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PMC:7408073 / 70864-82304 JSONTXT

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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T424 715-721 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T425 1812-1826 Body_part denotes left ventricle http://purl.org/sig/ont/fma/fma7101
T426 1861-1867 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T427 2432-2439 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T428 2460-2476 Body_part denotes pulmonary artery http://purl.org/sig/ont/fma/fma66326
T429 2477-2496 Body_part denotes smooth muscle cells http://purl.org/sig/ont/fma/fma14072
T430 2491-2496 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T431 4312-4316 Body_part denotes face http://purl.org/sig/ont/fma/fma24728
T432 4753-4760 Body_part denotes insulin http://purl.org/sig/ont/fma/fma83365
T433 4897-4901 Body_part denotes hand http://purl.org/sig/ont/fma/fma9712
T434 4918-4925 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T435 4953-4959 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T436 4967-4972 Body_part denotes urine http://purl.org/sig/ont/fma/fma12274
T437 5330-5336 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T438 5346-5350 Body_part denotes mRNA http://purl.org/sig/ont/fma/fma67122
T439 5361-5366 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T440 5389-5393 Body_part denotes hand http://purl.org/sig/ont/fma/fma9712
T441 5478-5483 Body_part denotes bowel http://purl.org/sig/ont/fma/fma7199
T442 5599-5604 Body_part denotes heart http://purl.org/sig/ont/fma/fma7088
T443 5696-5702 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T444 6275-6282 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T445 6863-6869 Body_part denotes kidney http://purl.org/sig/ont/fma/fma7203
T446 7107-7112 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670
T447 7129-7136 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T448 7155-7161 Body_part denotes kidney http://purl.org/sig/ont/fma/fma7203
T449 7404-7409 Body_part denotes urine http://purl.org/sig/ont/fma/fma12274
T450 7448-7455 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T451 7736-7741 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670
T452 8087-8092 Body_part denotes organ http://purl.org/sig/ont/fma/fma67498
T453 8107-8111 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T454 8112-8119 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T455 8241-8245 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T456 8427-8435 Body_part denotes intronic http://purl.org/sig/ont/fma/fma84121
T457 8633-8637 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T458 8658-8662 Body_part denotes hand http://purl.org/sig/ont/fma/fma9712
T459 10196-10201 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T139 2460-2476 Body_part denotes pulmonary artery http://purl.obolibrary.org/obo/UBERON_0002012
T140 2470-2476 Body_part denotes artery http://purl.obolibrary.org/obo/UBERON_0001637
T141 4312-4316 Body_part denotes face http://purl.obolibrary.org/obo/UBERON_0001456
T142 4897-4901 Body_part denotes hand http://purl.obolibrary.org/obo/UBERON_0002398
T143 4967-4972 Body_part denotes urine http://purl.obolibrary.org/obo/UBERON_0001088
T144 5389-5393 Body_part denotes hand http://purl.obolibrary.org/obo/UBERON_0002398
T145 5599-5604 Body_part denotes heart http://purl.obolibrary.org/obo/UBERON_0000948
T146 6863-6869 Body_part denotes kidney http://purl.obolibrary.org/obo/UBERON_0002113
T147 7107-7112 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T148 7155-7161 Body_part denotes kidney http://purl.obolibrary.org/obo/UBERON_0002113
T149 7404-7409 Body_part denotes urine http://purl.obolibrary.org/obo/UBERON_0001088
T150 7736-7741 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T151 7841-7844 Body_part denotes RAS http://purl.obolibrary.org/obo/UBERON_0018229
T152 8087-8092 Body_part denotes organ http://purl.obolibrary.org/obo/UBERON_0000062
T153 8658-8662 Body_part denotes hand http://purl.obolibrary.org/obo/UBERON_0002398
T154 9360-9363 Body_part denotes RAS http://purl.obolibrary.org/obo/UBERON_0018229
T155 10097-10100 Body_part denotes RAS http://purl.obolibrary.org/obo/UBERON_0018229
T156 10141-10144 Body_part denotes RAS http://purl.obolibrary.org/obo/UBERON_0018229
T157 10196-10201 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
2490 43-47 Gene denotes ACE2 Gene:59272
2491 108-116 Disease denotes COVID-19 MESH:C000657245
2562 1118-1122 Gene denotes ACE2 Gene:59272
2563 1302-1305 Gene denotes ACE Gene:59272
2564 1432-1436 Gene denotes ACE2 Gene:59272
2565 1671-1675 Gene denotes ACE2 Gene:59272
2566 1795-1799 Gene denotes ACE2 Gene:302668
2567 1885-1893 Gene denotes Ang (1–7 Gene:305843
2568 2074-2077 Gene denotes ACE Gene:302668
2569 2128-2132 Gene denotes ACE2 Gene:302668
2570 2143-2147 Gene denotes MasR Gene:116511
2571 2295-2299 Gene denotes ACE2 Gene:59272
2572 2427-2431 Gene denotes ACE2 Gene:59272
2573 2602-2605 Gene denotes AT1 Gene:185
2574 2615-2619 Gene denotes ACE2 Gene:59272
2575 2730-2734 Gene denotes ACE2 Gene:59272
2576 2833-2837 Gene denotes ACE2 Gene:59272
2577 4452-4456 Gene denotes ACE2 Gene:59272
2578 4468-4474 Gene denotes Ang II Gene:24179
2579 4516-4524 Gene denotes Ang (1–9 Gene:284
2580 4643-4647 Gene denotes ACE2 Gene:59272
2581 4648-4651 Gene denotes ACE Gene:59272
2582 4497-4505 Gene denotes Ang (1–7 Gene:284
2583 2133-2141 Gene denotes Ang (1–7 Gene:305843
2584 762-770 Species denotes patients Tax:9606
2585 1270-1278 Species denotes patients Tax:9606
2586 1570-1578 Species denotes patients Tax:9606
2587 1836-1840 Species denotes rats Tax:10116
2588 1977-1981 Species denotes rats Tax:10116
2589 2047-2051 Species denotes rats Tax:10116
2590 2193-2199 Species denotes humans Tax:9606
2591 2454-2459 Species denotes human Tax:9606
2592 3088-3096 Species denotes patients Tax:9606
2593 3289-3297 Species denotes patients Tax:9606
2594 3593-3601 Species denotes patients Tax:9606
2595 3649-3657 Species denotes patients Tax:9606
2596 4009-4017 Species denotes patients Tax:9606
2597 4148-4156 Species denotes patients Tax:9606
2598 4349-4357 Species denotes patients Tax:9606
2599 4409-4417 Species denotes patients Tax:9606
2600 2573-2579 Gene denotes Ang II Gene:24179
2601 568-575 Chemical denotes calcium MESH:D002118
2602 1611-1626 Chemical denotes cholecalciferol MESH:D002762
2603 1723-1731 Chemical denotes losartan MESH:D019808
2604 1750-1760 Chemical denotes lisinopril MESH:D017706
2605 3943-3951 Chemical denotes losartan MESH:D019808
2606 136-144 Disease denotes COVID-19 MESH:C000657245
2607 196-208 Disease denotes hypertension MESH:D006973
2608 210-218 Disease denotes diabetes MESH:D003920
2609 318-330 Disease denotes hypertensive MESH:D006973
2610 357-369 Disease denotes hypertensive MESH:D006973
2611 452-464 Disease denotes hypertension MESH:D006973
2612 1024-1036 Disease denotes hypertension MESH:D006973
