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PMC:7408073 / 3877-13772 JSONTXT

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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T21234 138-145 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T2030 204-209 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T47742 255-271 Body_part denotes epithelial cells http://purl.org/sig/ont/fma/fma66768
T6114 266-271 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T36553 285-302 Body_part denotes endothelial cells http://purl.org/sig/ont/fma/fma66772
T93384 297-302 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T78860 372-376 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T18627 434-441 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T66005 478-485 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T74461 535-539 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T26291 567-571 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T89422 572-577 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T39415 735-747 Body_part denotes cell surface http://purl.org/sig/ont/fma/fma67653
T6412 735-739 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T55226 764-773 Body_part denotes epithelia http://purl.org/sig/ont/fma/fma9639
T86589 855-862 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T74128 1121-1128 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T10664 1150-1154 Body_part denotes IL-1 http://purl.org/sig/ont/fma/fma86583
T4715 1178-1187 Body_part denotes cytokines http://purl.org/sig/ont/fma/fma84050
T30405 1194-1203 Body_part denotes cytokines http://purl.org/sig/ont/fma/fma84050
T89383 1368-1377 Body_part denotes epithelia http://purl.org/sig/ont/fma/fma9639
T34441 1478-1485 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T53940 1510-1517 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T48489 1551-1556 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T22482 1612-1619 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T54868 1991-1998 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T83587 2021-2026 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T57345 2658-2665 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T54062 2752-2767 Body_part denotes protein complex http://purl.org/sig/ont/fma/fma67906
T62408 3106-3110 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T81532 3149-3154 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T50862 3428-3448 Body_part denotes bronchial epithelium http://purl.org/sig/ont/fma/fma67782
T15477 3438-3448 Body_part denotes epithelium http://purl.org/sig/ont/fma/fma9639
T22792 3546-3562 Body_part denotes epithelial cells http://purl.org/sig/ont/fma/fma66768
T24903 3557-3562 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T67719 3733-3740 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T43 3837-3841 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T44 3960-3977 Body_part denotes protein complexes http://purl.org/sig/ont/fma/fma67906
T45 3960-3967 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T46 4044-4052 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T47 4150-4157 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T48 4321-4329 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T49 4360-4364 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T50 4365-4380 Body_part denotes plasma-membrane http://purl.org/sig/ont/fma/fma63841
T51 4417-4430 Body_part denotes glycoproteins http://purl.org/sig/ont/fma/fma62925
T52 4506-4513 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T53 4574-4582 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T54 4878-4890 Body_part denotes glycoprotein http://purl.org/sig/ont/fma/fma62925
T55 5062-5066 Body_part denotes hand http://purl.org/sig/ont/fma/fma9712
T56 5134-5138 Body_part denotes hand http://purl.org/sig/ont/fma/fma9712
T57 5173-5190 Body_part denotes cellular membrane http://purl.org/sig/ont/fma/fma63841
T58 5221-5225 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T59 5598-5608 Body_part denotes amino acid http://purl.org/sig/ont/fma/fma82739
T60 5675-5682 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T61 5753-5760 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T62 5958-5971 Body_part denotes cell membrane http://purl.org/sig/ont/fma/fma63841
T63 5958-5962 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T64 6154-6158 Body_part denotes neck http://purl.org/sig/ont/fma/fma7155
T65 6212-6217 Body_part denotes helix http://purl.org/sig/ont/fma/fma60992
T66 6322-6333 Body_part denotes amino acids http://purl.org/sig/ont/fma/fma82739
T67 6373-6377 Body_part denotes neck http://purl.org/sig/ont/fma/fma7155
T68 6642-6654 Body_part denotes cell surface http://purl.org/sig/ont/fma/fma67653
T69 6642-6646 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T70 6715-6720 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T71 6806-6810 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T72 6854-6863 Body_part denotes endosomal http://purl.org/sig/ont/fma/fma67180
T73 6934-6941 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T74 7215-7222 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T75 7353-7361 Body_part denotes cytokine http://purl.org/sig/ont/fma/fma84050
T76 7427-7435 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T77 7807-7812 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T78 7962-7968 Body_part denotes sputum http://purl.org/sig/ont/fma/fma312401
T79 8057-8063 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T80 8070-8073 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T81 8135-8146 Body_part denotes lymphocytes http://purl.org/sig/ont/fma/fma62863
T82 8164-8167 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T83 8200-8203 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T84 8209-8215 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T85 8231-8234 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T86 8332-8338 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T87 8586-8592 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T88 8593-8596 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T89 8926-8930 Body_part denotes hand http://purl.org/sig/ont/fma/fma9712
