> top > docs > PMC:7408073 > spans > 39383-43824 > annotations

PMC:7408073 / 39383-43824 JSONTXT

Annnotations TAB JSON ListView MergeView

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T251 654-660 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T252 844-850 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T253 1069-1075 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T254 1095-1102 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T255 1317-1322 Body_part denotes bowel http://purl.org/sig/ont/fma/fma7199
T256 1411-1417 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T257 1465-1471 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T258 1656-1662 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T259 1695-1701 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T260 1748-1754 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T261 1972-1978 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T262 2284-2290 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T263 2532-2537 Body_part denotes serum http://purl.org/sig/ont/fma/fma63083
T264 2743-2748 Body_part denotes serum http://purl.org/sig/ont/fma/fma63083
T265 2845-2851 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T266 2935-2940 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T267 3199-3205 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T268 3250-3255 Body_part denotes serum http://purl.org/sig/ont/fma/fma63083
T269 3435-3441 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T270 3560-3566 Body_part denotes kidney http://purl.org/sig/ont/fma/fma7203
T271 4291-4297 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T96 2532-2537 Body_part denotes serum http://purl.obolibrary.org/obo/UBERON_0001977
T97 2743-2748 Body_part denotes serum http://purl.obolibrary.org/obo/UBERON_0001977
T98 3250-3255 Body_part denotes serum http://purl.obolibrary.org/obo/UBERON_0001977
T99 3462-3465 Body_part denotes RAS http://purl.obolibrary.org/obo/UBERON_0018229
T100 3560-3566 Body_part denotes kidney http://purl.obolibrary.org/obo/UBERON_0002113

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
1576 0-4 Gene denotes ACE2 Gene:59272
1577 17-20 Gene denotes ACE Gene:59272
1578 443-446 Gene denotes ACE Gene:59272
1579 451-455 Gene denotes ACE2 Gene:59272
1580 484-492 Gene denotes Ang (1–9 Gene:284
1581 509-515 Gene denotes Ang II Gene:24179
1582 528-532 Gene denotes ACE2 Gene:59272
1583 576-580 Gene denotes ACE2 Gene:59272
1584 1362-1366 Gene denotes ACE2 Gene:59272
1585 3036-3039 Gene denotes ACE Gene:59272
1586 3044-3048 Gene denotes ACE2 Gene:59272
1587 3250-3263 Gene denotes serum albumin Gene:213
1588 3741-3745 Gene denotes ACE2 Gene:59272
1589 3985-3989 Gene denotes ACE2 Gene:59272
1590 1079-1086 Gene denotes albumin Gene:213
1591 4400-4407 Gene denotes albumin Gene:213
1592 4298-4305 Gene denotes albumin Gene:213
1593 3895-3902 Gene denotes albumin Gene:213
1594 3410-3417 Gene denotes albumin Gene:213
1595 2895-2902 Gene denotes albumin Gene:213
1596 2049-2056 Gene denotes albumin Gene:213
1597 1845-1852 Gene denotes albumin Gene:213
1598 1663-1670 Gene denotes albumin Gene:213
1599 1543-1550 Gene denotes albumin Gene:213
1600 1495-1502 Gene denotes albumin Gene:213
1601 1436-1443 Gene denotes albumin Gene:213
1602 681-689 Species denotes patients Tax:9606
1603 883-891 Species denotes patients Tax:9606
1604 1160-1170 Species denotes SARS-CoV-2 Tax:2697049
1605 1819-1827 Species denotes patients Tax:9606
1606 2001-2009 Species denotes patients Tax:9606
1607 3133-3141 Species denotes patients Tax:9606
1608 3539-3547 Species denotes patients Tax:9606
1609 3575-3583 Species denotes patients Tax:9606
1610 3836-3844 Species denotes patients Tax:9606
1611 4220-4228 Species denotes patients Tax:9606
1612 4332-4340 Species denotes patients Tax:9606
1613 4387-4395 Species denotes patients Tax:9606
1614 2526-2531 Species denotes human Tax:9606
1615 473-479 Gene denotes Ang II Gene:24179
1616 2349-2356 Gene denotes albumin Gene:213
1617 88-92 Chemical denotes EDTA MESH:D004492
1618 133-141 Chemical denotes chloride MESH:D002712
1619 145-153 Chemical denotes fluoride MESH:D005459
1620 212-220 Chemical denotes chloride MESH:D002712
1621 401-409 Chemical denotes chloride MESH:D002712
1622 550-558 Chemical denotes chloride MESH:D002712
1623 691-699 Chemical denotes chloride MESH:D002712
1624 2782-2787 Chemical denotes metal MESH:D008670
1625 2801-2805 Chemical denotes iron MESH:D007501
1626 3169-3180 Chemical denotes Ang peptide
1627 4084-4088 Chemical denotes Zn2+
1628 4182-4186 Chemical denotes Zn2+
1629 672-680 Disease denotes COVID–19 MESH:C000657245
1630 874-882 Disease denotes COVID-19 MESH:C000657245
1631 1189-1224 Disease denotes adult respiratory distress syndrome MESH:D012128
1632 1226-1230 Disease denotes ARDS MESH:D012128
1633 1234-1242 Disease denotes COVID-19 MESH:C000657245
1634 1304-1330 Disease denotes inflammatory bowel disease MESH:D015212
1635 1332-1335 Disease denotes IBD MESH:D015212
1636 1814-1818 Disease denotes ARDS MESH:D012128
1637 1922-1938 Disease denotes hypoalbuminaemia
1638 1996-2000 Disease denotes ARDS MESH:D012128
1639 3128-3132 Disease denotes ARDS MESH:D012128
1640 3224-3228 Disease denotes ARDS MESH:D012128
1641 3274-3282 Disease denotes COVID-19 MESH:C000657245
1642 3512-3538 Disease denotes asthmatic/allergic disease MESH:D004342
1643 3552-3574 Disease denotes chronic kidney disease MESH:D051436
1644 3605-3627 Disease denotes cardiovascular disease MESH:D002318
1645 3665-3673 Disease denotes COVID-19 MESH:C000657245
1646 3814-3835 Disease denotes chronic renal disease MESH:D051436
1647 4002-4024 Disease denotes chronic renal diseases MESH:D051436
1648 4213-4219 Disease denotes asthma MESH:D001249
1649 4325-4331 Disease denotes asthma MESH:D001249