2613 1038-1046 Disease denotes diabetes MESH:D003920
2614 1048-1060 Disease denotes dyslipidemia MESH:D050171
2615 1198-1210 Disease denotes hypertensive MESH:D006973
2616 1247-1255 Disease denotes COVID-19 MESH:C000657245
2617 1261-1269 Disease denotes diabetic MESH:D003920
2618 2343-2361 Disease denotes hypoxic conditions MESH:D000071069
2619 2752-2770 Disease denotes hypoxic conditions MESH:D000071069
2620 2779-2787 Disease denotes COVID-19 MESH:C000657245
2621 3102-3110 Disease denotes COVID-19 MESH:C000657245
2622 3205-3213 Disease denotes COVID-19 MESH:C000657245
2623 3325-3333 Disease denotes COVID-19 MESH:C000657245
2624 3392-3401 Disease denotes mortality MESH:D003643
2625 3553-3561 Disease denotes COVID-19 MESH:C000657245
2626 3773-3778 Disease denotes death MESH:D003643
2627 3971-3979 Disease denotes COVID-19 MESH:C000657245
2628 4126-4138 Disease denotes hypertensive MESH:D006973
2629 4139-4147 Disease denotes diabetic MESH:D003920
2630 4336-4348 Disease denotes hypertensive MESH:D006973
2631 4400-4408 Disease denotes COVID-19 MESH:C000657245
2728 4828-4832 Gene denotes ACE2 Gene:59272
2729 4913-4917 Gene denotes ACE2 Gene:59272
2730 5341-5345 Gene denotes ACE2 Gene:302668
2731 5523-5527 Gene denotes ACE2 Gene:59272
2732 5703-5707 Gene denotes ACE2 Gene:59272
2733 5934-5938 Gene denotes ACE2 Gene:59272
2734 6183-6187 Gene denotes ACE2 Gene:59272
2735 6270-6274 Gene denotes ACE2 Gene:59272
2736 6401-6405 Gene denotes ACE2 Gene:59272
2737 6463-6467 Gene denotes ACE2 Gene:59272
2738 6980-6984 Gene denotes ACE2 Gene:59272
2739 7681-7685 Gene denotes ACE2 Gene:59272
2740 7701-7704 Gene denotes ACE Gene:59272
2741 7705-7709 Gene denotes ACE2 Gene:59272
2742 8064-8068 Gene denotes ACE2 Gene:59272
2743 8102-8106 Gene denotes ACE2 Gene:59272
2744 8236-8240 Gene denotes ACE2 Gene:59272
2745 8628-8632 Gene denotes ACE2 Gene:59272
2746 9274-9278 Gene denotes ACE2 Gene:59272
2747 4753-4760 Gene denotes insulin Gene:3630
2748 4994-4997 Species denotes men Tax:9606
2749 5099-5103 Species denotes rats Tax:10116
2750 5422-5430 Species denotes patients Tax:9606
2751 5605-5613 Species denotes patients Tax:9606
2752 6689-6697 Species denotes patients Tax:9606
2753 6878-6886 Species denotes patients Tax:9606
2754 7170-7178 Species denotes patients Tax:9606
2755 7479-7487 Species denotes patients Tax:9606
2756 7536-7544 Species denotes patients Tax:9606
2757 7920-7930 Species denotes SARS-CoV-2 Tax:2697049
2758 8854-8862 Species denotes patients Tax:9606
2759 9456-9464 Species denotes patients Tax:9606
2760 10256-10269 Species denotes coronaviruses Tax:11118
2761 10360-10370 Species denotes SARS-CoV-2 Tax:2697049
2762 10443-10458 Species denotes influenza virus Tax:11308
2763 10521-10527 Species denotes humans Tax:9606
2764 10561-10574 Species denotes coronaviruses Tax:11118
2765 10767-10775 Species denotes SARS-CoV Tax:694009
2766 10780-10788 Species denotes MERS-CoV Tax:1335626
2767 11173-11183 Species denotes SARS-CoV-2 Tax:2697049
2768 6809-6814 Chemical denotes sACE2
2769 6822-6826 Chemical denotes Zn2+
2770 7351-7355 Chemical denotes Zn2+
2771 7599-7609 Chemical denotes olmesartan MESH:C437965
2772 5063-5075 Disease denotes hypertensive MESH:D006973
2773 5184-5190 Disease denotes asthma MESH:D001249
2774 5201-5218 Disease denotes allergic diseases MESH:D004342
2775 5250-5258 Disease denotes COVID-19 MESH:C000657245
2776 5436-5459 Disease denotes cardiovascular diseases MESH:D002318
2777 5465-5491 Disease denotes inflammatory bowel disease MESH:D015212
2778 5625-5633 Disease denotes COVID-19 MESH:C000657245
2779 5665-5684 Disease denotes atrial fibrillation MESH:D001281
2780 5760-5779 Disease denotes cardiac dysfunction MESH:D006331
2781 5813-5825 Disease denotes hypertension MESH:D006973
2782 5841-5857 Disease denotes vascular disease MESH:D000783
2783 6010-6018 Disease denotes COVID-19 MESH:C000657245
2784 6216-6231 Disease denotes viral infection MESH:D001102
2785 6438-6446 Disease denotes COVID-19 MESH:C000657245
2786 6537-6545 Disease denotes COVID-19 MESH:C000657245
2787 6642-6663 Disease denotes chronic renal disease MESH:D051436
2788 6667-6675 Disease denotes COVID-19 MESH:C000657245
2789 6855-6877 Disease denotes chronic kidney disease MESH:D051436
2790 6908-6930 Disease denotes cardiovascular disease MESH:D002318
2791 7069-7080 Disease denotes proteinuria MESH:D011507
2792 7147-7169 Disease denotes chronic kidney disease MESH:D051436
2793 7263-7285 Disease denotes chronic renal diseases MESH:D051436
2794 7493-7515 Disease denotes chronic renal diseases MESH:D051436
2795 7523-7535 Disease denotes hypertensive MESH:D006973
2796 7664-7677 Disease denotes hyperactivity MESH:D006948
2797 7793-7801 Disease denotes COVID-19 MESH:C000657245
2798 7899-7909 Disease denotes infections MESH:D007239
2799 8010-8030 Disease denotes SARS-CoV-2 infection MESH:C000657245
2800 8290-8302 Disease denotes hypertension MESH:D006973
2801 8304-8316 Disease denotes dyslipidemia MESH:D050171
2802 8325-8333 Disease denotes diabetes MESH:D003920
2803 8338-8364 Disease denotes cardiovascular dysfunction MESH:D002318
2804 8664-8672 Disease denotes COVID-19 MESH:C000657245
2805 8701-8724 Disease denotes obstructive sleep apnea MESH:D020181
2806 8782-8790 Disease denotes COVID-19 MESH:C000657245
2807 8845-8853 Disease denotes COVID-19 MESH:C000657245
2808 8955-8963 Disease denotes Covid-19 MESH:C000657245
2809 9021-9035 Disease denotes apnea/hypopnea MESH:D020181
2810 9053-9063 Disease denotes hypoxaemia
2811 9071-9076 Disease denotes sleep MESH:D012893
2812 9103-9115 Disease denotes hypertension MESH:D006973
2813 9117-9139 Disease denotes cardiovascular disease MESH:D002318
2814 9141-9149 Disease denotes diabetes MESH:D003920
2815 9151-9158 Disease denotes obesity MESH:D009765
2816 9172-9184 Disease denotes inflammation MESH:D007249
2817 9306-9313 Disease denotes hypoxia MESH:D000860
2818 9427-9447 Disease denotes SARS-CoV-2 infection MESH:C000657245
2819 9767-9772 Disease denotes sleep MESH:D012893
2820 9900-9908 Disease denotes COVID-19 MESH:C000657245
2821 10506-10517 Disease denotes common cold MESH:D003139
2822 10825-10845 Disease denotes SARS-CoV-2 infection MESH:C000657245
2823 11145-11161 Disease denotes virus infections MESH:D001102

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T347 108-116 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T348 136-144 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T349 196-208 Disease denotes hypertension http://purl.obolibrary.org/obo/MONDO_0005044
T350 210-218 Disease denotes diabetes http://purl.obolibrary.org/obo/MONDO_0005015
T351 452-464 Disease denotes hypertension http://purl.obolibrary.org/obo/MONDO_0005044
T352 1024-1036 Disease denotes hypertension http://purl.obolibrary.org/obo/MONDO_0005044
T353 1038-1046 Disease denotes diabetes http://purl.obolibrary.org/obo/MONDO_0005015
T354 1048-1060 Disease denotes dyslipidemia http://purl.obolibrary.org/obo/MONDO_0002525
