PMC:7408073 / 48149-48937 JSONTXT

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    LitCovid-PD-FMA-UBERON

    {"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T312","span":{"begin":0,"end":6},"obj":"Body_part"},{"id":"T313","span":{"begin":72,"end":82},"obj":"Body_part"},{"id":"T314","span":{"begin":242,"end":247},"obj":"Body_part"},{"id":"T315","span":{"begin":257,"end":262},"obj":"Body_part"},{"id":"T316","span":{"begin":326,"end":333},"obj":"Body_part"},{"id":"T317","span":{"begin":337,"end":343},"obj":"Body_part"},{"id":"T318","span":{"begin":358,"end":362},"obj":"Body_part"},{"id":"T319","span":{"begin":417,"end":419},"obj":"Body_part"},{"id":"T320","span":{"begin":566,"end":578},"obj":"Body_part"},{"id":"T321","span":{"begin":646,"end":663},"obj":"Body_part"},{"id":"T322","span":{"begin":658,"end":663},"obj":"Body_part"},{"id":"T323","span":{"begin":695,"end":712},"obj":"Body_part"},{"id":"T324","span":{"begin":707,"end":712},"obj":"Body_part"},{"id":"T325","span":{"begin":765,"end":771},"obj":"Body_part"},{"id":"T326","span":{"begin":775,"end":782},"obj":"Body_part"}],"attributes":[{"id":"A312","pred":"fma_id","subj":"T312","obj":"http://purl.org/sig/ont/fma/fma62970"},{"id":"A313","pred":"fma_id","subj":"T313","obj":"http://purl.org/sig/ont/fma/fma7199"},{"id":"A314","pred":"fma_id","subj":"T314","obj":"http://purl.org/sig/ont/fma/fma9670"},{"id":"A315","pred":"fma_id","subj":"T315","obj":"http://purl.org/sig/ont/fma/fma63083"},{"id":"A316","pred":"fma_id","subj":"T316","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A317","pred":"fma_id","subj":"T317","obj":"http://purl.org/sig/ont/fma/fma62970"},{"id":"A318","pred":"fma_id","subj":"T318","obj":"http://purl.org/sig/ont/fma/fma9712"},{"id":"A319","pred":"fma_id","subj":"T319","obj":"http://purl.org/sig/ont/fma/fma82739"},{"id":"A320","pred":"fma_id","subj":"T320","obj":"http://purl.org/sig/ont/fma/fma62970"},{"id":"A321","pred":"fma_id","subj":"T321","obj":"http://purl.org/sig/ont/fma/fma66772"},{"id":"A322","pred":"fma_id","subj":"T322","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A323","pred":"fma_id","subj":"T323","obj":"http://purl.org/sig/ont/fma/fma66772"},{"id":"A324","pred":"fma_id","subj":"T324","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A325","pred":"fma_id","subj":"T325","obj":"http://purl.org/sig/ont/fma/fma62970"},{"id":"A326","pred":"fma_id","subj":"T326","obj":"http://purl.org/sig/ont/fma/fma9637"}],"text":"Plasma zinc concentration is mainly regulated through a balance between intestinal absorption and renal excretion involving specific mechanisms sensitive to both dietary zinc availability and its cellular utilization. The majority of Zn2+ in blood binds to serum albumin, which represents the major zinc transporter/reservoir protein in plasma. On the other hand, labile-bound pool of Zn2+ labile complexes (e.g., of AA) and free Zn2+ are the biologically available forms of zinc for cellular internalization and/or enzymatic activities (0.1–1% of the total zinc in blood plasma under normal conditions). Free Zn2+ is subsequently accumulated by endothelial cells and zinc uptake and release by endothelial cells is the crucial step for redistribution of Zn2+ from plasma to tissues [91]."}

