PMC:7408073 / 5101-5621 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T89383","span":{"begin":144,"end":153},"obj":"Body_part"},{"id":"T34441","span":{"begin":254,"end":261},"obj":"Body_part"},{"id":"T53940","span":{"begin":286,"end":293},"obj":"Body_part"},{"id":"T48489","span":{"begin":327,"end":332},"obj":"Body_part"},{"id":"T22482","span":{"begin":388,"end":395},"obj":"Body_part"}],"attributes":[{"id":"A79507","pred":"fma_id","subj":"T89383","obj":"http://purl.org/sig/ont/fma/fma9639"},{"id":"A63244","pred":"fma_id","subj":"T34441","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A19387","pred":"fma_id","subj":"T53940","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A86102","pred":"fma_id","subj":"T48489","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A80521","pred":"fma_id","subj":"T22482","obj":"http://purl.org/sig/ont/fma/fma67257"}],"text":" relatively high concentration in COVID-19 patients [2]. Moreover, soluble (s)ACE2 (induced or not by virus binding) released from human airway epithelia has been demonstrated to retain both its enzymatic activity and its binding ability for spike viral protein, finally reducing spike protein-mediated viral entry into target cells [16,17]. Therefore, the interaction of ACE2 with spike protein of SARS-CoV induces a cellular “protective” ACE2 shedding feedback response that initially limits viral entry. Nevertheless,"}

{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T10","span":{"begin":144,"end":153},"obj":"Body_part"}],"attributes":[{"id":"A10","pred":"uberon_id","subj":"T10","obj":"http://purl.obolibrary.org/obo/UBERON_0000483"}],"text":" relatively high concentration in COVID-19 patients [2]. Moreover, soluble (s)ACE2 (induced or not by virus binding) released from human airway epithelia has been demonstrated to retain both its enzymatic activity and its binding ability for spike viral protein, finally reducing spike protein-mediated viral entry into target cells [16,17]. Therefore, the interaction of ACE2 with spike protein of SARS-CoV induces a cellular “protective” ACE2 shedding feedback response that initially limits viral entry. Nevertheless,"}

