PMC:7408073 / 58349-58704 JSONTXT

{"project":"LitCovid-PubTator","denotations":[{"id":"2117","span":{"begin":45,"end":49},"obj":"Gene"},{"id":"2118","span":{"begin":218,"end":222},"obj":"Gene"},{"id":"2119","span":{"begin":314,"end":318},"obj":"Gene"},{"id":"2129","span":{"begin":128,"end":131},"obj":"Gene"},{"id":"2130","span":{"begin":6,"end":9},"obj":"Gene"}],"attributes":[{"id":"A2117","pred":"tao:has_database_id","subj":"2117","obj":"Gene:59272"},{"id":"A2118","pred":"tao:has_database_id","subj":"2118","obj":"Gene:59272"},{"id":"A2119","pred":"tao:has_database_id","subj":"2119","obj":"Gene:59272"},{"id":"A2129","pred":"tao:has_database_id","subj":"2129","obj":"Gene:4295"},{"id":"A2130","pred":"tao:has_database_id","subj":"2130","obj":"Gene:4295"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Since MLN-4760 inhibitor promotes the closed ACE2 conformation [90] which is the preferential conformer for virus binding [28], MLN-4760 is expected to not prevent viral entry; nevertheless, its inhibitory function on ACE2 pathway might work on the positive feedback loops (above described) that ultimately favour ACE2 membrane expression and viral entry."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T722","span":{"begin":108,"end":113},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T723","span":{"begin":319,"end":327},"obj":"http://purl.obolibrary.org/obo/UBERON_0000158"}],"text":"Since MLN-4760 inhibitor promotes the closed ACE2 conformation [90] which is the preferential conformer for virus binding [28], MLN-4760 is expected to not prevent viral entry; nevertheless, its inhibitory function on ACE2 pathway might work on the positive feedback loops (above described) that ultimately favour ACE2 membrane expression and viral entry."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T3770","span":{"begin":15,"end":24},"obj":"Chemical"}],"attributes":[{"id":"A75692","pred":"chebi_id","subj":"T3770","obj":"http://purl.obolibrary.org/obo/CHEBI_35222"}],"text":"Since MLN-4760 inhibitor promotes the closed ACE2 conformation [90] which is the preferential conformer for virus binding [28], MLN-4760 is expected to not prevent viral entry; nevertheless, its inhibitory function on ACE2 pathway might work on the positive feedback loops (above described) that ultimately favour ACE2 membrane expression and viral entry."}

{"project":"LitCovid-sentences","denotations":[{"id":"T281","span":{"begin":0,"end":355},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Since MLN-4760 inhibitor promotes the closed ACE2 conformation [90] which is the preferential conformer for virus binding [28], MLN-4760 is expected to not prevent viral entry; nevertheless, its inhibitory function on ACE2 pathway might work on the positive feedback loops (above described) that ultimately favour ACE2 membrane expression and viral entry."}

{"project":"2_test","denotations":[{"id":"32708755-32132184-20678861","span":{"begin":123,"end":125},"obj":"32132184"}],"text":"Since MLN-4760 inhibitor promotes the closed ACE2 conformation [90] which is the preferential conformer for virus binding [28], MLN-4760 is expected to not prevent viral entry; nevertheless, its inhibitory function on ACE2 pathway might work on the positive feedback loops (above described) that ultimately favour ACE2 membrane expression and viral entry."}