T90 9315-9323 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T91 9385-9392 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T92 9465-9473 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T93 9774-9780 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T7 372-376 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T8 567-571 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T9 764-773 Body_part denotes epithelia http://purl.obolibrary.org/obo/UBERON_0000483
T10 1368-1377 Body_part denotes epithelia http://purl.obolibrary.org/obo/UBERON_0000483
T11 3428-3448 Body_part denotes bronchial epithelium http://purl.obolibrary.org/obo/UBERON_0002031
T12 3438-3448 Body_part denotes epithelium http://purl.obolibrary.org/obo/UBERON_0000483
T13 3837-3841 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T14 5062-5066 Body_part denotes hand http://purl.obolibrary.org/obo/UBERON_0002398
T15 5134-5138 Body_part denotes hand http://purl.obolibrary.org/obo/UBERON_0002398
T16 6154-6158 Body_part denotes neck http://purl.obolibrary.org/obo/UBERON_0000974
T17 6212-6217 Body_part denotes helix http://purl.obolibrary.org/obo/UBERON_0002488
T18 6373-6377 Body_part denotes neck http://purl.obolibrary.org/obo/UBERON_0000974
T19 7792-7798 Body_part denotes organs http://purl.obolibrary.org/obo/UBERON_0000062
T20 7962-7968 Body_part denotes sputum http://purl.obolibrary.org/obo/UBERON_0007311
T21 8926-8930 Body_part denotes hand http://purl.obolibrary.org/obo/UBERON_0002398

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
145 3-7 Gene denotes ACE2 Gene:59272
146 17-25 Species denotes SARS-CoV Tax:694009
147 30-51 Disease denotes SARS-CoV-2 Infections MESH:C000657245
226 52-83 Gene denotes Angiotensin-converting enzyme 2 Gene:59272
227 85-89 Gene denotes ACE2 Gene:59272
228 216-220 Gene denotes ACE2 Gene:59272
229 473-477 Gene denotes ACE2 Gene:70008
230 611-615 Gene denotes ACE2 Gene:70008
231 673-677 Gene denotes ACE2 Gene:59272
232 901-905 Gene denotes ACE2 Gene:59272
233 955-961 Gene denotes ADAM17 Gene:6868
234 1035-1039 Gene denotes TNFα Gene:7124
235 1064-1068 Gene denotes ACE2 Gene:59272
236 1150-1155 Gene denotes IL-1β Gene:3552
237 1160-1164 Gene denotes TNFα Gene:7124
238 1302-1306 Gene denotes ACE2 Gene:59272
239 1596-1600 Gene denotes ACE2 Gene:59272
240 1664-1668 Gene denotes ACE2 Gene:59272
241 1745-1751 Gene denotes ADAM17 Gene:6868
242 1752-1756 Gene denotes TACE Gene:6868
243 1766-1770 Gene denotes ACE2 Gene:59272
244 1783-1787 Gene denotes ACE2 Gene:59272
245 1968-1972 Gene denotes ACE2 Gene:59272
246 2008-2012 Gene denotes ACE2 Gene:59272
247 2082-2086 Gene denotes ACE2 Gene:59272
248 2245-2249 Gene denotes ACE2 Gene:59272
249 2539-2544 Gene denotes renin Gene:5972
250 2549-2562 Gene denotes angiotensin I Gene:183
251 2581-2584 Gene denotes ACE Gene:59272
252 2585-2589 Gene denotes ACE2 Gene:59272
253 2696-2700 Gene denotes ACE2 Gene:59272
254 2923-2927 Gene denotes ACE2 Gene:59272
255 3125-3129 Gene denotes ACE2 Gene:59272
256 3290-3294 Gene denotes ACE2 Gene:59272
257 3403-3407 Gene denotes ACE2 Gene:59272
258 3657-3661 Gene denotes ACE2 Gene:59272
259 3672-3676 Gene denotes ACE2 Gene:59272
260 3782-3786 Gene denotes ACE2 Gene:59272
261 3867-3871 Gene denotes ACE2 Gene:59272
262 849-854 Gene denotes spike Gene:43740568
263 425-430 Gene denotes spike Gene:43740568
264 128-133 Gene denotes spike Gene:43740568
265 149-157 Species denotes SARS-CoV Tax:694009
266 395-403 Species denotes SARS-CoV Tax:694009
267 581-585 Species denotes mice Tax:10090
268 751-756 Species denotes human Tax:9606
269 1267-1275 Species denotes patients Tax:9606
270 1355-1360 Species denotes human Tax:9606
271 1623-1631 Species denotes SARS-CoV Tax:694009
272 1938-1941 Species denotes CoV Tax:11118
273 2622-2630 Species denotes SARS-CoV Tax:694009
274 2631-2639 Species denotes patients Tax:9606
275 3133-3138 Species denotes human Tax:9606
276 3169-3177 Species denotes SARS-CoV Tax:694009
277 3597-3605 Species denotes patients Tax:9606
278 3638-3648 Species denotes SARS-CoV-2 Tax:2697049
279 3744-3754 Species denotes SARS-CoV-2 Tax:2697049
280 3810-3820 Species denotes SARS-CoV-2 Tax:2697049
281 3902-3910 Species denotes SARS-CoV Tax:694009
282 3727-3732 Gene denotes spike Gene:43740568
283 2746-2751 Gene denotes spike Gene:43740568
284 2652-2657 Gene denotes spike Gene:43740568
285 1985-1990 Gene denotes spike Gene:43740568
286 1606-1611 Gene denotes spike Gene:43740568
287 1504-1509 Gene denotes spike Gene:43740568
288 1466-1471 Gene denotes spike Gene:43740568
289 1115-1120 Gene denotes spike Gene:43740568
290 453-455 Chemical denotes 3h MESH:D014316
291 372-383 Disease denotes lung injury MESH:D055370
292 653-662 Disease denotes infection MESH:D007239
293 1258-1266 Disease denotes COVID-19 MESH:C000657245
294 1865-1880 Disease denotes viral infection MESH:D001102
295 2180-2198 Disease denotes SARS-CoV infection MESH:C000657245
296 2328-2343 Disease denotes viral infection MESH:D001102
297 2465-2493 Disease denotes cardiovascular complications MESH:D002318
298 2504-2515 Disease denotes hypotension MESH:D007022
299 2595-2606 Disease denotes tachycardia MESH:D013610
300 3155-3163 Disease denotes infected MESH:D007239
301 3214-3223 Disease denotes infection MESH:D007239
302 3344-3353 Disease denotes infection MESH:D007239
303 3837-3848 Disease denotes lung injury MESH:D055370
307 3955-3959 Gene denotes ACE2 Gene:59272
308 3991-3995 Gene denotes ACE2 Gene:59272
309 3949-3954 Gene denotes spike Gene:43740568
357 4116-4120 Gene denotes ACE2 Gene:59272
358 4316-4320 Gene denotes ACE2 Gene:59272
359 4471-4504 Gene denotes capsid-distal S1 and –proximal S2
360 4679-4683 Gene denotes ACE2 Gene:59272
361 4851-4855 Gene denotes ACE2 Gene:59272
362 4909-4915 Gene denotes ADAM17 Gene:6868
363 4925-4929 Gene denotes ACE2 Gene:59272
364 4986-4991 Gene denotes furin Gene:5045
365 5077-5081 Gene denotes ACE2 Gene:59272
366 5416-5420 Gene denotes ACE2 Gene:59272
367 5546-5550 Gene denotes ACE2 Gene:59272
368 5621-5626 Gene denotes B0AT1 Gene:340024
369 5643-5647 Gene denotes ACE2 Gene:59272
370 5699-5703 Gene denotes ACE2 Gene:59272
371 5775-5779 Gene denotes ACE2 Gene:59272
372 5812-5816 Gene denotes ACE2 Gene:59272
373 5998-6002 Gene denotes ACE2 Gene:59272
