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PMC:7408073 / 63262-64499 JSONTXT

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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T397 64-69 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670
T398 368-372 Body_part denotes body http://purl.org/sig/ont/fma/fma256135
T399 374-379 Body_part denotes Cells http://purl.org/sig/ont/fma/fma68646
T400 506-512 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T401 829-834 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T402 922-937 Body_part denotes plasma membrane http://purl.org/sig/ont/fma/fma63841

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T133 64-69 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
2267 409-412 Gene denotes ACE Gene:59272
2268 416-420 Gene denotes ACE2 Gene:59272
2269 556-559 Gene denotes ACE Gene:59272
2270 564-568 Gene denotes ACE2 Gene:59272
2271 628-631 Gene denotes ACE Gene:59272
2272 636-640 Gene denotes ACE2 Gene:59272
2273 863-867 Gene denotes ACE2 Gene:59272
2274 868-871 Gene denotes ACE Gene:59272
2275 972-976 Gene denotes ACE2 Gene:59272
2276 1211-1215 Gene denotes ACE2 Gene:59272
2277 1182-1185 Gene denotes MLN Gene:4295
2278 0-9 Chemical denotes CaNa2EDTA
2279 147-151 Chemical denotes iron MESH:D007501
2280 335-340 Chemical denotes metal MESH:D008670
2281 760-765 Chemical denotes metal MESH:D008670

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T794 64-69 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T795 64-69 http://www.ebi.ac.uk/efo/EFO_0000296 denotes blood
T796 82-83 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T797 374-379 http://purl.obolibrary.org/obo/GO_0005623 denotes Cells
T798 506-512 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T799 569-579 http://purl.obolibrary.org/obo/CLO_0001658 denotes activities
T800 829-834 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T801 922-928 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T802 929-937 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T803 1029-1034 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T53337 147-168 Chemical denotes iron chelating agents http://purl.obolibrary.org/obo/CHEBI_38157
T25372 147-151 Chemical denotes iron http://purl.obolibrary.org/obo/CHEBI_18248
T27100 152-168 Chemical denotes chelating agents http://purl.obolibrary.org/obo/CHEBI_38161
T154 200-208 Chemical denotes zinc ion http://purl.obolibrary.org/obo/CHEBI_27365
T155 200-204 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T83733 205-208 Chemical denotes ion http://purl.obolibrary.org/obo/CHEBI_24870
T158 306-322 Chemical denotes chelating agents http://purl.obolibrary.org/obo/CHEBI_38161
T43731 341-345 Chemical denotes ions http://purl.obolibrary.org/obo/CHEBI_24870
T75520 354-358 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T86735 466-470 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T55396 528-532 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T79616 704-708 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T58337 766-782 Chemical denotes chelating agents http://purl.obolibrary.org/obo/CHEBI_38161
T33902 821-825 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T76669 1076-1080 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T173 1095-1104 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T19266 1149-1153 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T127 595-613 http://purl.obolibrary.org/obo/GO_0044249 denotes cellular synthesis
T128 604-613 http://purl.obolibrary.org/obo/GO_0009058 denotes synthesis
T129 641-650 http://purl.obolibrary.org/obo/GO_0009058 denotes synthesis
T130 872-881 http://purl.obolibrary.org/obo/GO_0009058 denotes synthesis

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T303 0-105 Sentence denotes CaNa2EDTA was approved by FDA in chelation therapy for lowering blood lead levels a long time ago (1953).
T304 106-239 Sentence denotes Then, different (commercially available) iron chelating agents, expected to work in chelating zinc ion as well, were approved by FDA.
T305 240-373 Sentence denotes Chelation therapy comprises intravenous or oral administration of chelating agents that remove metal ions such as zinc from the body.
T306 374-471 Sentence denotes Cells synthesising high amounts of ACE or ACE2 needs of high amounts of bioavailable (free) zinc.
T307 472-614 Sentence denotes Therefore, it is conceivable that plasma levels of free zinc may influence not only ACE and ACE2 activities but also their cellular synthesis.
T308 615-746 Sentence denotes Indeed, both ACE and ACE2 synthesis might be particularly sensitive to reduction of free zinc levels in case of their upregulation.
T309 747-939 Sentence denotes In addition, metal chelating agents, by limiting the availability of free zinc to cells, might have effects on both ACE2/ACE synthesis and conformation (when assembled on the plasma membrane).
T310 940-1237 Sentence denotes Indeed, the closed conformer of ACE2 homodimer that is the preferential conformation for virus binding [28], needs the presence of both zinc and substrate/inhibitor in the catalytic site [90], suggesting that zinc chelation (differently from MLN-4760) might also inhibit ACE2-mediated viral entry.

2_test

Id Subject Object Predicate Lexical cue
32708755-32132184-20678873 1044-1046 32132184 denotes 28