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PMC:7408073 / 53765-61651 JSONTXT

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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T369 1114-1126 Body_part denotes cell surface http://purl.org/sig/ont/fma/fma67653
T370 1114-1118 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T371 1169-1176 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T372 1243-1250 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T373 1309-1324 Body_part denotes plasma membrane http://purl.org/sig/ont/fma/fma63841
T374 1511-1519 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T375 1596-1600 Body_part denotes hand http://purl.org/sig/ont/fma/fma9712
T376 1608-1615 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T377 1793-1801 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T378 2039-2047 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T379 3220-3225 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T380 4514-4520 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T381 5042-5047 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670
T382 5182-5187 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670
T383 5541-5546 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670
T384 5667-5679 Body_part denotes baroreceptor http://purl.org/sig/ont/fma/fma85601
T385 6421-6425 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T386 7557-7562 Body_part denotes heart http://purl.org/sig/ont/fma/fma7088
T387 7564-7568 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T388 7570-7575 Body_part denotes liver http://purl.org/sig/ont/fma/fma7197
T389 7577-7582 Body_part denotes colon http://purl.org/sig/ont/fma/fma14543
T390 7592-7599 Body_part denotes tissues http://purl.org/sig/ont/fma/fma9637
T391 7631-7636 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670
T392 7641-7658 Body_part denotes endothelial cells http://purl.org/sig/ont/fma/fma66772
T393 7653-7658 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T120 597-602 Body_part denotes shell http://purl.obolibrary.org/obo/UBERON_0006612
T121 1596-1600 Body_part denotes hand http://purl.obolibrary.org/obo/UBERON_0002398
T122 5042-5047 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T123 5182-5187 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T124 5541-5546 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T125 5667-5679 Body_part denotes baroreceptor http://purl.obolibrary.org/obo/UBERON_0004019
T126 6421-6425 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T127 7557-7562 Body_part denotes heart http://purl.obolibrary.org/obo/UBERON_0000948
T128 7564-7568 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T129 7570-7575 Body_part denotes liver http://purl.obolibrary.org/obo/UBERON_0002107
T130 7577-7582 Body_part denotes colon http://purl.obolibrary.org/obo/UBERON_0001155
T131 7600-7606 Body_part denotes organs http://purl.obolibrary.org/obo/UBERON_0000062
T132 7631-7636 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
1946 55-59 Gene denotes ACE2 Gene:59272
1947 37-44 Chemical denotes MLN4760 MESH:C486469
1977 112-116 Gene denotes ACE2 Gene:59272
1978 306-310 Gene denotes ACE2 Gene:59272
1979 609-613 Gene denotes ACE2 Gene:59272
1980 735-739 Gene denotes ACE2 Gene:59272
1981 975-979 Gene denotes ACE2 Gene:59272
1982 1029-1033 Gene denotes ACE2 Gene:59272
1983 1060-1064 Gene denotes ACE2 Gene:59272
1984 1093-1097 Gene denotes ACE2 Gene:59272
1985 1189-1193 Gene denotes ACE2 Gene:59272
1986 1291-1295 Gene denotes ACE2 Gene:59272
1987 1353-1357 Gene denotes ACE2 Gene:59272
1988 1436-1440 Gene denotes ACE2 Gene:59272
1989 1471-1475 Gene denotes ACE2 Gene:59272
1990 1489-1493 Gene denotes ACE2 Gene:59272
1991 1547-1551 Gene denotes ACE2 Gene:59272
1992 1650-1654 Gene denotes ACE2 Gene:59272
1993 1869-1873 Gene denotes ACE2 Gene:59272
1994 1958-1962 Gene denotes ACE2 Gene:59272
1995 1505-1510 Gene denotes spike Gene:43740568
1996 1330-1335 Gene denotes spike Gene:43740568
1997 1237-1242 Gene denotes spike Gene:43740568
1998 1163-1168 Gene denotes spike Gene:43740568
1999 1054-1059 Gene denotes spike Gene:43740568
2000 1894-1897 Gene denotes MLN Gene:4295
2001 969-974 Species denotes human Tax:9606
2002 1087-1092 Species denotes human Tax:9606
2003 2033-2038 Gene denotes spike Gene:43740568
2004 1787-1792 Gene denotes spike Gene:43740568
2005 2018-2023 Chemical denotes sACE2
2046 2094-2098 Gene denotes ACE2 Gene:59272
2047 2147-2151 Gene denotes ACE2 Gene:59272
2048 2493-2496 Gene denotes ACE Gene:59272
