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PMC:7408073 / 38009-70862 JSONTXT

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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T226 312-322 Body_part denotes amino acid http://purl.org/sig/ont/fma/fma82739
T227 498-505 Body_part denotes proline http://purl.org/sig/ont/fma/fma82761
T228 773-778 Body_part denotes heart http://purl.org/sig/ont/fma/fma7088
T229 780-787 Body_part denotes kidneys http://purl.org/sig/ont/fma/fma7203
T230 789-794 Body_part denotes liver http://purl.org/sig/ont/fma/fma7197
T231 796-801 Body_part denotes colon http://purl.org/sig/ont/fma/fma14543
T232 803-818 Body_part denotes small intestine http://purl.org/sig/ont/fma/fma7200
T233 820-824 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T234 826-831 Body_part denotes brain http://purl.org/sig/ont/fma/fma50801
T235 877-884 Body_part denotes tissues http://purl.org/sig/ont/fma/fma9637
T236 911-925 Body_part denotes cardiomyocytes http://purl.org/sig/ont/fma/fma14067
T237 927-938 Body_part denotes endothelium http://purl.org/sig/ont/fma/fma63916
T238 940-962 Body_part denotes alveolar type II cells http://purl.org/sig/ont/fma/fma62501
T239 957-962 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T240 980-985 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T241 987-1015 Body_part denotes vascular smooth muscle cells http://purl.org/sig/ont/fma/fma284560
T242 1010-1015 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T243 1031-1043 Body_part denotes Leydig cells http://purl.org/sig/ont/fma/fma72297
T244 1038-1043 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T245 1107-1134 Body_part denotes surface of epithelial cells http://purl.org/sig/ont/fma/fma82998
T246 1129-1134 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T247 1138-1151 Body_part denotes renal tubules http://purl.org/sig/ont/fma/fma15627
T248 1153-1157 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T249 1205-1210 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T250 1276-1280 Body_part denotes axis http://purl.org/sig/ont/fma/fma12520
T251 2028-2034 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T252 2218-2224 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T253 2443-2449 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T254 2469-2476 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T255 2691-2696 Body_part denotes bowel http://purl.org/sig/ont/fma/fma7199
T256 2785-2791 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T257 2839-2845 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T258 3030-3036 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T259 3069-3075 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T260 3122-3128 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T261 3346-3352 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T262 3658-3664 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T263 3906-3911 Body_part denotes serum http://purl.org/sig/ont/fma/fma63083
T264 4117-4122 Body_part denotes serum http://purl.org/sig/ont/fma/fma63083
T265 4219-4225 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T266 4309-4314 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T267 4573-4579 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T268 4624-4629 Body_part denotes serum http://purl.org/sig/ont/fma/fma63083
T269 4809-4815 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T270 4934-4940 Body_part denotes kidney http://purl.org/sig/ont/fma/fma7203
T271 5665-5671 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T272 5940-5946 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T273 6613-6619 Body_part denotes muscle http://purl.org/sig/ont/fma/fma32558
T274 6669-6678 Body_part denotes cytokines http://purl.org/sig/ont/fma/fma84050
T275 6689-6693 Body_part denotes IL-1 http://purl.org/sig/ont/fma/fma86583
T276 6737-6746 Body_part denotes cytokines http://purl.org/sig/ont/fma/fma84050
T277 6937-6946 Body_part denotes cytokines http://purl.org/sig/ont/fma/fma84050
T278 7086-7094 Body_part denotes cytokine http://purl.org/sig/ont/fma/fma84050
T279 7108-7117 Body_part denotes monocytes http://purl.org/sig/ont/fma/fma62864
T280 7138-7142 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T281 7330-7335 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670
T282 7336-7341 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T283 7435-7444 Body_part denotes cytokines http://purl.org/sig/ont/fma/fma84050
T284 7456-7460 Body_part denotes IL-1 http://purl.org/sig/ont/fma/fma86583
T285 7507-7515 Body_part denotes cytokine http://purl.org/sig/ont/fma/fma84050
T286 7543-7561 Body_part denotes pulmonary arterial http://purl.org/sig/ont/fma/fma66326
T287 7647-7651 Body_part denotes IL-1 http://purl.org/sig/ont/fma/fma86583
T288 7654-7658 Body_part denotes IL-2 http://purl.org/sig/ont/fma/fma84051
T289 7685-7690 Body_part denotes IL-12 http://purl.org/sig/ont/fma/fma86579
T290 7923-7931 Body_part denotes cytokine http://purl.org/sig/ont/fma/fma84050
T291 8350-8372 Body_part denotes gastrointestinal tract http://purl.org/sig/ont/fma/fma71132
