> top > docs > PMC:7408073 > spans > 75555-82304 > annotations

PMC:7408073 / 75555-82304 JSONTXT

Annnotations TAB JSON ListView MergeView

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T432 62-69 Body_part denotes insulin http://purl.org/sig/ont/fma/fma83365
T433 206-210 Body_part denotes hand http://purl.org/sig/ont/fma/fma9712
T434 227-234 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T435 262-268 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T436 276-281 Body_part denotes urine http://purl.org/sig/ont/fma/fma12274
T437 639-645 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T438 655-659 Body_part denotes mRNA http://purl.org/sig/ont/fma/fma67122
T439 670-675 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T440 698-702 Body_part denotes hand http://purl.org/sig/ont/fma/fma9712
T441 787-792 Body_part denotes bowel http://purl.org/sig/ont/fma/fma7199
T442 908-913 Body_part denotes heart http://purl.org/sig/ont/fma/fma7088
T443 1005-1011 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T444 1584-1591 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T445 2172-2178 Body_part denotes kidney http://purl.org/sig/ont/fma/fma7203
T446 2416-2421 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670
T447 2438-2445 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T448 2464-2470 Body_part denotes kidney http://purl.org/sig/ont/fma/fma7203
T449 2713-2718 Body_part denotes urine http://purl.org/sig/ont/fma/fma12274
T450 2757-2764 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T451 3045-3050 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670
T452 3396-3401 Body_part denotes organ http://purl.org/sig/ont/fma/fma67498
T453 3416-3420 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T454 3421-3428 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T455 3550-3554 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T456 3736-3744 Body_part denotes intronic http://purl.org/sig/ont/fma/fma84121
T457 3942-3946 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T458 3967-3971 Body_part denotes hand http://purl.org/sig/ont/fma/fma9712
T459 5505-5510 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T142 206-210 Body_part denotes hand http://purl.obolibrary.org/obo/UBERON_0002398
T143 276-281 Body_part denotes urine http://purl.obolibrary.org/obo/UBERON_0001088
T144 698-702 Body_part denotes hand http://purl.obolibrary.org/obo/UBERON_0002398
T145 908-913 Body_part denotes heart http://purl.obolibrary.org/obo/UBERON_0000948
T146 2172-2178 Body_part denotes kidney http://purl.obolibrary.org/obo/UBERON_0002113
T147 2416-2421 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T148 2464-2470 Body_part denotes kidney http://purl.obolibrary.org/obo/UBERON_0002113
T149 2713-2718 Body_part denotes urine http://purl.obolibrary.org/obo/UBERON_0001088
T150 3045-3050 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T151 3150-3153 Body_part denotes RAS http://purl.obolibrary.org/obo/UBERON_0018229
T152 3396-3401 Body_part denotes organ http://purl.obolibrary.org/obo/UBERON_0000062
T153 3967-3971 Body_part denotes hand http://purl.obolibrary.org/obo/UBERON_0002398
T154 4669-4672 Body_part denotes RAS http://purl.obolibrary.org/obo/UBERON_0018229
T155 5406-5409 Body_part denotes RAS http://purl.obolibrary.org/obo/UBERON_0018229
T156 5450-5453 Body_part denotes RAS http://purl.obolibrary.org/obo/UBERON_0018229
T157 5505-5510 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
2728 137-141 Gene denotes ACE2 Gene:59272
2729 222-226 Gene denotes ACE2 Gene:59272
2730 650-654 Gene denotes ACE2 Gene:302668
2731 832-836 Gene denotes ACE2 Gene:59272
2732 1012-1016 Gene denotes ACE2 Gene:59272
2733 1243-1247 Gene denotes ACE2 Gene:59272
2734 1492-1496 Gene denotes ACE2 Gene:59272
2735 1579-1583 Gene denotes ACE2 Gene:59272
2736 1710-1714 Gene denotes ACE2 Gene:59272
2737 1772-1776 Gene denotes ACE2 Gene:59272
2738 2289-2293 Gene denotes ACE2 Gene:59272
2739 2990-2994 Gene denotes ACE2 Gene:59272
2740 3010-3013 Gene denotes ACE Gene:59272
2741 3014-3018 Gene denotes ACE2 Gene:59272
2742 3373-3377 Gene denotes ACE2 Gene:59272
2743 3411-3415 Gene denotes ACE2 Gene:59272
2744 3545-3549 Gene denotes ACE2 Gene:59272
2745 3937-3941 Gene denotes ACE2 Gene:59272
2746 4583-4587 Gene denotes ACE2 Gene:59272
2747 62-69 Gene denotes insulin Gene:3630
2748 303-306 Species denotes men Tax:9606
2749 408-412 Species denotes rats Tax:10116
2750 731-739 Species denotes patients Tax:9606
2751 914-922 Species denotes patients Tax:9606
2752 1998-2006 Species denotes patients Tax:9606
2753 2187-2195 Species denotes patients Tax:9606