2049 3032-3036 Gene denotes ACE2 Gene:59272
2050 3230-3234 Gene denotes CD34 Gene:947
2051 3278-3282 Gene denotes ACE2 Gene:59272
2052 4200-4204 Gene denotes ACE2 Gene:59272
2053 4376-4380 Gene denotes ACE2 Gene:59272
2054 4430-4434 Gene denotes ACE2 Gene:59272
2055 4483-4487 Gene denotes ACE2 Gene:59272
2056 4562-4566 Gene denotes ACE2 Gene:59272
2057 3911-3919 Gene denotes Ang (1–7 Gene:284
2058 3748-3751 Gene denotes MLN Gene:4295
2059 3425-3428 Gene denotes MLN Gene:4295
2060 2373-2376 Gene denotes MLN Gene:4295
2061 3165-3170 Gene denotes mACE2 Gene:70008
2062 3051-3056 Gene denotes mACE2 Gene:70008
2063 2088-2093 Species denotes human Tax:9606
2064 2141-2146 Species denotes human Tax:9606
2065 2483-2488 Species denotes human Tax:9606
2066 4508-4513 Species denotes human Tax:9606
2067 3887-3893 Gene denotes Ang II Gene:24179
2068 2054-2061 Chemical denotes MLN4760 MESH:C486469
2069 2500-2506 Chemical denotes rhACE2
2070 2605-2610 Chemical denotes rhACE
2071 2697-2702 Chemical denotes rhACE
2072 2766-2772 Chemical denotes rhACE2
2073 2842-2848 Chemical denotes rhACE2
2074 2875-2881 Chemical denotes rhACE2
2075 2889-2894 Chemical denotes rhACE
2076 3294-3299 Chemical denotes Dx600
2077 3438-3443 Chemical denotes DX600
2078 3490-3499 Chemical denotes disulfide MESH:D004220
2079 3614-3620 Chemical denotes rhACE2
2080 3809-3815 Chemical denotes rhACE2
2081 3873-3879 Chemical denotes rhACE2
2082 3930-3935 Chemical denotes DX600
2083 3979-3985 Chemical denotes rhACE2
2084 4223-4228 Chemical denotes Dx600
2085 3698-3718 Disease denotes hypercapnic acidosis MESH:D000138
2117 4629-4633 Gene denotes ACE2 Gene:59272
2118 4802-4806 Gene denotes ACE2 Gene:59272
2119 4898-4902 Gene denotes ACE2 Gene:59272
2120 5009-5016 Gene denotes Ang 1–7 Gene:284
2121 5067-5071 Gene denotes ACE2 Gene:70008
2122 5444-5448 Gene denotes ACE2 Gene:302668
2123 5718-5722 Gene denotes ACE2 Gene:302668
2124 5805-5809 Gene denotes ACE2 Gene:70008
2125 5843-5846 Gene denotes ACE Gene:70008
2126 4982-4988 Gene denotes Ang II Gene:24179
2127 5815-5818 Gene denotes MLN Gene:69563
2128 5142-5145 Gene denotes MLN Gene:69563
2129 4712-4715 Gene denotes MLN Gene:4295
2130 4590-4593 Gene denotes MLN Gene:4295
2131 5259-5263 Species denotes mice Tax:10090
2132 5316-5320 Species denotes rats Tax:10116
2133 5690-5694 Species denotes rats Tax:10116
2134 5917-5921 Species denotes mice Tax:10090
2135 5292-5302 Species denotes transgenic Tax:10090
2136 5240-5245 Chemical denotes water MESH:D014867
2137 5595-5602 Chemical denotes MLN4760 MESH:C486469
2138 5885-5899 Chemical denotes streptozotocin MESH:D013311
2139 5105-5117 Disease denotes hypertensive MESH:D006973
2140 5303-5315 Disease denotes hypertensive MESH:D006973
2141 5410-5422 Disease denotes hypertensive MESH:D006973
2142 5528-5540 Disease denotes hypertensive MESH:D006973
2143 5747-5758 Disease denotes bradycardia MESH:D001919
2144 5848-5859 Disease denotes albuminuria MESH:D000419
2145 5864-5881 Disease denotes glomerular injury MESH:D007674
2146 5908-5916 Disease denotes diabetic MESH:D003920
2147 5982-5990 Disease denotes diabetic MESH:D003920
2177 6087-6091 Gene denotes ACE2 Gene:59272
2178 6545-6550 Gene denotes rACE2 Gene:302668
2179 6608-6612 Gene denotes ACE2 Gene:59272
2180 7332-7336 Gene denotes ACE2 Gene:302668
2181 7526-7530 Gene denotes ACE2 Gene:302668
2182 7618-7622 Gene denotes ACE2 Gene:302668
2183 7843-7846 Gene denotes ACE Gene:70008
2184 7847-7851 Gene denotes ACE2 Gene:70008
2185 7695-7698 Gene denotes MLN Gene:69563
2186 7390-7393 Gene denotes MLN Gene:100126231
2187 6980-6983 Gene denotes MLN Gene:100126231
2188 6813-6816 Gene denotes MLN Gene:4295
2189 6495-6498 Gene denotes MLN Gene:69563
2190 6254-6258 Species denotes mice Tax:10090
2191 6388-6393 Species denotes mouse Tax:10090
2192 6539-6544 Species denotes human Tax:9606
2193 6786-6791 Species denotes human Tax:9606
2194 6942-6961 Species denotes Sprague-Dawley rats Tax:10116
2195 7758-7763 Species denotes mouse Tax:10090
2196 6061-6066 Chemical denotes DX600
2197 7095-7100 Chemical denotes water MESH:D014867
2198 7675-7681 Chemical denotes GL1001 MESH:C486469
2199 6421-6438 Disease denotes lung inflammation MESH:D011014
2200 6669-6678 Disease denotes mortality MESH:D003643
2201 6908-6929 Disease denotes myocardial infarction MESH:D009203
2202 7170-7179 Disease denotes pressures MESH:D006973
2203 7356-7377 Disease denotes myocardial infarction MESH:D009203
2204 7429-7437 Disease denotes COVID-19 MESH:C000657245
2205 7773-7780 Disease denotes colitis MESH:D003092

