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PMC:7408073 / 70981-75554 JSONTXT

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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T424 598-604 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T425 1695-1709 Body_part denotes left ventricle http://purl.org/sig/ont/fma/fma7101
T426 1744-1750 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T427 2315-2322 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T428 2343-2359 Body_part denotes pulmonary artery http://purl.org/sig/ont/fma/fma66326
T429 2360-2379 Body_part denotes smooth muscle cells http://purl.org/sig/ont/fma/fma14072
T430 2374-2379 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T431 4195-4199 Body_part denotes face http://purl.org/sig/ont/fma/fma24728

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T139 2343-2359 Body_part denotes pulmonary artery http://purl.obolibrary.org/obo/UBERON_0002012
T140 2353-2359 Body_part denotes artery http://purl.obolibrary.org/obo/UBERON_0001637
T141 4195-4199 Body_part denotes face http://purl.obolibrary.org/obo/UBERON_0001456

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
2562 1001-1005 Gene denotes ACE2 Gene:59272
2563 1185-1188 Gene denotes ACE Gene:59272
2564 1315-1319 Gene denotes ACE2 Gene:59272
2565 1554-1558 Gene denotes ACE2 Gene:59272
2566 1678-1682 Gene denotes ACE2 Gene:302668
2567 1768-1776 Gene denotes Ang (1–7 Gene:305843
2568 1957-1960 Gene denotes ACE Gene:302668
2569 2011-2015 Gene denotes ACE2 Gene:302668
2570 2026-2030 Gene denotes MasR Gene:116511
2571 2178-2182 Gene denotes ACE2 Gene:59272
2572 2310-2314 Gene denotes ACE2 Gene:59272
2573 2485-2488 Gene denotes AT1 Gene:185
2574 2498-2502 Gene denotes ACE2 Gene:59272
2575 2613-2617 Gene denotes ACE2 Gene:59272
2576 2716-2720 Gene denotes ACE2 Gene:59272
2577 4335-4339 Gene denotes ACE2 Gene:59272
2578 4351-4357 Gene denotes Ang II Gene:24179
2579 4399-4407 Gene denotes Ang (1–9 Gene:284
2580 4526-4530 Gene denotes ACE2 Gene:59272
2581 4531-4534 Gene denotes ACE Gene:59272
2582 4380-4388 Gene denotes Ang (1–7 Gene:284
2583 2016-2024 Gene denotes Ang (1–7 Gene:305843
2584 645-653 Species denotes patients Tax:9606
2585 1153-1161 Species denotes patients Tax:9606
2586 1453-1461 Species denotes patients Tax:9606
2587 1719-1723 Species denotes rats Tax:10116
2588 1860-1864 Species denotes rats Tax:10116
2589 1930-1934 Species denotes rats Tax:10116
2590 2076-2082 Species denotes humans Tax:9606
2591 2337-2342 Species denotes human Tax:9606
2592 2971-2979 Species denotes patients Tax:9606
2593 3172-3180 Species denotes patients Tax:9606
2594 3476-3484 Species denotes patients Tax:9606
2595 3532-3540 Species denotes patients Tax:9606
2596 3892-3900 Species denotes patients Tax:9606
2597 4031-4039 Species denotes patients Tax:9606
2598 4232-4240 Species denotes patients Tax:9606
2599 4292-4300 Species denotes patients Tax:9606
2600 2456-2462 Gene denotes Ang II Gene:24179
2601 451-458 Chemical denotes calcium MESH:D002118
2602 1494-1509 Chemical denotes cholecalciferol MESH:D002762
2603 1606-1614 Chemical denotes losartan MESH:D019808
2604 1633-1643 Chemical denotes lisinopril MESH:D017706
2605 3826-3834 Chemical denotes losartan MESH:D019808
2606 19-27 Disease denotes COVID-19 MESH:C000657245
2607 79-91 Disease denotes hypertension MESH:D006973
2608 93-101 Disease denotes diabetes MESH:D003920
2609 201-213 Disease denotes hypertensive MESH:D006973
2610 240-252 Disease denotes hypertensive MESH:D006973
2611 335-347 Disease denotes hypertension MESH:D006973
2612 907-919 Disease denotes hypertension MESH:D006973
2613 921-929 Disease denotes diabetes MESH:D003920
2614 931-943 Disease denotes dyslipidemia MESH:D050171
2615 1081-1093 Disease denotes hypertensive MESH:D006973
2616 1130-1138 Disease denotes COVID-19 MESH:C000657245
2617 1144-1152 Disease denotes diabetic MESH:D003920
2618 2226-2244 Disease denotes hypoxic conditions MESH:D000071069
2619 2635-2653 Disease denotes hypoxic conditions MESH:D000071069
2620 2662-2670 Disease denotes COVID-19 MESH:C000657245
2621 2985-2993 Disease denotes COVID-19 MESH:C000657245
2622 3088-3096 Disease denotes COVID-19 MESH:C000657245
2623 3208-3216 Disease denotes COVID-19 MESH:C000657245
2624 3275-3284 Disease denotes mortality MESH:D003643
2625 3436-3444 Disease denotes COVID-19 MESH:C000657245
2626 3656-3661 Disease denotes death MESH:D003643
2627 3854-3862 Disease denotes COVID-19 MESH:C000657245
2628 4009-4021 Disease denotes hypertensive MESH:D006973
2629 4022-4030 Disease denotes diabetic MESH:D003920
2630 4219-4231 Disease denotes hypertensive MESH:D006973
2631 4283-4291 Disease denotes COVID-19 MESH:C000657245

