PMC:7408073 / 7989-10893 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7408073","sourcedb":"PMC","sourceid":"7408073","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7408073","text":"The ACE2 interacts with the spike (S) protein, thereby serves as an entry receptor for SARS-CoVs, and this event is likely followed by conformational changes, cleavages and fusion of both spike viral and ACE2 proteins at the level of infected host cell plasma-membrane. The SARS coronavirus surface spike glycoproteins consist of trimers formed by two spike, capsid-distal S1 and –proximal S2, protein regions, located on the outer envelope of the virion. Spike proteins are clove-shaped trimers with three S1 heads and a trimeric S2 stalk that can bind the cellular ACE2 receptor when one S1 (possessing the receptor-binding domain) in the trimer adopts an “up” conformation (see Figure later in the Section 4). The subsequent binding of ACE2 receptor to the spike glycoprotein triggers both the ADAM17-mediated ACE2 shedding and dissociation of S1 fragments by exogenous (furin-related or other) proteases from the spike trimer, which leads on one hand to one S1-ACE2 complex and two S1 free fragments, and on the other hand to fusion of S2 viral trimers and cellular membrane structures, finally producing cell infection. The molecular mechanism model for SARS-CoV recognition and infection was well described by Song and collaborators [26] and a similar molecular interactions between SARS-CoV-2 and ACE2 has been recently hypothesized [27,28]. To complete the picture, a recent structural work reveals that the full-length human ACE2 is assembled as a dimer associated or not with amino acid transporter B0AT1, which sandwich ACE2 [28]. Binding of the spike protein trimer onto the ACE2 dimer suggests simultaneous binding of two spike protein trimers to an ACE2 dimer [28]. Each monomer of the ACE2 homodimer is composed of a membrane-proximal collectrin-like domain mediating homodimerization and necessary to position the molecule to the cell membrane, and of a membrane-distal ACE2 peptidase domain responsible for ACE2 substrate cleavage. Collectrin-like domain consists of an extracellular ferredoxin-like fold domain, also called neck domain (residues 616 to 726), a single transmembrane helix and an intracellular segment. The ACE2 cleavage site mediated by ADAM17/TACE has been predicted between amino acids 716 and 741 [16], which corresponds to neck-transmembrane boundary of ACE2 collectrin-like domain. It is tempting to speculate that, after ACE2 shedding, S2 viral trimers may fuse with the residual ACE2 collectrin-like fragments (complexed or not with B0AT1 transporters) which are eventually exposed on the cell surface membranes. A model for SARS-CoV’s internalization by target cells that was already proposed several years ago [29]. Then, when the virus is inside the cell, a second proteolytic cleavage mediated by endosomal proteases (such as TMPRSS2) in the S2 region of the spike-ACE2 fusion protein might be necessary for intracellular virus “release” and active infection.","tracks":[{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T47","span":{"begin":38,"end":45},"obj":"Body_part"},{"id":"T48","span":{"begin":209,"end":217},"obj":"Body_part"},{"id":"T49","span":{"begin":248,"end":252},"obj":"Body_part"},{"id":"T50","span":{"begin":253,"end":268},"obj":"Body_part"},{"id":"T51","span":{"begin":305,"end":318},"obj":"Body_part"},{"id":"T52","span":{"begin":394,"end":401},"obj":"Body_part"},{"id":"T53","span":{"begin":462,"end":470},"obj":"Body_part"},{"id":"T54","span":{"begin":766,"end":778},"obj":"Body_part"},{"id":"T55","span":{"begin":950,"end":954},"obj":"Body_part"},{"id":"T56","span":{"begin":1022,"end":1026},"obj":"Body_part"},{"id":"T57","span":{"begin":1061,"end":1078},"obj":"Body_part"},{"id":"T58","span":{"begin":1109,"end":1113},"obj":"Body_part"},{"id":"T59","span":{"begin":1486,"end":1496},"obj":"Body_part"},{"id":"T60","span":{"begin":1563,"end":1570},"obj":"Body_part"},{"id":"T61","span":{"begin":1641,"end":1648},"obj":"Body_part"},{"id":"T62","span":{"begin":1846,"end":1859},"obj":"Body_part"},{"id":"T63","span":{"begin":1846,"end":1850},"obj":"Body_part"},{"id":"T64","span":{"begin":2042,"end":2046},"obj":"Body_part"},{"id":"T65","span":{"begin":2100,"end":2105},"obj":"Body_part"},{"id":"T66","span":{"begin":2210,"end":2221},"obj":"Body_part"},{"id":"T67","span":{"begin":2261,"end":2265},"obj":"Body_part"},{"id":"T68","span":{"begin":2530,"end":2542},"obj":"Body_part"},{"id":"T69","span":{"begin":2530,"end":2534},"obj":"Body_part"},{"id":"T