T292 8378-8389 Body_part denotes enterocytes http://purl.org/sig/ont/fma/fma62122
T293 8436-8443 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T294 8792-8802 Body_part denotes intestinal http://purl.org/sig/ont/fma/fma7199
T295 9070-9074 Body_part denotes hand http://purl.org/sig/ont/fma/fma9712
T296 9118-9129 Body_part denotes amino acids http://purl.org/sig/ont/fma/fma82739
T297 9131-9133 Body_part denotes AA http://purl.org/sig/ont/fma/fma82739
T298 9175-9183 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T299 9374-9376 Body_part denotes AA http://purl.org/sig/ont/fma/fma82739
T300 9404-9415 Body_part denotes enterocytes http://purl.org/sig/ont/fma/fma62122
T301 9466-9476 Body_part denotes enterocyte http://purl.org/sig/ont/fma/fma62122
T302 9506-9516 Body_part denotes intestinal http://purl.org/sig/ont/fma/fma7199
T303 9549-9554 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670
T304 9619-9621 Body_part denotes AA http://purl.org/sig/ont/fma/fma82739
T305 9720-9722 Body_part denotes AA http://purl.org/sig/ont/fma/fma82739
T306 9736-9738 Body_part denotes AA http://purl.org/sig/ont/fma/fma82739
T307 9761-9772 Body_part denotes enterocytes http://purl.org/sig/ont/fma/fma62122
T308 9801-9803 Body_part denotes AA http://purl.org/sig/ont/fma/fma82739
T309 9873-9875 Body_part denotes AA http://purl.org/sig/ont/fma/fma82739
T310 9928-9935 Body_part denotes insulin http://purl.org/sig/ont/fma/fma83365
T311 9975-9980 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T312 10140-10146 Body_part denotes Plasma http://purl.org/sig/ont/fma/fma62970
T313 10212-10222 Body_part denotes intestinal http://purl.org/sig/ont/fma/fma7199
T314 10382-10387 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670
T315 10397-10402 Body_part denotes serum http://purl.org/sig/ont/fma/fma63083
T316 10466-10473 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T317 10477-10483 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T318 10498-10502 Body_part denotes hand http://purl.org/sig/ont/fma/fma9712
T319 10557-10559 Body_part denotes AA http://purl.org/sig/ont/fma/fma82739
T320 10706-10718 Body_part denotes blood plasma http://purl.org/sig/ont/fma/fma62970
T321 10786-10803 Body_part denotes endothelial cells http://purl.org/sig/ont/fma/fma66772
T322 10798-10803 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T323 10835-10852 Body_part denotes endothelial cells http://purl.org/sig/ont/fma/fma66772
T324 10847-10852 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T325 10905-10911 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T326 10915-10922 Body_part denotes tissues http://purl.org/sig/ont/fma/fma9637
T327 11088-11092 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T328 11109-11115 Body_part denotes Plasma http://purl.org/sig/ont/fma/fma62970
T329 11174-11186 Body_part denotes cell surface http://purl.org/sig/ont/fma/fma67653
T330 11174-11178 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T331 11195-11200 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T332 11217-11223 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T333 11242-11247 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T334 11249-11266 Body_part denotes endothelial cells http://purl.org/sig/ont/fma/fma66772
T335 11261-11266 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T336 11268-11275 Body_part denotes neurons http://purl.org/sig/ont/fma/fma54527
T337 11280-11294 Body_part denotes cardiomyocytes http://purl.org/sig/ont/fma/fma14067
T338 11558-11573 Body_part denotes plasma to cells http://purl.org/sig/ont/fma/fma70574
T339 11558-11564 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T340 11568-11573 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T341 11662-11667 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670
T342 12391-12395 Body_part denotes hand http://purl.org/sig/ont/fma/fma9712
T343 12407-12413 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T344 12659-12670 Body_part denotes neural cell http://purl.org/sig/ont/fma/fma70333
T345 12666-12670 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T346 12745-12751 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T347 12780-12787 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T348 12860-12870 Body_part denotes fatty acid http://purl.org/sig/ont/fma/fma82738
T349 12872-12875 Body_part denotes FFA http://purl.org/sig/ont/fma/fma82738
T350 13172-13175 Body_part denotes FFA http://purl.org/sig/ont/fma/fma82738
T351 13408-13414 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T352 13597-13603 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T353 13867-13874 Body_part denotes heparin http://purl.org/sig/ont/fma/fma82839
T354 14075-14081 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T355 14145-14151 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T356 14255-14259 Body_part denotes hand http://purl.org/sig/ont/fma/fma9712
T357 14287-14293 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T358 14356-14362 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T359 14746-14751 Body_part denotes serum http://purl.org/sig/ont/fma/fma63083
