PMC:7408073 / 4287-4540 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T18627","span":{"begin":24,"end":31},"obj":"Body_part"},{"id":"T66005","span":{"begin":68,"end":75},"obj":"Body_part"},{"id":"T74461","span":{"begin":125,"end":129},"obj":"Body_part"},{"id":"T26291","span":{"begin":157,"end":161},"obj":"Body_part"},{"id":"T89422","span":{"begin":162,"end":167},"obj":"Body_part"}],"attributes":[{"id":"A51983","pred":"fma_id","subj":"T18627","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A50982","pred":"fma_id","subj":"T66005","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A60686","pred":"fma_id","subj":"T74461","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A59604","pred":"fma_id","subj":"T26291","obj":"http://purl.org/sig/ont/fma/fma7195"},{"id":"A32979","pred":"fma_id","subj":"T89422","obj":"http://purl.org/sig/ont/fma/fma68646"}],"text":"The ability of spike-Fc protein treatment (3h) to downregulate ACE2 protein expression has been shown in an in vitro system (cell lines) and also in vivo in lung cells of mice [14,15], suggesting that ACE2 pathway may be down-modulated during infection."}

{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T8","span":{"begin":157,"end":161},"obj":"Body_part"}],"attributes":[{"id":"A8","pred":"uberon_id","subj":"T8","obj":"http://purl.obolibrary.org/obo/UBERON_0002048"}],"text":"The ability of spike-Fc protein treatment (3h) to downregulate ACE2 protein expression has been shown in an in vitro system (cell lines) and also in vivo in lung cells of mice [14,15], suggesting that ACE2 pathway may be down-modulated during infection."}

{"project":"LitCovid-PubTator","denotations":[{"id":"229","span":{"begin":63,"end":67},"obj":"Gene"},{"id":"230","span":{"begin":201,"end":205},"obj":"Gene"},{"id":"263","span":{"begin":15,"end":20},"obj":"Gene"},{"id":"267","span":{"begin":171,"end":175},"obj":"Species"},{"id":"290","span":{"begin":43,"end":45},"obj":"Chemical"},{"id":"292","span":{"begin":243,"end":252},"obj":"Disease"}],"attributes":[{"id":"A229","pred":"tao:has_database_id","subj":"229","obj":"Gene:70008"},{"id":"A230","pred":"tao:has_database_id","subj":"230","obj":"Gene:70008"},{"id":"A263","pred":"tao:has_database_id","subj":"263","obj":"Gene:43740568"},{"id":"A267","pred":"tao:has_database_id","subj":"267","obj":"Tax:10090"},{"id":"A290","pred":"tao:has_database_id","subj":"290","obj":"MESH:D014316"},{"id":"A292","pred":"tao:has_database_id","subj":"292","obj":"MESH:D007239"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"The ability of spike-Fc protein treatment (3h) to downregulate ACE2 protein expression has been shown in an in vitro system (cell lines) and also in vivo in lung cells of mice [14,15], suggesting that ACE2 pathway may be down-modulated during infection."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T59","span":{"begin":243,"end":252},"obj":"Disease"}],"attributes":[{"id":"A59","pred":"mondo_id","subj":"T59","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"}],"text":"The ability of spike-Fc protein treatment (3h) to downregulate ACE2 protein expression has been shown in an in vitro system (cell lines) and also in vivo in lung cells of mice [14,15], suggesting that ACE2 pathway may be down-modulated during infection."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T49004","span":{"begin":21,"end":23},"obj":"http://purl.obolibrary.org/obo/CLO_0052676"},{"id":"T42150","span":{"begin":87,"end":90},"obj":"http://purl.obolibrary.org/obo/CLO_0051582"},{"id":"T92578","span":{"begin":125,"end":135},"obj":"http://purl.obolibrary.org/obo/CLO_0000031"},{"id":"T47002","span":{"begin":157,"end":161},"obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"id":"T41775","span":{"begin":157,"end":161},"obj":"http://www.ebi.ac.uk/efo/EFO_0000934"},{"id":"T33694","span":{"begin":162,"end":167},"obj":"http://purl.obolibrary.org/obo/GO_0005623"}],"text":"The ability of spike-Fc protein treatment (3h) to downregulate ACE2 protein expression has been shown in an in vitro system (cell lines) and also in vivo in lung cells of mice [14,15], suggesting that ACE2 pathway may be down-modulated during infection."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T31","span":{"begin":24,"end":31},"obj":"Chemical"},{"id":"T32","span":{"begin":68,"end":75},"obj":"Chemical"}],"attributes":[{"id":"A31","pred":"chebi_id","subj":"T31","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A32","pred":"chebi_id","subj":"T32","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"}],"text":"The ability of spike-Fc protein treatment (3h) to downregulate ACE2 protein expression has been shown in an in vitro system (cell lines) and also in vivo in lung cells of mice [14,15], suggesting that ACE2 pathway may be down-modulated during infection."}

{"project":"LitCovid-sentences","denotations":[{"id":"T24","span":{"begin":0,"end":253},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"The ability of spike-Fc protein treatment (3h) to downregulate ACE2 protein expression has been shown in an in vitro system (cell lines) and also in vivo in lung cells of mice [14,15], suggesting that ACE2 pathway may be down-modulated during infection."}

{"project":"2_test","denotations":[{"id":"32708755-16007097-20678657","span":{"begin":177,"end":179},"obj":"16007097"},{"id":"32708755-16001071-20678658","span":{"begin":180,"end":182},"obj":"16001071"}],"text":"The ability of spike-Fc protein treatment (3h) to downregulate ACE2 protein expression has been shown in an in vitro system (cell lines) and also in vivo in lung cells of mice [14,15], suggesting that ACE2 pathway may be down-modulated during infection."}