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T311 592-596 Disease denotes clam http://purl.obolibrary.org/obo/MONDO_0011948
T312 3710-3718 Disease denotes acidosis http://purl.obolibrary.org/obo/MONDO_0006022
T313 3742-3746 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T314 5030-5056 Disease denotes increase of blood pressure http://purl.obolibrary.org/obo/MONDO_0005044
T315 5875-5881 Disease denotes injury http://purl.obolibrary.org/obo/MONDO_0021178
T316 6426-6438 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T317 6908-6929 Disease denotes myocardial infarction http://purl.obolibrary.org/obo/MONDO_0005068
T318 7356-7377 Disease denotes myocardial infarction http://purl.obolibrary.org/obo/MONDO_0005068
T319 7429-7437 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T320 7773-7780 Disease denotes colitis http://purl.obolibrary.org/obo/MONDO_0005292

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T659 159-167 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T660 193-201 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T661 368-369 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T662 382-389 http://purl.obolibrary.org/obo/CLO_0001927 denotes bending
T663 406-414 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T664 466-474 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T665 590-591 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T666 758-759 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T667 775-783 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T668 882-890 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T669 969-974 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T670 1087-1092 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T671 1114-1118 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T672 1130-1131 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T673 1309-1315 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T674 1316-1324 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T675 1392-1400 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T676 1562-1570 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T677 1634-1642 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T678 1904-1907 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T679 2065-2066 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T680 2088-2093 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T681 2141-2146 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T682 2178-2179 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T683 2252-2253 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T684 2262-2263 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T685 2298-2299 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T686 2359-2362 http://purl.obolibrary.org/obo/CLO_0053001 denotes 114
T687 2365-2372 http://purl.obolibrary.org/obo/UBERON_0000473 denotes Testing
T688 2431-2432 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T689 2483-2488 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T690 2490-2492 http://purl.obolibrary.org/obo/CLO_0008812 denotes rh
T691 2507-2517 http://purl.obolibrary.org/obo/CLO_0001658 denotes activities
T692 2545-2548 http://purl.obolibrary.org/obo/CLO_0053001 denotes 114
T693 2562-2563 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T694 2673-2674 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T695 2826-2827 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T696 2896-2899 http://purl.obolibrary.org/obo/CLO_0053001 denotes 114
T697 2941-2942 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T698 2975-2983 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T699 3005-3013 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T700 3096-3097 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T701 3159-3160 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T702 3208-3225 http://purl.obolibrary.org/obo/CL_0000842 denotes mononuclear cells
T703 3263-3266 http://purl.obolibrary.org/obo/CLO_0053001 denotes 114
T704 3269-3270 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T705 3360-3361 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T706 3363-3366 http://purl.obolibrary.org/obo/CLO_0053001 denotes 114
T707 3408-3416 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T708 3600-3601 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T709 3653-3661 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T710 3671-3672 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T711 3816-3824 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T712 4054-4058 http://purl.obolibrary.org/obo/CLO_0050171 denotes M–10
