","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T58","pred":"source","obj":"LitCovid-PD-FMA-UBERON"}]},{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T14","span":{"begin":237,"end":241},"obj":"Body_part"},{"id":"T15","span":{"begin":309,"end":313},"obj":"Body_part"}],"attributes":[{"id":"A14","pred":"uberon_id","subj":"T14","obj":"http://purl.obolibrary.org/obo/UBERON_0002398"},{"id":"A15","pred":"uberon_id","subj":"T15","obj":"http://purl.obolibrary.org/obo/UBERON_0002398"},{"subj":"T14","pred":"source","obj":"LitCovid-PD-UBERON"},{"subj":"T15","pred":"source","obj":"LitCovid-PD-UBERON"}]},{"project":"LitCovid-PubTator","denotations":[{"id":"361","span":{"begin":26,"end":30},"obj":"Gene"},{"id":"362","span":{"begin":84,"end":90},"obj":"Gene"},{"id":"363","span":{"begin":100,"end":104},"obj":"Gene"},{"id":"364","span":{"begin":161,"end":166},"obj":"Gene"},{"id":"365","span":{"begin":252,"end":256},"obj":"Gene"},{"id":"387","span":{"begin":204,"end":209},"obj":"Gene"},{"id":"399","span":{"begin":47,"end":52},"obj":"Gene"},{"id":"401","span":{"begin":401,"end":410},"obj":"Disease"}],"attributes":[{"id":"A361","pred":"tao:has_database_id","subj":"361","obj":"Gene:59272"},{"id":"A362","pred":"tao:has_database_id","subj":"362","obj":"Gene:6868"},{"id":"A363","pred":"tao:has_database_id","subj":"363","obj":"Gene:59272"},{"id":"A364","pred":"tao:has_database_id","subj":"364","obj":"Gene:5045"},{"id":"A365","pred":"tao:has_database_id","subj":"365","obj":"Gene:59272"},{"id":"A387","pred":"tao:has_database_id","subj":"387","obj":"Gene:43740568"},{"id":"A399","pred":"tao:has_database_id","subj":"399","obj":"Gene:43740568"},{"id":"A401","pred":"tao:has_database_id","subj":"401","obj":"MESH:D007239"},{"subj":"361","pred":"source","obj":"LitCovid-PubTator"},{"subj":"362","pred":"source","obj":"LitCovid-PubTator"},{"subj":"363","pred":"source","obj":"LitCovid-PubTator"},{"subj":"364","pred":"source","obj":"LitCovid-PubTator"},{"subj":"365","pred":"source","obj":"LitCovid-PubTator"},{"subj":"387","pred":"source","obj":"LitCovid-PubTator"},{"subj":"399","pred":"source","obj":"LitCovid-PubTator"},{"subj":"401","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]},{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T90","span":{"begin":401,"end":410},"obj":"Disease"}],"attributes":[{"id":"A90","pred":"mondo_id","subj":"T90","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"subj":"T90","pred":"source","obj":"LitCovid-PD-MONDO"}]},{"project":"LitCovid-PD-CLO","denotations":[{"id":"T30598","span":{"begin":134,"end":136},"obj":"http://purl.obolibrary.org/obo/CLO_0050050"},{"id":"T86794","span":{"begin":249,"end":251},"obj":"http://purl.obolibrary.org/obo/CLO_0050050"},{"id":"T58803","span":{"begin":273,"end":275},"obj":"http://purl.obolibrary.org/obo/CLO_0050050"},{"id":"T15028","span":{"begin":327,"end":329},"obj":"http://purl.obolibrary.org/obo/CLO_0008922"},{"id":"T80157","span":{"begin":327,"end":329},"obj":"http://purl.obolibrary.org/obo/CLO_0050052"},{"id":"T19942","span":{"begin":357,"end":365},"obj":"http://purl.obolibrary.org/obo/UBERON_0000158"},{"id":"T91194","span":{"begin":396,"end":400},"obj":"http://purl.obolibrary.org/obo/GO_0005623"}],"attributes":[{"subj":"T30598","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T86794","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T58803","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T15028","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T80157","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T19942","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T91194","pred":"source","obj":"LitCovid-PD-CLO"}]},{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T54","span":{"begin":53,"end":65},"obj":"Chemical"},{"id":"T55","span":{"begin":327,"end":329},"obj":"Chemical"}],"attributes":[{"id":"A54","pred":"chebi_id","subj":"T54","obj":"http://purl.obolibrary.org/obo/CHEBI_17089"},{"id":"A55","pred":"chebi_id","subj":"T55","obj":"http://purl.obolibrary.org/obo/CHEBI_29387"},{"subj":"T54","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T55","pred":"source","obj":"LitCovid-PD-CHEBI"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T44","span":{"begin":0,"end":411},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T44","pred":"source","obj":"LitCovid-sentences"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-PD-FMA-UBERON","color":"#d8ec93","default":true},{"id":"LitCovid-PD-UBERON","color":"#e593ec"},{"id":"LitCovid-PubTator","color":"#93eccb"},{"id":"LitCovid-PD-MONDO","color":"#ecb193"},{"id":"LitCovid-PD-CLO","color":"#9793ec"},{"id":"LitCovid-PD-CHEBI","color":"#a8ec93"},{"id":"LitCovid-sentences","color":"#ec93c2"}]}]}}