2754 2479-2487 Species denotes patients Tax:9606
2755 2788-2796 Species denotes patients Tax:9606
2756 2845-2853 Species denotes patients Tax:9606
2757 3229-3239 Species denotes SARS-CoV-2 Tax:2697049
2758 4163-4171 Species denotes patients Tax:9606
2759 4765-4773 Species denotes patients Tax:9606
2760 5565-5578 Species denotes coronaviruses Tax:11118
2761 5669-5679 Species denotes SARS-CoV-2 Tax:2697049
2762 5752-5767 Species denotes influenza virus Tax:11308
2763 5830-5836 Species denotes humans Tax:9606
2764 5870-5883 Species denotes coronaviruses Tax:11118
2765 6076-6084 Species denotes SARS-CoV Tax:694009
2766 6089-6097 Species denotes MERS-CoV Tax:1335626
2767 6482-6492 Species denotes SARS-CoV-2 Tax:2697049
2768 2118-2123 Chemical denotes sACE2
2769 2131-2135 Chemical denotes Zn2+
2770 2660-2664 Chemical denotes Zn2+
2771 2908-2918 Chemical denotes olmesartan MESH:C437965
2772 372-384 Disease denotes hypertensive MESH:D006973
2773 493-499 Disease denotes asthma MESH:D001249
2774 510-527 Disease denotes allergic diseases MESH:D004342
2775 559-567 Disease denotes COVID-19 MESH:C000657245
2776 745-768 Disease denotes cardiovascular diseases MESH:D002318
2777 774-800 Disease denotes inflammatory bowel disease MESH:D015212
2778 934-942 Disease denotes COVID-19 MESH:C000657245
2779 974-993 Disease denotes atrial fibrillation MESH:D001281
2780 1069-1088 Disease denotes cardiac dysfunction MESH:D006331
2781 1122-1134 Disease denotes hypertension MESH:D006973
2782 1150-1166 Disease denotes vascular disease MESH:D000783
2783 1319-1327 Disease denotes COVID-19 MESH:C000657245
2784 1525-1540 Disease denotes viral infection MESH:D001102
2785 1747-1755 Disease denotes COVID-19 MESH:C000657245
2786 1846-1854 Disease denotes COVID-19 MESH:C000657245
2787 1951-1972 Disease denotes chronic renal disease MESH:D051436
2788 1976-1984 Disease denotes COVID-19 MESH:C000657245
2789 2164-2186 Disease denotes chronic kidney disease MESH:D051436
2790 2217-2239 Disease denotes cardiovascular disease MESH:D002318
2791 2378-2389 Disease denotes proteinuria MESH:D011507
2792 2456-2478 Disease denotes chronic kidney disease MESH:D051436
2793 2572-2594 Disease denotes chronic renal diseases MESH:D051436
2794 2802-2824 Disease denotes chronic renal diseases MESH:D051436
2795 2832-2844 Disease denotes hypertensive MESH:D006973
2796 2973-2986 Disease denotes hyperactivity MESH:D006948
2797 3102-3110 Disease denotes COVID-19 MESH:C000657245
2798 3208-3218 Disease denotes infections MESH:D007239
2799 3319-3339 Disease denotes SARS-CoV-2 infection MESH:C000657245
2800 3599-3611 Disease denotes hypertension MESH:D006973
2801 3613-3625 Disease denotes dyslipidemia MESH:D050171
2802 3634-3642 Disease denotes diabetes MESH:D003920
2803 3647-3673 Disease denotes cardiovascular dysfunction MESH:D002318
2804 3973-3981 Disease denotes COVID-19 MESH:C000657245
2805 4010-4033 Disease denotes obstructive sleep apnea MESH:D020181
2806 4091-4099 Disease denotes COVID-19 MESH:C000657245
2807 4154-4162 Disease denotes COVID-19 MESH:C000657245
2808 4264-4272 Disease denotes Covid-19 MESH:C000657245
2809 4330-4344 Disease denotes apnea/hypopnea MESH:D020181
2810 4362-4372 Disease denotes hypoxaemia
2811 4380-4385 Disease denotes sleep MESH:D012893
2812 4412-4424 Disease denotes hypertension MESH:D006973
2813 4426-4448 Disease denotes cardiovascular disease MESH:D002318
2814 4450-4458 Disease denotes diabetes MESH:D003920
2815 4460-4467 Disease denotes obesity MESH:D009765
2816 4481-4493 Disease denotes inflammation MESH:D007249
2817 4615-4622 Disease denotes hypoxia MESH:D000860
2818 4736-4756 Disease denotes SARS-CoV-2 infection MESH:C000657245
2819 5076-5081 Disease denotes sleep MESH:D012893
2820 5209-5217 Disease denotes COVID-19 MESH:C000657245
2821 5815-5826 Disease denotes common cold MESH:D003139
2822 6134-6154 Disease denotes SARS-CoV-2 infection MESH:C000657245
2823 6454-6470 Disease denotes virus infections MESH:D001102

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T378 493-499 Disease denotes asthma http://purl.obolibrary.org/obo/MONDO_0004979
T379 510-527 Disease denotes allergic diseases http://purl.obolibrary.org/obo/MONDO_0005271
T380 510-518 Disease denotes allergic http://purl.obolibrary.org/obo/MONDO_0004980
T381 559-567 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T382 745-768 Disease denotes cardiovascular diseases http://purl.obolibrary.org/obo/MONDO_0004995
T383 774-800 Disease denotes inflammatory bowel disease http://purl.obolibrary.org/obo/MONDO_0005265
T384 934-942 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T385 974-993 Disease denotes atrial fibrillation http://purl.obolibrary.org/obo/MONDO_0004981