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T234 672-680 Disease denotes COVID–19 http://purl.obolibrary.org/obo/MONDO_0100096
T235 874-882 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T236 1160-1168 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T237 1160-1164 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T238 1189-1224 Disease denotes adult respiratory distress syndrome http://purl.obolibrary.org/obo/MONDO_0006502
T239 1195-1224 Disease denotes respiratory distress syndrome http://purl.obolibrary.org/obo/MONDO_0009971
T240 1226-1230 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T241 1234-1242 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T242 1304-1330 Disease denotes inflammatory bowel disease http://purl.obolibrary.org/obo/MONDO_0005265
T243 1332-1335 Disease denotes IBD http://purl.obolibrary.org/obo/MONDO_0005052|http://purl.obolibrary.org/obo/MONDO_0005265
T245 1814-1818 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T246 1996-2000 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T247 3128-3132 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T248 3224-3228 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T249 3274-3282 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T250 3522-3538 Disease denotes allergic disease http://purl.obolibrary.org/obo/MONDO_0005271
T251 3522-3530 Disease denotes allergic http://purl.obolibrary.org/obo/MONDO_0004980
T252 3552-3574 Disease denotes chronic kidney disease http://purl.obolibrary.org/obo/MONDO_0005300
T253 3560-3574 Disease denotes kidney disease http://purl.obolibrary.org/obo/MONDO_0001343|http://purl.obolibrary.org/obo/MONDO_0005240
T255 3605-3627 Disease denotes cardiovascular disease http://purl.obolibrary.org/obo/MONDO_0004995
T256 3665-3673 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T257 3814-3835 Disease denotes chronic renal disease http://purl.obolibrary.org/obo/MONDO_0005300
T258 3822-3835 Disease denotes renal disease http://purl.obolibrary.org/obo/MONDO_0002118|http://purl.obolibrary.org/obo/MONDO_0005240
T260 4002-4024 Disease denotes chronic renal diseases http://purl.obolibrary.org/obo/MONDO_0005300
T261 4046-4050 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T262 4213-4219 Disease denotes asthma http://purl.obolibrary.org/obo/MONDO_0004979
T263 4325-4331 Disease denotes asthma http://purl.obolibrary.org/obo/MONDO_0004979