374 6036-6040 Gene denotes ACE2 Gene:59272
375 6252-6256 Gene denotes ACE2 Gene:59272
376 6283-6289 Gene denotes ADAM17 Gene:6868
377 6290-6294 Gene denotes TACE Gene:6868
378 6404-6408 Gene denotes ACE2 Gene:59272
379 6473-6477 Gene denotes ACE2 Gene:59272
380 6532-6536 Gene denotes ACE2 Gene:59272
381 6586-6591 Gene denotes B0AT1 Gene:340024
382 6883-6890 Gene denotes TMPRSS2 Gene:7113
383 6922-6926 Gene denotes ACE2 Gene:59272
384 6916-6921 Gene denotes spike Gene:43740568
385 5747-5752 Gene denotes spike Gene:43740568
386 5669-5674 Gene denotes spike Gene:43740568
387 5029-5034 Gene denotes spike Gene:43740568
388 4568-4573 Gene denotes Spike Gene:43740568
389 4464-4469 Gene denotes spike Gene:43740568
390 4411-4416 Gene denotes spike Gene:43740568
391 4300-4305 Gene denotes spike Gene:43740568
392 4199-4208 Species denotes SARS-CoVs Tax:694009
393 4386-4402 Species denotes SARS coronavirus Tax:694009
394 4587-4592 Species denotes clove Tax:219868
395 5271-5279 Species denotes SARS-CoV Tax:694009
396 5401-5411 Species denotes SARS-CoV-2 Tax:2697049
397 5540-5545 Species denotes human Tax:9606
398 6678-6686 Species denotes SARS-CoV Tax:694009
399 4872-4877 Gene denotes spike Gene:43740568
400 4346-4354 Disease denotes infected MESH:D007239
401 5226-5235 Disease denotes infection MESH:D007239
402 5296-5305 Disease denotes infection MESH:D007239
403 7006-7015 Disease denotes infection MESH:D007239
437 7150-7154 Gene denotes ACE2 Gene:59272
438 7311-7315 Gene denotes ACE2 Gene:59272
439 7422-7426 Gene denotes ACE2 Gene:59272
440 7824-7828 Gene denotes ACE2 Gene:59272
441 8730-8734 Gene denotes ACE2 Gene:59272
442 9191-9195 Gene denotes ACE2 Gene:59272
443 9379-9384 Gene denotes spike Gene:43740568
444 9309-9314 Gene denotes spike Gene:43740568
445 7140-7145 Gene denotes spike Gene:43740568
446 7128-7136 Species denotes patients Tax:9606
447 7488-7498 Species denotes SARS-CoV-2 Tax:2697049
448 7556-7566 Species denotes SARS-CoV-2 Tax:2697049
449 7660-7670 Species denotes SARS-CoV-2 Tax:2697049
450 7978-7986 Species denotes SARS-CoV Tax:694009
451 7987-7995 Species denotes patients Tax:9606
452 8191-8199 Species denotes SARS-CoV Tax:694009
453 8277-8285 Species denotes patients Tax:9606
454 8353-8361 Species denotes patients Tax:9606
455 8541-8549 Species denotes patients Tax:9606
456 8630-8638 Species denotes patients Tax:9606
457 8701-8709 Species denotes children Tax:9606
458 9097-9107 Species denotes SARS-CoV-2 Tax:2697049
459 9262-9272 Species denotes SARS-CoV-2 Tax:2697049
460 9588-9601 Species denotes coronaviruses Tax:11118
461 7110-7118 Disease denotes COVID-19 MESH:C000657245
462 7119-7127 Disease denotes infected MESH:D007239
463 8344-8352 Disease denotes COVID-19 MESH:C000657245
464 8430-8438 Disease denotes COVID-19 MESH:C000657245
465 8513-8530 Disease denotes SARS-CoV infected MESH:C000657245
466 8766-8782 Disease denotes Kawasaki disease MESH:D009080
467 9631-9640 Disease denotes infection MESH:D007239
468 9786-9794 Disease denotes COVID-19 MESH:C000657245
469 9866-9874 Disease denotes COVID-19 MESH:C000657245

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T48 17-25 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T49 17-21 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T50 30-38 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T51 30-34 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T52 149-157 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T53 149-153 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T54 366-383 Disease denotes acute lung injury http://purl.obolibrary.org/obo/MONDO_0006502|http://purl.obolibrary.org/obo/MONDO_0015796
T56 377-383 Disease denotes injury http://purl.obolibrary.org/obo/MONDO_0021178
T57 395-403 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T58 395-399 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T59 653-662 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T60 1258-1266 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T61 1623-1631 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T62 1623-1627 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T63 1865-1880 Disease denotes viral infection http://purl.obolibrary.org/obo/MONDO_0005108
T64 1871-1880 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T65 2050-2061 Disease denotes common cold http://purl.obolibrary.org/obo/MONDO_0005709
T66 2100-2104 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T67 2180-2198 Disease denotes SARS-CoV infection http://purl.obolibrary.org/obo/MONDO_0005091
T68 2180-2184 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T69 2189-2198 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T70 2328-2343 Disease denotes viral infection http://purl.obolibrary.org/obo/MONDO_0005108
T71 2334-2343 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T72 2504-2515 Disease denotes hypotension http://purl.obolibrary.org/obo/MONDO_0005468
T73 2622-2630 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T74 2622-2626 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T75 3169-3177 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T76 3169-3173 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T77 3214-3223 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T78 3344-3353 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T79 3638-3646 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T80 3638-3642 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T81 3744-3752 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T82 3744-3748 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T83 3810-3818 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T84 3810-3814 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T85 3842-3848 Disease denotes injury http://purl.obolibrary.org/obo/MONDO_0021178