70","span":{"begin":2603,"end":2608},"obj":"Body_part"},{"id":"T71","span":{"begin":2694,"end":2698},"obj":"Body_part"},{"id":"T72","span":{"begin":2742,"end":2751},"obj":"Body_part"},{"id":"T73","span":{"begin":2822,"end":2829},"obj":"Body_part"}],"attributes":[{"id":"A47","pred":"fma_id","subj":"T47","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A48","pred":"fma_id","subj":"T48","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A49","pred":"fma_id","subj":"T49","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A50","pred":"fma_id","subj":"T50","obj":"http://purl.org/sig/ont/fma/fma63841"},{"id":"A51","pred":"fma_id","subj":"T51","obj":"http://purl.org/sig/ont/fma/fma62925"},{"id":"A52","pred":"fma_id","subj":"T52","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A53","pred":"fma_id","subj":"T53","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A54","pred":"fma_id","subj":"T54","obj":"http://purl.org/sig/ont/fma/fma62925"},{"id":"A55","pred":"fma_id","subj":"T55","obj":"http://purl.org/sig/ont/fma/fma9712"},{"id":"A56","pred":"fma_id","subj":"T56","obj":"http://purl.org/sig/ont/fma/fma9712"},{"id":"A57","pred":"fma_id","subj":"T57","obj":"http://purl.org/sig/ont/fma/fma63841"},{"id":"A58","pred":"fma_id","subj":"T58","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A59","pred":"fma_id","subj":"T59","obj":"http://purl.org/sig/ont/fma/fma82739"},{"id":"A60","pred":"fma_id","subj":"T60","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A61","pred":"fma_id","subj":"T61","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A62","pred":"fma_id","subj":"T62","obj":"http://purl.org/sig/ont/fma/fma63841"},{"id":"A63","pred":"fma_id","subj":"T63","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A64","pred":"fma_id","subj":"T64","obj":"http://purl.org/sig/ont/fma/fma7155"},{"id":"A65","pred":"fma_id","subj":"T65","obj":"http://purl.org/sig/ont/fma/fma60992"},{"id":"A66","pred":"fma_id","subj":"T66","obj":"http://purl.org/sig/ont/fma/fma82739"},{"id":"A67","pred":"fma_id","subj":"T67","obj":"http://purl.org/sig/ont/fma/fma7155"},{"id":"A68","pred":"fma_id","subj":"T68","obj":"http://purl.org/sig/ont/fma/fma67653"},{"id":"A69","pred":"fma_id","subj":"T69","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A70","pred":"fma_id","subj":"T70","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A71","pred":"fma_id","subj":"T71","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A72","pred":"fma_id","subj":"T72","obj":"http://purl.org/sig/ont/fma/fma67180"},{"id":"A73","pred":"fma_id","subj":"T73","obj":"http://purl.org/sig/ont/fma/fma67257"},{"subj":"T47","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T48","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T49","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T50","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T51","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T52","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T53","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T54","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T55","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T56","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T57","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T58","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T59","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T60","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T61","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T62","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T63","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T64","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T65","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T66","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T67","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T68","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T69","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T70","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T71","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T72","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T73","pred":"source","obj":"LitCovid-PD-FMA-UBERON"}]},{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T14","span":{"begin":950,"end":954},"obj":"Body_part"},{"id":"T15","span":{"begin":1022,"end":1026},"obj":"Body_part"},{"id":"T16","span":{"begin":2042,"end":2046},"obj":"Body_part"},{"id":"T17","span":{"begin":2100,"end":2105},"obj":"Body_part"},{"id":"T18","span":{"begin":2261,"end":2265},"obj":"Body_part"}],"attributes":[{"id":"A14","pred":"uberon_id","subj":"T14","obj":"http://purl.obolibrary.org/obo/UBERON_0002398"},{"id":"A15","pred":"uberon_id","subj":"T15","obj":"http://purl.obolibrary.org/obo/UBERON_0002398"},{"id":"A16","pred":"uberon_id","subj":"T16","obj":"http://purl.obolibrary.org/obo/UBERON_0000974"},{"id":"A17","pred":"uberon_id","subj":"T17","obj":"http://purl.obolibrary.org/obo/UBERON_0002488"},{"id":"A18","pred":"uberon_id","subj":"T18","obj":"http://purl.obolibrary.org/obo/UBERON_0000974"},{"subj":"T14","pred":"source","obj":"LitCovid-PD-UBERON"},{"subj":"T15","pred":"source","obj":"LitCovid-PD-UBERON"},{"subj":"T16","pred":"source","obj":"LitCovid-PD-UBERON"},{"subj":"T17","pred":"source","obj":"LitCovid-PD-UBERON"},{"subj":"T18","pred":"source","obj":"LitCovid-PD-UBERON"}]},{"project":"LitCovid-PubTator","denotations":[{"id":"357","span":{"begin":4,"end":8},"obj":"Gene"},{"id":"358","span":{"begin":204,"end":208},"obj":"Gene"},{"id":"359","span":{"begin":359,"end":392},"obj":"Gene"},{"id":"360","span":{"begin":567,"end":571},"obj":"Gene"},{"id":"361","span":{"begin":739,"end":743},"obj":"Gene"},{"id":"362","span":{"begin":797,"end":803},"obj":"Gene"},{"id":"363","span":{"begin":813,"end":817},"obj":"Gene"},{"id":"364","span":{"begin":874,"end":879},"obj":"Gene"},{"id":"365","span":{"begin":965,"end":969},"obj":"Gene"},{"id":"366","span":{"begin":1304,"end":1308},"obj":"Gene"},{"id":"367","span":{"begin":1434,"end":1438},"obj":"Gene"},{"id":"368","span":{"begin":1509,"end":1514},"obj":"Gene"},{"id":"369","span":{"begin":1531,"end":1535},"obj":"Gene"},{"id":"370","span":{"begin":1587,"end":1591},"obj":"Gene"},{"id":"371","span":{"begin":1663,"end":1667},"obj":"Gene"},{"id":"372","span":{"begin":1700,"end":1704},"obj":"Gene"},{"id":"373","span":{"begin":1886,"end":1890},"obj":"Gene"},{"id":"374","span":{"begin":1924,"end":1928},"obj":"Gene"},{"id":"375","span":{"begin":2140,"end":2144},"obj":"Gene"},{"id":"376","span":{"begin":2171,"end":2177},"obj":"Gene"},{"id":"377","span":{"begin":2178,"end":2182},"obj":"Gene"},{"id":"378","span":{"begin":2292,"end":2296},"obj":"Gene"},{"id":"379","span":{"begin":2361,"end":2365},"obj":"Gene"},{"id":"380","span":{"begin":2420,"end":2424},"obj":"Gene"},{"id":"381","span":{"begin":2474,"end":2479},"obj":"Gene"},{"id":"382","span":{"begin":2771,"end":2778},"obj":"Gene"},{"id":"383","span":{"begin":2810,"end":2814},"obj":"Gene"},{"id":"384","span":{"begin":2804,"end":2809},"obj":"Gene"},{"id":"385","span":{"begin":1635,"end":1640},"obj":"Gene"},{"id":"386","span":{"begin":1557,"end":1562},"obj":"Gene"},{"id":"387","span":{"begin":917,"end":922},"obj":"Gene"},{"id":"388","span":{"begin":456,"end":461},"obj":"Gene"},{"id":"389","span":{"begin":352,"end":357},"obj":"Gene"},{"id":"390","span":{"begin":299,"end":304},"obj":"Gene"},{"id":"391","span":{"begin":188,"end":193},"obj":"Gene"},{"id":"392","span":{"begin":87,"end":96},"obj":"Species"},{"id":"393","span":{"begin":274,"end":290},"obj":"Species"},{"id":"394","span":{"begin":475,"end":480},"obj":"Species"},{"id":"395","span":{"begin":1159,"end":1167},"obj":"Species"},{"id":"396","span":{"begin":1289,"end":1299},"obj":"Species"},{"id":"397","span":{"begin":1428,"end":1433},"obj":"Species"},{"id":"398","span":{"begin":2566,"end":2574},"obj":"Species"},{"id":"399","span":{"begin":760,"end":765},"obj":"Gene"},{"id":"400","span":{"begin":234,"end":242},"obj":"Disease"},{"id":"401","span":{"begin":1114,"end":1123},"obj":"Disease"},{"id":"402","span":{"begin":1184,"end":1193},"obj":"Disease"},{"id":"403","span":{"begin":2894,"end":2903},"obj":"Disease"}],"attributes":[{"id":"A357","pred":"tao:has_database_id","subj":"357","obj":"Gene:59272"},{"id":"A358","pred":"tao:has_database_id","subj":"358","obj":"Gene:59272"},{"id":"A360","pred":"tao:has_database_id","subj":"360","obj":"Gene:59272"},{"id":"A361","pred":"tao:has_database_id","subj":"361","obj":"Gene:59272"},{"id":"A362","pred":"tao:has_database_id","subj":"362","obj":"Gene:6868"},{"id":"A363","pred":"tao:has_database_id","subj":"363","obj":"Gene:59272"},{"id":"A364","pred":"tao:has_database_id","subj":"364","obj":"Gene:5045"},{"id":"A365","pred":"tao:has_database_id","subj":"365","obj":"Gene:59272"},{"id":"A366","pred":"tao:has_database_id","subj":"366","obj":"Gene:59272"},{"id":"A367","pred":"tao:has_database_id","subj":"367","obj":"Gene:59272"},{"id":"A368","pred":"tao:has_database_id","subj":"368","obj":"Gene:340024"},{"id":"A369","pred":"tao:has_database_id","subj":"369","obj":"Gene:59272"},{"id":"A370","pred":"tao:has_database_id","subj":"370","obj":"Gene:59272"},{"id":"A371","pred":"tao:has_database_id","subj":"371","obj":"Gene:59272"},{"id":"A372","pred":"tao:has_database_id","subj":"372","obj":"Gene:59272"},{"id":"A373","pred":"tao:has_database_id","subj":"373","obj":"Gene:59272"},{"id":"A374","pred":"tao:has_database_id","subj":"374","obj":"Gene:59272"},{"id":"A375","pred":"tao:has_database_id","subj":"375","obj":"Gene:59272"},{"id":"A376","pred":"tao:has_database_id","subj":"376","obj":"Gene:6868"},{"id":"A377","pred":"tao:has_database_id","subj":"377","obj":"Gene:6868"},{"id":"A378","pred":"tao:has_database_id","subj":"378","obj":"Gene:59272"},{"id":"A379","pred":"tao:has_database_id","subj":"379","obj":"Gene:59272"},{"id":"A380","pred":"tao:has_database_id","subj":"380","obj":"Gene:59272"},{"id":"A381","pred":"tao:has_database_id","subj":"381","obj":"Gene:340024"},{"id":"A382","pred":"tao:has_database_id","subj":"382","obj":"Gene:7113"},{"id":"A383","pred":"tao:has_database_id","subj":"383","obj":"Gene:59272"},{"id":"A384","pred":"tao:has_database_id","subj":"384","obj":"Gene:43740568"},{"id":"A385","pred":"tao:has_database_id","subj":"385","obj":"Gene:43740568"},{"id":"A386","pred":"tao:has_database_id","subj":"386","obj":"Gene:43740568"},{"id":"A387","pred":"tao:has_database_id","subj":"387","obj":"Gene:43740568"},{"id":"A388","pred":"tao:has_database_id","subj":"388","obj":"Gene:43740568"},{"id":"A389","pred":"tao:has_database_id","subj":"389","obj":"Gene:43740568"},{"id":"A390","pred":"tao:has_database_id","subj":"390","obj":"Gene:43740568"},{"id":"A391","pred":"tao:has_database_id","subj":"391","obj":"Gene:43740568"},{"id":"A392","pred":"tao:has_database_id","subj":"392","obj":"Tax:694009"},{"id":"A393","pred":"tao:has_database_id","subj":"393","obj":"Tax:694009"},{"id":"A394","pred":"tao:has_database_id","subj":"394","obj":"Tax:219868"},{"id":"A395","pred":"tao:has_database_id","subj":"395","obj":"Tax:694009"},{"id":"A396","pred":"tao:has_database_id","subj":"396","obj":"Tax:2697049"},{"id":"A397","pred":"tao:has_database_id","subj":"397","obj":"Tax:9606"},{"id":"A398","pred":"tao:has_database_id","subj":"398","obj":"Tax:694009"},{"id":"A399","pred":"tao:has_database_id","subj":"399","obj":"Gene:43740568"},{"id":"A400","pred":"tao:has_database_id","subj":"400","obj":"MESH:D007239"},{"id":"A401","pred":"tao:has_database_id","subj":"401","obj":"MESH:D007239"},{"id":"A402","pred":"tao:has_database_id","subj":"402","obj":"MESH:D007239"},{"id":"A403","pred":"tao:has_database_id","subj":"403","obj":"MESH:D007239"},{"subj":"357","pred":"source","obj":"LitCovid-PubTator"},{"subj":"358","pred":"source","obj":"LitCovid-PubTator"},{"subj":"359","pred":"source","obj":"LitCovid-PubTator"},{"subj":"360","pred":"source","obj":"LitCovid-PubTator"},{"subj":"361","pred":"source","obj":"LitCovid-PubTator"},{"subj":"362","pred":"source","obj":"LitCovid-PubTator"},{"subj":"363","pred":"source","obj":"LitCovid-PubTator"},{"subj":"364","pred":"source","obj":"LitCovid-PubTator"},{"subj":"365","pred":"source","obj":"LitCovid-PubTator"},{"subj":"366","pred":"source","obj":"LitCovid-PubTator"},{"subj":"367","pred":"source","obj":"LitCovid-PubTator"},{"subj":"368","pred":"source","obj":"LitCovid-PubTator"},{"subj":"369","pred":"source","obj":"LitCovid-PubTator"},{"subj":"370","pred":"source","obj":"LitCovid-PubTator"},{"subj":"371","pred":"source","obj":"LitCovid-PubTator"},{"subj":"372","pred":"source","obj":"LitCovid-PubTator"},{"subj":"373","pred":"source","obj":"LitCovid-PubTator"},{"subj":"374","pred":"source","obj":"LitCovid-PubTator"},{"subj":"375","pred":"source","obj":"LitCovid-PubTator"},{"subj":"376","pred":"source","obj":"LitCovid-PubTator"},{"subj":"377","pred":"source","obj":"LitCovid-PubTator"},{"subj":"378","pred":"source","obj":"LitCovid-PubTator"},{"subj":"379","pred":"source","obj":"LitCovid-PubTator"},{"subj":"380","pred":"source","obj":"LitCovid-PubTator"},{"subj":"381","pred":"source","obj":"LitCovid-PubTator"},{"subj":"382","pred":"source","obj":"LitCovid-PubTator"},{"subj":"383","pred":"source","obj":"LitCovid-PubTator"},{"subj":"384","pred":"source","obj":"LitCovid-PubTator"},{"subj":"385","pred":"source","obj":"LitCovid-PubTator"},{"subj":"386","pred":"source","obj":"LitCovid-PubTator"},{"subj":"387","pred":"source","obj":"LitCovid-PubTator"},{"subj":"388","pred":"source","obj":"LitCovid-PubTator"},{"subj":"389","pred":"source","obj":"LitCovid-PubTator"},{"subj":"390","pred":"source","obj":"LitCovid-PubTator"},{"subj":"391","pred":"source","obj":"LitCovid-PubTator"},{"subj":"392","pred":"source","obj":"LitCovid-PubTator"},{"subj":"393","pred":"source","obj":"LitCovid-PubTator"},{"subj":"394","pred":"source","obj":"LitCovid-PubTator"},{"subj":"395","pred":"source","obj":"LitCovid-PubTator"},{"subj":"396","pred":"source","obj":"LitCovid-PubTator"},{"subj":"397","pred":"source","obj":"LitCovid-PubTator"},{"subj":"398","pred":"source","obj":"LitCovid-PubTator"},{"subj":"399","pred":"source","obj":"LitCovid-PubTator"},{"subj":"400","pred":"source","obj":"LitCovid-PubTator"},{"subj":"401","pred":"source","obj":"LitCovid-PubTator"},{"subj":"402","pred":"source","obj":"LitCovid-PubTator"},{"subj":"403","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]},{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T88","span":{"begin":87,"end":91},"obj":"Disease"},{"id":"T89","span":{"begin":274,"end":278},"obj":"Disease"},{"id":"T90","span":{"begin":1114,"end":1123},"obj":"Disease"},{"id":"T91","span":{"begin":1159,"end":1167},"obj":"Disease"},{"id":"T92","span":{"begin":1159,"end":1163},"obj":"Disease"},{"id":"T93","span":{"begin":1184,"end":1193},"obj":"Disease"},{"id":"T94","span":{"begin":1289,"end":1297},"obj":"Disease"},{"id":"T95","span":{"begin":1289,"end":1293},"obj":"Disease"},{"id":"T96","span":{"begin":2566,"end":2570},"obj":"Disease"},{"id":"T97","span":{"begin":2894,"end":2903},"obj":"Disease"}],"attributes":[{"id":"A88","pred":"mondo_id","subj":"T88","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A89","pred":"mondo_id","subj":"T89","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A90","pred":"mondo_id","subj":"T90","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A91","pred":"mondo_id","subj":"T91","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A92","pred":"mondo_id","subj":"T92","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A93","pred":"mondo_id","subj":"T93","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A94","pred":"mondo_id","subj":"T94","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A95","pred":"mondo_id","subj":"T95","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A96","pred":"mondo_id","subj":"T96","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A97","pred":"mondo_id","subj":"T97","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"subj":"T88","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T89","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T90","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T91","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T92","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T93","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T94","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T95","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T96","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T97","pred":"source","obj":"LitCovid-PD-MONDO"}]},{"project":"LitCovid-PD-CLO","denotations":[{"id":"T76112","span":{"begin":248,"end":252},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T85916","span":{"begin":253,"end":259},"obj":"http://purl.obolibrary.org/obo/UBERON_0001969"},{"id":"T42262","span":{"begin":260,"end":268},"obj":"http://purl.obolibrary.org/obo/UBERON_0000158"},{"id":"T4712","span":{"begin":373,"end":375},"obj":"http://purl.obolibrary.org/obo/CLO_0050050"},{"id":"T12859","span":{"begin":390,"end":392},"obj":"http://purl.obolibrary.org/obo/CLO_0008922"},{"id":"T72988","span":{"begin":390,"end":392},"obj":"http://purl.obolibrary.org/obo/CLO_0050052"},{"id":"T53244","span":{"begin":507,"end":509},"obj":"http://purl.obolibrary.org/obo/CLO_0050050"},{"id":"T93889","span":{"begin":510,"end":519},"obj":"http://purl.obolibrary.org/obo/UBERON_0000033"},{"id":"T73899","span":{"begin":510,"end":519},"obj":"http://www.ebi.ac.uk/efo/EFO_0000964"},{"id":"T50671","span":{"begin":520,"end":521},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T1263","span":{"begin":531,"end":533},"obj":"http://purl.obolibrary.org/obo/CLO_0008922"},{"id":"T61883","span":{"begin":531,"end":533},"obj":"http://purl.obolibrary.org/obo/CLO_0050052"},{"id":"T24540","span":{"begin":590,"end":592},"obj":"http://purl.obolibrary.org/obo/CLO_0050050"},{"id":"T30598","span":{"begin":847,"end":849},"obj":"http://purl.obolibrary.org/obo/CLO_0050050"},{"id":"T86794","span":{"begin":962,"end":964},"obj":"http://purl.obolibrary.org/obo/CLO_0050050"},{"id":"T58803","span":{"begin":986,"end":988},"obj":"http://purl.obolibrary.org/obo/CLO_0050050"},{"id":"T15028","span":{"begin":1040,"end":1042},"obj":"http://purl.obolibrary.org/obo/CLO_0008922"},{"id":"T80157","span":{"begin":1040,"end":1042},"obj":"http://purl.obolibrary.org/obo/CLO_0050052"},{"id":"T19942","span":{"begin":1070,"end":1078},"obj":"http://purl.obolibrary.org/obo/UBERON_0000158"},{"id":"T91194","span