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T492 25-26 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T493 97-106 http://purl.obolibrary.org/obo/CLO_0001658 denotes activated
T494 325-335 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T495 611-617 http://purl.obolibrary.org/obo/CLO_0001658 denotes active
T496 654-660 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T497 844-850 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T498 930-940 http://purl.obolibrary.org/obo/CLO_0001658 denotes activities
T499 1069-1075 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T500 1093-1094 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T501 1232-1233 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T502 1337-1338 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T503 1367-1375 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T504 1411-1417 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T505 1465-1471 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T506 1656-1662 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T507 1695-1701 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T508 1748-1754 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T509 1781-1782 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T510 1972-1978 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T511 2284-2290 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T512 2372-2373 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T513 2451-2452 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T514 2526-2531 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T515 2624-2631 http://purl.obolibrary.org/obo/UBERON_0003100 denotes females
T516 2664-2669 http://purl.obolibrary.org/obo/UBERON_0003101 denotes males
T517 2664-2669 http://www.ebi.ac.uk/efo/EFO_0000970 denotes males
T518 2845-2851 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T519 2935-2940 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T520 3068-3076 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T521 3173-3180 http://purl.obolibrary.org/obo/PR_000018263 denotes peptide
T522 3199-3205 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T523 3379-3380 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T524 3435-3441 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T525 3466-3474 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T526 3560-3566 http://purl.obolibrary.org/obo/UBERON_0002113 denotes kidney
T527 3560-3566 http://www.ebi.ac.uk/efo/EFO_0000927 denotes kidney
T528 3560-3566 http://www.ebi.ac.uk/efo/EFO_0000929 denotes kidney
T529 3592-3593 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T530 3682-3683 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T531 3746-3754 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T532 3990-3998 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T533 4070-4071 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T534 4106-4107 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T535 4138-4139 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T536 4291-4297 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T362 27-31 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T364 73-77 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T366 88-92 Chemical denotes EDTA http://purl.obolibrary.org/obo/CHEBI_42191|http://purl.obolibrary.org/obo/CHEBI_64755
T368 133-141 Chemical denotes chloride http://purl.obolibrary.org/obo/CHEBI_17996
T369 145-153 Chemical denotes fluoride http://purl.obolibrary.org/obo/CHEBI_17051
T370 154-160 Chemical denotes anions http://purl.obolibrary.org/obo/CHEBI_22563
T371 165-176 Chemical denotes zinc cation http://purl.obolibrary.org/obo/CHEBI_29105|http://purl.obolibrary.org/obo/CHEBI_63056
T373 165-169 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T375 170-176 Chemical denotes cation http://purl.obolibrary.org/obo/CHEBI_36916
T376 212-220 Chemical denotes chloride http://purl.obolibrary.org/obo/CHEBI_17996
T377 226-230 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T379 310-315 Chemical denotes anion http://purl.obolibrary.org/obo/CHEBI_22563
T380 320-324 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T382 401-409 Chemical denotes chloride http://purl.obolibrary.org/obo/CHEBI_17996
T383 410-414 Chemical denotes ions http://purl.obolibrary.org/obo/CHEBI_24870
T384 425-428 Chemical denotes Ang http://purl.obolibrary.org/obo/CHEBI_48433
T385 473-476 Chemical denotes Ang http://purl.obolibrary.org/obo/CHEBI_48433
T386 477-479 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T387 484-487 Chemical denotes Ang http://purl.obolibrary.org/obo/CHEBI_48433
T388 509-512 Chemical denotes Ang http://purl.obolibrary.org/obo/CHEBI_48433
T389 513-515 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T390 550-558 Chemical denotes chloride http://purl.obolibrary.org/obo/CHEBI_17996
T391 691-699 Chemical denotes chloride http://purl.obolibrary.org/obo/CHEBI_17996
T392 851-855 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T394 1061-1065 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T396 1095-1102 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T397 1403-1407 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T399 1472-1476 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T401 1566-1570 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T403 1717-1721 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T405 1755-1759 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T407 1904-1908 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T409 1957-1961 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T411 2040-2044 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T413 2098-2102 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T415 2125-2129 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T417 2177-2181 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T419 2291-2295 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T421 2344-2348 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T423 2399-2403 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T425 2504-2508 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T427 2592-2596 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T429 2691-2695 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T431 2767-2771 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T433 2788-2792 Chemical denotes ions http://purl.obolibrary.org/obo/CHEBI_24870
T434 2801-2805 Chemical denotes iron http://purl.obolibrary.org/obo/CHEBI_18248
T435 2852-2856 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T437 2918-2922 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T439 3008-3012 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T441 3169-3172 Chemical denotes Ang http://purl.obolibrary.org/obo/CHEBI_48433
T442 3173-3180 Chemical denotes peptide http://purl.obolibrary.org/obo/CHEBI_16670
T443 3462-3465 Chemical denotes RAS http://purl.obolibrary.org/obo/CHEBI_63620
T444 3725-3729 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T446 3854-3858 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T448 3922-3926 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T450 4084-4087 Chemical denotes Zn2 http://purl.obolibrary.org/obo/CHEBI_37256
T451 4182-4185 Chemical denotes Zn2 http://purl.obolibrary.org/obo/CHEBI_37256

