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PMC:7408073 / 55819-58348 JSONTXT

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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T379 1166-1171 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T380 2460-2466 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
2046 40-44 Gene denotes ACE2 Gene:59272
2047 93-97 Gene denotes ACE2 Gene:59272
2048 439-442 Gene denotes ACE Gene:59272
2049 978-982 Gene denotes ACE2 Gene:59272
2050 1176-1180 Gene denotes CD34 Gene:947
2051 1224-1228 Gene denotes ACE2 Gene:59272
2052 2146-2150 Gene denotes ACE2 Gene:59272
2053 2322-2326 Gene denotes ACE2 Gene:59272
2054 2376-2380 Gene denotes ACE2 Gene:59272
2055 2429-2433 Gene denotes ACE2 Gene:59272
2056 2508-2512 Gene denotes ACE2 Gene:59272
2057 1857-1865 Gene denotes Ang (1–7 Gene:284
2058 1694-1697 Gene denotes MLN Gene:4295
2059 1371-1374 Gene denotes MLN Gene:4295
2060 319-322 Gene denotes MLN Gene:4295
2061 1111-1116 Gene denotes mACE2 Gene:70008
2062 997-1002 Gene denotes mACE2 Gene:70008
2063 34-39 Species denotes human Tax:9606
2064 87-92 Species denotes human Tax:9606
2065 429-434 Species denotes human Tax:9606
2066 2454-2459 Species denotes human Tax:9606
2067 1833-1839 Gene denotes Ang II Gene:24179
2068 0-7 Chemical denotes MLN4760 MESH:C486469
2069 446-452 Chemical denotes rhACE2
2070 551-556 Chemical denotes rhACE
2071 643-648 Chemical denotes rhACE
2072 712-718 Chemical denotes rhACE2
2073 788-794 Chemical denotes rhACE2
2074 821-827 Chemical denotes rhACE2
2075 835-840 Chemical denotes rhACE
2076 1240-1245 Chemical denotes Dx600
2077 1384-1389 Chemical denotes DX600
2078 1436-1445 Chemical denotes disulfide MESH:D004220
2079 1560-1566 Chemical denotes rhACE2
2080 1755-1761 Chemical denotes rhACE2
2081 1819-1825 Chemical denotes rhACE2
2082 1876-1881 Chemical denotes DX600
2083 1925-1931 Chemical denotes rhACE2
2084 2169-2174 Chemical denotes Dx600
2085 1644-1664 Disease denotes hypercapnic acidosis MESH:D000138

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T312 1656-1664 Disease denotes acidosis http://purl.obolibrary.org/obo/MONDO_0006022
T313 1688-1692 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T679 11-12 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T680 34-39 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T681 87-92 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T682 124-125 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T683 198-199 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T684 208-209 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T685 244-245 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T686 305-308 http://purl.obolibrary.org/obo/CLO_0053001 denotes 114
T687 311-318 http://purl.obolibrary.org/obo/UBERON_0000473 denotes Testing
T688 377-378 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T689 429-434 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T690 436-438 http://purl.obolibrary.org/obo/CLO_0008812 denotes rh
T691 453-463 http://purl.obolibrary.org/obo/CLO_0001658 denotes activities
T692 491-494 http://purl.obolibrary.org/obo/CLO_0053001 denotes 114
T693 508-509 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T694 619-620 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T695 772-773 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T696 842-845 http://purl.obolibrary.org/obo/CLO_0053001 denotes 114
T697 887-888 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T698 921-929 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T699 951-959 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T700 1042-1043 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T701 1105-1106 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T702 1154-1171 http://purl.obolibrary.org/obo/CL_0000842 denotes mononuclear cells
T703 1209-1212 http://purl.obolibrary.org/obo/CLO_0053001 denotes 114
T704 1215-1216 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T705 1306-1307 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T706 1309-1312 http://purl.obolibrary.org/obo/CLO_0053001 denotes 114
T707 1354-1362 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T708 1546-1547 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T709 1599-1607 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T710 1617-1618 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T711 1762-1770 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T712 2000-2004 http://purl.obolibrary.org/obo/CLO_0050171 denotes M–10
T713 2094-2095 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T714 2163-2164 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T715 2291-2299 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T716 2327-2335 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T717 2347-2355 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T718 2405-2413 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T719 2454-2459 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T720 2460-2466 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T721 2524-2527 http://purl.obolibrary.org/obo/CLO_0001046 denotes 116

