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PMC:7408073 / 59774-61651 JSONTXT

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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T385 412-416 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T386 1548-1553 Body_part denotes heart http://purl.org/sig/ont/fma/fma7088
T387 1555-1559 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T388 1561-1566 Body_part denotes liver http://purl.org/sig/ont/fma/fma7197
T389 1568-1573 Body_part denotes colon http://purl.org/sig/ont/fma/fma14543
T390 1583-1590 Body_part denotes tissues http://purl.org/sig/ont/fma/fma9637
T391 1622-1627 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670
T392 1632-1649 Body_part denotes endothelial cells http://purl.org/sig/ont/fma/fma66772
T393 1644-1649 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T126 412-416 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T127 1548-1553 Body_part denotes heart http://purl.obolibrary.org/obo/UBERON_0000948
T128 1555-1559 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T129 1561-1566 Body_part denotes liver http://purl.obolibrary.org/obo/UBERON_0002107
T130 1568-1573 Body_part denotes colon http://purl.obolibrary.org/obo/UBERON_0001155
T131 1591-1597 Body_part denotes organs http://purl.obolibrary.org/obo/UBERON_0000062
T132 1622-1627 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
2177 78-82 Gene denotes ACE2 Gene:59272
2178 536-541 Gene denotes rACE2 Gene:302668
2179 599-603 Gene denotes ACE2 Gene:59272
2180 1323-1327 Gene denotes ACE2 Gene:302668
2181 1517-1521 Gene denotes ACE2 Gene:302668
2182 1609-1613 Gene denotes ACE2 Gene:302668
2183 1834-1837 Gene denotes ACE Gene:70008
2184 1838-1842 Gene denotes ACE2 Gene:70008
2185 1686-1689 Gene denotes MLN Gene:69563
2186 1381-1384 Gene denotes MLN Gene:100126231
2187 971-974 Gene denotes MLN Gene:100126231
2188 804-807 Gene denotes MLN Gene:4295
2189 486-489 Gene denotes MLN Gene:69563
2190 245-249 Species denotes mice Tax:10090
2191 379-384 Species denotes mouse Tax:10090
2192 530-535 Species denotes human Tax:9606
2193 777-782 Species denotes human Tax:9606
2194 933-952 Species denotes Sprague-Dawley rats Tax:10116
2195 1749-1754 Species denotes mouse Tax:10090
2196 52-57 Chemical denotes DX600
2197 1086-1091 Chemical denotes water MESH:D014867
2198 1666-1672 Chemical denotes GL1001 MESH:C486469
2199 412-429 Disease denotes lung inflammation MESH:D011014
2200 660-669 Disease denotes mortality MESH:D003643
2201 899-920 Disease denotes myocardial infarction MESH:D009203
2202 1161-1170 Disease denotes pressures MESH:D006973
2203 1347-1368 Disease denotes myocardial infarction MESH:D009203
2204 1420-1428 Disease denotes COVID-19 MESH:C000657245
2205 1764-1771 Disease denotes colitis MESH:D003092

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T316 417-429 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T317 899-920 Disease denotes myocardial infarction http://purl.obolibrary.org/obo/MONDO_0005068
T318 1347-1368 Disease denotes myocardial infarction http://purl.obolibrary.org/obo/MONDO_0005068
T319 1420-1428 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T320 1764-1771 Disease denotes colitis http://purl.obolibrary.org/obo/MONDO_0005292

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T741 59-60 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T742 70-77 http://purl.obolibrary.org/obo/PR_000018263 denotes peptide
T743 108-109 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T744 285-286 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T745 377-378 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T746 379-384 http://purl.obolibrary.org/obo/CLO_0007836 denotes mouse
T747 412-416 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T748 412-416 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T749 431-434 http://purl.obolibrary.org/obo/CLO_0001053 denotes 121
T750 530-535 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T751 686-693 http://purl.obolibrary.org/obo/NCBITaxon_33208 denotes animals
T752 777-782 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T753 863-864 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T754 928-932 http://purl.obolibrary.org/obo/UBERON_0003101 denotes male
T755 928-932 http://www.ebi.ac.uk/efo/EFO_0000970 denotes male
T756 993-996 http://purl.obolibrary.org/obo/CLO_0002096 denotes C16
T757 1050-1051 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T758 1152-1160 http://purl.obolibrary.org/obo/UBERON_0001637 denotes arterial
T759 1152-1160 http://www.ebi.ac.uk/efo/EFO_0000814 denotes arterial
T760 1277-1279 http://purl.obolibrary.org/obo/CLO_0001407 denotes 52
T761 1293-1294 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T762 1522-1530 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T763 1548-1553 http://purl.obolibrary.org/obo/UBERON_0000948 denotes heart
T764 1548-1553 http://purl.obolibrary.org/obo/UBERON_0007100 denotes heart
T765 1548-1553 http://purl.obolibrary.org/obo/UBERON_0015228 denotes heart
T766 1548-1553 http://www.ebi.ac.uk/efo/EFO_0000815 denotes heart
T767 1555-1559 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T768 1555-1559 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T769 1561-1566 http://purl.obolibrary.org/obo/UBERON_0002107 denotes liver
T770 1561-1566 http://www.ebi.ac.uk/efo/EFO_0000887 denotes liver
T771 1568-1573 http://purl.obolibrary.org/obo/UBERON_0001155 denotes colon
T772 1591-1597 http://purl.obolibrary.org/obo/UBERON_0003103 denotes organs
T773 1622-1627 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T774 1622-1627 http://www.ebi.ac.uk/efo/EFO_0000296 denotes blood
T775 1632-1649 http://purl.obolibrary.org/obo/CL_0000115 denotes endothelial cells
T776 1735-1743 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T777 1747-1748 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T778 1749-1754 http://purl.obolibrary.org/obo/CLO_0007836 denotes mouse