{"project":"LitCovid-PubTator","denotations":[{"id":"238","span":{"begin":78,"end":82},"obj":"Gene"},{"id":"239","span":{"begin":372,"end":376},"obj":"Gene"},{"id":"240","span":{"begin":440,"end":444},"obj":"Gene"},{"id":"269","span":{"begin":43,"end":51},"obj":"Species"},{"id":"270","span":{"begin":131,"end":136},"obj":"Species"},{"id":"271","span":{"begin":399,"end":407},"obj":"Species"},{"id":"286","span":{"begin":382,"end":387},"obj":"Gene"},{"id":"287","span":{"begin":280,"end":285},"obj":"Gene"},{"id":"288","span":{"begin":242,"end":247},"obj":"Gene"},{"id":"293","span":{"begin":34,"end":42},"obj":"Disease"}],"attributes":[{"id":"A238","pred":"tao:has_database_id","subj":"238","obj":"Gene:59272"},{"id":"A239","pred":"tao:has_database_id","subj":"239","obj":"Gene:59272"},{"id":"A240","pred":"tao:has_database_id","subj":"240","obj":"Gene:59272"},{"id":"A269","pred":"tao:has_database_id","subj":"269","obj":"Tax:9606"},{"id":"A270","pred":"tao:has_database_id","subj":"270","obj":"Tax:9606"},{"id":"A271","pred":"tao:has_database_id","subj":"271","obj":"Tax:694009"},{"id":"A286","pred":"tao:has_database_id","subj":"286","obj":"Gene:43740568"},{"id":"A287","pred":"tao:has_database_id","subj":"287","obj":"Gene:43740568"},{"id":"A288","pred":"tao:has_database_id","subj":"288","obj":"Gene:43740568"},{"id":"A293","pred":"tao:has_database_id","subj":"293","obj":"MESH:C000657245"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":" relatively high concentration in COVID-19 patients [2]. Moreover, soluble (s)ACE2 (induced or not by virus binding) released from human airway epithelia has been demonstrated to retain both its enzymatic activity and its binding ability for spike viral protein, finally reducing spike protein-mediated viral entry into target cells [16,17]. Therefore, the interaction of ACE2 with spike protein of SARS-CoV induces a cellular “protective” ACE2 shedding feedback response that initially limits viral entry. Nevertheless,"}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T60","span":{"begin":34,"end":42},"obj":"Disease"},{"id":"T61","span":{"begin":399,"end":407},"obj":"Disease"},{"id":"T62","span":{"begin":399,"end":403},"obj":"Disease"}],"attributes":[{"id":"A60","pred":"mondo_id","subj":"T60","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A61","pred":"mondo_id","subj":"T61","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A62","pred":"mondo_id","subj":"T62","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"}],"text":" relatively high concentration in COVID-19 patients [2]. Moreover, soluble (s)ACE2 (induced or not by virus binding) released from human airway epithelia has been demonstrated to retain both its enzymatic activity and its binding ability for spike viral protein, finally reducing spike protein-mediated viral entry into target cells [16,17]. Therefore, the interaction of ACE2 with spike protein of SARS-CoV induces a cellular “protective” ACE2 shedding feedback response that initially limits viral entry. Nevertheless,"}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T15128","span":{"begin":102,"end":107},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T47491","span":{"begin":131,"end":136},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9606"},{"id":"T61686","span":{"begin":137,"end":143},"obj":"http://purl.obolibrary.org/obo/UBERON_0001005"},{"id":"T23099","span":{"begin":154,"end":157},"obj":"http://purl.obolibrary.org/obo/CLO_0051582"},{"id":"T34964","span":{"begin":205,"end":213},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T56294","span":{"begin":327,"end":332},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T5722","span":{"begin":416,"end":417},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"}],"text":" relatively high concentration in COVID-19 patients [2]. Moreover, soluble (s)ACE2 (induced or not by virus binding) released from human airway epithelia has been demonstrated to retain both its enzymatic activity and its binding ability for spike viral protein, finally reducing spike protein-mediated viral entry into target cells [16,17]. Therefore, the interaction of ACE2 with spike protein of SARS-CoV induces a cellular “protective” ACE2 shedding feedback response that initially limits viral entry. Nevertheless,"}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T37","span":{"begin":254,"end":261},"obj":"Chemical"},{"id":"T38","span":{"begin":286,"end":293},"obj":"Chemical"},{"id":"T39","span":{"begin":388,"end":395},"obj":"Chemical"}],"attributes":[{"id":"A37","pred":"chebi_id","subj":"T37","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A38","pred":"chebi_id","subj":"T38","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A39","pred":"chebi_id","subj":"T39","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"}],"text":" relatively high concentration in COVID-19 patients [2]. Moreover, soluble (s)ACE2 (induced or not by virus binding) released from human airway epithelia has been demonstrated to retain both its enzymatic activity and its binding ability for spike viral protein, finally reducing spike protein-mediated viral entry into target cells [16,17]. Therefore, the interaction of ACE2 with spike protein of SARS-CoV induces a cellular “protective” ACE2 shedding feedback response that initially limits viral entry. Nevertheless,"}

{"project":"LitCovid-sentences","denotations":[{"id":"T28","span":{"begin":57,"end":341},"obj":"Sentence"},{"id":"T29","span":{"begin":342,"end":506},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":" relatively high concentration in COVID-19 patients [2]. Moreover, soluble (s)ACE2 (induced or not by virus binding) released from human airway epithelia has been demonstrated to retain both its enzymatic activity and its binding ability for spike viral protein, finally reducing spike protein-mediated viral entry into target cells [16,17]. Therefore, the interaction of ACE2 with spike protein of SARS-CoV induces a cellular “protective” ACE2 shedding feedback response that initially limits viral entry. Nevertheless,"}

{"project":"2_test","denotations":[{"id":"32708755-32161940-20678663","span":{"begin":53,"end":54},"obj":"32161940"},{"id":"32708755-18490652-20678664","span":{"begin":337,"end":339},"obj":"18490652"}],"text":" relatively high concentration in COVID-19 patients [2]. Moreover, soluble (s)ACE2 (induced or not by virus binding) released from human airway epithelia has been demonstrated to retain both its enzymatic activity and its binding ability for spike viral protein, finally reducing spike protein-mediated viral entry into target cells [16,17]. Therefore, the interaction of ACE2 with spike protein of SARS-CoV induces a cellular “protective” ACE2 shedding feedback response that initially limits viral entry. Nevertheless,"}