T386 1122-1134 Disease denotes hypertension http://purl.obolibrary.org/obo/MONDO_0005044
T387 1150-1166 Disease denotes vascular disease http://purl.obolibrary.org/obo/MONDO_0005385
T388 1319-1327 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T389 1398-1402 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T390 1525-1540 Disease denotes viral infection http://purl.obolibrary.org/obo/MONDO_0005108
T391 1531-1540 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T392 1747-1755 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T393 1846-1854 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T394 1951-1972 Disease denotes chronic renal disease http://purl.obolibrary.org/obo/MONDO_0005300
T395 1959-1972 Disease denotes renal disease http://purl.obolibrary.org/obo/MONDO_0002118|http://purl.obolibrary.org/obo/MONDO_0005240
T397 1976-1984 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T398 2164-2186 Disease denotes chronic kidney disease http://purl.obolibrary.org/obo/MONDO_0005300
T399 2172-2186 Disease denotes kidney disease http://purl.obolibrary.org/obo/MONDO_0001343|http://purl.obolibrary.org/obo/MONDO_0005240
T401 2217-2239 Disease denotes cardiovascular disease http://purl.obolibrary.org/obo/MONDO_0004995
T402 2378-2389 Disease denotes proteinuria http://purl.obolibrary.org/obo/MONDO_0003634
T403 2456-2478 Disease denotes chronic kidney disease http://purl.obolibrary.org/obo/MONDO_0005300
T404 2464-2478 Disease denotes kidney disease http://purl.obolibrary.org/obo/MONDO_0001343|http://purl.obolibrary.org/obo/MONDO_0005240
T406 2572-2594 Disease denotes chronic renal diseases http://purl.obolibrary.org/obo/MONDO_0005300
T407 2615-2619 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T408 2802-2824 Disease denotes chronic renal diseases http://purl.obolibrary.org/obo/MONDO_0005300
T409 2903-2906 Disease denotes ARB http://purl.obolibrary.org/obo/MONDO_0012733
T410 3102-3110 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T411 3208-3218 Disease denotes infections http://purl.obolibrary.org/obo/MONDO_0005550
T412 3229-3237 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T413 3229-3233 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T414 3319-3327 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T415 3319-3323 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T416 3330-3339 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T417 3599-3611 Disease denotes hypertension http://purl.obolibrary.org/obo/MONDO_0005044
T418 3613-3625 Disease denotes dyslipidemia http://purl.obolibrary.org/obo/MONDO_0002525
T419 3627-3642 Disease denotes type 2 diabetes http://purl.obolibrary.org/obo/MONDO_0005148
T420 3634-3642 Disease denotes diabetes http://purl.obolibrary.org/obo/MONDO_0005015
T421 3973-3981 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T422 4010-4033 Disease denotes obstructive sleep apnea http://purl.obolibrary.org/obo/MONDO_0007147
T423 4022-4033 Disease denotes sleep apnea http://purl.obolibrary.org/obo/MONDO_0005296
T424 4035-4038 Disease denotes OSA http://purl.obolibrary.org/obo/MONDO_0007147
T425 4083-4086 Disease denotes OSA http://purl.obolibrary.org/obo/MONDO_0007147
T426 4091-4099 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T427 4147-4150 Disease denotes OSA http://purl.obolibrary.org/obo/MONDO_0007147
T428 4154-4162 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T429 4217-4220 Disease denotes OSA http://purl.obolibrary.org/obo/MONDO_0007147
T430 4274-4277 Disease denotes OSA http://purl.obolibrary.org/obo/MONDO_0007147
T431 4412-4448 Disease denotes hypertension, cardiovascular disease http://purl.obolibrary.org/obo/MONDO_0001302
T432 4412-4424 Disease denotes hypertension http://purl.obolibrary.org/obo/MONDO_0005044
T433 4426-4448 Disease denotes cardiovascular disease http://purl.obolibrary.org/obo/MONDO_0004995
T434 4450-4458 Disease denotes diabetes http://purl.obolibrary.org/obo/MONDO_0005015
T435 4460-4467 Disease denotes obesity http://purl.obolibrary.org/obo/MONDO_0011122
T436 4481-4493 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T437 4685-4688 Disease denotes OSA http://purl.obolibrary.org/obo/MONDO_0007147
T438 4736-4744 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T439 4736-4740 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T440 4747-4756 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T441 4761-4764 Disease denotes OSA http://purl.obolibrary.org/obo/MONDO_0007147
T442 4985-4988 Disease denotes OSA http://purl.obolibrary.org/obo/MONDO_0007147