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T58470 70-77 Chemical denotes peptide http://purl.obolibrary.org/obo/CHEBI_16670
T85380 78-92 Chemical denotes ACE2 inhibitor http://purl.obolibrary.org/obo/CHEBI_147289
T2332 83-92 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T27493 217-226 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T56128 451-460 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T23596 599-614 Chemical denotes ACE2 inhibitors http://purl.obolibrary.org/obo/CHEBI_147289
T10113 604-614 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T6036 928-932 Chemical denotes male http://purl.obolibrary.org/obo/CHEBI_30780
T60127 993-996 Chemical denotes C16 http://purl.obolibrary.org/obo/CHEBI_15756
T121 1052-1060 Chemical denotes solution http://purl.obolibrary.org/obo/CHEBI_75958
T93537 1086-1091 Chemical denotes water http://purl.obolibrary.org/obo/CHEBI_15377
T27633 1243-1248 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T124 417-429 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T286 0-173 Sentence denotes Extensive experiments have been also performed with DX600, a specific peptide ACE2 inhibitor that exhibited a mixed competitive and non-competitive type of inhibition [120].
T287 174-271 Sentence denotes Actually, several reports describing Dx600 inhibitor administration in mice suggest its safe use.
T288 272-552 Sentence denotes Of interest, a report described its (safe) use alone (1 mg/kg per day) by nasal inhalation for 3 days in a mouse model of endotoxin-induced lung inflammation [121]; however, this inhibitor is less efficacious than MLN-4760 in inhibiting the soluble forms of human rACE2 [114,115].
T289 553-749 Sentence denotes Altogether these reports on administration of ACE2 inhibitors do not reveal significant adverse impacts or mortality in experimental animals, which suggests their safety in chronic administration.
T290 750-849 Sentence denotes This was also confirmed in human clinical trials with MLN-4760 (clinical name: ORE1001, see later).
T291 850-1369 Sentence denotes Of interest, a report showed that on day 28 post-myocardial infarction, adult male Sprague-Dawley rats that had received MLN-4760 (also called C16) 25 mg/mL/day by daily intraperitoneal injection (as a solution of 42 mg/mL in distilled water) tended to have lower left ventricular pulse pressure, mean arterial pressures and left ventricular relaxation time constant-Tau compared to untreated group (see table 2 of the paper) [52], suggesting a possible protective role of ACE2 inhibition in post-myocardial infarction.
T292 1370-1650 Sentence denotes Therefore, MLN-4760 might be helpful not only for COVID-19 but also in targeted therapies for pathologies correlated with an excessive increase of ACE2 activity that may involve heart, lung, liver, colon or other tissues/organs expressing ACE2 such as blood and endothelial cells.
T293 1651-1877 Sentence denotes As an example, GL1001 (old name of MLN-4760) showed to produce an anti-inflammatory activity in a mouse model of colitis [122], highlighting the importance of the yin-yang balance of ACE/ACE2 pathways (“in medio stat virtus”).

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T97 899-920 Phenotype denotes myocardial infarction http://purl.obolibrary.org/obo/HP_0001658
T98 1347-1368 Phenotype denotes myocardial infarction http://purl.obolibrary.org/obo/HP_0001658
T99 1764-1771 Phenotype denotes colitis http://purl.obolibrary.org/obo/HP_0002583

2_test

Id Subject Object Predicate Lexical cue
32708755-26851370-20678866 543-546 26851370 denotes 114
32708755-22777933-20678867 547-550 22777933 denotes 115
32708755-20797602-20678868 1277-1279 20797602 denotes 52
32708755-19517214-20678869 1773-1776 19517214 denotes 122