PMC:7408073 / 5599-6136 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7408073","sourcedb":"PMC","sourceid":"7408073","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7408073","text":"l entry. Nevertheless, ADAM17/TACE-mediated ACE2 shedding or ACE2 enzymatic activity have been shown to intriguingly correlate positively with viral infection and disease complications [17,19,20]. In contrast, HNL63-CoV, which similarly binds to ACE2 through its spike protein, infects ACE2-bearing cells and mainly induces the common cold, leading to neither ACE2 shedding nor SARS [17]. Moreover, catalytically inactive forms of sACE2 can potently inhibit SARS-CoV infection [19,21], suggesting that events downstream of ACE2 shedding ","tracks":[{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T54868","span":{"begin":269,"end":276},"obj":"Body_part"},{"id":"T83587","span":{"begin":299,"end":304},"obj":"Body_part"}],"attributes":[{"id":"A52084","pred":"fma_id","subj":"T54868","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A9818","pred":"fma_id","subj":"T83587","obj":"http://purl.org/sig/ont/fma/fma68646"},{"subj":"T54868","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T83587","pred":"source","obj":"LitCovid-PD-FMA-UBERON"}]},{"project":"LitCovid-PubTator","denotations":[{"id":"241","span":{"begin":23,"end":29},"obj":"Gene"},{"id":"242","span":{"begin":30,"end":34},"obj":"Gene"},{"id":"243","span":{"begin":44,"end":48},"obj":"Gene"},{"id":"244","span":{"begin":61,"end":65},"obj":"Gene"},{"id":"245","span":{"begin":246,"end":250},"obj":"Gene"},{"id":"246","span":{"begin":286,"end":290},"obj":"Gene"},{"id":"247","span":{"begin":360,"end":364},"obj":"Gene"},{"id":"248","span":{"begin":523,"end":527},"obj":"Gene"},{"id":"272","span":{"begin":216,"end":219},"obj":"Species"},{"id":"285","span":{"begin":263,"end":268},"obj":"Gene"},{"id":"294","span":{"begin":143,"end":158},"obj":"Disease"},{"id":"295","span":{"begin":458,"end":476},"obj":"Disease"}],"attributes":[{"id":"A241","pred":"tao:has_database_id","subj":"241","obj":"Gene:6868"},{"id":"A242","pred":"tao:has_database_id","subj":"242","obj":"Gene:6868"},{"id":"A243","pred":"tao:has_database_id","subj":"243","obj":"Gene:59272"},{"id":"A244","pred":"tao:has_database_id","subj":"244","obj":"Gene:59272"},{"id":"A245","pred":"tao:has_database_id","subj":"245","obj":"Gene:59272"},{"id":"A246","pred":"tao:has_database_id","subj":"246","obj":"Gene:59272"},{"id":"A247","pred":"tao:has_database_id","subj":"247","obj":"Gene:59272"},{"id":"A248","pred":"tao:has_database_id","subj":"248","obj":"Gene:59272"},{"id":"A272","pred":"tao:has_database_id","subj":"272","obj":"Tax:11118"},{"id":"A285","pred":"tao:has_database_id","subj":"285","obj":"Gene:43740568"},{"id":"A294","pred":"tao:has_database_id","subj":"294","obj":"MESH:D001102"},{"id":"A295","pred":"tao:has_database_id","subj":"295","obj":"MESH:C000657245"},{"subj":"241","pred":"source","obj":"LitCovid-PubTator"},{"subj":"242","pred":"source","obj":"LitCovid-PubTator"},{"subj":"243","pred":"source","obj":"LitCovid-PubTator"},{"subj":"244","pred":"source","obj":"LitCovid-PubTator"},{"subj":"245","pred":"source","obj":"LitCovid-PubTator"},{"subj":"246","pred":"source","obj":"LitCovid-PubTator"},{"subj":"247","pred":"source","obj":"LitCovid-PubTator"},{"subj":"248","pred":"source","obj":"LitCovid-PubTator"},{"subj":"272","pred":"source","obj":"LitCovid-PubTator"},{"subj":"285","pred":"source","obj":"LitCovid-PubTator"},{"subj":"294","pred":"source","obj":"LitCovid-PubTator"},{"subj":"295","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]},{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T63","span":{"begin":143,"end":158},"obj":"Disease"},{"id":"T64","span":{"begin":149,"end":158},"obj":"Disease"},{"id":"T65","span":{"begin":328,"end":339},"obj":"Disease"},{"id":"T66","span":