T443 5209-5217 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T444 5669-5677 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T445 5669-5673 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T446 5722-5725 Disease denotes flu http://purl.obolibrary.org/obo/MONDO_0005812
T447 5752-5761 Disease denotes influenza http://purl.obolibrary.org/obo/MONDO_0005812
T448 5815-5826 Disease denotes common cold http://purl.obolibrary.org/obo/MONDO_0005709
T449 5963-5966 Disease denotes flu http://purl.obolibrary.org/obo/MONDO_0005812
T450 6076-6084 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T451 6076-6080 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T452 6134-6142 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T453 6134-6138 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T454 6145-6154 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T455 6454-6470 Disease denotes virus infections http://purl.obolibrary.org/obo/MONDO_0005108
T456 6482-6490 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T457 6482-6486 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T913 62-69 http://purl.obolibrary.org/obo/PR_000009054 denotes insulin
T914 142-150 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T915 262-268 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T916 296-302 http://purl.obolibrary.org/obo/CLO_0001658 denotes active
T917 639-645 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T918 663-669 http://purl.obolibrary.org/obo/UBERON_0001005 denotes airway
T919 670-675 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T920 908-913 http://purl.obolibrary.org/obo/UBERON_0000948 denotes heart
T921 908-913 http://purl.obolibrary.org/obo/UBERON_0007100 denotes heart
T922 908-913 http://purl.obolibrary.org/obo/UBERON_0015228 denotes heart
T923 908-913 http://www.ebi.ac.uk/efo/EFO_0000815 denotes heart
T924 962-963 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T925 1005-1011 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T926 1017-1025 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T927 1106-1110 http://purl.obolibrary.org/obo/UBERON_0003101 denotes male
T928 1106-1110 http://www.ebi.ac.uk/efo/EFO_0000970 denotes male
T929 1202-1203 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T930 1248-1256 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T931 1372-1373 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T932 1476-1484 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T933 1875-1884 http://www.ebi.ac.uk/efo/EFO_0000876 denotes extremely
T934 2071-2073 http://purl.obolibrary.org/obo/CLO_0053733 denotes 11
T935 2109-2110 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T936 2172-2178 http://purl.obolibrary.org/obo/UBERON_0002113 denotes kidney
T937 2172-2178 http://www.ebi.ac.uk/efo/EFO_0000927 denotes kidney
T938 2172-2178 http://www.ebi.ac.uk/efo/EFO_0000929 denotes kidney
T939 2204-2205 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T940 2251-2252 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T941 2294-2302 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T942 2416-2421 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T943 2416-2421 http://www.ebi.ac.uk/efo/EFO_0000296 denotes blood
T944 2464-2470 http://purl.obolibrary.org/obo/UBERON_0002113 denotes kidney
T945 2464-2470 http://www.ebi.ac.uk/efo/EFO_0000927 denotes kidney
T946 2464-2470 http://www.ebi.ac.uk/efo/EFO_0000929 denotes kidney
T947 2560-2568 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T948 2638-2639 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T949 2965-2966 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T950 3045-3050 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T951 3045-3050 http://www.ebi.ac.uk/efo/EFO_0000296 denotes blood
T952 3138-3142 http://www.ebi.ac.uk/efo/EFO_0001410 denotes arms
T953 3181-3189 http://purl.obolibrary.org/obo/OBI_0100026 denotes organism
T954 3181-3189 http://purl.obolibrary.org/obo/UBERON_0000468 denotes organism
T955 3396-3401 http://purl.obolibrary.org/obo/UBERON_0003103 denotes organ
T956 3416-3420 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T957 3550-3554 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T958 3772-3781 http://purl.obolibrary.org/obo/UBERON_0007651 denotes junctions
T959 3942-3946 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T960 3982-3985 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T961 4052-4053 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T962 4172-4175 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T963 4230-4231 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T964 4309-4315 http://purl.obolibrary.org/obo/UBERON_0001005 denotes airway