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T348 19-27 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T349 79-91 Disease denotes hypertension http://purl.obolibrary.org/obo/MONDO_0005044
T350 93-101 Disease denotes diabetes http://purl.obolibrary.org/obo/MONDO_0005015
T351 335-347 Disease denotes hypertension http://purl.obolibrary.org/obo/MONDO_0005044
T352 907-919 Disease denotes hypertension http://purl.obolibrary.org/obo/MONDO_0005044
T353 921-929 Disease denotes diabetes http://purl.obolibrary.org/obo/MONDO_0005015
T354 931-943 Disease denotes dyslipidemia http://purl.obolibrary.org/obo/MONDO_0002525
T355 1130-1138 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T356 1619-1622 Disease denotes ARB http://purl.obolibrary.org/obo/MONDO_0012733
T357 1918-1921 Disease denotes ARB http://purl.obolibrary.org/obo/MONDO_0012733
T358 2267-2270 Disease denotes ARB http://purl.obolibrary.org/obo/MONDO_0012733
T359 2395-2398 Disease denotes ARB http://purl.obolibrary.org/obo/MONDO_0012733
T360 2485-2488 Disease denotes AT1 http://purl.obolibrary.org/obo/MONDO_0008840
T361 2662-2670 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T362 2812-2815 Disease denotes ARB http://purl.obolibrary.org/obo/MONDO_0012733
T363 2952-2955 Disease denotes ARB http://purl.obolibrary.org/obo/MONDO_0012733
T364 2985-2993 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T365 3011-3014 Disease denotes ARB http://purl.obolibrary.org/obo/MONDO_0012733
T366 3088-3096 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T367 3160-3163 Disease denotes ARB http://purl.obolibrary.org/obo/MONDO_0012733
T368 3208-3216 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T369 3226-3229 Disease denotes ARB http://purl.obolibrary.org/obo/MONDO_0012733
T370 3315-3318 Disease denotes ARB http://purl.obolibrary.org/obo/MONDO_0012733
T371 3436-3444 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T372 3494-3497 Disease denotes ARB http://purl.obolibrary.org/obo/MONDO_0012733
T373 3854-3862 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T374 4053-4056 Disease denotes ARB http://purl.obolibrary.org/obo/MONDO_0012733
T375 4123-4127 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T376 4195-4211 Disease denotes face the disease http://purl.obolibrary.org/obo/MONDO_0044987
T377 4283-4291 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T880 111-115 http://purl.obolibrary.org/obo/UBERON_0003101 denotes male
T881 111-115 http://www.ebi.ac.uk/efo/EFO_0000970 denotes male
T882 395-397 http://purl.obolibrary.org/obo/CLO_0053794 denotes 41
T883 517-519 http://purl.obolibrary.org/obo/CLO_0053733 denotes 11
T884 586-594 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T885 598-604 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T886 664-665 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T887 694-695 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T888 783-787 http://purl.obolibrary.org/obo/UBERON_0003101 denotes male
T889 783-787 http://www.ebi.ac.uk/efo/EFO_0000970 denotes male
T890 865-873 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T891 1006-1014 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T892 1237-1238 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T893 1320-1328 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T894 1559-1567 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T895 1683-1691 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T896 1744-1750 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T897 1993-2003 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T898 2076-2082 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes humans
T899 2301-2309 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T900 2337-2342 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T901 2343-2359 http://purl.obolibrary.org/obo/UBERON_0002012 denotes pulmonary artery
T902 2343-2359 http://www.ebi.ac.uk/efo/EFO_0001399 denotes pulmonary artery
T903 2360-2379 http://purl.obolibrary.org/obo/CL_0000192 denotes smooth muscle cells
T904 2574-2575 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T905 2604-2612 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T906 2701-2709 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T907 3048-3049 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T908 3259-3260 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T909 3838-3839 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T910 4195-4199 http://purl.obolibrary.org/obo/UBERON_0001456 denotes face
T911 4242-4243 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T912 4474-4475 http://purl.obolibrary.org/obo/CLO_0001020 denotes a