T355 1247-1255 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T356 1736-1739 Disease denotes ARB http://purl.obolibrary.org/obo/MONDO_0012733
T357 2035-2038 Disease denotes ARB http://purl.obolibrary.org/obo/MONDO_0012733
T358 2384-2387 Disease denotes ARB http://purl.obolibrary.org/obo/MONDO_0012733
T359 2512-2515 Disease denotes ARB http://purl.obolibrary.org/obo/MONDO_0012733
T360 2602-2605 Disease denotes AT1 http://purl.obolibrary.org/obo/MONDO_0008840
T361 2779-2787 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T362 2929-2932 Disease denotes ARB http://purl.obolibrary.org/obo/MONDO_0012733
T363 3069-3072 Disease denotes ARB http://purl.obolibrary.org/obo/MONDO_0012733
T364 3102-3110 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T365 3128-3131 Disease denotes ARB http://purl.obolibrary.org/obo/MONDO_0012733
T366 3205-3213 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T367 3277-3280 Disease denotes ARB http://purl.obolibrary.org/obo/MONDO_0012733
T368 3325-3333 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T369 3343-3346 Disease denotes ARB http://purl.obolibrary.org/obo/MONDO_0012733
T370 3432-3435 Disease denotes ARB http://purl.obolibrary.org/obo/MONDO_0012733
T371 3553-3561 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T372 3611-3614 Disease denotes ARB http://purl.obolibrary.org/obo/MONDO_0012733
T373 3971-3979 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T374 4170-4173 Disease denotes ARB http://purl.obolibrary.org/obo/MONDO_0012733
T375 4240-4244 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T376 4312-4328 Disease denotes face the disease http://purl.obolibrary.org/obo/MONDO_0044987
T377 4400-4408 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T378 5184-5190 Disease denotes asthma http://purl.obolibrary.org/obo/MONDO_0004979
T379 5201-5218 Disease denotes allergic diseases http://purl.obolibrary.org/obo/MONDO_0005271
T380 5201-5209 Disease denotes allergic http://purl.obolibrary.org/obo/MONDO_0004980
T381 5250-5258 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T382 5436-5459 Disease denotes cardiovascular diseases http://purl.obolibrary.org/obo/MONDO_0004995
T383 5465-5491 Disease denotes inflammatory bowel disease http://purl.obolibrary.org/obo/MONDO_0005265
T384 5625-5633 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T385 5665-5684 Disease denotes atrial fibrillation http://purl.obolibrary.org/obo/MONDO_0004981
T386 5813-5825 Disease denotes hypertension http://purl.obolibrary.org/obo/MONDO_0005044
T387 5841-5857 Disease denotes vascular disease http://purl.obolibrary.org/obo/MONDO_0005385
T388 6010-6018 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T389 6089-6093 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T390 6216-6231 Disease denotes viral infection http://purl.obolibrary.org/obo/MONDO_0005108
T391 6222-6231 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T392 6438-6446 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T393 6537-6545 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T394 6642-6663 Disease denotes chronic renal disease http://purl.obolibrary.org/obo/MONDO_0005300
T395 6650-6663 Disease denotes renal disease http://purl.obolibrary.org/obo/MONDO_0002118|http://purl.obolibrary.org/obo/MONDO_0005240
T397 6667-6675 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T398 6855-6877 Disease denotes chronic kidney disease http://purl.obolibrary.org/obo/MONDO_0005300
T399 6863-6877 Disease denotes kidney disease http://purl.obolibrary.org/obo/MONDO_0001343|http://purl.obolibrary.org/obo/MONDO_0005240
T401 6908-6930 Disease denotes cardiovascular disease http://purl.obolibrary.org/obo/MONDO_0004995
T402 7069-7080 Disease denotes proteinuria http://purl.obolibrary.org/obo/MONDO_0003634
T403 7147-7169 Disease denotes chronic kidney disease http://purl.obolibrary.org/obo/MONDO_0005300
T404 7155-7169 Disease denotes kidney disease http://purl.obolibrary.org/obo/MONDO_0001343|http://purl.obolibrary.org/obo/MONDO_0005240
T406 7263-7285 Disease denotes chronic renal diseases http://purl.obolibrary.org/obo/MONDO_0005300
T407 7306-7310 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T408 7493-7515 Disease denotes chronic renal diseases http://purl.obolibrary.org/obo/MONDO_0005300
T409 7594-7597 Disease denotes ARB http://purl.obolibrary.org/obo/MONDO_0012733
T410 7793-7801 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T411 7899-7909 Disease denotes infections http://purl.obolibrary.org/obo/MONDO_0005550
T412 7920-7928 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T413 7920-7924 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T414 8010-8018 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T415 8010-8014 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T416 8021-8030 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T417 8290-8302 Disease denotes hypertension http://purl.obolibrary.org/obo/MONDO_0005044
T418 8304-8316 Disease denotes dyslipidemia http://purl.obolibrary.org/obo/MONDO_0002525
T419 8318-8333 Disease denotes type 2 diabetes http://purl.obolibrary.org/obo/MONDO_0005148
T420 8325-8333 Disease denotes diabetes http://purl.obolibrary.org/obo/MONDO_0005015
T421 8664-8672 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T422 8701-8724 Disease denotes obstructive sleep apnea http://purl.obolibrary.org/obo/MONDO_0007147
T423 8713-8724 Disease denotes sleep apnea http://purl.obolibrary.org/obo/MONDO_0005296
T424 8726-8729 Disease denotes OSA http://purl.obolibrary.org/obo/MONDO_0007147
T425 8774-8777 Disease denotes OSA http://purl.obolibrary.org/obo/MONDO_0007147
T426 8782-8790 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T427 8838-8841 Disease denotes OSA http://purl.obolibrary.org/obo/MONDO_0007147
T428 8845-8853 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T429 8908-8911 Disease denotes OSA http://purl.obolibrary.org/obo/MONDO_0007147
T430 8965-8968 Disease denotes OSA http://purl.obolibrary.org/obo/MONDO_0007147
T431 9103-9139 Disease denotes hypertension, cardiovascular disease http://purl.obolibrary.org/obo/MONDO_0001302
T432 9103-9115 Disease denotes hypertension http://purl.obolibrary.org/obo/MONDO_0005044
T433 9117-9139 Disease denotes cardiovascular disease http://purl.obolibrary.org/obo/MONDO_0004995
T434 9141-9149 Disease denotes diabetes http://purl.obolibrary.org/obo/MONDO_0005015
T435 9151-9158 Disease denotes obesity http://purl.obolibrary.org/obo/MONDO_0011122
T436 9172-9184 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T437 9376-9379 Disease denotes OSA http://purl.obolibrary.org/obo/MONDO_0007147
T438 9427-9435 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T439 9427-9431 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T440 9438-9447 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T441 9452-9455 Disease denotes OSA http://purl.obolibrary.org/obo/MONDO_0007147