":{"begin":1109,"end":1113},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T77366","span":{"begin":1248,"end":1249},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T97236","span":{"begin":1309,"end":1312},"obj":"http://purl.obolibrary.org/obo/CLO_0051582"},{"id":"T81091","span":{"begin":1374,"end":1375},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T93457","span":{"begin":1428,"end":1433},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9606"},{"id":"T78563","span":{"begin":1455,"end":1456},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T86342","span":{"begin":1730,"end":1731},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T89948","span":{"begin":1732,"end":1740},"obj":"http://purl.obolibrary.org/obo/UBERON_0000158"},{"id":"T27116","span":{"begin":1846,"end":1850},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T53807","span":{"begin":1851,"end":1859},"obj":"http://purl.obolibrary.org/obo/UBERON_0000158"},{"id":"T96275","span":{"begin":1868,"end":1869},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T91518","span":{"begin":1870,"end":1878},"obj":"http://purl.obolibrary.org/obo/UBERON_0000158"},{"id":"T1576","span":{"begin":2042,"end":2046},"obj":"http://www.ebi.ac.uk/efo/EFO_0000967"},{"id":"T13416","span":{"begin":2077,"end":2078},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T7903","span":{"begin":2183,"end":2186},"obj":"http://purl.obolibrary.org/obo/CLO_0051582"},{"id":"T48778","span":{"begin":2261,"end":2265},"obj":"http://www.ebi.ac.uk/efo/EFO_0000967"},{"id":"T3704","span":{"begin":2376,"end":2378},"obj":"http://purl.obolibrary.org/obo/CLO_0008922"},{"id":"T6824","span":{"begin":2376,"end":2378},"obj":"http://purl.obolibrary.org/obo/CLO_0050052"},{"id":"T65411","span":{"begin":2530,"end":2534},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T93631","span":{"begin":2543,"end":2552},"obj":"http://purl.obolibrary.org/obo/UBERON_0000158"},{"id":"T36180","span":{"begin":2554,"end":2555},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T98795","span":{"begin":2603,"end":2608},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T83678","span":{"begin":2674,"end":2679},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T26776","span":{"begin":2694,"end":2698},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T81513","span":{"begin":2700,"end":2701},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T17871","span":{"begin":2787,"end":2789},"obj":"http://purl.obolibrary.org/obo/CLO_0008922"},{"id":"T75662","span":{"begin":2787,"end":2789},"obj":"http://purl.obolibrary.org/obo/CLO_0050052"},{"id":"T61344","span":{"begin":2867,"end":2872},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T2057","span":{"begin":2887,"end":2893},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"}],"attributes":[{"subj":"T76112","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T85916","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T42262","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T4712","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T12859","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T72988","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T53244","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T93889","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T73899","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T50671","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T1263","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T61883","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T24540","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T30598","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T86794","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T58803","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T15028","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T80157","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T19942","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T91194","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T77366","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T97236","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T81091","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T93457","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T78563","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T86342","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T89948","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T27116","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T53807","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T96