T965 4623-4626 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T966 4657-4661 http://www.ebi.ac.uk/efo/EFO_0001410 denotes arms
T967 4781-4787 http://purl.obolibrary.org/obo/UBERON_0001005 denotes airway
T968 4869-4874 http://purl.obolibrary.org/obo/UBERON_0003101 denotes males
T969 4869-4874 http://www.ebi.ac.uk/efo/EFO_0000970 denotes males
T970 4883-4890 http://purl.obolibrary.org/obo/UBERON_0003100 denotes females
T971 4937-4944 http://purl.obolibrary.org/obo/UBERON_0001005 denotes airways
T972 4955-4961 http://purl.obolibrary.org/obo/UBERON_0001005 denotes airway
T973 5013-5020 http://purl.obolibrary.org/obo/UBERON_0001005 denotes airways
T974 5024-5031 http://purl.obolibrary.org/obo/UBERON_0003100 denotes females
T975 5090-5095 http://purl.obolibrary.org/obo/UBERON_0003101 denotes males
T976 5090-5095 http://www.ebi.ac.uk/efo/EFO_0000970 denotes males
T977 5410-5420 http://purl.obolibrary.org/obo/CLO_0001658 denotes activities
T978 5454-5464 http://purl.obolibrary.org/obo/CLO_0001658 denotes activities
T979 5505-5510 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T980 5505-5510 http://www.ebi.ac.uk/efo/EFO_0000296 denotes blood
T981 5614-5615 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T982 5762-5767 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T983 5830-5836 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes humans
T984 5999-6000 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T985 6023-6033 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T986 6099-6100 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T987 6155-6158 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T988 6454-6459 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T989 6571-6578 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T990 6714-6723 http://purl.obolibrary.org/obo/OBI_0100026 denotes organisms
T991 6714-6723 http://purl.obolibrary.org/obo/UBERON_0000468 denotes organisms

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T70014 62-69 Chemical denotes insulin http://purl.obolibrary.org/obo/CHEBI_145810
T54852 227-234 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T20423 631-635 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T36620 1106-1110 Chemical denotes male http://purl.obolibrary.org/obo/CHEBI_30780
T5528 1385-1394 Chemical denotes biomarker http://purl.obolibrary.org/obo/CHEBI_59163
T81193 1584-1591 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T20258 2131-2134 Chemical denotes Zn2 http://purl.obolibrary.org/obo/CHEBI_37256
T31895 2307-2311 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T31980 2438-2445 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T64545 2507-2511 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T71170 2660-2663 Chemical denotes Zn2 http://purl.obolibrary.org/obo/CHEBI_37256
T91526 2757-2764 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T21622 2875-2877 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T17216 2908-2918 Chemical denotes olmesartan http://purl.obolibrary.org/obo/CHEBI_48416
T323 3150-3153 Chemical denotes RAS http://purl.obolibrary.org/obo/CHEBI_63620
T37828 3421-3428 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T325 4669-4672 Chemical denotes RAS http://purl.obolibrary.org/obo/CHEBI_63620
T326 5262-5266 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T10662 5406-5409 Chemical denotes RAS http://purl.obolibrary.org/obo/CHEBI_63620
T32041 5450-5453 Chemical denotes RAS http://purl.obolibrary.org/obo/CHEBI_63620

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T142 1525-1540 http://purl.obolibrary.org/obo/GO_0016032 denotes viral infection
T143 2142-2151 http://purl.obolibrary.org/obo/GO_0007588 denotes excretion
T144 2512-2521 http://purl.obolibrary.org/obo/GO_0007588 denotes excretion
T145 2671-2680 http://purl.obolibrary.org/obo/GO_0007588 denotes excretion
T146 4022-4027 http://purl.obolibrary.org/obo/GO_0030431 denotes sleep
T147 4380-4385 http://purl.obolibrary.org/obo/GO_0030431 denotes sleep
T148 4481-4493 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T149 5076-5081 http://purl.obolibrary.org/obo/GO_0030431 denotes sleep
T150 6034-6040 http://purl.obolibrary.org/obo/GO_0007613 denotes memory
T151 6044-6059 http://purl.obolibrary.org/obo/GO_0006955 denotes immune response

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T372 0-192 Sentence denotes To complete the picture, smokers and subjects on therapy with insulin tend to have an increased (although not significantly) circulating ACE2 activity when compared with control subjects [96].
