PMC:7408073 / 4684-4925 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T86589","span":{"begin":48,"end":55},"obj":"Body_part"}],"attributes":[{"id":"A7793","pred":"fma_id","subj":"T86589","obj":"http://purl.org/sig/ont/fma/fma67257"}],"text":"Of note, its surface down-modulation upon spike protein challenge has been shown to be due to ACE2 shedding mediated by activation of extracellular ADAM17/TACE metalloprotease, which concomitantly induces shedding/production of TNFα [17,18]."}

{"project":"LitCovid-PubTator","denotations":[{"id":"232","span":{"begin":94,"end":98},"obj":"Gene"},{"id":"233","span":{"begin":148,"end":154},"obj":"Gene"},{"id":"234","span":{"begin":228,"end":232},"obj":"Gene"},{"id":"262","span":{"begin":42,"end":47},"obj":"Gene"}],"attributes":[{"id":"A232","pred":"tao:has_database_id","subj":"232","obj":"Gene:59272"},{"id":"A233","pred":"tao:has_database_id","subj":"233","obj":"Gene:6868"},{"id":"A234","pred":"tao:has_database_id","subj":"234","obj":"Gene:7124"},{"id":"A262","pred":"tao:has_database_id","subj":"262","obj":"Gene:43740568"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Of note, its surface down-modulation upon spike protein challenge has been shown to be due to ACE2 shedding mediated by activation of extracellular ADAM17/TACE metalloprotease, which concomitantly induces shedding/production of TNFα [17,18]."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T85406","span":{"begin":66,"end":69},"obj":"http://purl.obolibrary.org/obo/CLO_0051582"},{"id":"T60699","span":{"begin":120,"end":130},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"}],"text":"Of note, its surface down-modulation upon spike protein challenge has been shown to be due to ACE2 shedding mediated by activation of extracellular ADAM17/TACE metalloprotease, which concomitantly induces shedding/production of TNFα [17,18]."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T33","span":{"begin":48,"end":55},"obj":"Chemical"}],"attributes":[{"id":"A33","pred":"chebi_id","subj":"T33","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"}],"text":"Of note, its surface down-modulation upon spike protein challenge has been shown to be due to ACE2 shedding mediated by activation of extracellular ADAM17/TACE metalloprotease, which concomitantly induces shedding/production of TNFα [17,18]."}

{"project":"LitCovid-sentences","denotations":[{"id":"T26","span":{"begin":0,"end":241},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Of note, its surface down-modulation upon spike protein challenge has been shown to be due to ACE2 shedding mediated by activation of extracellular ADAM17/TACE metalloprotease, which concomitantly induces shedding/production of TNFα [17,18]."}

{"project":"2_test","denotations":[{"id":"32708755-18490652-20678659","span":{"begin":234,"end":236},"obj":"18490652"},{"id":"32708755-19864379-20678660","span":{"begin":237,"end":239},"obj":"19864379"}],"text":"Of note, its surface down-modulation upon spike protein challenge has been shown to be due to ACE2 shedding mediated by activation of extracellular ADAM17/TACE metalloprotease, which concomitantly induces shedding/production of TNFα [17,18]."}