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T71 1036-1047 http://purl.obolibrary.org/obo/GO_0006810 denotes transporter
T72 2918-2929 http://purl.obolibrary.org/obo/GO_0071578 denotes zinc import
T73 3927-3936 http://purl.obolibrary.org/obo/GO_0007588 denotes excretion
T74 4095-4104 http://purl.obolibrary.org/obo/GO_0007588 denotes excretion

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T188 0-185 Sentence denotes ACE2, as well as ACE, is a zinc metalloprotease that can be inhibited by zinc chelating EDTA and activated by high concentrations of chloride or fluoride anions and zinc cation [79,90].
T189 186-250 Sentence denotes Indeed, both enzymes have chloride- and zinc-binding sites [90].
T190 251-375 Sentence denotes It is conceivable that these sites are responsible for the anion and zinc activation effect in both homologous enzymes [90].
T191 376-634 Sentence denotes However, the presence of chloride ions increases Ang I cleavage by ACE and ACE2 (increasing both Ang II and Ang (1–9)) and decreases Ang II cleavage by ACE2, suggesting that chloride induces specific ACE2 conformational changes in its active site (see [44]).
T192 635-805 Sentence denotes To this regard, in plasma samples of COVID–19 patients, chloride range is usually normal or slightly higher (99.6–107.0 mmol/L) than normal values (96.–106.0 mmol/L) [5].
T193 806-892 Sentence denotes Unfortunately, I was not able to find plasma zinc concentrations in COVID-19 patients.
T194 893-1012 Sentence denotes Zinc is involved in several cellular activities and its systemic concentration is tightly regulated by several factors.
T195 1013-1613 Sentence denotes Of interest, the major transporter/reservoir of zinc in plasma is albumin [91], a protein that was detected at significantly low concentrations in SARS-CoV-2 as well as severe adult respiratory distress syndrome (ARDS, a COVID-19-like disease) (usually < 3.5 g/dL, normal range 3.5–5.4) and inflammatory bowel disease (IBD, a disease with increased ACE2 activity) [6,8,66,92] Since most of zinc in plasma is sequestered by albumin, the total amount of plasma zinc mostly depends on albumin concentration and even small changes in albumin’s capacity for zinc binding may have significant consequences.
T196 1614-1836 Sentence denotes To this regard, reduced concentrations of plasma albumin is believed to increase plasma levels of free zinc, while reducing the total plasma zinc concentrations [91], a condition that was observed in ARDS patients [93,94].
T197 1837-1979 Sentence denotes Indeed, albumin can potentially deplete free bioavailable forms of zinc; vice versa, hypoalbuminaemia may increase free zinc levels in plasma.
T198 1980-2115 Sentence denotes Therefore, some ARDS patients with low levels of both total zinc and albumin might have rather higher than lower free zinc levels [93].
T199 2116-2330 Sentence denotes The free zinc concentration, which describes the fraction of zinc that is loosely bound and easily exchangeable, represents the highly bioavailable (and toxic) part of plasma zinc but it is not clinically detected.
T200 2331-2411 Sentence denotes To that end, zinc/albumin ratio might be a surrogate marker of free zinc levels.
T201 2412-2551 Sentence denotes Indeed, only recently it was described a fluorescence-based method for determining the free zinc concentration in human serum samples [95].
T202 2552-2675 Sentence denotes With this method it was shown that free zinc concentration in sera from females was significantly lower than in males [95].
T203 2676-2825 Sentence denotes Moreover, free zinc concentration did correlate neither with total serum concentrations of zinc (or other metal ions such as iron) nor with age [95].
T204 2826-3049 Sentence denotes Notably, increased plasma zinc bioavailability consequent to reduced albumin levels induces zinc import into cells and likely increases the cellular functions associated to cellular zinc concentrations such as ACE and ACE2.
T205 3050-3236 Sentence denotes Indeed, enzymatic activity of both enzymes seems significantly upregulated in ARDS patients as detected by analysis of Ang peptide concentrations in plasma (see Box later in ARDS topic).
T206 3237-3475 Sentence denotes In addition, serum albumin levels in COVID-19 were usually very low (in severe forms is usually < 3.1 g/dL) [6,8], raising the possibility of a negative correlation between albumin concentration in plasma and increase of the RAS activity.
T207 3476-3798 Sentence denotes In line with these hypotheses, both asthmatic/allergic disease patients and chronic kidney disease patients without a history of cardiovascular disease, which are protected from developing COVID-19, showed a significant decrease in both circulating zinc levels and ACE2 activity as compared to normal values [96,97,98,99].
T208 3799-4105 Sentence denotes Interestingly, chronic renal disease patients with low zinc levels had normal concentrations of albumin but higher urinary zinc excretion than healthy controls [97], suggesting that low ACE2 activity in chronic renal diseases (and protection from SARS) might derive from a higher free Zn2+ renal excretion.
T209 4106-4243 Sentence denotes A similar mechanism mediated by a reduction of extracellular levels of free Zn2+ might be hypothesised for asthma patients, as well [98].
T210 4244-4441 Sentence denotes Unfortunately, I could not find information on plasma albumin concentrations for asthma patients; nevertheless, we might suppose that in these patients the albumin concentration is in normal range.