T373 193-454 Sentence denotes On the other hand, increased ACE2 protein expression was reported in plasma and/or urine of physically active men after acute aerobic training or in renal cortices of spontaneous hypertensive, but not normotensive, rats after chronic aerobic training [149,150].
T374 455-684 Sentence denotes In addition, recent works reveal that asthma and other allergic diseases, which protect from developing COVID-19, were associated with significant reductions in levels of both zinc in plasma and ACE2 mRNA in airway cells [98,99].
T375 685-943 Sentence denotes On the other hand, as already mentioned, some patients with cardiovascular diseases (and inflammatory bowel disease) have an increased circulating ACE2 [22,49,151,152], which might explain the higher probability of elderly heart patients to develop COVID-19.
T376 944-1173 Sentence denotes Interestingly, in a report on atrial fibrillation, increased plasma ACE2 activity was significantly associated not only with cardiac dysfunction, increasing age, male gender and hypertension, but also with vascular disease [152].
T377 1174-1415 Sentence denotes Altogether the data suggest a strong correlation between circulating ACE2 activity and the predisposition to develop the most severe symptoms of COVID-19, suggesting that circulating sACE2 might be a predictive biomarker of SARS development.
T378 1416-1651 Sentence denotes The surprising aspect is that circulating (differently from membrane bound) ACE2 is expected to protect from viral infection and clinical trials using recombinant ACE2 protein are being pursued (ClinicalTrials.gov number, NCT04287686).
T379 1652-1855 Sentence denotes However, even if it might not be detrimental, recombinant ACE2 is not expected to protect from COVID-19, as circulating ACE2 upregulation correlates with the most common comorbidities in severe COVID-19.
T380 1856-2152 Sentence denotes The correlation is extremely impressive and striking if we also consider the low prevalence of chronic renal disease in COVID-19 hospitalized patients (0–3%) [1,2,3,4,5,6,7,8,9] (prevalence of the disease in China ~11% [12]) which might be protected by a higher sACE2 and/or Zn2+ renal excretion.
T381 2153-2371 Sentence denotes Indeed, in chronic kidney disease patients without a history of cardiovascular disease, there was a significant decrease in circulating ACE2 activity and zinc levels when compared with healthy control subjects [96,97].
T382 2372-2681 Sentence denotes Since proteinuria was associated with lower blood levels of sACE2 protein [153] and chronic kidney disease patients had higher urinary zinc excretion than healthy controls [97], low sACE2 activity in chronic renal diseases and protection from SARS might derive from a higher sACE2 and/or Zn2+ renal excretion.
T383 2682-2928 Sentence denotes Indeed, sACE2 is detectable in urine of healthy subjects and urinary sACE2 protein levels are elevated in patients with chronic renal diseases and in hypertensive patients treated with the Ang II type 1 receptor blocker (ARB) olmesartan [41,154].
T384 2929-3154 Sentence denotes It can, therefore, be supposed that a basal hyperactivity of ACE2 and consequent ACE/ACE2 pathway disequilibrium in blood might predispose to the development of more severe COVID-19 symptoms that involve both arms of the RAS.
T385 3155-3531 Sentence denotes In this regard, different organism predisposition to infections including SARS-CoV-2 or to pathologies associated with an increased risk to develop severe forms of SARS-CoV-2 infection might depend not only on genetic ACE2 polymorphisms and organ-specific ACE2 gene/protein expression [138,155,156,157,158,159,160,161,162,163] but also on anatomical and environmental factors.
T386 3532-3708 Sentence denotes For example, ACE2 gene variants have been associated with risk for hypertension, dyslipidemia, type 2 diabetes and cardiovascular dysfunction [138,155,156,157,158,159,160,161].
T387 3709-3953 Sentence denotes Most of these variants are intronic and located in splice-site junctions or in enhancer regions while the others are placed in the 3’ UTR promoter region, suggesting their involvement in the structure/function and expression of ACE2 gene [138].