T442 9676-9679 Disease denotes OSA http://purl.obolibrary.org/obo/MONDO_0007147
T443 9900-9908 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T444 10360-10368 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T445 10360-10364 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T446 10413-10416 Disease denotes flu http://purl.obolibrary.org/obo/MONDO_0005812
T447 10443-10452 Disease denotes influenza http://purl.obolibrary.org/obo/MONDO_0005812
T448 10506-10517 Disease denotes common cold http://purl.obolibrary.org/obo/MONDO_0005709
T449 10654-10657 Disease denotes flu http://purl.obolibrary.org/obo/MONDO_0005812
T450 10767-10775 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T451 10767-10771 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T452 10825-10833 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T453 10825-10829 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T454 10836-10845 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T455 11145-11161 Disease denotes virus infections http://purl.obolibrary.org/obo/MONDO_0005108
T456 11173-11181 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T457 11173-11177 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T879 48-56 http://purl.obolibrary.org/obo/CLO_0001658 denotes Activity
T880 228-232 http://purl.obolibrary.org/obo/UBERON_0003101 denotes male
T881 228-232 http://www.ebi.ac.uk/efo/EFO_0000970 denotes male
T882 512-514 http://purl.obolibrary.org/obo/CLO_0053794 denotes 41
T883 634-636 http://purl.obolibrary.org/obo/CLO_0053733 denotes 11
T884 703-711 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T885 715-721 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T886 781-782 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T887 811-812 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T888 900-904 http://purl.obolibrary.org/obo/UBERON_0003101 denotes male
T889 900-904 http://www.ebi.ac.uk/efo/EFO_0000970 denotes male
T890 982-990 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T891 1123-1131 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T892 1354-1355 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T893 1437-1445 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T894 1676-1684 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T895 1800-1808 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T896 1861-1867 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T897 2110-2120 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T898 2193-2199 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes humans
T899 2418-2426 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T900 2454-2459 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T901 2460-2476 http://purl.obolibrary.org/obo/UBERON_0002012 denotes pulmonary artery
T902 2460-2476 http://www.ebi.ac.uk/efo/EFO_0001399 denotes pulmonary artery
T903 2477-2496 http://purl.obolibrary.org/obo/CL_0000192 denotes smooth muscle cells
T904 2691-2692 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T905 2721-2729 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T906 2818-2826 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T907 3165-3166 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T908 3376-3377 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T909 3955-3956 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T910 4312-4316 http://purl.obolibrary.org/obo/UBERON_0001456 denotes face
T911 4359-4360 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T912 4591-4592 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T913 4753-4760 http://purl.obolibrary.org/obo/PR_000009054 denotes insulin
T914 4833-4841 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T915 4953-4959 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T916 4987-4993 http://purl.obolibrary.org/obo/CLO_0001658 denotes active
T917 5330-5336 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T918 5354-5360 http://purl.obolibrary.org/obo/UBERON_0001005 denotes airway
T919 5361-5366 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T920 5599-5604 http://purl.obolibrary.org/obo/UBERON_0000948 denotes heart
T921 5599-5604 http://purl.obolibrary.org/obo/UBERON_0007100 denotes heart
T922 5599-5604 http://purl.obolibrary.org/obo/UBERON_0015228 denotes heart
T923 5599-5604 http://www.ebi.ac.uk/efo/EFO_0000815 denotes heart
T924 5653-5654 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T925 5696-5702 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T926 5708-5716 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T927 5797-5801 http://purl.obolibrary.org/obo/UBERON_0003101 denotes male
T928 5797-5801 http://www.ebi.ac.uk/efo/EFO_0000970 denotes male
T929 5893-5894 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T930 5939-5947 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T931 6063-6064 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T932 6167-6175 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T933 6566-6575 http://www.ebi.ac.uk/efo/EFO_0000876 denotes extremely
T934 6762-6764 http://purl.obolibrary.org/obo/CLO_0053733 denotes 11
T935 6800-6801 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T936 6863-6869 http://purl.obolibrary.org/obo/UBERON_0002113 denotes kidney
T937 6863-6869 http://www.ebi.ac.uk/efo/EFO_0000927 denotes kidney
T938 6863-6869 http://www.ebi.ac.uk/efo/EFO_0000929 denotes kidney
T939 6895-6896 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T940 6942-6943 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T941 6985-6993 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T942 7107-7112 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T943 7107-7112 http://www.ebi.ac.uk/efo/EFO_0000296 denotes blood
T944 7155-7161 http://purl.obolibrary.org/obo/UBERON_0002113 denotes kidney
T945 7155-7161 http://www.ebi.ac.uk/efo/EFO_0000927 denotes kidney
T946 7155-7161 http://www.ebi.ac.uk/efo/EFO_0000929 denotes kidney
T947 7251-7259 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T948 7329-7330 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T949 7656-7657 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T950 7736-7741 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T951 7736-7741 http://www.ebi.ac.uk/efo/EFO_0000296 denotes blood
T952 7829-7833 http://www.ebi.ac.uk/efo/EFO_0001410 denotes arms
T953 7872-7880 http://purl.obolibrary.org/obo/OBI_0100026 denotes organism
T954 7872-7880 http://purl.obolibrary.org/obo/UBERON_0000468 denotes organism
T955 8087-8092 http://purl.obolibrary.org/obo/UBERON_0003103 denotes organ
T956 8107-8111 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T957 8241-8245 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T958 8463-8472 http://purl.obolibrary.org/obo/UBERON_0007651 denotes junctions