275","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T91518","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T1576","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T13416","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T7903","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T48778","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T3704","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T6824","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T65411","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T93631","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T36180","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T98795","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T83678","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T26776","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T81513","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T17871","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T75662","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T61344","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T2057","pred":"source","obj":"LitCovid-PD-CLO"}]},{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T47","span":{"begin":38,"end":45},"obj":"Chemical"},{"id":"T48","span":{"begin":209,"end":217},"obj":"Chemical"},{"id":"T49","span":{"begin":305,"end":318},"obj":"Chemical"},{"id":"T50","span":{"begin":390,"end":392},"obj":"Chemical"},{"id":"T51","span":{"begin":394,"end":401},"obj":"Chemical"},{"id":"T52","span":{"begin":462,"end":470},"obj":"Chemical"},{"id":"T53","span":{"begin":531,"end":533},"obj":"Chemical"},{"id":"T54","span":{"begin":766,"end":778},"obj":"Chemical"},{"id":"T55","span":{"begin":1040,"end":1042},"obj":"Chemical"},{"id":"T56","span":{"begin":1486,"end":1496},"obj":"Chemical"},{"id":"T57","span":{"begin":1486,"end":1491},"obj":"Chemical"},{"id":"T58","span":{"begin":1492,"end":1496},"obj":"Chemical"},{"id":"T59","span":{"begin":1563,"end":1570},"obj":"Chemical"},{"id":"T60","span":{"begin":1641,"end":1648},"obj":"Chemical"},{"id":"T61","span":{"begin":1830,"end":1838},"obj":"Chemical"},{"id":"T62","span":{"begin":2001,"end":2011},"obj":"Chemical"},{"id":"T63","span":{"begin":2210,"end":2221},"obj":"Chemical"},{"id":"T64","span":{"begin":2210,"end":2215},"obj":"Chemical"},{"id":"T65","span":{"begin":2216,"end":2221},"obj":"Chemical"},{"id":"T66","span":{"begin":2376,"end":2378},"obj":"Chemical"},{"id":"T67","span":{"begin":2787,"end":2789},"obj":"Chemical"},{"id":"T68","span":{"begin":2822,"end":2829},"obj":"Chemical"}],"attributes":[{"id":"A47","pred":"chebi_id","subj":"T47","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A48","pred":"chebi_id","subj":"T48","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A49","pred":"chebi_id","subj":"T49","obj":"http://purl.obolibrary.org/obo/CHEBI_17089"},{"id":"A50","pred":"chebi_id","subj":"T50","obj":"http://purl.obolibrary.org/obo/CHEBI_29387"},{"id":"A51","pred":"chebi_id","subj":"T51","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A52","pred":"chebi_id","subj":"T52","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A53","pred":"chebi_id","subj":"T53","obj":"http://purl.obolibrary.org/obo/CHEBI_29387"},{"id":"A54","pred":"chebi_id","subj":"T54","obj":"http://purl.obolibrary.org/obo/CHEBI_17089"},{"id":"A55","pred":"chebi_id","subj":"T55","obj":"http://purl.obolibrary.org/obo/CHEBI_29387"},{"id":"A56","pred":"chebi_id","subj":"T56","obj":"http://purl.obolibrary.org/obo/CHEBI_33709"},{"id":"A57","pred":"chebi_id","subj":"T57","obj":"http://purl.obolibrary.org/obo/CHEBI_46882"},{"id":"A58","pred":"chebi_id","subj":"T58","obj":"http://purl.obolibrary.org/obo/CHEBI_37527"},{"id":"A59","pred":"chebi_id","subj":"T59","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A60","pred":"chebi_id","subj":"T60","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A61","pred":"chebi_id","subj":"T61","obj":"http://purl.obolibrary.org/obo/CHEBI_25367"},{"id":"A62","pred":"chebi_id","subj":"T62","obj":"http://purl.obolibrary.org/obo/CHEBI_5017"},{"id":"A63","pred":"chebi_id","subj":"T63","obj":"http://purl.obolibrary.org/obo/CHEBI_33709"},{"id":"A64","pred":"chebi_id","subj":"T64","obj":"http://purl.obolibrary.org/obo/CHEBI_46882"},{"id":"A65","pred":"chebi_id","subj":"T65","obj":"http://purl.obolibrary.org/obo/CHEBI_37527"},{"id":"A66","pred":"chebi_id","subj":"T66","obj":"http://purl.obolibrary.org/obo/CHEBI_29387"},{"id":"A67","pred":"chebi_id","subj":"T67","obj":"http://purl.obolibrary.org/obo/CHEBI_29387"},{"id":"A68","pred":"chebi_id","subj":"T68","