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PMC:7408073 / 65338-66544 JSONTXT

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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T408 792-804 Body_part denotes renal artery http://purl.org/sig/ont/fma/fma14751
T409 1069-1079 Body_part denotes neutrophil http://purl.org/sig/ont/fma/fma62860

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T134 221-224 Body_part denotes RAS http://purl.obolibrary.org/obo/UBERON_0018229
T135 792-804 Body_part denotes renal artery http://purl.obolibrary.org/obo/UBERON_0001184
T136 798-804 Body_part denotes artery http://purl.obolibrary.org/obo/UBERON_0001637
T137 1155-1158 Body_part denotes RAS http://purl.obolibrary.org/obo/UBERON_0018229

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
2329 978-985 Species denotes patient Tax:9606
2330 320-325 Chemical denotes metal MESH:D008670
2331 745-749 Chemical denotes EDTA MESH:D004492
2332 941-946 Chemical denotes metal MESH:D008670
2333 144-152 Disease denotes COVID-19 MESH:C000657245
2334 153-162 Disease denotes infection MESH:D007239
2335 195-202 Disease denotes hypoxia MESH:D000860
2336 404-436 Disease denotes fatal renal toxicity and failure MESH:D051437
2337 438-466 Disease denotes hepatic toxicity and failure MESH:D056486
2338 468-496 Disease denotes gastrointestinal haemorrhage MESH:D006471
2339 498-509 Disease denotes arrhythmias MESH:D001145
2340 511-517 Disease denotes tetany MESH:D013746
2341 519-532 Disease denotes hypocalcaemia
2342 534-545 Disease denotes hypotension MESH:D007022
2343 547-558 Disease denotes convulsions MESH:D012640
2344 560-578 Disease denotes respiratory arrest MESH:D012131
2345 584-599 Disease denotes agranulocytosis MESH:D000380
2346 625-635 Disease denotes infections MESH:D007239
2347 640-645 Disease denotes death MESH:D003643
2348 691-705 Disease denotes renal toxicity MESH:D007674
2349 792-813 Disease denotes renal artery diseases MESH:D007674

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T323 144-152 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T324 153-162 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T325 498-509 Disease denotes arrhythmias http://purl.obolibrary.org/obo/MONDO_0007263
T326 534-545 Disease denotes hypotension http://purl.obolibrary.org/obo/MONDO_0005468
T327 584-599 Disease denotes agranulocytosis http://purl.obolibrary.org/obo/MONDO_0001609
T328 625-635 Disease denotes infections http://purl.obolibrary.org/obo/MONDO_0005550
T329 792-813 Disease denotes renal artery diseases http://purl.obolibrary.org/obo/MONDO_0002286

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T814 209-213 http://www.ebi.ac.uk/efo/EFO_0001410 denotes arms
T815 242-243 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T816 349-350 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T817 750-753 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T818 798-804 http://purl.obolibrary.org/obo/UBERON_0001637 denotes artery
T819 798-804 http://www.ebi.ac.uk/efo/EFO_0000814 denotes artery
T820 915-916 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T821 1019-1024 http://purl.obolibrary.org/obo/UBERON_0000473 denotes tests

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T188 30-36 Chemical denotes cation http://purl.obolibrary.org/obo/CHEBI_36916
T41096 37-53 Chemical denotes chelating agents http://purl.obolibrary.org/obo/CHEBI_38161
T99407 221-224 Chemical denotes RAS http://purl.obolibrary.org/obo/CHEBI_63620
T191 326-342 Chemical denotes chelating agents http://purl.obolibrary.org/obo/CHEBI_38161
T97596 729-733 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T61973 745-749 Chemical denotes EDTA http://purl.obolibrary.org/obo/CHEBI_42191|http://purl.obolibrary.org/obo/CHEBI_64755
T73647 863-867 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T92153 947-963 Chemical denotes chelating agents http://purl.obolibrary.org/obo/CHEBI_38161
T53011 1155-1158 Chemical denotes RAS http://purl.obolibrary.org/obo/CHEBI_63620

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T137 734-743 http://purl.obolibrary.org/obo/GO_0007588 denotes excretion

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T314 0-241 Sentence denotes For all of the above reasons, cation chelating agents, administered alone or in combination with other therapies, might be effective to counter COVID-19 infection, in particular when, induced by hypoxia, both arms of the RAS are upregulated.
T315 242-289 Sentence denotes A scenario that would deserve an investigation.
T316 290-652 Sentence denotes However, some formulations of metal chelating agents carry a black box warning because they may cause serious and fatal renal toxicity and failure, hepatic toxicity and failure, gastrointestinal haemorrhage, arrhythmias, tetany, hypocalcaemia, hypotension, convulsions, respiratory arrest, and agranulocytosis that can lead to serious infections and death [123].
T317 653-820 Sentence denotes For the sake of completeness, besides renal toxicity linked to the route of drug excretion, EDTA has been shown to be effective in chronic renal artery diseases [123].
T318 821-911 Sentence denotes Finally, for its teratogenic effects, the drug is also contraindicated in pregnancy [123].
T319 912-1134 Sentence denotes As a result, treatments with metal chelating agents require close patient monitoring, including laboratory tests of renal and hepatic function, and absolute neutrophil count should be monitored before and during treatment.
T320 1135-1206 Sentence denotes Alternative ways of RAS pathway inhibition are also described in Box 5.

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T100 195-202 Phenotype denotes hypoxia http://purl.obolibrary.org/obo/HP_0012418
T101 468-496 Phenotype denotes gastrointestinal haemorrhage http://purl.obolibrary.org/obo/HP_0002239
T102 498-509 Phenotype denotes arrhythmias http://purl.obolibrary.org/obo/HP_0011675
T103 511-517 Phenotype denotes tetany http://purl.obolibrary.org/obo/HP_0001281
T104 519-532 Phenotype denotes hypocalcaemia http://purl.obolibrary.org/obo/HP_0002901
T105 534-545 Phenotype denotes hypotension http://purl.obolibrary.org/obo/HP_0002615
T106 560-578 Phenotype denotes respiratory arrest http://purl.obolibrary.org/obo/HP_0005943
T107 584-599 Phenotype denotes agranulocytosis http://purl.obolibrary.org/obo/HP_0012234

2_test

Id Subject Object Predicate Lexical cue
32708755-20717537-20678878 647-650 20717537 denotes 123
32708755-20717537-20678879 815-818 20717537 denotes 123
32708755-20717537-20678880 906-909 20717537 denotes 123