T959 8633-8637 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T960 8673-8676 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T961 8743-8744 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T962 8863-8866 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T963 8921-8922 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T964 9000-9006 http://purl.obolibrary.org/obo/UBERON_0001005 denotes airway
T965 9314-9317 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T966 9348-9352 http://www.ebi.ac.uk/efo/EFO_0001410 denotes arms
T967 9472-9478 http://purl.obolibrary.org/obo/UBERON_0001005 denotes airway
T968 9560-9565 http://purl.obolibrary.org/obo/UBERON_0003101 denotes males
T969 9560-9565 http://www.ebi.ac.uk/efo/EFO_0000970 denotes males
T970 9574-9581 http://purl.obolibrary.org/obo/UBERON_0003100 denotes females
T971 9628-9635 http://purl.obolibrary.org/obo/UBERON_0001005 denotes airways
T972 9646-9652 http://purl.obolibrary.org/obo/UBERON_0001005 denotes airway
T973 9704-9711 http://purl.obolibrary.org/obo/UBERON_0001005 denotes airways
T974 9715-9722 http://purl.obolibrary.org/obo/UBERON_0003100 denotes females
T975 9781-9786 http://purl.obolibrary.org/obo/UBERON_0003101 denotes males
T976 9781-9786 http://www.ebi.ac.uk/efo/EFO_0000970 denotes males
T977 10101-10111 http://purl.obolibrary.org/obo/CLO_0001658 denotes activities
T978 10145-10155 http://purl.obolibrary.org/obo/CLO_0001658 denotes activities
T979 10196-10201 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T980 10196-10201 http://www.ebi.ac.uk/efo/EFO_0000296 denotes blood
T981 10305-10306 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T982 10453-10458 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T983 10521-10527 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes humans
T984 10690-10691 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T985 10714-10724 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T986 10790-10791 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T987 10846-10849 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T988 11145-11150 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T989 11262-11269 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T990 11405-11414 http://purl.obolibrary.org/obo/OBI_0100026 denotes organisms
T991 11405-11414 http://purl.obolibrary.org/obo/UBERON_0000468 denotes organisms

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T27957 228-232 Chemical denotes male http://purl.obolibrary.org/obo/CHEBI_30780
T23518 532-548 Chemical denotes antihypertensive http://purl.obolibrary.org/obo/CHEBI_35674
T31593 568-592 Chemical denotes calcium channel blockers http://purl.obolibrary.org/obo/CHEBI_38215
T57795 568-575 Chemical denotes calcium http://purl.obolibrary.org/obo/CHEBI_22984|http://purl.obolibrary.org/obo/CHEBI_29320
T11914 900-904 Chemical denotes male http://purl.obolibrary.org/obo/CHEBI_30780
T62420 1302-1316 Chemical denotes ACE inhibitors http://purl.obolibrary.org/obo/CHEBI_35457
T88754 1306-1316 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T52738 1318-1323 Chemical denotes ACEIs http://purl.obolibrary.org/obo/CHEBI_35457
T63223 1521-1533 Chemical denotes antidiabetic http://purl.obolibrary.org/obo/CHEBI_35526
T53003 1601-1606 Chemical denotes ACEIs http://purl.obolibrary.org/obo/CHEBI_35457
T85209 1723-1731 Chemical denotes losartan http://purl.obolibrary.org/obo/CHEBI_6541
T35617 1750-1760 Chemical denotes lisinopril http://purl.obolibrary.org/obo/CHEBI_43755
T72244 2432-2439 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T44056 2577-2579 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T66080 2655-2660 Chemical denotes ACEIs http://purl.obolibrary.org/obo/CHEBI_35457
T91113 2933-2949 Chemical denotes antihypertensive http://purl.obolibrary.org/obo/CHEBI_35674
T28525 3436-3458 Chemical denotes antihypertensive drugs http://purl.obolibrary.org/obo/CHEBI_35674
T296 3453-3458 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T83523 3615-3620 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T76894 3630-3635 Chemical denotes ACEIs http://purl.obolibrary.org/obo/CHEBI_35457
T83214 3670-3675 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T89355 3736-3741 Chemical denotes ACEIs http://purl.obolibrary.org/obo/CHEBI_35457
T57644 3943-3951 Chemical denotes losartan http://purl.obolibrary.org/obo/CHEBI_6541
T96201 4072-4077 Chemical denotes ACEIs http://purl.obolibrary.org/obo/CHEBI_35457
T89890 4256-4261 Chemical denotes ACEIs http://purl.obolibrary.org/obo/CHEBI_35457
T31128 4391-4396 Chemical denotes ACEIs http://purl.obolibrary.org/obo/CHEBI_35457
T305 4472-4474 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T70014 4753-4760 Chemical denotes insulin http://purl.obolibrary.org/obo/CHEBI_145810
T54852 4918-4925 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T20423 5322-5326 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T36620 5797-5801 Chemical denotes male http://purl.obolibrary.org/obo/CHEBI_30780
T5528 6076-6085 Chemical denotes biomarker http://purl.obolibrary.org/obo/CHEBI_59163
T81193 6275-6282 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T20258 6822-6825 Chemical denotes Zn2 http://purl.obolibrary.org/obo/CHEBI_37256
T31895 6998-7002 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T31980 7129-7136 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T64545 7198-7202 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T71170 7351-7354 Chemical denotes Zn2 http://purl.obolibrary.org/obo/CHEBI_37256
T91526 7448-7455 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T21622 7566-7568 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T17216 7599-7609 Chemical denotes olmesartan http://purl.obolibrary.org/obo/CHEBI_48416
T323 7841-7844 Chemical denotes RAS http://purl.obolibrary.org/obo/CHEBI_63620
T37828 8112-8119 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T325 9360-9363 Chemical denotes RAS http://purl.obolibrary.org/obo/CHEBI_63620
T326 9953-9957 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T10662 10097-10100 Chemical denotes RAS http://purl.obolibrary.org/obo/CHEBI_63620
T32041 10141-10144 Chemical denotes RAS http://purl.obolibrary.org/obo/CHEBI_63620

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T142 6216-6231 http://purl.obolibrary.org/obo/GO_0016032 denotes viral infection
T143 6833-6842 http://purl.obolibrary.org/obo/GO_0007588 denotes excretion
T144 7203-7212 http://purl.obolibrary.org/obo/GO_0007588 denotes excretion
T145 7362-7371 http://purl.obolibrary.org/obo/GO_0007588 denotes excretion
T146 8713-8718 http://purl.obolibrary.org/obo/GO_0030431 denotes sleep
T147 9071-9076 http://purl.obolibrary.org/obo/GO_0030431 denotes sleep
T148 9172-9184 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T149 9767-9772 http://purl.obolibrary.org/obo/GO_0030431 denotes sleep
T150 10725-10731 http://purl.obolibrary.org/obo/GO_0007613 denotes memory
T151 10735-10750 http://purl.obolibrary.org/obo/GO_0006955 denotes immune response

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T349 0-2 Sentence denotes 6.