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T27957 111-115 Chemical denotes male http://purl.obolibrary.org/obo/CHEBI_30780
T23518 415-431 Chemical denotes antihypertensive http://purl.obolibrary.org/obo/CHEBI_35674
T31593 451-475 Chemical denotes calcium channel blockers http://purl.obolibrary.org/obo/CHEBI_38215
T57795 451-458 Chemical denotes calcium http://purl.obolibrary.org/obo/CHEBI_22984|http://purl.obolibrary.org/obo/CHEBI_29320
T11914 783-787 Chemical denotes male http://purl.obolibrary.org/obo/CHEBI_30780
T62420 1185-1199 Chemical denotes ACE inhibitors http://purl.obolibrary.org/obo/CHEBI_35457
T88754 1189-1199 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T52738 1201-1206 Chemical denotes ACEIs http://purl.obolibrary.org/obo/CHEBI_35457
T63223 1404-1416 Chemical denotes antidiabetic http://purl.obolibrary.org/obo/CHEBI_35526
T53003 1484-1489 Chemical denotes ACEIs http://purl.obolibrary.org/obo/CHEBI_35457
T85209 1606-1614 Chemical denotes losartan http://purl.obolibrary.org/obo/CHEBI_6541
T35617 1633-1643 Chemical denotes lisinopril http://purl.obolibrary.org/obo/CHEBI_43755
T72244 2315-2322 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T44056 2460-2462 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T66080 2538-2543 Chemical denotes ACEIs http://purl.obolibrary.org/obo/CHEBI_35457
T91113 2816-2832 Chemical denotes antihypertensive http://purl.obolibrary.org/obo/CHEBI_35674
T28525 3319-3341 Chemical denotes antihypertensive drugs http://purl.obolibrary.org/obo/CHEBI_35674
T296 3336-3341 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T83523 3498-3503 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T76894 3513-3518 Chemical denotes ACEIs http://purl.obolibrary.org/obo/CHEBI_35457
T83214 3553-3558 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T89355 3619-3624 Chemical denotes ACEIs http://purl.obolibrary.org/obo/CHEBI_35457
T57644 3826-3834 Chemical denotes losartan http://purl.obolibrary.org/obo/CHEBI_6541
T96201 3955-3960 Chemical denotes ACEIs http://purl.obolibrary.org/obo/CHEBI_35457
T89890 4139-4144 Chemical denotes ACEIs http://purl.obolibrary.org/obo/CHEBI_35457
T31128 4274-4279 Chemical denotes ACEIs http://purl.obolibrary.org/obo/CHEBI_35457
T305 4355-4357 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T351 0-143 Sentence denotes Severe symptoms of COVID-19 have been described to correlate with pre-existing hypertension, diabetes, age and male gender [1,2,3,4,5,6,7,8,9].
T352 144-521 Sentence denotes It is not still clear whether it depends on constitutive hypertensive conditions and/or on anti-hypertensive treatments or on other age-related conditions, considering that the prevalence of hypertension in Chinese adults is ~ 23% and that only about 41% take prescribed antihypertensive medications, being calcium channel blockers the most commonly used (~ 50%) in China [11].
T353 522-760 Sentence denotes To this regard, there is an interesting report describing sACE2 activity in plasma samples of Spanish healthy subjects and patients, in which a total of 2572 subjects from a multicenter study (NEFRONA project, 2009–2011) was studied [96].
T354 761-879 Sentence denotes The report shows that male and advanced age were identified as independent predictors of enhanced sACE2 activity [96].
T355 880-1071 Sentence denotes Furthermore, subjects with hypertension, diabetes, dyslipidemia, or plaques also had significantly increased circulating ACE2 activity when compared with those without these pathologies [96].
T356 1072-1287 Sentence denotes Notably, hypertensive (the most frequent comorbidity with COVID-19) and diabetic patients are often treated with ACE inhibitors (ACEIs) and/or with ARBs, suggesting a possible positive correlation [135,136,137,138].
T357 1288-1573 Sentence denotes Interestingly, circulating ACE2 activity is significantly increased in subjects on therapy with ARBs or taking oral antidiabetic agents as compared with non-treated patients, while treatment with ACEIs and cholecalciferol had no significant influence on circulating ACE2 activity [96].
T358 1574-1729 Sentence denotes In line with this observations, losartan (an ARB), but not lisinopril (an ACEI), was able to upregulate ACE2 activity in left ventricle of Lewis rats [75].
T359 1730-2039 Sentence denotes Nevertheless, plasma concentration of Ang (1–7) was significantly increased with both treatments when compared to vehicle-treated rats and it was significantly higher in ACEI-treated than ARB-treated rats [75], suggesting that ACE inhibition is able to induce an activation of the ACE2/Ang (1–7)/MasR pathway.
T360 2040-2211 Sentence denotes Although more evidence is needed in humans, the above observations suggest that ARBs should be precautionarily avoided to reduce possible ACE2-mediated viral consequences.
T361 2212-2385 Sentence denotes Indeed, under hypoxic conditions, either an ACEI or an ARB have been shown to upregulate membrane ACE2 protein expression on human pulmonary artery smooth muscle cells [58].
T362 2386-2537 Sentence denotes ACEI and ARB have been shown to work by reducing the concentration of Ang II and by inhibiting its AT1-mediated ACE2 downregulation, respectively [58].
T363 2538-2793 Sentence denotes ACEIs and ARBs might therefore play a role in the upregulation of membrane ACE2 expression under hypoxic conditions such as COVID-19, knowing that the increase of membrane bound ACE2 (before its shedding) will also increase the probability of viral entry.
T364 2794-2896 Sentence denotes Of note, ACEI and ARB antihypertensive medications are more commonly used in Europe/USA than in China.
T365 2897-3121 Sentence denotes Nevertheless, recent reports show that the use of ACEI/ARB medications in patients with COVID-19 is safe and ACEI/ARB exposure was not associated with a higher risk of having severe forms of COVID-19 [6,139,140,141,142,143].
T366 3122-3364 Sentence denotes Moreover, some reports show that ACEI/ARB treated patients may even be protected from COVID-19 and ACEI/ARB exposure was associated with a lower risk of mortality compared to those on non-ACEI/ARB antihypertensive drugs [144,145,146,147,148].
T367 3365-3565 Sentence denotes Among these reports, one indicates that the risk of severe symptoms of COVID-19 was significantly decreased in patients who took ARB drugs (but not ACEIs) compared to patients who took no drugs [144].
T368 3566-3792 Sentence denotes Differently, another report suggests that the use of ACEIs (but not ARBs) reduced risk of death and/or critical disease [146], suggesting that some of these reports did not adjust for confounders and further analyses are need.
T369 3793-3991 Sentence denotes Nevertheless, clinical trials of losartan as a treatment for COVID-19, are actually underway among patients who have not previously been treated with ARBs and/or ACEIs (NCT04312009 and NCT04311177).
T370 3992-4241 Sentence denotes However, most of hypertensive/diabetic patients are ACEI- or ARB-“pretreated”, nevertheless they have an increased risk to develop SARS, therefore ACEIs and ARBs, if not detrimental, are not expected to face the disease in non-hypertensive patients.
T371 4242-4573 Sentence denotes A possible beneficial effect of ACEIs in COVID-19 patients could indirectly come by reducing ACE2 substrate, Ang II, and finally limiting Ang (1–7) [but not Ang (1–9)] production and its (detrimental) effects; however, this is only a hypothetical possibility since, in this case, the ACE2/ACE pathway might be even more unbalanced.