T713 4148-4149 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T714 4217-4218 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T715 4345-4353 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T716 4381-4389 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T717 4401-4409 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T718 4459-4467 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T719 4508-4513 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T720 4514-4520 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T721 4578-4581 http://purl.obolibrary.org/obo/CLO_0001046 denotes 116
T722 4692-4697 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T723 4903-4911 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T724 4940-4941 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T725 5042-5047 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T726 5042-5047 http://www.ebi.ac.uk/efo/EFO_0000296 denotes blood
T727 5155-5158 http://purl.obolibrary.org/obo/CLO_0053799 denotes 4-5
T728 5182-5187 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T729 5182-5187 http://www.ebi.ac.uk/efo/EFO_0000296 denotes blood
T730 5277-5281 http://purl.obolibrary.org/obo/UBERON_0003101 denotes male
T731 5277-5281 http://www.ebi.ac.uk/efo/EFO_0000970 denotes male
T732 5289-5291 http://purl.obolibrary.org/obo/CLO_0050509 denotes 27
T733 5423-5431 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T734 5541-5546 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T735 5541-5546 http://www.ebi.ac.uk/efo/EFO_0000296 denotes blood
T736 5638-5641 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T737 5707-5708 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T738 5738-5739 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T739 5934-5935 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T740 5980-5981 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T741 6068-6069 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T742 6079-6086 http://purl.obolibrary.org/obo/PR_000018263 denotes peptide
T743 6117-6118 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T744 6294-6295 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T745 6386-6387 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T746 6388-6393 http://purl.obolibrary.org/obo/CLO_0007836 denotes mouse
T747 6421-6425 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T748 6421-6425 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T749 6440-6443 http://purl.obolibrary.org/obo/CLO_0001053 denotes 121
T750 6539-6544 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T751 6695-6702 http://purl.obolibrary.org/obo/NCBITaxon_33208 denotes animals
T752 6786-6791 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T753 6872-6873 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T754 6937-6941 http://purl.obolibrary.org/obo/UBERON_0003101 denotes male
T755 6937-6941 http://www.ebi.ac.uk/efo/EFO_0000970 denotes male
T756 7002-7005 http://purl.obolibrary.org/obo/CLO_0002096 denotes C16
T757 7059-7060 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T758 7161-7169 http://purl.obolibrary.org/obo/UBERON_0001637 denotes arterial
T759 7161-7169 http://www.ebi.ac.uk/efo/EFO_0000814 denotes arterial
T760 7286-7288 http://purl.obolibrary.org/obo/CLO_0001407 denotes 52
T761 7302-7303 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T762 7531-7539 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T763 7557-7562 http://purl.obolibrary.org/obo/UBERON_0000948 denotes heart
T764 7557-7562 http://purl.obolibrary.org/obo/UBERON_0007100 denotes heart
T765 7557-7562 http://purl.obolibrary.org/obo/UBERON_0015228 denotes heart
T766 7557-7562 http://www.ebi.ac.uk/efo/EFO_0000815 denotes heart
T767 7564-7568 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T768 7564-7568 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T769 7570-7575 http://purl.obolibrary.org/obo/UBERON_0002107 denotes liver
T770 7570-7575 http://www.ebi.ac.uk/efo/EFO_0000887 denotes liver
T771 7577-7582 http://purl.obolibrary.org/obo/UBERON_0001155 denotes colon
T772 7600-7606 http://purl.obolibrary.org/obo/UBERON_0003103 denotes organs
T773 7631-7636 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T774 7631-7636 http://www.ebi.ac.uk/efo/EFO_0000296 denotes blood
T775 7641-7658 http://purl.obolibrary.org/obo/CL_0000115 denotes endothelial cells