T86 3902-3910 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T87 3902-3906 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T88 4199-4203 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T89 4386-4390 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T90 5226-5235 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T91 5271-5279 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T92 5271-5275 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T93 5296-5305 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T94 5401-5409 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T95 5401-5405 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T96 6678-6682 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T97 7006-7015 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T98 7110-7118 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T99 7488-7496 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T100 7488-7492 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T101 7556-7564 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T102 7556-7560 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T103 7660-7668 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T104 7660-7664 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T105 7978-7986 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T106 7978-7982 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T107 8191-8199 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T108 8191-8195 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T109 8344-8352 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T110 8430-8438 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T111 8513-8521 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T112 8513-8517 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T113 8766-8782 Disease denotes Kawasaki disease http://purl.obolibrary.org/obo/MONDO_0012727
T114 9097-9105 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T115 9097-9101 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T116 9262-9270 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T117 9262-9266 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T118 9631-9640 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T119 9786-9794 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T120 9866-9874 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T27253 109-110 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T11956 204-209 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T59818 248-254 http://purl.obolibrary.org/obo/UBERON_0001005 denotes airway
T25048 255-265 http://purl.obolibrary.org/obo/CL_0000066 denotes epithelial
T45947 266-271 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T10170 285-302 http://purl.obolibrary.org/obo/CL_0000115 denotes endothelial cells
T36367 331-332 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T94559 372-376 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T18915 372-376 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T49004 431-433 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T42150 497-500 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T92578 535-545 http://purl.obolibrary.org/obo/CLO_0000031 denotes cell lines
T47002 567-571 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T41775 567-571 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T33694 572-577 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T62919 735-739 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T14814 751-756 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T56060 757-763 http://purl.obolibrary.org/obo/UBERON_0001005 denotes airway
T1792 779-785 http://purl.obolibrary.org/obo/UBERON_0001005 denotes airway
T85406 873-876 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T60699 927-937 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T15128 1326-1331 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T47491 1355-1360 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T61686 1361-1367 http://purl.obolibrary.org/obo/UBERON_0001005 denotes airway
T23099 1378-1381 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T34964 1429-1437 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T56294 1551-1556 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T5722 1640-1641 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T91276 1798-1806 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T71067 2021-2026 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T32655 2280-2288 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T83841 2457-2459 http://purl.obolibrary.org/obo/CLO_0050507 denotes 22
T42024 2666-2669 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T66445 2711-2719 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T1462 2752-2767 http://purl.obolibrary.org/obo/GO_0043234 denotes protein complex
T66948 2826-2834 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T82513 2889-2890 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T95692 3021-3029 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T65495 3046-3047 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T74464 3106-3110 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T56108 3133-3138 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T38701 3149-3154 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T36055 3240-3241 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T77642 3314-3315 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T15238 3383-3386 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T38031 3438-3448 http://purl.obolibrary.org/obo/UBERON_0000483 denotes epithelium
T71674 3546-3556 http://purl.obolibrary.org/obo/CL_0000066 denotes epithelial
T31054 3557-3562 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T46684 3837-3841 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T19001 3837-3841 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T91433 3960-3977 http://purl.obolibrary.org/obo/GO_0043234 denotes protein complexes
T66620 4084-4086 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T76112 4360-4364 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T85916 4365-4371 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T42262 4372-4380 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T4712 4485-4487 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T12859 4502-4504 http://purl.obolibrary.org/obo/CLO_0008922 denotes S2
T72988 4502-4504 http://purl.obolibrary.org/obo/CLO_0050052 denotes S2
T53244 4619-4621 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T93889 4622-4631 http://purl.obolibrary.org/obo/UBERON_0000033 denotes heads and