    LitCovid-PD-UBERON

    {"project":"LitCovid-PD-UBERON","denotations":[{"id":"T106","span":{"begin":242,"end":247},"obj":"Body_part"},{"id":"T107","span":{"begin":257,"end":262},"obj":"Body_part"},{"id":"T108","span":{"begin":358,"end":362},"obj":"Body_part"},{"id":"T109","span":{"begin":566,"end":578},"obj":"Body_part"},{"id":"T110","span":{"begin":566,"end":571},"obj":"Body_part"}],"attributes":[{"id":"A106","pred":"uberon_id","subj":"T106","obj":"http://purl.obolibrary.org/obo/UBERON_0000178"},{"id":"A107","pred":"uberon_id","subj":"T107","obj":"http://purl.obolibrary.org/obo/UBERON_0001977"},{"id":"A108","pred":"uberon_id","subj":"T108","obj":"http://purl.obolibrary.org/obo/UBERON_0002398"},{"id":"A109","pred":"uberon_id","subj":"T109","obj":"http://purl.obolibrary.org/obo/UBERON_0001969"},{"id":"A110","pred":"uberon_id","subj":"T110","obj":"http://purl.obolibrary.org/obo/UBERON_0000178"}],"text":"Plasma zinc concentration is mainly regulated through a balance between intestinal absorption and renal excretion involving specific mechanisms sensitive to both dietary zinc availability and its cellular utilization. The majority of Zn2+ in blood binds to serum albumin, which represents the major zinc transporter/reservoir protein in plasma. On the other hand, labile-bound pool of Zn2+ labile complexes (e.g., of AA) and free Zn2+ are the biologically available forms of zinc for cellular internalization and/or enzymatic activities (0.1–1% of the total zinc in blood plasma under normal conditions). Free Zn2+ is subsequently accumulated by endothelial cells and zinc uptake and release by endothelial cells is the crucial step for redistribution of Zn2+ from plasma to tissues [91]."}

    LitCovid-PubTator

    {"project":"LitCovid-PubTator","denotations":[{"id":"1800","span":{"begin":257,"end":270},"obj":"Gene"},{"id":"1801","span":{"begin":234,"end":238},"obj":"Chemical"},{"id":"1802","span":{"begin":385,"end":389},"obj":"Chemical"},{"id":"1803","span":{"begin":430,"end":434},"obj":"Chemical"},{"id":"1804","span":{"begin":610,"end":614},"obj":"Chemical"},{"id":"1805","span":{"begin":755,"end":759},"obj":"Chemical"}],"attributes":[{"id":"A1800","pred":"tao:has_database_id","subj":"1800","obj":"Gene:213"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Plasma zinc concentration is mainly regulated through a balance between intestinal absorption and renal excretion involving specific mechanisms sensitive to both dietary zinc availability and its cellular utilization. The majority of Zn2+ in blood binds to serum albumin, which represents the major zinc transporter/reservoir protein in plasma. On the other hand, labile-bound pool of Zn2+ labile complexes (e.g., of AA) and free Zn2+ are the biologically available forms of zinc for cellular internalization and/or enzymatic activities (0.1–1% of the total zinc in blood plasma under normal conditions). Free Zn2+ is subsequently accumulated by endothelial cells and zinc uptake and release by endothelial cells is the crucial step for redistribution of Zn2+ from plasma to tissues [91]."}

    LitCovid-PD-CLO

    {"project":"LitCovid-PD-CLO","denotations":[{"id":"T589","span":{"begin":0,"end":6},"obj":"http://purl.obolibrary.org/obo/UBERON_0001969"},{"id":"T590","span":{"begin":54,"end":55},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T591","span":{"begin":72,"end":82},"obj":"http://purl.obolibrary.org/obo/UBERON_0000160"},{"id":"T592","span":{"begin":72,"end":82},"obj":"http://www.ebi.ac.uk/efo/EFO_0000834"},{"id":"T593","span":{"begin":242,"end":247},"obj":"http://purl.obolibrary.org/obo/UBERON_0000178"},{"id":"T594","span":{"begin":242,"end":247},"obj":"http://www.ebi.ac.uk/efo/EFO_0000296"},{"id":"T595","span":{"begin":337,"end":343},"obj":"http://purl.obolibrary.org/obo/UBERON_0001969"},{"id":"T596","span":{"begin":417,"end":419},"obj":"http://purl.obolibrary.org/obo/CLO_0001627"},{"id":"T597","span":{"begin":526,"end":536},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T598","span":{"begin":566,"end":578},"obj":"http://purl.obolibrary.org/obo/UBERON_0001969"},{"id":"T599","span":{"begin":646,"end":663},"obj":"http://purl.obolibrary.org/obo/CL_0000115"},{"id":"T600","span":{"begin":695,"end":712},"obj":"http://purl.obolibrary.org/obo/CL_0000115"},{"id":"T601","span":{"begin":765,"end":771},"obj":"http://purl.obolibrary.org/obo/UBERON_0001969"}],"text":"Plasma zinc concentration is mainly regulated through a balance between intestinal absorption and renal excretion involving specific mechanisms sensitive to both dietary zinc availability and its cellular utilization. The majority of Zn2+ in blood binds to serum albumin, which represents the major zinc transporter/reservoir protein in plasma. On the other hand, labile-bound pool of Zn2+ labile complexes (e.g., of AA) and free Zn2+ are the biologically available forms of zinc for cellular internalization and/or enzymatic activities (0.1–1% of the total zinc in blood plasma under normal conditions). Free Zn2+ is subsequently accumulated by endothelial cells and zinc uptake and release by endothelial cells is the crucial step for redistribution of Zn2+ from plasma to tissues [91]."}