T776 7744-7752 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T777 7756-7757 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T778 7758-7763 http://purl.obolibrary.org/obo/CLO_0007836 denotes mouse

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T75 707-717 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T47611 837-846 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T93730 923-931 Chemical denotes electron http://purl.obolibrary.org/obo/CHEBI_10545
T82543 1169-1176 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T74998 1243-1250 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T37661 1511-1519 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T59859 1608-1615 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T68655 1793-1801 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T22243 1883-1892 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T66791 1941-1950 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T85 2039-2047 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T26019 2094-2108 Chemical denotes ACE2 inhibitor http://purl.obolibrary.org/obo/CHEBI_147289
T54501 2099-2108 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T75789 2180-2195 Chemical denotes racemic mixture http://purl.obolibrary.org/obo/CHEBI_60911
T7082 2188-2195 Chemical denotes mixture http://purl.obolibrary.org/obo/CHEBI_60004
T14426 2382-2397 Chemical denotes racemic mixture http://purl.obolibrary.org/obo/CHEBI_60911
T52319 2390-2397 Chemical denotes mixture http://purl.obolibrary.org/obo/CHEBI_60004
T74419 2533-2543 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T93878 2650-2658 Chemical denotes racemate http://purl.obolibrary.org/obo/CHEBI_60911
T90533 2803-2811 Chemical denotes racemate http://purl.obolibrary.org/obo/CHEBI_60911
T46386 2922-2932 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T96 3136-3144 Chemical denotes racemate http://purl.obolibrary.org/obo/CHEBI_60911
T36982 3278-3292 Chemical denotes ACE2 inhibitor http://purl.obolibrary.org/obo/CHEBI_147289
T92521 3283-3292 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T41578 3490-3499 Chemical denotes disulfide http://purl.obolibrary.org/obo/CHEBI_48343
T100 3524-3534 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T22298 3891-3893 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T60880 4125-4133 Chemical denotes racemate http://purl.obolibrary.org/obo/CHEBI_60911
T91051 4247-4257 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T32362 4562-4576 Chemical denotes ACE2 inhibitor http://purl.obolibrary.org/obo/CHEBI_147289
T91312 4567-4576 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T3770 4599-4608 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T42358 4986-4988 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T84420 5240-5245 Chemical denotes water http://purl.obolibrary.org/obo/CHEBI_15377
T69860 5277-5281 Chemical denotes male http://purl.obolibrary.org/obo/CHEBI_30780
T80273 5612-5619 Chemical denotes nucleus http://purl.obolibrary.org/obo/CHEBI_33252
T43819 5967-5976 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T58470 6079-6086 Chemical denotes peptide http://purl.obolibrary.org/obo/CHEBI_16670
T85380 6087-6101 Chemical denotes ACE2 inhibitor http://purl.obolibrary.org/obo/CHEBI_147289
T2332 6092-6101 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T27493 6226-6235 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T56128 6460-6469 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T23596 6608-6623 Chemical denotes ACE2 inhibitors http://purl.obolibrary.org/obo/CHEBI_147289
T10113 6613-6623 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T6036 6937-6941 Chemical denotes male http://purl.obolibrary.org/obo/CHEBI_30780
T60127 7002-7005 Chemical denotes C16 http://purl.obolibrary.org/obo/CHEBI_15756
T121 7061-7069 Chemical denotes solution http://purl.obolibrary.org/obo/CHEBI_75958
T93537 7095-7100 Chemical denotes water http://purl.obolibrary.org/obo/CHEBI_15377
T27633 7252-7257 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T119 2159-2168 http://purl.obolibrary.org/obo/GO_0009058 denotes synthesis
T120 3621-3632 http://purl.obolibrary.org/obo/GO_0006508 denotes proteolysis
T121 3894-3905 http://purl.obolibrary.org/obo/GO_0009056 denotes degradation
T122 5680-5686 http://purl.obolibrary.org/obo/GO_0060004 denotes reflex
T123 5740-5746 http://purl.obolibrary.org/obo/GO_0060004 denotes reflex
T124 6426-6438 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T259 0-4 Sentence denotes 5.2.