T73899 4622-4631 http://www.ebi.ac.uk/efo/EFO_0000964 denotes heads and
T50671 4632-4633 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T1263 4643-4645 http://purl.obolibrary.org/obo/CLO_0008922 denotes S2
T61883 4643-4645 http://purl.obolibrary.org/obo/CLO_0050052 denotes S2
T24540 4702-4704 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T30598 4959-4961 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T86794 5074-5076 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T58803 5098-5100 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T15028 5152-5154 http://purl.obolibrary.org/obo/CLO_0008922 denotes S2
T80157 5152-5154 http://purl.obolibrary.org/obo/CLO_0050052 denotes S2
T19942 5182-5190 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T91194 5221-5225 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T77366 5360-5361 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T97236 5421-5424 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T81091 5486-5487 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T93457 5540-5545 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T78563 5567-5568 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T86342 5842-5843 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T89948 5844-5852 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T27116 5958-5962 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T53807 5963-5971 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T96275 5980-5981 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T91518 5982-5990 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T1576 6154-6158 http://www.ebi.ac.uk/efo/EFO_0000967 denotes neck
T13416 6189-6190 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T7903 6295-6298 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T48778 6373-6377 http://www.ebi.ac.uk/efo/EFO_0000967 denotes neck
T3704 6488-6490 http://purl.obolibrary.org/obo/CLO_0008922 denotes S2
T6824 6488-6490 http://purl.obolibrary.org/obo/CLO_0050052 denotes S2
T65411 6642-6646 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T93631 6655-6664 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membranes
T36180 6666-6667 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T98795 6715-6720 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T83678 6786-6791 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T26776 6806-6810 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T81513 6812-6813 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T17871 6899-6901 http://purl.obolibrary.org/obo/CLO_0008922 denotes S2
T75662 6899-6901 http://purl.obolibrary.org/obo/CLO_0050052 denotes S2
T61344 6979-6984 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T2057 6999-7005 http://purl.obolibrary.org/obo/CLO_0001658 denotes active
T72343 7025-7027 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T25654 7050-7052 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T15557 7247-7252 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T67356 7261-7264 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T824 7362-7372 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T96980 7471-7473 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T60119 7543-7545 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T36399 7601-7607 http://purl.obolibrary.org/obo/CLO_0001658 denotes active
T97656 7746-7754 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T10969 7792-7798 http://purl.obolibrary.org/obo/UBERON_0003103 denotes organs
T24009 7807-7812 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T60151 7846-7854 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T130 8057-8063 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T131 8209-8215 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T132 8332-8338 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T133 8586-8592 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T134 8656-8657 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T135 8799-8801 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T136 8821-8822 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T137 8868-8870 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T138 8938-8940 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T139 8959-8961 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T140 9049-9051 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T141 9087-9089 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T142 9215-9217 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T143 9405-9407 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T144 9494-9495 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T145 9530-9539 http://purl.obolibrary.org/obo/OBI_0000245 denotes organized
T146 9606-9611 http://www.ebi.ac.uk/efo/EFO_0001410 denotes armed
T147 9774-9780 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T148 9815-9816 http://purl.obolibrary.org/obo/CLO_0001020 denotes a

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T29 52-63 Chemical denotes Angiotensin http://purl.obolibrary.org/obo/CHEBI_2719
T30 138-145 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T31 434-441 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T32 478-485 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T33 855-862 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T34 1121-1128 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T35 1150-1152 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T37 1478-1485 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T38 1510-1517 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T39 1612-1619 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T40 1991-1998 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T41 2549-2560 Chemical denotes angiotensin http://purl.obolibrary.org/obo/CHEBI_48433
T42 2658-2665 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T43 2752-2759 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T44 2904-2913 Chemical denotes biomarker http://purl.obolibrary.org/obo/CHEBI_59163
T45 3733-3740 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T46 3960-3967 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T47 4150-4157 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T48 4321-4329 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T49 4417-4430 Chemical denotes glycoproteins http://purl.obolibrary.org/obo/CHEBI_17089