{"begin":378,"end":382},"obj":"Disease"},{"id":"T67","span":{"begin":458,"end":476},"obj":"Disease"},{"id":"T68","span":{"begin":458,"end":462},"obj":"Disease"},{"id":"T69","span":{"begin":467,"end":476},"obj":"Disease"}],"attributes":[{"id":"A63","pred":"mondo_id","subj":"T63","obj":"http://purl.obolibrary.org/obo/MONDO_0005108"},{"id":"A64","pred":"mondo_id","subj":"T64","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A65","pred":"mondo_id","subj":"T65","obj":"http://purl.obolibrary.org/obo/MONDO_0005709"},{"id":"A66","pred":"mondo_id","subj":"T66","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A67","pred":"mondo_id","subj":"T67","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A68","pred":"mondo_id","subj":"T68","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A69","pred":"mondo_id","subj":"T69","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"subj":"T63","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T64","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T65","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T66","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T67","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T68","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T69","pred":"source","obj":"LitCovid-PD-MONDO"}]},{"project":"LitCovid-PD-CLO","denotations":[{"id":"T91276","span":{"begin":76,"end":84},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T71067","span":{"begin":299,"end":304},"obj":"http://purl.obolibrary.org/obo/GO_0005623"}],"attributes":[{"subj":"T91276","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T71067","pred":"source","obj":"LitCovid-PD-CLO"}]},{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T40","span":{"begin":269,"end":276},"obj":"Chemical"}],"attributes":[{"id":"A40","pred":"chebi_id","subj":"T40","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"subj":"T40","pred":"source","obj":"LitCovid-PD-CHEBI"}]},{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T52159","span":{"begin":143,"end":158},"obj":"http://purl.obolibrary.org/obo/GO_0016032"}],"attributes":[{"subj":"T52159","pred":"source","obj":"LitCovid-PD-GO-BP"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T30","span":{"begin":9,"end":196},"obj":"Sentence"},{"id":"T31","span":{"begin":197,"end":388},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T30","pred":"source","obj":"LitCovid-sentences"},{"subj":"T31","pred":"source","obj":"LitCovid-sentences"}]},{"project":"2_test","denotations":[{"id":"32708755-18490652-20678665","span":{"begin":186,"end":188},"obj":"18490652"},{"id":"32708755-15367630-20678666","span":{"begin":189,"end":191},"obj":"15367630"},{"id":"32708755-19995578-20678667","span":{"begin":192,"end":194},"obj":"19995578"},{"id":"32708755-18490652-20678668","span":{"begin":384,"end":386},"obj":"18490652"},{"id":"32708755-15367630-20678669","span":{"begin":478,"end":480},"obj":"15367630"},{"id":"32708755-16510163-20678670","span":{"begin":481,"end":483},"obj":"16510163"}],"attributes":[{"subj":"32708755-18490652-20678665","pred":"source","obj":"2_test"},{"subj":"32708755-15367630-20678666","pred":"source","obj":"2_test"},{"subj":"32708755-19995578-20678667","pred":"source","obj":"2_test"},{"subj":"32708755-18490652-20678668","pred":"source","obj":"2_test"},{"subj":"32708755-15367630-20678669","pred":"source","obj":"2_test"},{"subj":"32708755-16510163-20678670","pred":"source","obj":"2_test"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-PD-FMA-UBERON","color":"#ec9c93","default":true},{"id":"LitCovid-PubTator","color":"#93a4ec"},{"id":"LitCovid-PD-MONDO","color":"#beec93"},{"id":"LitCovid-PD-CLO","color":"#ec93d8"},{"id":"LitCovid-PD-CHEBI","color":"#93ece6"},{"id":"LitCovid-PD-GO-BP","color":"#eccc93"},{"id":"LitCovid-sentences","color":"#b293ec"},{"id":"2_test","color":"#93ec98"}]}]}}