T260 5-71 Sentence denotes Safety and Efficacy Concerns of MLN4760 and Dx600 ACE2 Inhibitors.
T261 72-211 Sentence denotes It is known that the catalytic cleft of ACE2 consists of two peptidase subdomains: one membrane-distal and the other one membrane-proximal.
T262 212-332 Sentence denotes Their weak interactions are consistent with the ability to transition from open to the closed ACE2 conformation [28,90].
T263 333-608 Sentence denotes Indeed, the two subdomains undergo a large hinge-bending motion in which membrane-proximal subdomain remains almost unchanged, while membrane-distal subdomain moves to close the distance between the two subdomains, mimicking the opening/closing movement of a clam shell [90].
T264 609-899 Sentence denotes ACE2 open conformation likely reflects free state of the enzyme available to catch substrates (or inhibitors), then, when the ACE2 receptor binds to a substrate, the membrane-distal subdomain closes around the substrate (or the inhibitor), finally performing the enzymatic activity [24,90].
T265 900-1080 Sentence denotes Interestingly, in cryo–electron microscopy structures of full-length human ACE2, only the closed/substrate-bound conformation of ACE2 was observed in the spike-ACE2 complexes [28].
T266 1081-1325 Sentence denotes Since human ACE2 is assembled on cell surface as a homodimer [28], binding of the spike protein trimer onto ACE2 dimer suggests simultaneous binding of two spike protein trimers to substrate-bound conformer of ACE2 homodimer on plasma membrane.
T267 1326-1582 Sentence denotes The spike binding sites on ACE2 homodimer are localized above the membrane-distal peptidase subdomain of each ACE2 monomer, nevertheless neither ACE2 shedding nor ACE2 binding to spike proteins have been shown to inhibit ACE2 enzymatic activity [16,17,24].
T268 1583-1850 Sentence denotes On the other hand, the S-protein-binding region of membrane-distal ACE2 subdomain is not significantly perturbed by the receptor conformational changes and maintains the ability to associate with soluble spike proteins independently on open/closed conformations [24].
T269 1851-2053 Sentence denotes Interestingly, an ACE2 specific inhibitor (MLN-4760) has been shown to induce the closed (inhibitor-bound) ACE2 structure [90] and to retain its inhibitory effects on sACE2 bound to spike proteins [24].
T270 2054-2254 Sentence denotes MLN4760 is a potent and selective human ACE2 inhibitor (IC50 = 0.44 nM against soluble human ACE2) whose synthesis produces a racemic mixture of two diastereomers that showed 75:25 ratio for Isomer A:
T271 2255-2364 Sentence denotes Isomer B [113,114] and the purified isomer B is the isomer commercially available from Merck Millipore [114].
T272 2365-2550 Sentence denotes Testing MLN-4760 racemic mixture and its isomers, it was observed a concentration-dependent inhibition of recombinant human (rh)ACE or rhACE2 activities with all three inhibitors [114].
T273 2551-2901 Sentence denotes The isomer B was less selective (near minimal-maximal rhACE inhibition range 10−6M-10−4M) than the racemate or the isomer A (near minimal-maximal rhACE inhibition range 10−6M-10−2M) and less effective (near maximal rhACE2 inhibition at 10−7M) than the racemate or the isomer A (near maximal rhACE2 inhibition at 10−8 M) for rhACE2 versus rhACE [114].
