PMC:7408073 / 430-761 JSONTXT

{"project":"LitCovid-PubTator","denotations":[{"id":"21","span":{"begin":87,"end":90},"obj":"Gene"},{"id":"22","span":{"begin":95,"end":99},"obj":"Gene"},{"id":"23","span":{"begin":233,"end":238},"obj":"Gene"},{"id":"27","span":{"begin":11,"end":17},"obj":"Species"},{"id":"28","span":{"begin":164,"end":172},"obj":"Species"},{"id":"30","span":{"begin":206,"end":211},"obj":"Chemical"},{"id":"32","span":{"begin":155,"end":163},"obj":"Disease"}],"attributes":[{"id":"A21","pred":"tao:has_database_id","subj":"21","obj":"Gene:59272"},{"id":"A22","pred":"tao:has_database_id","subj":"22","obj":"Gene:59272"},{"id":"A23","pred":"tao:has_database_id","subj":"23","obj":"Gene:5972"},{"id":"A27","pred":"tao:has_database_id","subj":"27","obj":"Tax:9606"},{"id":"A28","pred":"tao:has_database_id","subj":"28","obj":"Tax:9606"},{"id":"A30","pred":"tao:has_database_id","subj":"30","obj":"MESH:D008670"},{"id":"A32","pred":"tao:has_database_id","subj":"32","obj":"MESH:C000657245"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"in vivo to humans/rodents, a reasonable hypothesis of using inhibitors that block both ACE and ACE2 zinc metalloproteases and their downstream pathways in COVID-19 patients will be proposed. In particular, metal (zinc) chelators and renin inhibitors may work alone or in combination to inhibit the positive feedback loops (initiall"}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T4","span":{"begin":155,"end":163},"obj":"Disease"}],"attributes":[{"id":"A4","pred":"mondo_id","subj":"T4","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"}],"text":"in vivo to humans/rodents, a reasonable hypothesis of using inhibitors that block both ACE and ACE2 zinc metalloproteases and their downstream pathways in COVID-19 patients will be proposed. In particular, metal (zinc) chelators and renin inhibitors may work alone or in combination to inhibit the positive feedback loops (initiall"}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T1177","span":{"begin":11,"end":17},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9606"},{"id":"T48692","span":{"begin":27,"end":28},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"}],"text":"in vivo to humans/rodents, a reasonable hypothesis of using inhibitors that block both ACE and ACE2 zinc metalloproteases and their downstream pathways in COVID-19 patients will be proposed. In particular, metal (zinc) chelators and renin inhibitors may work alone or in combination to inhibit the positive feedback loops (initiall"}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T7","span":{"begin":60,"end":70},"obj":"Chemical"},{"id":"T8","span":{"begin":100,"end":104},"obj":"Chemical"},{"id":"T10","span":{"begin":213,"end":217},"obj":"Chemical"},{"id":"T12","span":{"begin":219,"end":228},"obj":"Chemical"},{"id":"T13","span":{"begin":239,"end":249},"obj":"Chemical"}],"attributes":[{"id":"A7","pred":"chebi_id","subj":"T7","obj":"http://purl.obolibrary.org/obo/CHEBI_35222"},{"id":"A8","pred":"chebi_id","subj":"T8","obj":"http://purl.obolibrary.org/obo/CHEBI_27363"},{"id":"A9","pred":"chebi_id","subj":"T8","obj":"http://purl.obolibrary.org/obo/CHEBI_30185"},{"id":"A10","pred":"chebi_id","subj":"T10","obj":"http://purl.obolibrary.org/obo/CHEBI_27363"},{"id":"A11","pred":"chebi_id","subj":"T10","obj":"http://purl.obolibrary.org/obo/CHEBI_30185"},{"id":"A12","pred":"chebi_id","subj":"T12","obj":"http://purl.obolibrary.org/obo/CHEBI_38161"},{"id":"A13","pred":"chebi_id","subj":"T13","obj":"http://purl.obolibrary.org/obo/CHEBI_35222"}],"text":"in vivo to humans/rodents, a reasonable hypothesis of using inhibitors that block both ACE and ACE2 zinc metalloproteases and their downstream pathways in COVID-19 patients will be proposed. In particular, metal (zinc) chelators and renin inhibitors may work alone or in combination to inhibit the positive feedback loops (initiall"}