PMC:7408073 / 621-983 JSONTXT

{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T5","span":{"begin":252,"end":276},"obj":"Body_part"}],"attributes":[{"id":"A5","pred":"uberon_id","subj":"T5","obj":"http://purl.obolibrary.org/obo/UBERON_0018229"}],"text":"In particular, metal (zinc) chelators and renin inhibitors may work alone or in combination to inhibit the positive feedback loops (initially triggered by SARS-CoV-2 and subsequently sustained by hypoxia independently on viral trigger) as both arms of renin-angiotensin system are upregulated, leading to critical, advanced and untreatable stages of the disease."}

{"project":"LitCovid-PubTator","denotations":[{"id":"23","span":{"begin":42,"end":47},"obj":"Gene"},{"id":"24","span":{"begin":252,"end":257},"obj":"Gene"},{"id":"29","span":{"begin":155,"end":165},"obj":"Species"},{"id":"30","span":{"begin":15,"end":20},"obj":"Chemical"},{"id":"33","span":{"begin":196,"end":203},"obj":"Disease"}],"attributes":[{"id":"A23","pred":"tao:has_database_id","subj":"23","obj":"Gene:5972"},{"id":"A24","pred":"tao:has_database_id","subj":"24","obj":"Gene:5972"},{"id":"A29","pred":"tao:has_database_id","subj":"29","obj":"Tax:2697049"},{"id":"A30","pred":"tao:has_database_id","subj":"30","obj":"MESH:D008670"},{"id":"A33","pred":"tao:has_database_id","subj":"33","obj":"MESH:D000860"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"In particular, metal (zinc) chelators and renin inhibitors may work alone or in combination to inhibit the positive feedback loops (initially triggered by SARS-CoV-2 and subsequently sustained by hypoxia independently on viral trigger) as both arms of renin-angiotensin system are upregulated, leading to critical, advanced and untreatable stages of the disease."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T5","span":{"begin":155,"end":163},"obj":"Disease"},{"id":"T6","span":{"begin":155,"end":159},"obj":"Disease"}],"attributes":[{"id":"A5","pred":"mondo_id","subj":"T5","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A6","pred":"mondo_id","subj":"T6","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"}],"text":"In particular, metal (zinc) chelators and renin inhibitors may work alone or in combination to inhibit the positive feedback loops (initially triggered by SARS-CoV-2 and subsequently sustained by hypoxia independently on viral trigger) as both arms of renin-angiotensin system are upregulated, leading to critical, advanced and untreatable stages of the disease."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T76251","span":{"begin":244,"end":248},"obj":"http://www.ebi.ac.uk/efo/EFO_0001410"}],"text":"In particular, metal (zinc) chelators and renin inhibitors may work alone or in combination to inhibit the positive feedback loops (initially triggered by SARS-CoV-2 and subsequently sustained by hypoxia independently on viral trigger) as both arms of renin-angiotensin system are upregulated, leading to critical, advanced and untreatable stages of the disease."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T10","span":{"begin":22,"end":26},"obj":"Chemical"},{"id":"T12","span":{"begin":28,"end":37},"obj":"Chemical"},{"id":"T13","span":{"begin":48,"end":58},"obj":"Chemical"},{"id":"T14","span":{"begin":258,"end":269},"obj":"Chemical"}],"attributes":[{"id":"A10","pred":"chebi_id","subj":"T10","obj":"http://purl.obolibrary.org/obo/CHEBI_27363"},{"id":"A11","pred":"chebi_id","subj":"T10","obj":"http://purl.obolibrary.org/obo/CHEBI_30185"},{"id":"A12","pred":"chebi_id","subj":"T12","obj":"http://purl.obolibrary.org/obo/CHEBI_38161"},{"id":"A13","pred":"chebi_id","subj":"T13","obj":"http://purl.obolibrary.org/obo/CHEBI_35222"},{"id":"A14","pred":"chebi_id","subj":"T14","obj":"http://purl.obolibrary.org/obo/CHEBI_48433"}],"text":"In particular, metal (zinc) chelators and renin inhibitors may work alone or in combination to inhibit the positive feedback loops (initially triggered by SARS-CoV-2 and subsequently sustained by hypoxia independently on viral trigger) as both arms of renin-angiotensin system are upregulated, leading to critical, advanced and untreatable stages of the disease."}

{"project":"LitCovid-sentences","denotations":[{"id":"T6","span":{"begin":0,"end":362},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"In particular, metal (zinc) chelators and renin inhibitors may work alone or in combination to inhibit the positive feedback loops (initially triggered by SARS-CoV-2 and subsequently sustained by hypoxia independently on viral trigger) as both arms of renin-angiotensin system are upregulated, leading to critical, advanced and untreatable stages of the disease."}

{"project":"LitCovid-PD-HP","denotations":[{"id":"T1","span":{"begin":196,"end":203},"obj":"Phenotype"}],"attributes":[{"id":"A1","pred":"hp_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/HP_0012418"}],"text":"In particular, metal (zinc) chelators and renin inhibitors may work alone or in combination to inhibit the positive feedback loops (initially triggered by SARS-CoV-2 and subsequently sustained by hypoxia independently on viral trigger) as both arms of renin-angiotensin system are upregulated, leading to critical, advanced and untreatable stages of the disease."}