T350 3-116 Sentence denotes Correlation of Pre-existing Circulating ACE2 Activity and Increased Potential to Develop Severe Forms of COVID-19
T351 117-260 Sentence denotes Severe symptoms of COVID-19 have been described to correlate with pre-existing hypertension, diabetes, age and male gender [1,2,3,4,5,6,7,8,9].
T352 261-638 Sentence denotes It is not still clear whether it depends on constitutive hypertensive conditions and/or on anti-hypertensive treatments or on other age-related conditions, considering that the prevalence of hypertension in Chinese adults is ~ 23% and that only about 41% take prescribed antihypertensive medications, being calcium channel blockers the most commonly used (~ 50%) in China [11].
T353 639-877 Sentence denotes To this regard, there is an interesting report describing sACE2 activity in plasma samples of Spanish healthy subjects and patients, in which a total of 2572 subjects from a multicenter study (NEFRONA project, 2009–2011) was studied [96].
T354 878-996 Sentence denotes The report shows that male and advanced age were identified as independent predictors of enhanced sACE2 activity [96].
T355 997-1188 Sentence denotes Furthermore, subjects with hypertension, diabetes, dyslipidemia, or plaques also had significantly increased circulating ACE2 activity when compared with those without these pathologies [96].
T356 1189-1404 Sentence denotes Notably, hypertensive (the most frequent comorbidity with COVID-19) and diabetic patients are often treated with ACE inhibitors (ACEIs) and/or with ARBs, suggesting a possible positive correlation [135,136,137,138].
T357 1405-1690 Sentence denotes Interestingly, circulating ACE2 activity is significantly increased in subjects on therapy with ARBs or taking oral antidiabetic agents as compared with non-treated patients, while treatment with ACEIs and cholecalciferol had no significant influence on circulating ACE2 activity [96].
T358 1691-1846 Sentence denotes In line with this observations, losartan (an ARB), but not lisinopril (an ACEI), was able to upregulate ACE2 activity in left ventricle of Lewis rats [75].
T359 1847-2156 Sentence denotes Nevertheless, plasma concentration of Ang (1–7) was significantly increased with both treatments when compared to vehicle-treated rats and it was significantly higher in ACEI-treated than ARB-treated rats [75], suggesting that ACE inhibition is able to induce an activation of the ACE2/Ang (1–7)/MasR pathway.
T360 2157-2328 Sentence denotes Although more evidence is needed in humans, the above observations suggest that ARBs should be precautionarily avoided to reduce possible ACE2-mediated viral consequences.
T361 2329-2502 Sentence denotes Indeed, under hypoxic conditions, either an ACEI or an ARB have been shown to upregulate membrane ACE2 protein expression on human pulmonary artery smooth muscle cells [58].
T362 2503-2654 Sentence denotes ACEI and ARB have been shown to work by reducing the concentration of Ang II and by inhibiting its AT1-mediated ACE2 downregulation, respectively [58].
T363 2655-2910 Sentence denotes ACEIs and ARBs might therefore play a role in the upregulation of membrane ACE2 expression under hypoxic conditions such as COVID-19, knowing that the increase of membrane bound ACE2 (before its shedding) will also increase the probability of viral entry.
T364 2911-3013 Sentence denotes Of note, ACEI and ARB antihypertensive medications are more commonly used in Europe/USA than in China.
T365 3014-3238 Sentence denotes Nevertheless, recent reports show that the use of ACEI/ARB medications in patients with COVID-19 is safe and ACEI/ARB exposure was not associated with a higher risk of having severe forms of COVID-19 [6,139,140,141,142,143].
T366 3239-3481 Sentence denotes Moreover, some reports show that ACEI/ARB treated patients may even be protected from COVID-19 and ACEI/ARB exposure was associated with a lower risk of mortality compared to those on non-ACEI/ARB antihypertensive drugs [144,145,146,147,148].
T367 3482-3682 Sentence denotes Among these reports, one indicates that the risk of severe symptoms of COVID-19 was significantly decreased in patients who took ARB drugs (but not ACEIs) compared to patients who took no drugs [144].
T368 3683-3909 Sentence denotes Differently, another report suggests that the use of ACEIs (but not ARBs) reduced risk of death and/or critical disease [146], suggesting that some of these reports did not adjust for confounders and further analyses are need.
T369 3910-4108 Sentence denotes Nevertheless, clinical trials of losartan as a treatment for COVID-19, are actually underway among patients who have not previously been treated with ARBs and/or ACEIs (NCT04312009 and NCT04311177).
T370 4109-4358 Sentence denotes However, most of hypertensive/diabetic patients are ACEI- or ARB-“pretreated”, nevertheless they have an increased risk to develop SARS, therefore ACEIs and ARBs, if not detrimental, are not expected to face the disease in non-hypertensive patients.
T371 4359-4690 Sentence denotes A possible beneficial effect of ACEIs in COVID-19 patients could indirectly come by reducing ACE2 substrate, Ang II, and finally limiting Ang (1–7) [but not Ang (1–9)] production and its (detrimental) effects; however, this is only a hypothetical possibility since, in this case, the ACE2/ACE pathway might be even more unbalanced.
T372 4691-4883 Sentence denotes To complete the picture, smokers and subjects on therapy with insulin tend to have an increased (although not significantly) circulating ACE2 activity when compared with control subjects [96].
T373 4884-5145 Sentence denotes On the other hand, increased ACE2 protein expression was reported in plasma and/or urine of physically active men after acute aerobic training or in renal cortices of spontaneous hypertensive, but not normotensive, rats after chronic aerobic training [149,150].
T374 5146-5375 Sentence denotes In addition, recent works reveal that asthma and other allergic diseases, which protect from developing COVID-19, were associated with significant reductions in levels of both zinc in plasma and ACE2 mRNA in airway cells [98,99].
T375 5376-5634 Sentence denotes On the other hand, as already mentioned, some patients with cardiovascular diseases (and inflammatory bowel disease) have an increased circulating ACE2 [22,49,151,152], which might explain the higher probability of elderly heart patients to develop COVID-19.
T376 5635-5864 Sentence denotes Interestingly, in a report on atrial fibrillation, increased plasma ACE2 activity was significantly associated not only with cardiac dysfunction, increasing age, male gender and hypertension, but also with vascular disease [152].