T388 3954-4106 Sentence denotes On the other hand, COVID-19 has similar risk factors of obstructive sleep apnea (OSA), suggesting a possible association between OSA and COVID-19 [164].
T389 4107-4273 Sentence denotes Indeed, high prevalence of pre-existing OSA in COVID-19 patients has been reported [165,166], indicating that OSA could be a risk factor for severe forms of Covid-19.
T390 4274-4500 Sentence denotes OSA is characterised by repetitive airway collapse with apnea/hypopnea and intermittent hypoxaemia during sleep and it is associated with hypertension, cardiovascular disease, diabetes, obesity and systemic inflammation [167].
T391 4501-4757 Sentence denotes Most of these diseases are known to predispose to increased levels of circulating ACE2 and, as already mentioned, hypoxia has been shown to upregulate both arms of the RAS; therefore, OSA might predispose to the deleterious effects of SARS-CoV-2 infection.
T392 4758-4998 Sentence denotes In OSA patients, upper airway collapsibility under passive conditions (critical closing pressure) is higher in males than in females due to anatomical factors, i.e., longer upper airways, as upper airway length correlates with OSA severity.
T393 4999-5239 Sentence denotes Indeed, upper airways in females are less collapsible and more stable during sleep than in males [167], suggesting that an anatomical factor might contribute to and result in different gender susceptibility to COVID-19 and disease severity.
T394 5240-5421 Sentence denotes Moreover, diet (e.g., zinc assumption), physical exercise and external temperature and UV radiation are all “environmental” aspects that can seasonally influence the RAS activities.
T395 5422-5535 Sentence denotes Seasonal differences of the RAS activities leading, for example, to differences in blood pressure are well known.
T396 5536-5658 Sentence denotes Of interest, the majority of coronaviruses cause cold-like illnesses and have a relatively low mutational frequency [168].
T397 5659-5732 Sentence denotes Similarly SARS-CoV-2 seems to mutate much slower than seasonal flu [169].
T398 5733-5967 Sentence denotes Nevertheless, like influenza virus, they are responsible for seasonal episodes of common cold in humans worldwide [168], suggesting that coronaviruses may possess an ability to evade immune control that is different from seasonal flu.
T399 5968-6060 Sentence denotes For example, they might favour a relatively short-term activation/memory of immune response.
T400 6061-6197 Sentence denotes Indeed, as for SARS-CoV and MERS-CoV, a short duration of immunity after SARS-CoV-2 infection has been recently suggested [170,171,172].
T401 6198-6378 Sentence denotes Seasonal cold is an annually recurring time period characterized by the prevalence of outbreaks of cold and the season occurs during the cold period of the year in each hemisphere.
T402 6379-6749 Sentence denotes Altogether these observations suggest that seasonal predisposition to some virus infections (including SARS-CoV-2) might not depend only on environmental features that directly inactivate the viruses “unprotected” outside the host (e.g., higher ultraviolet rays and temperatures), but also on seasonal indirect effects produced in the organisms by environmental changes.

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T113 493-499 Phenotype denotes asthma http://purl.obolibrary.org/obo/HP_0002099
T114 745-768 Phenotype denotes cardiovascular diseases http://purl.obolibrary.org/obo/HP_0001626
T115 774-800 Phenotype denotes inflammatory bowel disease http://purl.obolibrary.org/obo/HP_0002037
T116 974-993 Phenotype denotes atrial fibrillation http://purl.obolibrary.org/obo/HP_0005110
T117 1122-1134 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822
T118 2164-2186 Phenotype denotes chronic kidney disease http://purl.obolibrary.org/obo/HP_0012622
T119 2217-2239 Phenotype denotes cardiovascular disease http://purl.obolibrary.org/obo/HP_0001626
T120 2378-2389 Phenotype denotes proteinuria http://purl.obolibrary.org/obo/HP_0000093
T121 2456-2478 Phenotype denotes chronic kidney disease http://purl.obolibrary.org/obo/HP_0012622
