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PMC:7408073 / 53837-55818 JSONTXT

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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T369 1042-1054 Body_part denotes cell surface http://purl.org/sig/ont/fma/fma67653
T370 1042-1046 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T371 1097-1104 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T372 1171-1178 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T373 1237-1252 Body_part denotes plasma membrane http://purl.org/sig/ont/fma/fma63841
T374 1439-1447 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T375 1524-1528 Body_part denotes hand http://purl.org/sig/ont/fma/fma9712
T376 1536-1543 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T377 1721-1729 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T378 1967-1975 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T120 525-530 Body_part denotes shell http://purl.obolibrary.org/obo/UBERON_0006612
T121 1524-1528 Body_part denotes hand http://purl.obolibrary.org/obo/UBERON_0002398

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
1977 40-44 Gene denotes ACE2 Gene:59272
1978 234-238 Gene denotes ACE2 Gene:59272
1979 537-541 Gene denotes ACE2 Gene:59272
1980 663-667 Gene denotes ACE2 Gene:59272
1981 903-907 Gene denotes ACE2 Gene:59272
1982 957-961 Gene denotes ACE2 Gene:59272
1983 988-992 Gene denotes ACE2 Gene:59272
1984 1021-1025 Gene denotes ACE2 Gene:59272
1985 1117-1121 Gene denotes ACE2 Gene:59272
1986 1219-1223 Gene denotes ACE2 Gene:59272
1987 1281-1285 Gene denotes ACE2 Gene:59272
1988 1364-1368 Gene denotes ACE2 Gene:59272
1989 1399-1403 Gene denotes ACE2 Gene:59272
1990 1417-1421 Gene denotes ACE2 Gene:59272
1991 1475-1479 Gene denotes ACE2 Gene:59272
1992 1578-1582 Gene denotes ACE2 Gene:59272
1993 1797-1801 Gene denotes ACE2 Gene:59272
1994 1886-1890 Gene denotes ACE2 Gene:59272
1995 1433-1438 Gene denotes spike Gene:43740568
1996 1258-1263 Gene denotes spike Gene:43740568
1997 1165-1170 Gene denotes spike Gene:43740568
1998 1091-1096 Gene denotes spike Gene:43740568
1999 982-987 Gene denotes spike Gene:43740568
2000 1822-1825 Gene denotes MLN Gene:4295
2001 897-902 Species denotes human Tax:9606
2002 1015-1020 Species denotes human Tax:9606
2003 1961-1966 Gene denotes spike Gene:43740568
2004 1715-1720 Gene denotes spike Gene:43740568
2005 1946-1951 Chemical denotes sACE2

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T311 520-524 Disease denotes clam http://purl.obolibrary.org/obo/MONDO_0011948

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T659 87-95 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T660 121-129 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T661 296-297 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T662 310-317 http://purl.obolibrary.org/obo/CLO_0001927 denotes bending
T663 334-342 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T664 394-402 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T665 518-519 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T666 686-687 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T667 703-711 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T668 810-818 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T669 897-902 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T670 1015-1020 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T671 1042-1046 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T672 1058-1059 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T673 1237-1243 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T674 1244-1252 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T675 1320-1328 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T676 1490-1498 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T677 1562-1570 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T678 1832-1835 http://purl.obolibrary.org/obo/CLO_0051582 denotes has

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T75 635-645 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T47611 765-774 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T93730 851-859 Chemical denotes electron http://purl.obolibrary.org/obo/CHEBI_10545
T82543 1097-1104 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T74998 1171-1178 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T37661 1439-1447 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T59859 1536-1543 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T68655 1721-1729 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T22243 1811-1820 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T66791 1869-1878 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T85 1967-1975 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T261 0-139 Sentence denotes It is known that the catalytic cleft of ACE2 consists of two peptidase subdomains: one membrane-distal and the other one membrane-proximal.
T262 140-260 Sentence denotes Their weak interactions are consistent with the ability to transition from open to the closed ACE2 conformation [28,90].
T263 261-536 Sentence denotes Indeed, the two subdomains undergo a large hinge-bending motion in which membrane-proximal subdomain remains almost unchanged, while membrane-distal subdomain moves to close the distance between the two subdomains, mimicking the opening/closing movement of a clam shell [90].
T264 537-827 Sentence denotes ACE2 open conformation likely reflects free state of the enzyme available to catch substrates (or inhibitors), then, when the ACE2 receptor binds to a substrate, the membrane-distal subdomain closes around the substrate (or the inhibitor), finally performing the enzymatic activity [24,90].
T265 828-1008 Sentence denotes Interestingly, in cryo–electron microscopy structures of full-length human ACE2, only the closed/substrate-bound conformation of ACE2 was observed in the spike-ACE2 complexes [28].
T266 1009-1253 Sentence denotes Since human ACE2 is assembled on cell surface as a homodimer [28], binding of the spike protein trimer onto ACE2 dimer suggests simultaneous binding of two spike protein trimers to substrate-bound conformer of ACE2 homodimer on plasma membrane.
T267 1254-1510 Sentence denotes The spike binding sites on ACE2 homodimer are localized above the membrane-distal peptidase subdomain of each ACE2 monomer, nevertheless neither ACE2 shedding nor ACE2 binding to spike proteins have been shown to inhibit ACE2 enzymatic activity [16,17,24].
T268 1511-1778 Sentence denotes On the other hand, the S-protein-binding region of membrane-distal ACE2 subdomain is not significantly perturbed by the receptor conformational changes and maintains the ability to associate with soluble spike proteins independently on open/closed conformations [24].
T269 1779-1981 Sentence denotes Interestingly, an ACE2 specific inhibitor (MLN-4760) has been shown to induce the closed (inhibitor-bound) ACE2 structure [90] and to retain its inhibitory effects on sACE2 bound to spike proteins [24].

2_test

Id Subject Object Predicate Lexical cue
32708755-32132184-20678843 253-255 32132184 denotes 28
32708755-15791205-20678844 820-822 15791205 denotes 24
32708755-32132184-20678845 1004-1006 32132184 denotes 28
32708755-32132184-20678846 1071-1073 32132184 denotes 28
32708755-18490652-20678847 1503-1505 18490652 denotes 17
32708755-15791205-20678848 1506-1508 15791205 denotes 24
32708755-15791205-20678849 1774-1776 15791205 denotes 24
32708755-15791205-20678850 1977-1979 15791205 denotes 24