    LitCovid-PD-CHEBI

    {"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T601","span":{"begin":7,"end":11},"obj":"Chemical"},{"id":"T603","span":{"begin":162,"end":174},"obj":"Chemical"},{"id":"T604","span":{"begin":170,"end":174},"obj":"Chemical"},{"id":"T606","span":{"begin":234,"end":237},"obj":"Chemical"},{"id":"T607","span":{"begin":299,"end":303},"obj":"Chemical"},{"id":"T609","span":{"begin":326,"end":333},"obj":"Chemical"},{"id":"T610","span":{"begin":385,"end":388},"obj":"Chemical"},{"id":"T611","span":{"begin":417,"end":419},"obj":"Chemical"},{"id":"T614","span":{"begin":430,"end":433},"obj":"Chemical"},{"id":"T615","span":{"begin":475,"end":479},"obj":"Chemical"},{"id":"T617","span":{"begin":558,"end":562},"obj":"Chemical"},{"id":"T619","span":{"begin":610,"end":613},"obj":"Chemical"},{"id":"T620","span":{"begin":668,"end":672},"obj":"Chemical"},{"id":"T622","span":{"begin":755,"end":758},"obj":"Chemical"}],"attributes":[{"id":"A601","pred":"chebi_id","subj":"T601","obj":"http://purl.obolibrary.org/obo/CHEBI_27363"},{"id":"A602","pred":"chebi_id","subj":"T601","obj":"http://purl.obolibrary.org/obo/CHEBI_30185"},{"id":"A603","pred":"chebi_id","subj":"T603","obj":"http://purl.obolibrary.org/obo/CHEBI_29105"},{"id":"A604","pred":"chebi_id","subj":"T604","obj":"http://purl.obolibrary.org/obo/CHEBI_27363"},{"id":"A605","pred":"chebi_id","subj":"T604","obj":"http://purl.obolibrary.org/obo/CHEBI_30185"},{"id":"A606","pred":"chebi_id","subj":"T606","obj":"http://purl.obolibrary.org/obo/CHEBI_37256"},{"id":"A607","pred":"chebi_id","subj":"T607","obj":"http://purl.obolibrary.org/obo/CHEBI_27363"},{"id":"A608","pred":"chebi_id","subj":"T607","obj":"http://purl.obolibrary.org/obo/CHEBI_30185"},{"id":"A609","pred":"chebi_id","subj":"T609","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A610","pred":"chebi_id","subj":"T610","obj":"http://purl.obolibrary.org/obo/CHEBI_37256"},{"id":"A611","pred":"chebi_id","subj":"T611","obj":"http://purl.obolibrary.org/obo/CHEBI_15843"},{"id":"A612","pred":"chebi_id","subj":"T611","obj":"http://purl.obolibrary.org/obo/CHEBI_72816"},{"id":"A613","pred":"chebi_id","subj":"T611","obj":"http://purl.obolibrary.org/obo/CHEBI_33709"},{"id":"A614","pred":"chebi_id","subj":"T614","obj":"http://purl.obolibrary.org/obo/CHEBI_37256"},{"id":"A615","pred":"chebi_id","subj":"T615","obj":"http://purl.obolibrary.org/obo/CHEBI_27363"},{"id":"A616","pred":"chebi_id","subj":"T615","obj":"http://purl.obolibrary.org/obo/CHEBI_30185"},{"id":"A617","pred":"chebi_id","subj":"T617","obj":"http://purl.obolibrary.org/obo/CHEBI_27363"},{"id":"A618","pred":"chebi_id","subj":"T617","obj":"http://purl.obolibrary.org/obo/CHEBI_30185"},{"id":"A619","pred":"chebi_id","subj":"T619","obj":"http://purl.obolibrary.org/obo/CHEBI_37256"},{"id":"A620","pred":"chebi_id","subj":"T620","obj":"http://purl.obolibrary.org/obo/CHEBI_27363"},{"id":"A621","pred":"chebi_id","subj":"T620","obj":"http://purl.obolibrary.org/obo/CHEBI_30185"},{"id":"A622","pred":"chebi_id","subj":"T622","obj":"http://purl.obolibrary.org/obo/CHEBI_37256"}],"text":"Plasma zinc concentration is mainly regulated through a balance between intestinal absorption and renal excretion involving specific mechanisms sensitive to both dietary zinc availability and its cellular utilization. The majority of Zn2+ in blood binds to serum albumin, which represents the major zinc transporter/reservoir protein in plasma. On the other hand, labile-bound pool of Zn2+ labile complexes (e.g., of AA) and free Zn2+ are the biologically available forms of zinc for cellular internalization and/or enzymatic activities (0.1–1% of the total zinc in blood plasma under normal conditions). Free Zn2+ is subsequently accumulated by endothelial cells and zinc uptake and release by endothelial cells is the crucial step for redistribution of Zn2+ from plasma to tissues [91]."}