T122 2973-2986 Phenotype denotes hyperactivity http://purl.obolibrary.org/obo/HP_0000752
T123 3190-3218 Phenotype denotes predisposition to infections http://purl.obolibrary.org/obo/HP_0002719
T124 3599-3611 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822
T125 3613-3625 Phenotype denotes dyslipidemia http://purl.obolibrary.org/obo/HP_0003119
T126 3627-3642 Phenotype denotes type 2 diabetes http://purl.obolibrary.org/obo/HP_0005978
T127 4010-4033 Phenotype denotes obstructive sleep apnea http://purl.obolibrary.org/obo/HP_0002870
T128 4035-4038 Phenotype denotes OSA http://purl.obolibrary.org/obo/HP_0002870
T129 4083-4086 Phenotype denotes OSA http://purl.obolibrary.org/obo/HP_0002870
T130 4147-4150 Phenotype denotes OSA http://purl.obolibrary.org/obo/HP_0002870
T131 4217-4220 Phenotype denotes OSA http://purl.obolibrary.org/obo/HP_0002870
T132 4274-4277 Phenotype denotes OSA http://purl.obolibrary.org/obo/HP_0002870
T133 4330-4335 Phenotype denotes apnea http://purl.obolibrary.org/obo/HP_0002104
T134 4336-4344 Phenotype denotes hypopnea http://purl.obolibrary.org/obo/HP_0040213
T135 4412-4424 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822
T136 4426-4448 Phenotype denotes cardiovascular disease http://purl.obolibrary.org/obo/HP_0001626
T137 4460-4467 Phenotype denotes obesity http://purl.obolibrary.org/obo/HP_0001513
T138 4615-4622 Phenotype denotes hypoxia http://purl.obolibrary.org/obo/HP_0012418
T139 4685-4688 Phenotype denotes OSA http://purl.obolibrary.org/obo/HP_0002870
T140 4761-4764 Phenotype denotes OSA http://purl.obolibrary.org/obo/HP_0002870
T141 4985-4988 Phenotype denotes OSA http://purl.obolibrary.org/obo/HP_0002870

2_test

Id Subject Object Predicate Lexical cue
32708755-25813276-20678924 188-190 25813276 denotes 96
32708755-31989052-20678925 445-448 31989052 denotes 149
32708755-21895524-20678926 449-452 21895524 denotes 150
32708755-19700132-20678927 838-840 19700132 denotes 22
32708755-23630610-20678928 841-843 23630610 denotes 49
32708755-29897923-20678929 844-847 29897923 denotes 151
32708755-27738071-20678930 848-851 27738071 denotes 152
32708755-27738071-20678931 1168-1171 27738071 denotes 152
32708755-32077115-20678932 2015-2016 32077115 denotes 1
32708755-32161940-20678933 2017-2018 32161940 denotes 2
32708755-32171076-20678934 2019-2020 32171076 denotes 3
32708755-32109013-20678935 2023-2024 32109013 denotes 5
32708755-32294485-20678936 2025-2026 32294485 denotes 6
32708755-32091533-20678937 2027-2028 32091533 denotes 7
32708755-31986264-20678938 2029-2030 31986264 denotes 8
32708755-32297671-20678939 2031-2032 32297671 denotes 9
32708755-22386035-20678940 2076-2078 22386035 denotes 12
32708755-25813276-20678941 2364-2366 25813276 denotes 96
32708755-30554115-20678942 2920-2922 30554115 denotes 41
32708755-24842388-20678943 2923-2926 24842388 denotes 154
32708755-32665962-20678944 3441-3444 32665962 denotes 138
32708755-30227878-20678945 3445-3448 30227878 denotes 155
32708755-30675038-20678946 3449-3452 30675038 denotes 156
32708755-30335025-20678947 3457-3460 30335025 denotes 158
32708755-16283142-20678948 3461-3464 16283142 denotes 159
32708755-27310975-20678949 3465-3468 27310975 denotes 160
32708755-30917908-20678950 3469-3472 30917908 denotes 161
32708755-32133153-20678951 3473-3476 32133153 denotes 162
32708755-32170560-20678952 3477-3480 32170560 denotes 163
32708755-32665962-20678953 3675-3678 32665962 denotes 138
32708755-30227878-20678954 3679-3682 30227878 denotes 155
32708755-30675038-20678955 3683-3686 30675038 denotes 156
32708755-30335025-20678956 3691-3694 30335025 denotes 158
32708755-16283142-20678957 3695-3698 16283142 denotes 159
32708755-27310975-20678958 3699-3702 27310975 denotes 160
32708755-30917908-20678959 3703-3706 30917908 denotes 161
32708755-32665962-20678960 3948-3951 32665962 denotes 138
32708755-32342265-20678961 4101-4104 32342265 denotes 164
32708755-31694839-20678962 4495-4498 31694839 denotes 167
32708755-31694839-20678963 5097-5100 31694839 denotes 167
32708755-32555424-20678964 6184-6187 32555424 denotes 170
32708755-32505227-20678965 6192-6195 32505227 denotes 172