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PMC:7408073 / 58349-59773 JSONTXT

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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T381 458-463 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670
T382 598-603 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670
T383 957-962 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670
T384 1083-1095 Body_part denotes baroreceptor http://purl.org/sig/ont/fma/fma85601

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T122 458-463 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T123 598-603 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T124 957-962 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T125 1083-1095 Body_part denotes baroreceptor http://purl.obolibrary.org/obo/UBERON_0004019

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
2117 45-49 Gene denotes ACE2 Gene:59272
2118 218-222 Gene denotes ACE2 Gene:59272
2119 314-318 Gene denotes ACE2 Gene:59272
2120 425-432 Gene denotes Ang 1–7 Gene:284
2121 483-487 Gene denotes ACE2 Gene:70008
2122 860-864 Gene denotes ACE2 Gene:302668
2123 1134-1138 Gene denotes ACE2 Gene:302668
2124 1221-1225 Gene denotes ACE2 Gene:70008
2125 1259-1262 Gene denotes ACE Gene:70008
2126 398-404 Gene denotes Ang II Gene:24179
2127 1231-1234 Gene denotes MLN Gene:69563
2128 558-561 Gene denotes MLN Gene:69563
2129 128-131 Gene denotes MLN Gene:4295
2130 6-9 Gene denotes MLN Gene:4295
2131 675-679 Species denotes mice Tax:10090
2132 732-736 Species denotes rats Tax:10116
2133 1106-1110 Species denotes rats Tax:10116
2134 1333-1337 Species denotes mice Tax:10090
2135 708-718 Species denotes transgenic Tax:10090
2136 656-661 Chemical denotes water MESH:D014867
2137 1011-1018 Chemical denotes MLN4760 MESH:C486469
2138 1301-1315 Chemical denotes streptozotocin MESH:D013311
2139 521-533 Disease denotes hypertensive MESH:D006973
2140 719-731 Disease denotes hypertensive MESH:D006973
2141 826-838 Disease denotes hypertensive MESH:D006973
2142 944-956 Disease denotes hypertensive MESH:D006973
2143 1163-1174 Disease denotes bradycardia MESH:D001919
2144 1264-1275 Disease denotes albuminuria MESH:D000419
2145 1280-1297 Disease denotes glomerular injury MESH:D007674
2146 1324-1332 Disease denotes diabetic MESH:D003920
2147 1398-1406 Disease denotes diabetic MESH:D003920

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T314 446-472 Disease denotes increase of blood pressure http://purl.obolibrary.org/obo/MONDO_0005044
T315 1291-1297 Disease denotes injury http://purl.obolibrary.org/obo/MONDO_0021178

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T722 108-113 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T723 319-327 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T724 356-357 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T725 458-463 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T726 458-463 http://www.ebi.ac.uk/efo/EFO_0000296 denotes blood
T727 571-574 http://purl.obolibrary.org/obo/CLO_0053799 denotes 4-5
T728 598-603 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T729 598-603 http://www.ebi.ac.uk/efo/EFO_0000296 denotes blood
T730 693-697 http://purl.obolibrary.org/obo/UBERON_0003101 denotes male
T731 693-697 http://www.ebi.ac.uk/efo/EFO_0000970 denotes male
T732 705-707 http://purl.obolibrary.org/obo/CLO_0050509 denotes 27
T733 839-847 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T734 957-962 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T735 957-962 http://www.ebi.ac.uk/efo/EFO_0000296 denotes blood
T736 1054-1057 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T737 1123-1124 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T738 1154-1155 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T739 1350-1351 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T740 1396-1397 http://purl.obolibrary.org/obo/CLO_0001020 denotes a

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T3770 15-24 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T42358 402-404 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T84420 656-661 Chemical denotes water http://purl.obolibrary.org/obo/CHEBI_15377
T69860 693-697 Chemical denotes male http://purl.obolibrary.org/obo/CHEBI_30780
T80273 1028-1035 Chemical denotes nucleus http://purl.obolibrary.org/obo/CHEBI_33252
T43819 1383-1392 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T122 1096-1102 http://purl.obolibrary.org/obo/GO_0060004 denotes reflex
T123 1156-1162 http://purl.obolibrary.org/obo/GO_0060004 denotes reflex

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T281 0-355 Sentence denotes Since MLN-4760 inhibitor promotes the closed ACE2 conformation [90] which is the preferential conformer for virus binding [28], MLN-4760 is expected to not prevent viral entry; nevertheless, its inhibitory function on ACE2 pathway might work on the positive feedback loops (above described) that ultimately favour ACE2 membrane expression and viral entry.
T282 356-473 Sentence denotes A potential risk factor of inhibiting the Ang II metabolization into Ang 1–7 could be the increase of blood pressure.
T283 474-983 Sentence denotes Although ACE2 pathway inhibition might lead to hypertensive effects, treatment with MLN-4760 for 4-5 weeks had no effect on blood pressure when administered 10 mg/kg/day in drinking water in wild type mice [117] nor in male (mRen2)27 transgenic hypertensive rats (administered 30 mg/kg/day subcutaneously via mini-osmotic pumps) [118], suggesting that hypertensive activity mediated by ACE2 inhibition is promptly balanced by compensatory mechanisms either in normal or hypertensive blood pressure conditions.
T284 984-1189 Sentence denotes In addition, injections of MLN4760 into the nucleus tractus solitarii has been shown to reduce the baroreceptor reflex in rats, suggesting a role for ACE2 in controlling a reflex bradycardia (see [39,44]).
T285 1190-1424 Sentence denotes Finally, chronic inhibition of ACE2 with MLN-4760 led to increase of ACE, albuminuria and glomerular injury in streptozotocin-induced diabetic mice, indicating a possible adverse effect of the inhibitor in a diabetic background [119].

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T94 446-472 Phenotype denotes increase of blood pressure http://purl.obolibrary.org/obo/HP_0032263
T95 1163-1174 Phenotype denotes bradycardia http://purl.obolibrary.org/obo/HP_0001662
T96 1264-1275 Phenotype denotes albuminuria http://purl.obolibrary.org/obo/HP_0012592

2_test

Id Subject Object Predicate Lexical cue
32708755-32132184-20678861 123-125 32132184 denotes 28
32708755-18235039-20678862 681-684 18235039 denotes 117
32708755-20300067-20678863 804-807 20300067 denotes 118
32708755-20599443-20678864 1184-1186 20599443 denotes 44
32708755-17579661-20678865 1419-1422 17579661 denotes 119