T50 4502-4504 Chemical denotes S2 http://purl.obolibrary.org/obo/CHEBI_29387
T51 4506-4513 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T52 4574-4582 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T53 4643-4645 Chemical denotes S2 http://purl.obolibrary.org/obo/CHEBI_29387
T54 4878-4890 Chemical denotes glycoprotein http://purl.obolibrary.org/obo/CHEBI_17089
T55 5152-5154 Chemical denotes S2 http://purl.obolibrary.org/obo/CHEBI_29387
T56 5598-5608 Chemical denotes amino acid http://purl.obolibrary.org/obo/CHEBI_33709
T57 5598-5603 Chemical denotes amino http://purl.obolibrary.org/obo/CHEBI_46882
T58 5604-5608 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T59 5675-5682 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T60 5753-5760 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T61 5942-5950 Chemical denotes molecule http://purl.obolibrary.org/obo/CHEBI_25367
T62 6113-6123 Chemical denotes ferredoxin http://purl.obolibrary.org/obo/CHEBI_5017
T63 6322-6333 Chemical denotes amino acids http://purl.obolibrary.org/obo/CHEBI_33709
T64 6322-6327 Chemical denotes amino http://purl.obolibrary.org/obo/CHEBI_46882
T65 6328-6333 Chemical denotes acids http://purl.obolibrary.org/obo/CHEBI_37527
T66 6488-6490 Chemical denotes S2 http://purl.obolibrary.org/obo/CHEBI_29387
T67 6899-6901 Chemical denotes S2 http://purl.obolibrary.org/obo/CHEBI_29387
T68 6934-6941 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T69 7215-7222 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T70 7427-7435 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T71 9315-9323 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T72 9385-9392 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T52159 1865-1880 http://purl.obolibrary.org/obo/GO_0016032 denotes viral infection
T47565 2328-2343 http://purl.obolibrary.org/obo/GO_0016032 denotes viral infection
T51579 3106-3121 http://purl.obolibrary.org/obo/GO_0010467 denotes gene expression
T1132 3794-3806 http://purl.obolibrary.org/obo/GO_0009405 denotes pathogenesis
T66720 3936-3945 http://purl.obolibrary.org/obo/GO_0009058 denotes formation
T54884 5598-5620 http://purl.obolibrary.org/obo/GO_0006865 denotes amino acid transporter
T58005 7316-7329 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T37916 7882-7889 http://purl.obolibrary.org/obo/GO_0009606 denotes tropism
T72358 8674-8681 http://purl.obolibrary.org/obo/GO_0009606 denotes tropism
T98067 9665-9681 http://purl.obolibrary.org/obo/GO_0006955 denotes immune responses

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T20 0-2 Sentence denotes 2.
T21 3-51 Sentence denotes ACE2-mediated SARS-CoV and SARS-CoV-2 Infections
T22 52-215 Sentence denotes Angiotensin-converting enzyme 2 (ACE2) was identified as a receptor for the spike (S) protein of SARS-CoV, finally facilitating viral entry into target cells [13].
T23 216-409 Sentence denotes ACE2 is abundantly expressed in airway epithelial cells and vascular endothelial cells, and it is believed to play a crucial role in the mechanism of acute lung injury induced by SARS-CoV [14].
T24 410-663 Sentence denotes The ability of spike-Fc protein treatment (3h) to downregulate ACE2 protein expression has been shown in an in vitro system (cell lines) and also in vivo in lung cells of mice [14,15], suggesting that ACE2 pathway may be down-modulated during infection.
T25 664-806 Sentence denotes However, ACE2 is constitutively expressed and released from the apical cell surface of human airway epithelia into airway surface liquid [16].
T26 807-1048 Sentence denotes Of note, its surface down-modulation upon spike protein challenge has been shown to be due to ACE2 shedding mediated by activation of extracellular ADAM17/TACE metalloprotease, which concomitantly induces shedding/production of TNFα [17,18].
T27 1049-1280 Sentence denotes Interestingly, ACE2 shedding is enhanced not only by binding with spike protein [17,18], but also by IL-1β and TNFα inflammatory cytokines [16], cytokines that are secreted at relatively high concentration in COVID-19 patients [2].
T28 1281-1565 Sentence denotes Moreover, soluble (s)ACE2 (induced or not by virus binding) released from human airway epithelia has been demonstrated to retain both its enzymatic activity and its binding ability for spike viral protein, finally reducing spike protein-mediated viral entry into target cells [16,17].
T29 1566-1730 Sentence denotes Therefore, the interaction of ACE2 with spike protein of SARS-CoV induces a cellular “protective” ACE2 shedding feedback response that initially limits viral entry.
T30 1731-1918 Sentence denotes Nevertheless, ADAM17/TACE-mediated ACE2 shedding or ACE2 enzymatic activity have been shown to intriguingly correlate positively with viral infection and disease complications [17,19,20].
T31 1919-2110 Sentence denotes In contrast, HNL63-CoV, which similarly binds to ACE2 through its spike protein, infects ACE2-bearing cells and mainly induces the common cold, leading to neither ACE2 shedding nor SARS [17].
T32 2111-2373 Sentence denotes Moreover, catalytically inactive forms of sACE2 can potently inhibit SARS-CoV infection [19,21], suggesting that events downstream of ACE2 shedding and/or its enzymatic activity may indirectly and subsequently favour viral infection and/or disease complications.
T33 2374-2645 Sentence denotes To this regard, sACE2 was also associated with myocardial pathological conditions [22] and cardiovascular complications including hypotension (known to enhance both renin and angiotensin I, the substrate of ACE/ACE2) and tachycardia were common in SARS-CoV patients [23].
T34 2646-2914 Sentence denotes Since spike protein has been shown to not inhibit ACE2 enzymatic activity that is retained by sACE2-spike protein complex [16,17,24] and, in general, sACE2 maintains its enzymatic activity, we cannot consider its higher circulating expression a mere disease biomarker.
T35 2915-3030 Sentence denotes Indeed, ACE2 shedding might repress its local function but it certainly enhances its circulating/systemic activity.
