PMC:7408073 / 57513-57849 JSONTXT

{"project":"LitCovid-PubTator","denotations":[{"id":"2057","span":{"begin":163,"end":171},"obj":"Gene"},{"id":"2058","span":{"begin":0,"end":3},"obj":"Gene"},{"id":"2067","span":{"begin":139,"end":145},"obj":"Gene"},{"id":"2080","span":{"begin":61,"end":67},"obj":"Chemical"},{"id":"2081","span":{"begin":125,"end":131},"obj":"Chemical"},{"id":"2082","span":{"begin":182,"end":187},"obj":"Chemical"},{"id":"2083","span":{"begin":231,"end":237},"obj":"Chemical"}],"attributes":[{"id":"A2057","pred":"tao:has_database_id","subj":"2057","obj":"Gene:284"},{"id":"A2058","pred":"tao:has_database_id","subj":"2058","obj":"Gene:4295"},{"id":"A2067","pred":"tao:has_database_id","subj":"2067","obj":"Gene:24179"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"MLN-4760 was still able to strongly and specifically inhibit rhACE2 activity (near maximal inhibition at 10−8 M), preventing rhACE2-driven Ang II degradation into Ang (1–7), whereas DX600 (either linear or cyclic variant) inhibits rhACE2 at relatively higher concentration (near maximal inhibition at 10−6 M–10−7 M, respectively) [115]."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T711","span":{"begin":68,"end":76},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T712","span":{"begin":306,"end":310},"obj":"http://purl.obolibrary.org/obo/CLO_0050171"}],"text":"MLN-4760 was still able to strongly and specifically inhibit rhACE2 activity (near maximal inhibition at 10−8 M), preventing rhACE2-driven Ang II degradation into Ang (1–7), whereas DX600 (either linear or cyclic variant) inhibits rhACE2 at relatively higher concentration (near maximal inhibition at 10−6 M–10−7 M, respectively) [115]."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T22298","span":{"begin":143,"end":145},"obj":"Chemical"}],"attributes":[{"id":"A47005","pred":"chebi_id","subj":"T22298","obj":"http://purl.obolibrary.org/obo/CHEBI_74067"}],"text":"MLN-4760 was still able to strongly and specifically inhibit rhACE2 activity (near maximal inhibition at 10−8 M), preventing rhACE2-driven Ang II degradation into Ang (1–7), whereas DX600 (either linear or cyclic variant) inhibits rhACE2 at relatively higher concentration (near maximal inhibition at 10−6 M–10−7 M, respectively) [115]."}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T121","span":{"begin":146,"end":157},"obj":"http://purl.obolibrary.org/obo/GO_0009056"}],"text":"MLN-4760 was still able to strongly and specifically inhibit rhACE2 activity (near maximal inhibition at 10−8 M), preventing rhACE2-driven Ang II degradation into Ang (1–7), whereas DX600 (either linear or cyclic variant) inhibits rhACE2 at relatively higher concentration (near maximal inhibition at 10−6 M–10−7 M, respectively) [115]."}

{"project":"LitCovid-sentences","denotations":[{"id":"T278","span":{"begin":0,"end":336},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"MLN-4760 was still able to strongly and specifically inhibit rhACE2 activity (near maximal inhibition at 10−8 M), preventing rhACE2-driven Ang II degradation into Ang (1–7), whereas DX600 (either linear or cyclic variant) inhibits rhACE2 at relatively higher concentration (near maximal inhibition at 10−6 M–10−7 M, respectively) [115]."}

{"project":"2_test","denotations":[{"id":"32708755-22777933-20678859","span":{"begin":331,"end":334},"obj":"22777933"}],"text":"MLN-4760 was still able to strongly and specifically inhibit rhACE2 activity (near maximal inhibition at 10−8 M), preventing rhACE2-driven Ang II degradation into Ang (1–7), whereas DX600 (either linear or cyclic variant) inhibits rhACE2 at relatively higher concentration (near maximal inhibition at 10−6 M–10−7 M, respectively) [115]."}