    LitCovid-PD-GO-BP

    {"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T97","span":{"begin":72,"end":93},"obj":"http://purl.obolibrary.org/obo/GO_0050892"},{"id":"T98","span":{"begin":104,"end":113},"obj":"http://purl.obolibrary.org/obo/GO_0007588"},{"id":"T99","span":{"begin":299,"end":315},"obj":"http://purl.obolibrary.org/obo/GO_0006829"},{"id":"T100","span":{"begin":668,"end":679},"obj":"http://purl.obolibrary.org/obo/GO_0071578"},{"id":"T101","span":{"begin":673,"end":679},"obj":"http://purl.obolibrary.org/obo/GO_0098739"},{"id":"T102","span":{"begin":673,"end":679},"obj":"http://purl.obolibrary.org/obo/GO_0098657"}],"text":"Plasma zinc concentration is mainly regulated through a balance between intestinal absorption and renal excretion involving specific mechanisms sensitive to both dietary zinc availability and its cellular utilization. The majority of Zn2+ in blood binds to serum albumin, which represents the major zinc transporter/reservoir protein in plasma. On the other hand, labile-bound pool of Zn2+ labile complexes (e.g., of AA) and free Zn2+ are the biologically available forms of zinc for cellular internalization and/or enzymatic activities (0.1–1% of the total zinc in blood plasma under normal conditions). Free Zn2+ is subsequently accumulated by endothelial cells and zinc uptake and release by endothelial cells is the crucial step for redistribution of Zn2+ from plasma to tissues [91]."}

    LitCovid-sentences

    {"project":"LitCovid-sentences","denotations":[{"id":"T230","span":{"begin":0,"end":217},"obj":"Sentence"},{"id":"T231","span":{"begin":218,"end":344},"obj":"Sentence"},{"id":"T232","span":{"begin":345,"end":604},"obj":"Sentence"},{"id":"T233","span":{"begin":605,"end":788},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Plasma zinc concentration is mainly regulated through a balance between intestinal absorption and renal excretion involving specific mechanisms sensitive to both dietary zinc availability and its cellular utilization. The majority of Zn2+ in blood binds to serum albumin, which represents the major zinc transporter/reservoir protein in plasma. On the other hand, labile-bound pool of Zn2+ labile complexes (e.g., of AA) and free Zn2+ are the biologically available forms of zinc for cellular internalization and/or enzymatic activities (0.1–1% of the total zinc in blood plasma under normal conditions). Free Zn2+ is subsequently accumulated by endothelial cells and zinc uptake and release by endothelial cells is the crucial step for redistribution of Zn2+ from plasma to tissues [91]."}

    2_test

    {"project":"2_test","denotations":[{"id":"32708755-30266430-20678823","span":{"begin":784,"end":786},"obj":"30266430"}],"text":"Plasma zinc concentration is mainly regulated through a balance between intestinal absorption and renal excretion involving specific mechanisms sensitive to both dietary zinc availability and its cellular utilization. The majority of Zn2+ in blood binds to serum albumin, which represents the major zinc transporter/reservoir protein in plasma. On the other hand, labile-bound pool of Zn2+ labile complexes (e.g., of AA) and free Zn2+ are the biologically available forms of zinc for cellular internalization and/or enzymatic activities (0.1–1% of the total zinc in blood plasma under normal conditions). Free Zn2+ is subsequently accumulated by endothelial cells and zinc uptake and release by endothelial cells is the crucial step for redistribution of Zn2+ from plasma to tissues [91]."}