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T64 1195-1215 Phenotype denotes respiratory distress http://purl.obolibrary.org/obo/HP_0002098
T65 1304-1330 Phenotype denotes inflammatory bowel disease http://purl.obolibrary.org/obo/HP_0002037
T66 1922-1938 Phenotype denotes hypoalbuminaemia http://purl.obolibrary.org/obo/HP_0003073
T67 3552-3574 Phenotype denotes chronic kidney disease http://purl.obolibrary.org/obo/HP_0012622
T68 3605-3627 Phenotype denotes cardiovascular disease http://purl.obolibrary.org/obo/HP_0001626
T69 4213-4219 Phenotype denotes asthma http://purl.obolibrary.org/obo/HP_0002099
T70 4325-4331 Phenotype denotes asthma http://purl.obolibrary.org/obo/HP_0002099

2_test

Id Subject Object Predicate Lexical cue
32708755-20599443-20678782 629-631 20599443 denotes 44
32708755-32109013-20678783 802-803 32109013 denotes 5
32708755-30266430-20678784 1088-1090 30266430 denotes 91
32708755-32294485-20678785 1378-1379 32294485 denotes 6
32708755-31986264-20678786 1380-1381 31986264 denotes 8
32708755-24505094-20678787 1382-1384 24505094 denotes 66
32708755-30845246-20678788 1385-1387 30845246 denotes 92
32708755-30266430-20678789 1776-1778 30266430 denotes 91
32708755-21827444-20678790 1829-1831 21827444 denotes 93
32708755-28570269-20678791 1832-1834 28570269 denotes 94
32708755-21827444-20678792 2111-2113 21827444 denotes 93
32708755-31426452-20678793 2547-2549 31426452 denotes 95
32708755-31426452-20678794 2671-2673 31426452 denotes 95
32708755-31426452-20678795 2821-2823 31426452 denotes 95
32708755-32294485-20678796 3346-3347 32294485 denotes 6
32708755-31986264-20678797 3348-3349 31986264 denotes 8
32708755-25813276-20678798 3785-3787 25813276 denotes 96