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"subj":"T47","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T48","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T49","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T50","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T51","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T52","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T53","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T54","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T55","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T56","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T57","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T58","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T59","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T60","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T61","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T62","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T63","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T64","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T65","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T66","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T67","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T68","pred":"source","obj":"LitCovid-PD-CHEBI"}]},{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T54884","span":{"begin":1486,"end":1508},"obj":"http://purl.obolibrary.org/obo/GO_0006865"}],"attributes":[{"subj":"T54884","pred":"source","obj":"LitCovid-PD-GO-BP"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T41","span":{"begin":0,"end":269},"obj":"Sentence"},{"id":"T42","span":{"begin":270,"end":455},"obj":"Sentence"},{"id":"T43","span":{"begin":456,"end":712},"obj":"Sentence"},{"id":"T44","span":{"begin":713,"end":1124},"obj":"Sentence"},{"id":"T45","span":{"begin":1125,"end":1348},"obj":"Sentence"},{"id":"T46","span":{"begin":1349,"end":1541},"obj":"Sentence"},{"id":"T47","span":{"begin":1542,"end":1679},"obj":"Sentence"},{"id":"T48","span":{"begin":1680,"end":1948},"obj":"Sentence"},{"id":"T49","span":{"begin":1949,"end":2135},"obj":"Sentence"},{"id":"T50","span":{"begin":2136,"end":2320},"obj":"Sentence"},{"id":"T51","span":{"begin":2321,"end":2553},"obj":"Sentence"},{"id":"T52","span":{"begin":2554,"end":2658},"obj":"Sentence"},{"id":"T53","span":{"begin":2659,"end":2904},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T41","pred":"source","obj":"LitCovid-sentences"},{"subj":"T42","pred":"source","obj":"LitCovid-sentences"},{"subj":"T43","pred":"source","obj":"LitCovid-sentences"},{"subj":"T44","pred":"source","obj":"LitCovid-sentences"},{"subj":"T45","pred":"source","obj":"LitCovid-sentences"},{"subj":"T46","pred":"source","obj":"LitCovid-sentences"},{"subj":"T47","pred":"source","obj":"LitCovid-sentences"},{"subj":"T48","pred":"source","obj":"LitCovid-sentences"},{"subj":"T49","pred":"source","obj":"LitCovid-sentences"},{"subj":"T50","pred":"source","obj":"LitCovid-sentences"},{"subj":"T51","pred":"source","obj":"LitCovid-sentences"},{"subj":"T52","pred":"source","obj":"LitCovid-sentences"},{"subj":"T53","pred":"source","obj":"LitCovid-sentences"}]},{"project":"2_test","denotations":[{"id":"32708755-30102747-20678677","span":{"begin":1240,"end":1242},"obj":"30102747"},{"id":"32708755-32075877-20678678","span":{"begin":1341,"end":1343},"obj":"32075877"},{"id":"32708755-32132184-20678679","span":{"begin":1344,"end":1346},"obj":"32132184"},{"id":"32708755-32132184-20678680","span":{"begin":1537,"end":1539},"obj":"32132184"},{"id":"32708755-32132184-20678681","span":{"begin":1675,"end":1677},"obj":"32132184"},{"id":"32708755-17522231-20678682","span":{"begin":2654,"end":2656},"obj":"17522231"}],"attributes":[{"subj":"32708755-30102747-20678677","pred":"source","obj":"2_test"},{"subj":"32708755-32075877-20678678","pred":"source","obj":"2_test"},{"subj":"32708755-32132184-20678679","pred":"source","obj":"2_test"},{"subj":"32708755-32132184-20678680","pred":"source","obj":"2_test"},{"subj":"32708755-32132184-20678681","pred":"source","obj":"2_test"},{"subj":"32708755-17522231-20678682","pred":"source","obj":"2_test"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-PD-FMA-UBERON","color":"#b0ec93","default":true},{"id":"LitCovid-PD-UBERON","color":"#ec93ca"},{"id":"LitCovid-PubTator","color":"#93e4ec"},{"id":"LitCovid-PD-MONDO","color":"#ecda93"},{"id":"LitCovid-PD-CLO","color":"#c093ec"},{"id":"LitCovid-PD-CHEBI","color":"#93eca5"},{"id":"LitCovid-PD-GO-BP","color":"#ec939a"},{"id":"LitCovid-sentences","color":"#93b4ec"},{"id":"2_test","color":"#ceec93"}]}]}}