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T26019 40-54 Chemical denotes ACE2 inhibitor http://purl.obolibrary.org/obo/CHEBI_147289
T54501 45-54 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T75789 126-141 Chemical denotes racemic mixture http://purl.obolibrary.org/obo/CHEBI_60911
T7082 134-141 Chemical denotes mixture http://purl.obolibrary.org/obo/CHEBI_60004
T14426 328-343 Chemical denotes racemic mixture http://purl.obolibrary.org/obo/CHEBI_60911
T52319 336-343 Chemical denotes mixture http://purl.obolibrary.org/obo/CHEBI_60004
T74419 479-489 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T93878 596-604 Chemical denotes racemate http://purl.obolibrary.org/obo/CHEBI_60911
T90533 749-757 Chemical denotes racemate http://purl.obolibrary.org/obo/CHEBI_60911
T46386 868-878 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T96 1082-1090 Chemical denotes racemate http://purl.obolibrary.org/obo/CHEBI_60911
T36982 1224-1238 Chemical denotes ACE2 inhibitor http://purl.obolibrary.org/obo/CHEBI_147289
T92521 1229-1238 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T41578 1436-1445 Chemical denotes disulfide http://purl.obolibrary.org/obo/CHEBI_48343
T100 1470-1480 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T22298 1837-1839 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T60880 2071-2079 Chemical denotes racemate http://purl.obolibrary.org/obo/CHEBI_60911
T91051 2193-2203 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T32362 2508-2522 Chemical denotes ACE2 inhibitor http://purl.obolibrary.org/obo/CHEBI_147289
T91312 2513-2522 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T119 105-114 http://purl.obolibrary.org/obo/GO_0009058 denotes synthesis
T120 1567-1578 http://purl.obolibrary.org/obo/GO_0006508 denotes proteolysis
T121 1840-1851 http://purl.obolibrary.org/obo/GO_0009056 denotes degradation

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T270 0-200 Sentence denotes MLN4760 is a potent and selective human ACE2 inhibitor (IC50 = 0.44 nM against soluble human ACE2) whose synthesis produces a racemic mixture of two diastereomers that showed 75:25 ratio for Isomer A:
T271 201-310 Sentence denotes Isomer B [113,114] and the purified isomer B is the isomer commercially available from Merck Millipore [114].
T272 311-496 Sentence denotes Testing MLN-4760 racemic mixture and its isomers, it was observed a concentration-dependent inhibition of recombinant human (rh)ACE or rhACE2 activities with all three inhibitors [114].
T273 497-847 Sentence denotes The isomer B was less selective (near minimal-maximal rhACE inhibition range 10−6M-10−4M) than the racemate or the isomer A (near minimal-maximal rhACE inhibition range 10−6M-10−2M) and less effective (near maximal rhACE2 inhibition at 10−7M) than the racemate or the isomer A (near maximal rhACE2 inhibition at 10−8 M) for rhACE2 versus rhACE [114].
T274 848-1214 Sentence denotes Moreover, all three inhibitors exerted a significantly higher inhibitory activity against soluble than membrane-bound forms of (m)ACE2 (near maximal mACE2 inhibition at 10−6M), being the isomer B more selective and effective than the racemate or the isomer A for mACE2 vs. mACE expressed on the surface of mononuclear cells (or CD34 hematopoietic progenitors) [114].
T275 1215-1314 Sentence denotes A second ACE2 inhibitor, Dx600, produced similar results to those obtained with the isomer B [114].
T276 1315-1481 Sentence denotes Another study evaluated the inhibitory activity of both MLN-4760 and DX600 (either the linear conformational form or the disulfide bridged cyclic variant) inhibitors.
T277 1482-1693 Sentence denotes In this report, the experiments were performed at pH 6.5 [115], a pH at which rhACE2 proteolysis operates at maximal activity [79] and a condition that resembles hypercapnic acidosis which may occur during SARS.
T278 1694-2030 Sentence denotes MLN-4760 was still able to strongly and specifically inhibit rhACE2 activity (near maximal inhibition at 10−8 M), preventing rhACE2-driven Ang II degradation into Ang (1–7), whereas DX600 (either linear or cyclic variant) inhibits rhACE2 at relatively higher concentration (near maximal inhibition at 10−6 M–10−7 M, respectively) [115].
T279 2031-2175 Sentence denotes Altogether these data indicate that the racemate or the isomer A are more effective in inhibiting soluble forms of ACE2 than isomer B and Dx600.
T280 2176-2529 Sentence denotes Therefore, these inhibitors at opportune (low) concentrations are expected to preferentially reduce systemic sACE2 activity, while preserving the ACE2 activity of (local) membrane-associated forms of ACE2, knowing that catalytic activity of circulating ACE2 was undetectable in human plasma of healthy subjects due to an endogenous ACE2 inhibitor [116].

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T93 1656-1664 Phenotype denotes acidosis http://purl.obolibrary.org/obo/HP_0001941

2_test

Id Subject Object Predicate Lexical cue
32708755-12358520-20678851 211-214 12358520 denotes 113
32708755-26851370-20678852 215-218 26851370 denotes 114
32708755-26851370-20678853 305-308 26851370 denotes 114
32708755-26851370-20678854 491-494 26851370 denotes 114
32708755-26851370-20678855 842-845 26851370 denotes 114
32708755-26851370-20678856 1209-1212 26851370 denotes 114
32708755-26851370-20678857 1309-1312 26851370 denotes 114
32708755-22777933-20678858 1540-1543 22777933 denotes 115
32708755-22777933-20678859 2025-2028 22777933 denotes 115
32708755-18223027-20678860 2524-2527 18223027 denotes 116