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T109 79-91 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822
T110 335-347 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822
T111 907-919 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822
T112 931-943 Phenotype denotes dyslipidemia http://purl.obolibrary.org/obo/HP_0003119

2_test

Id Subject Object Predicate Lexical cue
32708755-32077115-20678898 124-125 32077115 denotes 1
32708755-32161940-20678899 126-127 32161940 denotes 2
32708755-32171076-20678900 128-129 32171076 denotes 3
32708755-32109013-20678901 132-133 32109013 denotes 5
32708755-32294485-20678902 134-135 32294485 denotes 6
32708755-32091533-20678903 136-137 32091533 denotes 7
32708755-31986264-20678904 138-139 31986264 denotes 8
32708755-32297671-20678905 140-141 32297671 denotes 9
32708755-29449338-20678906 517-519 29449338 denotes 11
32708755-25813276-20678907 756-758 25813276 denotes 96
32708755-25813276-20678908 875-877 25813276 denotes 96
32708755-25813276-20678909 1067-1069 25813276 denotes 96
32708755-32171062-20678910 1270-1273 32171062 denotes 135
32708755-32222168-20678911 1274-1277 32222168 denotes 136
32708755-32222169-20678912 1278-1281 32222169 denotes 137
32708755-32665962-20678913 1282-1285 32665962 denotes 138
32708755-25813276-20678914 1569-1571 25813276 denotes 96
32708755-15897343-20678915 1725-1727 15897343 denotes 75
32708755-15897343-20678916 1936-1938 15897343 denotes 75
32708755-32294485-20678917 3098-3099 32294485 denotes 6
32708755-32356628-20678918 3116-3119 32356628 denotes 143
32708755-32228222-20678919 3347-3350 32228222 denotes 145
32708755-32474043-20678920 3351-3354 32474043 denotes 146
32708755-32422341-20678921 3355-3358 32422341 denotes 147
32708755-32302265-20678922 3359-3362 32302265 denotes 148
32708755-32474043-20678923 3687-3690 32474043 denotes 146