T274 2902-3268 Sentence denotes Moreover, all three inhibitors exerted a significantly higher inhibitory activity against soluble than membrane-bound forms of (m)ACE2 (near maximal mACE2 inhibition at 10−6M), being the isomer B more selective and effective than the racemate or the isomer A for mACE2 vs. mACE expressed on the surface of mononuclear cells (or CD34 hematopoietic progenitors) [114].
T275 3269-3368 Sentence denotes A second ACE2 inhibitor, Dx600, produced similar results to those obtained with the isomer B [114].
T276 3369-3535 Sentence denotes Another study evaluated the inhibitory activity of both MLN-4760 and DX600 (either the linear conformational form or the disulfide bridged cyclic variant) inhibitors.
T277 3536-3747 Sentence denotes In this report, the experiments were performed at pH 6.5 [115], a pH at which rhACE2 proteolysis operates at maximal activity [79] and a condition that resembles hypercapnic acidosis which may occur during SARS.
T278 3748-4084 Sentence denotes MLN-4760 was still able to strongly and specifically inhibit rhACE2 activity (near maximal inhibition at 10−8 M), preventing rhACE2-driven Ang II degradation into Ang (1–7), whereas DX600 (either linear or cyclic variant) inhibits rhACE2 at relatively higher concentration (near maximal inhibition at 10−6 M–10−7 M, respectively) [115].
T279 4085-4229 Sentence denotes Altogether these data indicate that the racemate or the isomer A are more effective in inhibiting soluble forms of ACE2 than isomer B and Dx600.
T280 4230-4583 Sentence denotes Therefore, these inhibitors at opportune (low) concentrations are expected to preferentially reduce systemic sACE2 activity, while preserving the ACE2 activity of (local) membrane-associated forms of ACE2, knowing that catalytic activity of circulating ACE2 was undetectable in human plasma of healthy subjects due to an endogenous ACE2 inhibitor [116].
T281 4584-4939 Sentence denotes Since MLN-4760 inhibitor promotes the closed ACE2 conformation [90] which is the preferential conformer for virus binding [28], MLN-4760 is expected to not prevent viral entry; nevertheless, its inhibitory function on ACE2 pathway might work on the positive feedback loops (above described) that ultimately favour ACE2 membrane expression and viral entry.
T282 4940-5057 Sentence denotes A potential risk factor of inhibiting the Ang II metabolization into Ang 1–7 could be the increase of blood pressure.
T283 5058-5567 Sentence denotes Although ACE2 pathway inhibition might lead to hypertensive effects, treatment with MLN-4760 for 4-5 weeks had no effect on blood pressure when administered 10 mg/kg/day in drinking water in wild type mice [117] nor in male (mRen2)27 transgenic hypertensive rats (administered 30 mg/kg/day subcutaneously via mini-osmotic pumps) [118], suggesting that hypertensive activity mediated by ACE2 inhibition is promptly balanced by compensatory mechanisms either in normal or hypertensive blood pressure conditions.
T284 5568-5773 Sentence denotes In addition, injections of MLN4760 into the nucleus tractus solitarii has been shown to reduce the baroreceptor reflex in rats, suggesting a role for ACE2 in controlling a reflex bradycardia (see [39,44]).
T285 5774-6008 Sentence denotes Finally, chronic inhibition of ACE2 with MLN-4760 led to increase of ACE, albuminuria and glomerular injury in streptozotocin-induced diabetic mice, indicating a possible adverse effect of the inhibitor in a diabetic background [119].
T286 6009-6182 Sentence denotes Extensive experiments have been also performed with DX600, a specific peptide ACE2 inhibitor that exhibited a mixed competitive and non-competitive type of inhibition [120].
T287 6183-6280 Sentence denotes Actually, several reports describing Dx600 inhibitor administration in mice suggest its safe use.
T288 6281-6561 Sentence denotes Of interest, a report described its (safe) use alone (1 mg/kg per day) by nasal inhalation for 3 days in a mouse model of endotoxin-induced lung inflammation [121]; however, this inhibitor is less efficacious than MLN-4760 in inhibiting the soluble forms of human rACE2 [114,115].