T377 5865-6106 Sentence denotes Altogether the data suggest a strong correlation between circulating ACE2 activity and the predisposition to develop the most severe symptoms of COVID-19, suggesting that circulating sACE2 might be a predictive biomarker of SARS development.
T378 6107-6342 Sentence denotes The surprising aspect is that circulating (differently from membrane bound) ACE2 is expected to protect from viral infection and clinical trials using recombinant ACE2 protein are being pursued (ClinicalTrials.gov number, NCT04287686).
T379 6343-6546 Sentence denotes However, even if it might not be detrimental, recombinant ACE2 is not expected to protect from COVID-19, as circulating ACE2 upregulation correlates with the most common comorbidities in severe COVID-19.
T380 6547-6843 Sentence denotes The correlation is extremely impressive and striking if we also consider the low prevalence of chronic renal disease in COVID-19 hospitalized patients (0–3%) [1,2,3,4,5,6,7,8,9] (prevalence of the disease in China ~11% [12]) which might be protected by a higher sACE2 and/or Zn2+ renal excretion.
T381 6844-7062 Sentence denotes Indeed, in chronic kidney disease patients without a history of cardiovascular disease, there was a significant decrease in circulating ACE2 activity and zinc levels when compared with healthy control subjects [96,97].
T382 7063-7372 Sentence denotes Since proteinuria was associated with lower blood levels of sACE2 protein [153] and chronic kidney disease patients had higher urinary zinc excretion than healthy controls [97], low sACE2 activity in chronic renal diseases and protection from SARS might derive from a higher sACE2 and/or Zn2+ renal excretion.
T383 7373-7619 Sentence denotes Indeed, sACE2 is detectable in urine of healthy subjects and urinary sACE2 protein levels are elevated in patients with chronic renal diseases and in hypertensive patients treated with the Ang II type 1 receptor blocker (ARB) olmesartan [41,154].
T384 7620-7845 Sentence denotes It can, therefore, be supposed that a basal hyperactivity of ACE2 and consequent ACE/ACE2 pathway disequilibrium in blood might predispose to the development of more severe COVID-19 symptoms that involve both arms of the RAS.
T385 7846-8222 Sentence denotes In this regard, different organism predisposition to infections including SARS-CoV-2 or to pathologies associated with an increased risk to develop severe forms of SARS-CoV-2 infection might depend not only on genetic ACE2 polymorphisms and organ-specific ACE2 gene/protein expression [138,155,156,157,158,159,160,161,162,163] but also on anatomical and environmental factors.
T386 8223-8399 Sentence denotes For example, ACE2 gene variants have been associated with risk for hypertension, dyslipidemia, type 2 diabetes and cardiovascular dysfunction [138,155,156,157,158,159,160,161].
T387 8400-8644 Sentence denotes Most of these variants are intronic and located in splice-site junctions or in enhancer regions while the others are placed in the 3’ UTR promoter region, suggesting their involvement in the structure/function and expression of ACE2 gene [138].
T388 8645-8797 Sentence denotes On the other hand, COVID-19 has similar risk factors of obstructive sleep apnea (OSA), suggesting a possible association between OSA and COVID-19 [164].
T389 8798-8964 Sentence denotes Indeed, high prevalence of pre-existing OSA in COVID-19 patients has been reported [165,166], indicating that OSA could be a risk factor for severe forms of Covid-19.
T390 8965-9191 Sentence denotes OSA is characterised by repetitive airway collapse with apnea/hypopnea and intermittent hypoxaemia during sleep and it is associated with hypertension, cardiovascular disease, diabetes, obesity and systemic inflammation [167].
T391 9192-9448 Sentence denotes Most of these diseases are known to predispose to increased levels of circulating ACE2 and, as already mentioned, hypoxia has been shown to upregulate both arms of the RAS; therefore, OSA might predispose to the deleterious effects of SARS-CoV-2 infection.
T392 9449-9689 Sentence denotes In OSA patients, upper airway collapsibility under passive conditions (critical closing pressure) is higher in males than in females due to anatomical factors, i.e., longer upper airways, as upper airway length correlates with OSA severity.
T393 9690-9930 Sentence denotes Indeed, upper airways in females are less collapsible and more stable during sleep than in males [167], suggesting that an anatomical factor might contribute to and result in different gender susceptibility to COVID-19 and disease severity.
T394 9931-10112 Sentence denotes Moreover, diet (e.g., zinc assumption), physical exercise and external temperature and UV radiation are all “environmental” aspects that can seasonally influence the RAS activities.
T395 10113-10226 Sentence denotes Seasonal differences of the RAS activities leading, for example, to differences in blood pressure are well known.
T396 10227-10349 Sentence denotes Of interest, the majority of coronaviruses cause cold-like illnesses and have a relatively low mutational frequency [168].
T397 10350-10423 Sentence denotes Similarly SARS-CoV-2 seems to mutate much slower than seasonal flu [169].
T398 10424-10658 Sentence denotes Nevertheless, like influenza virus, they are responsible for seasonal episodes of common cold in humans worldwide [168], suggesting that coronaviruses may possess an ability to evade immune control that is different from seasonal flu.
T399 10659-10751 Sentence denotes For example, they might favour a relatively short-term activation/memory of immune response.
T400 10752-10888 Sentence denotes Indeed, as for SARS-CoV and MERS-CoV, a short duration of immunity after SARS-CoV-2 infection has been recently suggested [170,171,172].
T401 10889-11069 Sentence denotes Seasonal cold is an annually recurring time period characterized by the prevalence of outbreaks of cold and the season occurs during the cold period of the year in each hemisphere.
T402 11070-11440 Sentence denotes Altogether these observations suggest that seasonal predisposition to some virus infections (including SARS-CoV-2) might not depend only on environmental features that directly inactivate the viruses “unprotected” outside the host (e.g., higher ultraviolet rays and temperatures), but also on seasonal indirect effects produced in the organisms by environmental changes.