T36 3031-3359 Sentence denotes Interestingly, a recent integrative bioinformatics analysis shows that the gene expression of ACE2 in human bronchial cells infected with SARS-CoV is dramatically increased 24h after infection and remained at a high level for at least 2 days, suggesting that ACE2 may be involved in a positive feedback loop post-infection [25].
T37 3360-3662 Sentence denotes In the same report, it has been shown that ACE2 expression level in bronchial epithelium obtained by brushing from asthmatic and normal subjects was similar, suggesting that respiratory epithelial cells of healthy subjects and asthmatic patients have similar ability to bind to SARS-CoV-2 through ACE2.
T38 3663-3760 Sentence denotes Of note, ACE2 was also identified as the receptor for the novel spike protein of SARS-CoV-2 [13].
T39 3761-3924 Sentence denotes Although the role of ACE2 in the pathogenesis of SARS-CoV-2 and in inducing lung injury is still unknown, ACE2 behaves similarly to original SARS-CoV [13] (Box 1).
T40 3925-4111 Sentence denotes Box 1 The formation of spike-ACE2 protein complexes may initiate ACE2 systemic upregulation and may impair autologous antibody generation/recognition of anti-S1-Receptor Binding Domain.
T41 4112-4381 Sentence denotes The ACE2 interacts with the spike (S) protein, thereby serves as an entry receptor for SARS-CoVs, and this event is likely followed by conformational changes, cleavages and fusion of both spike viral and ACE2 proteins at the level of infected host cell plasma-membrane.
T42 4382-4567 Sentence denotes The SARS coronavirus surface spike glycoproteins consist of trimers formed by two spike, capsid-distal S1 and –proximal S2, protein regions, located on the outer envelope of the virion.
T43 4568-4824 Sentence denotes Spike proteins are clove-shaped trimers with three S1 heads and a trimeric S2 stalk that can bind the cellular ACE2 receptor when one S1 (possessing the receptor-binding domain) in the trimer adopts an “up” conformation (see Figure later in the Section 4).
T44 4825-5236 Sentence denotes The subsequent binding of ACE2 receptor to the spike glycoprotein triggers both the ADAM17-mediated ACE2 shedding and dissociation of S1 fragments by exogenous (furin-related or other) proteases from the spike trimer, which leads on one hand to one S1-ACE2 complex and two S1 free fragments, and on the other hand to fusion of S2 viral trimers and cellular membrane structures, finally producing cell infection.
T45 5237-5460 Sentence denotes The molecular mechanism model for SARS-CoV recognition and infection was well described by Song and collaborators [26] and a similar molecular interactions between SARS-CoV-2 and ACE2 has been recently hypothesized [27,28].
T46 5461-5653 Sentence denotes To complete the picture, a recent structural work reveals that the full-length human ACE2 is assembled as a dimer associated or not with amino acid transporter B0AT1, which sandwich ACE2 [28].
T47 5654-5791 Sentence denotes Binding of the spike protein trimer onto the ACE2 dimer suggests simultaneous binding of two spike protein trimers to an ACE2 dimer [28].
T48 5792-6060 Sentence denotes Each monomer of the ACE2 homodimer is composed of a membrane-proximal collectrin-like domain mediating homodimerization and necessary to position the molecule to the cell membrane, and of a membrane-distal ACE2 peptidase domain responsible for ACE2 substrate cleavage.
T49 6061-6247 Sentence denotes Collectrin-like domain consists of an extracellular ferredoxin-like fold domain, also called neck domain (residues 616 to 726), a single transmembrane helix and an intracellular segment.
T50 6248-6432 Sentence denotes The ACE2 cleavage site mediated by ADAM17/TACE has been predicted between amino acids 716 and 741 [16], which corresponds to neck-transmembrane boundary of ACE2 collectrin-like domain.
T51 6433-6665 Sentence denotes It is tempting to speculate that, after ACE2 shedding, S2 viral trimers may fuse with the residual ACE2 collectrin-like fragments (complexed or not with B0AT1 transporters) which are eventually exposed on the cell surface membranes.
T52 6666-6770 Sentence denotes A model for SARS-CoV’s internalization by target cells that was already proposed several years ago [29].
T53 6771-7016 Sentence denotes Then, when the virus is inside the cell, a second proteolytic cleavage mediated by endosomal proteases (such as TMPRSS2) in the S2 region of the spike-ACE2 fusion protein might be necessary for intracellular virus “release” and active infection.
T54 7017-7174 Sentence denotes Several S1-sACE2 complexes, free S1 fragments or sACE2 are likely released in bloodstream of COVID-19 infected patients by spike and ACE2 receptor cleavages.
T55 7175-7650 Sentence denotes As already mentioned, circulating sACE2 protein shedding independent on virus contact has been also described either spontaneously when ACE2 transcription is upregulated or upon cytokine activation; it is therefore likely that in the bloodstreams ACE2 proteins are available to bind to both free S1 fragments and SARS-CoV-2 particles, finally leading to more and more S1-sACE2 and SARS-CoV-2-sACE2 complexes bearing enzymatic active sACE2 (see Figure later in the Section 4).