T289 6562-6758 Sentence denotes Altogether these reports on administration of ACE2 inhibitors do not reveal significant adverse impacts or mortality in experimental animals, which suggests their safety in chronic administration.
T290 6759-6858 Sentence denotes This was also confirmed in human clinical trials with MLN-4760 (clinical name: ORE1001, see later).
T291 6859-7378 Sentence denotes Of interest, a report showed that on day 28 post-myocardial infarction, adult male Sprague-Dawley rats that had received MLN-4760 (also called C16) 25 mg/mL/day by daily intraperitoneal injection (as a solution of 42 mg/mL in distilled water) tended to have lower left ventricular pulse pressure, mean arterial pressures and left ventricular relaxation time constant-Tau compared to untreated group (see table 2 of the paper) [52], suggesting a possible protective role of ACE2 inhibition in post-myocardial infarction.
T292 7379-7659 Sentence denotes Therefore, MLN-4760 might be helpful not only for COVID-19 but also in targeted therapies for pathologies correlated with an excessive increase of ACE2 activity that may involve heart, lung, liver, colon or other tissues/organs expressing ACE2 such as blood and endothelial cells.
T293 7660-7886 Sentence denotes As an example, GL1001 (old name of MLN-4760) showed to produce an anti-inflammatory activity in a mouse model of colitis [122], highlighting the importance of the yin-yang balance of ACE/ACE2 pathways (“in medio stat virtus”).

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T93 3710-3718 Phenotype denotes acidosis http://purl.obolibrary.org/obo/HP_0001941
T94 5030-5056 Phenotype denotes increase of blood pressure http://purl.obolibrary.org/obo/HP_0032263
T95 5747-5758 Phenotype denotes bradycardia http://purl.obolibrary.org/obo/HP_0001662
T96 5848-5859 Phenotype denotes albuminuria http://purl.obolibrary.org/obo/HP_0012592
T97 6908-6929 Phenotype denotes myocardial infarction http://purl.obolibrary.org/obo/HP_0001658
T98 7356-7377 Phenotype denotes myocardial infarction http://purl.obolibrary.org/obo/HP_0001658
T99 7773-7780 Phenotype denotes colitis http://purl.obolibrary.org/obo/HP_0002583

2_test

Id Subject Object Predicate Lexical cue
32708755-32132184-20678843 325-327 32132184 denotes 28
32708755-15791205-20678844 892-894 15791205 denotes 24
32708755-32132184-20678845 1076-1078 32132184 denotes 28
32708755-32132184-20678846 1143-1145 32132184 denotes 28
32708755-18490652-20678847 1575-1577 18490652 denotes 17
32708755-15791205-20678848 1578-1580 15791205 denotes 24
32708755-15791205-20678849 1846-1848 15791205 denotes 24
32708755-15791205-20678850 2049-2051 15791205 denotes 24
32708755-12358520-20678851 2265-2268 12358520 denotes 113
32708755-26851370-20678852 2269-2272 26851370 denotes 114
32708755-26851370-20678853 2359-2362 26851370 denotes 114
32708755-26851370-20678854 2545-2548 26851370 denotes 114
32708755-26851370-20678855 2896-2899 26851370 denotes 114
32708755-26851370-20678856 3263-3266 26851370 denotes 114
32708755-26851370-20678857 3363-3366 26851370 denotes 114
32708755-22777933-20678858 3594-3597 22777933 denotes 115
32708755-22777933-20678859 4079-4082 22777933 denotes 115
32708755-18223027-20678860 4578-4581 18223027 denotes 116
32708755-32132184-20678861 4707-4709 32132184 denotes 28
32708755-18235039-20678862 5265-5268 18235039 denotes 117
32708755-20300067-20678863 5388-5391 20300067 denotes 118
32708755-20599443-20678864 5768-5770 20599443 denotes 44
32708755-17579661-20678865 6003-6006 17579661 denotes 119
32708755-26851370-20678866 6552-6555 26851370 denotes 114
32708755-22777933-20678867 6556-6559 22777933 denotes 115
32708755-20797602-20678868 7286-7288 20797602 denotes 52
32708755-19517214-20678869 7782-7785 19517214 denotes 122