PMC:7408073 / 68826-69964 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7408073","sourcedb":"PMC","sourceid":"7408073","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7408073","text":"Among natural metal-chelating agents, phytates and folic acid are two chelating agents from vegetables that might reduce zinc intestinal absorption and possibly its systemic concentration (see Box 4 and [111]). Similarly, nicotianamine that is extracted from plants (soybean) is a low-molecular weight metal chelator with high affinity for divalent metal cations. Nicotianamine has been shown to inhibit the activity of both zinc metalloproteases, ACE2 and ACE [130]. In addition, zeolites might also be effective in reducing free zinc availability. Zeolites are a group of aluminosilicate minerals with crystalline microporous structure that are originated from volcanic rocks. Their molecular structure generates cavities that allow high absorbency capacity for a wide range of charged elements such as water, heavy metals, cations and many toxins. Clinoptilolite is one of the zeolites that has been widely studied in veterinary and human medicine. The increased usage of clinoptilolite-based products in vivo has stimulated several investigations on its safety and its positive medical effects related to human health (see 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