T56 7651-7926 Sentence denotes Of note, SARS-CoV-2-sACE2 complexes, sequestrating sACE2, can drive part of the sACE2 systemic activity and concentrate it locally where the organs possess cells expressing ACE2 on their surface membrane, i.e., following the viral tropism (see Figure later in the Section 4).
T57 7927-8221 Sentence denotes Indeed, although the viral load in sputum of adult SARS-CoV patients was usually higher than 104 copies/mL, reports indicate that plasma viral RNA concentrations are low, usually lower than 190 copies/mL and lymphocytes have much higher RNA-copy concentrations of SARS-CoV RNA than plasma [30].
T58 8222-8367 Sentence denotes Very low RNA concentrations with no difference between patients with mild or severe symptoms were detected in plasma from COVID-19 patients [30].
T59 8368-8499 Sentence denotes The viral load in nasal swabs of asymptomatic and symptomatic COVID-19-positive subjects was also not significantly different [31].
T60 8500-8784 Sentence denotes Of interest, SARS-CoV infected pediatric patients have more than double the amount of plasma RNA copies/mL when compared to adult patients [30], suggesting a different viral tropism between adults and children (different cellular ACE2 expression possibly leading to Kawasaki disease).
T61 8785-8912 Sentence denotes Notably, free S1 fragments may have a decoy function for autologous/exogenous anti-S1-receptor binding domain (RBD) antibodies.
T62 8913-9143 Sentence denotes On the other hand, sACE2-S1 complexes masking S1-RBD might also impair either generation of autologous high affinity antibodies against S1-RBD or recognition/inactivation of S1-RBD on SARS-CoV-2 by autologous/exogenous antibodies.
T63 9144-9516 Sentence denotes Therefore, antibodies that do not compete with ACE2 for the binding to S1-RBD might be more effective in neutralizing SARS-CoV-2 [32,33], knowing that the number of spike proteins per virion is estimated to be around 70 and that every spike protein bears three S1 receptor binding domains, which are masked to autologous antibody recognition when in a “down” conformation.
T64 9517-9712 Sentence denotes These highly organized molecular features clearly demonstrate that the coronaviruses are armed with sophisticated infection machinery able to evade immune responses induced or not by vaccination.
T65 9713-9895 Sentence denotes Nevertheless, passive immunotherapy by means of convalescent plasma from COVID-19 recovered donors is a promising option for prevention and treatment of COVID-19 [32,33,34,35,36,37].

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T13 366-383 Phenotype denotes acute lung injury http://www.orpha.net/ORDO/Orphanet_178320
T14 2504-2515 Phenotype denotes hypotension http://purl.obolibrary.org/obo/HP_0002615
T15 2595-2606 Phenotype denotes tachycardia http://purl.obolibrary.org/obo/HP_0001649

2_test

Id Subject Object Predicate Lexical cue
32708755-32142651-20678655 211-213 32142651 denotes 13
32708755-16007097-20678656 405-407 16007097 denotes 14
32708755-16007097-20678657 587-589 16007097 denotes 14
32708755-16001071-20678658 590-592 16001071 denotes 15
32708755-18490652-20678659 1041-1043 18490652 denotes 17
32708755-19864379-20678660 1044-1046 19864379 denotes 18
32708755-18490652-20678661 1130-1132 18490652 denotes 17
32708755-19864379-20678662 1133-1135 19864379 denotes 18
32708755-32161940-20678663 1277-1278 32161940 denotes 2
32708755-18490652-20678664 1561-1563 18490652 denotes 17
32708755-18490652-20678665 1908-1910 18490652 denotes 17
32708755-15367630-20678666 1911-1913 15367630 denotes 19
32708755-19995578-20678667 1914-1916 19995578 denotes 20
32708755-18490652-20678668 2106-2108 18490652 denotes 17
32708755-15367630-20678669 2200-2202 15367630 denotes 19
32708755-16510163-20678670 2203-2205 16510163 denotes 21
32708755-19700132-20678671 2457-2459 19700132 denotes 22
32708755-16461478-20678672 2641-2643 16461478 denotes 23
32708755-18490652-20678673 2772-2774 18490652 denotes 17
32708755-15791205-20678674 2775-2777 15791205 denotes 24
32708755-32142651-20678675 3756-3758 32142651 denotes 13
32708755-32142651-20678676 3912-3914 32142651 denotes 13
32708755-30102747-20678677 5352-5354 30102747 denotes 26
32708755-32075877-20678678 5453-5455 32075877 denotes 27
32708755-32132184-20678679 5456-5458 32132184 denotes 28
32708755-32132184-20678680 5649-5651 32132184 denotes 28
32708755-32132184-20678681 5787-5789 32132184 denotes 28
32708755-17522231-20678682 6766-6768 17522231 denotes 29
32708755-32107119-20678683 8217-8219 32107119 denotes 30
32708755-32107119-20678684 8363-8365 32107119 denotes 30
32708755-32107119-20678685 8640-8642 32107119 denotes 30
32708755-32065055-20678686 9274-9276 32065055 denotes 32
32708755-32366817-20678687 9277-9279 32366817 denotes 33
32708755-32065055-20678688 9876-9878 32065055 denotes 32
32708755-32366817-20678689 9879-9881 32366817 denotes 33
32708755-32404477-20678690 9882-9884 32404477 denotes 34
32708755-32253318-20678691 9888-9890 32253318 denotes 36
32708755-32243945-20678692 9891-9893 32243945 denotes 37