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T109 196-208 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822
T110 452-464 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822
T111 1024-1036 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822
T112 1048-1060 Phenotype denotes dyslipidemia http://purl.obolibrary.org/obo/HP_0003119
T113 5184-5190 Phenotype denotes asthma http://purl.obolibrary.org/obo/HP_0002099
T114 5436-5459 Phenotype denotes cardiovascular diseases http://purl.obolibrary.org/obo/HP_0001626
T115 5465-5491 Phenotype denotes inflammatory bowel disease http://purl.obolibrary.org/obo/HP_0002037
T116 5665-5684 Phenotype denotes atrial fibrillation http://purl.obolibrary.org/obo/HP_0005110
T117 5813-5825 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822
T118 6855-6877 Phenotype denotes chronic kidney disease http://purl.obolibrary.org/obo/HP_0012622
T119 6908-6930 Phenotype denotes cardiovascular disease http://purl.obolibrary.org/obo/HP_0001626
T120 7069-7080 Phenotype denotes proteinuria http://purl.obolibrary.org/obo/HP_0000093
T121 7147-7169 Phenotype denotes chronic kidney disease http://purl.obolibrary.org/obo/HP_0012622
T122 7664-7677 Phenotype denotes hyperactivity http://purl.obolibrary.org/obo/HP_0000752
T123 7881-7909 Phenotype denotes predisposition to infections http://purl.obolibrary.org/obo/HP_0002719
T124 8290-8302 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822
T125 8304-8316 Phenotype denotes dyslipidemia http://purl.obolibrary.org/obo/HP_0003119
T126 8318-8333 Phenotype denotes type 2 diabetes http://purl.obolibrary.org/obo/HP_0005978
T127 8701-8724 Phenotype denotes obstructive sleep apnea http://purl.obolibrary.org/obo/HP_0002870
T128 8726-8729 Phenotype denotes OSA http://purl.obolibrary.org/obo/HP_0002870
T129 8774-8777 Phenotype denotes OSA http://purl.obolibrary.org/obo/HP_0002870
T130 8838-8841 Phenotype denotes OSA http://purl.obolibrary.org/obo/HP_0002870
T131 8908-8911 Phenotype denotes OSA http://purl.obolibrary.org/obo/HP_0002870
T132 8965-8968 Phenotype denotes OSA http://purl.obolibrary.org/obo/HP_0002870
T133 9021-9026 Phenotype denotes apnea http://purl.obolibrary.org/obo/HP_0002104
T134 9027-9035 Phenotype denotes hypopnea http://purl.obolibrary.org/obo/HP_0040213
T135 9103-9115 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822
T136 9117-9139 Phenotype denotes cardiovascular disease http://purl.obolibrary.org/obo/HP_0001626
T137 9151-9158 Phenotype denotes obesity http://purl.obolibrary.org/obo/HP_0001513
T138 9306-9313 Phenotype denotes hypoxia http://purl.obolibrary.org/obo/HP_0012418
T139 9376-9379 Phenotype denotes OSA http://purl.obolibrary.org/obo/HP_0002870
T140 9452-9455 Phenotype denotes OSA http://purl.obolibrary.org/obo/HP_0002870
T141 9676-9679 Phenotype denotes OSA http://purl.obolibrary.org/obo/HP_0002870

2_test

Id Subject Object Predicate Lexical cue
32708755-32077115-20678898 241-242 32077115 denotes 1
32708755-32161940-20678899 243-244 32161940 denotes 2
32708755-32171076-20678900 245-246 32171076 denotes 3
32708755-32109013-20678901 249-250 32109013 denotes 5
32708755-32294485-20678902 251-252 32294485 denotes 6
32708755-32091533-20678903 253-254 32091533 denotes 7
32708755-31986264-20678904 255-256 31986264 denotes 8
32708755-32297671-20678905 257-258 32297671 denotes 9
32708755-29449338-20678906 634-636 29449338 denotes 11
32708755-25813276-20678907 873-875 25813276 denotes 96
32708755-25813276-20678908 992-994 25813276 denotes 96
32708755-25813276-20678909 1184-1186 25813276 denotes 96
32708755-32171062-20678910 1387-1390 32171062 denotes 135
32708755-32222168-20678911 1391-1394 32222168 denotes 136
32708755-32222169-20678912 1395-1398 32222169 denotes 137
32708755-32665962-20678913 1399-1402 32665962 denotes 138
32708755-25813276-20678914 1686-1688 25813276 denotes 96
32708755-15897343-20678915 1842-1844 15897343 denotes 75
32708755-15897343-20678916 2053-2055 15897343 denotes 75
32708755-32294485-20678917 3215-3216 32294485 denotes 6
32708755-32356628-20678918 3233-3236 32356628 denotes 143
32708755-32228222-20678919 3464-3467 32228222 denotes 145
32708755-32474043-20678920 3468-3471 32474043 denotes 146
32708755-32422341-20678921 3472-3475 32422341 denotes 147
32708755-32302265-20678922 3476-3479 32302265 denotes 148
32708755-32474043-20678923 3804-3807 32474043 denotes 146
32708755-25813276-20678924 4879-4881 25813276 denotes 96
32708755-31989052-20678925 5136-5139 31989052 denotes 149
32708755-21895524-20678926 5140-5143 21895524 denotes 150
32708755-19700132-20678927 5529-5531 19700132 denotes 22
32708755-23630610-20678928 5532-5534 23630610 denotes 49
32708755-29897923-20678929 5535-5538 29897923 denotes 151
32708755-27738071-20678930 5539-5542 27738071 denotes 152
32708755-27738071-20678931 5859-5862 27738071 denotes 152
32708755-32077115-20678932 6706-6707 32077115 denotes 1
32708755-32161940-20678933 6708-6709 32161940 denotes 2
32708755-32171076-20678934 6710-6711 32171076 denotes 3
32708755-32109013-20678935 6714-6715 32109013 denotes 5
32708755-32294485-20678936 6716-6717 32294485 denotes 6
32708755-32091533-20678937 6718-6719 32091533 denotes 7
32708755-31986264-20678938 6720-6721 31986264 denotes 8
32708755-32297671-20678939 6722-6723 32297671 denotes 9
32708755-22386035-20678940 6767-6769 22386035 denotes 12
32708755-25813276-20678941 7055-7057 25813276 denotes 96
32708755-30554115-20678942 7611-7613 30554115 denotes 41
32708755-24842388-20678943 7614-7617 24842388 denotes 154
32708755-32665962-20678944 8132-8135 32665962 denotes 138
32708755-30227878-20678945 8136-8139 30227878 denotes 155
32708755-30675038-20678946 8140-8143 30675038 denotes 156
32708755-30335025-20678947 8148-8151 30335025 denotes 158
32708755-16283142-20678948 8152-8155 16283142 denotes 159
32708755-27310975-20678949 8156-8159 27310975 denotes 160
32708755-30917908-20678950 8160-8163 30917908 denotes 161
32708755-32133153-20678951 8164-8167 32133153 denotes 162
32708755-32170560-20678952 8168-8171 32170560 denotes 163
32708755-32665962-20678953 8366-8369 32665962 denotes 138
32708755-30227878-20678954 8370-8373 30227878 denotes 155
32708755-30675038-20678955 8374-8377 30675038 denotes 156
32708755-30335025-20678956 8382-8385 30335025 denotes 158
32708755-16283142-20678957 8386-8389 16283142 denotes 159
32708755-27310975-20678958 8390-8393 27310975 denotes 160
32708755-30917908-20678959 8394-8397 30917908 denotes 161
32708755-32665962-20678960 8639-8642 32665962 denotes 138
32708755-32342265-20678961 8792-8795 32342265 denotes 164
32708755-31694839-20678962 9186-9189 31694839 denotes 167
32708755-31694839-20678963 9788-9791 31694839 denotes 167
32708755-32555424-20678964 10875-10878 32555424 denotes 170
32708755-32505227-20678965 10883-10886 32505227 denotes 172