T360 14965-14971 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T361 15037-15042 Body_part denotes liver http://purl.org/sig/ont/fma/fma7197
T362 15220-15236 Body_part denotes endothelial cell http://purl.org/sig/ont/fma/fma66772
T363 15232-15236 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T364 15292-15310 Body_part denotes pulmonary arteries http://purl.org/sig/ont/fma/fma66326
T365 15302-15310 Body_part denotes arteries http://purl.org/sig/ont/fma/fma63812
T366 15414-15422 Body_part denotes alveolar http://purl.org/sig/ont/fma/fma264783
T367 15568-15572 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T368 15623-15627 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T369 16870-16882 Body_part denotes cell surface http://purl.org/sig/ont/fma/fma67653
T370 16870-16874 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T371 16925-16932 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T372 16999-17006 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T373 17065-17080 Body_part denotes plasma membrane http://purl.org/sig/ont/fma/fma63841
T374 17267-17275 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T375 17352-17356 Body_part denotes hand http://purl.org/sig/ont/fma/fma9712
T376 17364-17371 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T377 17549-17557 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T378 17795-17803 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T379 18976-18981 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T380 20270-20276 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T381 20798-20803 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670
T382 20938-20943 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670
T383 21297-21302 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670
T384 21423-21435 Body_part denotes baroreceptor http://purl.org/sig/ont/fma/fma85601
T385 22177-22181 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T386 23313-23318 Body_part denotes heart http://purl.org/sig/ont/fma/fma7088
T387 23320-23324 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T388 23326-23331 Body_part denotes liver http://purl.org/sig/ont/fma/fma7197
T389 23333-23338 Body_part denotes colon http://purl.org/sig/ont/fma/fma14543
T390 23348-23355 Body_part denotes tissues http://purl.org/sig/ont/fma/fma9637
T391 23387-23392 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670
T392 23397-23414 Body_part denotes endothelial cells http://purl.org/sig/ont/fma/fma66772
T393 23409-23414 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T394 24135-24141 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T395 24277-24283 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T396 24353-24359 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T397 25317-25322 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670
T398 25621-25625 Body_part denotes body http://purl.org/sig/ont/fma/fma256135
T399 25627-25632 Body_part denotes Cells http://purl.org/sig/ont/fma/fma68646
T400 25759-25765 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T401 26082-26087 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T402 26175-26190 Body_part denotes plasma membrane http://purl.org/sig/ont/fma/fma63841
T403 26610-26619 Body_part denotes lysosomes http://purl.org/sig/ont/fma/fma63836
T404 26921-26929 Body_part denotes platelet http://purl.org/sig/ont/fma/fma62851
T405 26969-26977 Body_part denotes platelet http://purl.org/sig/ont/fma/fma62851
T406 27026-27044 Body_part denotes secretory granules http://purl.org/sig/ont/fma/fma84758
T407 27108-27116 Body_part denotes platelet http://purl.org/sig/ont/fma/fma62851
T408 28121-28133 Body_part denotes renal artery http://purl.org/sig/ont/fma/fma14751
T409 28398-28408 Body_part denotes neutrophil http://purl.org/sig/ont/fma/fma62860
T410 28673-28679 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T411 28817-28824 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T412 28828-28834 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T413 28878-28880 Body_part denotes AA http://purl.org/sig/ont/fma/fma82739
T414 28980-28982 Body_part denotes AA http://purl.org/sig/ont/fma/fma82739
T415 29033-29044 Body_part denotes amino acids http://purl.org/sig/ont/fma/fma82739
T416 29096-29098 Body_part denotes AA http://purl.org/sig/ont/fma/fma82739
T417 29483-29493 Body_part denotes amino acid http://purl.org/sig/ont/fma/fma82739
T418 29658-29666 Body_part denotes arginine http://purl.org/sig/ont/fma/fma82763
T419 29897-29904 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T420 30584-30590 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T421 30943-30953 Body_part denotes intestinal http://purl.org/sig/ont/fma/fma7199
T422 31532-31540 Body_part denotes cavities http://purl.org/sig/ont/fma/fma76576
T423 32600-32607 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T84 51-54 Body_part denotes RAS http://purl.obolibrary.org/obo/UBERON_0018229
T85 588-591 Body_part denotes RAS http://purl.obolibrary.org/obo/UBERON_0018229
T86 773-778 Body_part denotes heart http://purl.obolibrary.org/obo/UBERON_0000948
T87 789-794 Body_part denotes liver http://purl.obolibrary.org/obo/UBERON_0002107
T88 796-801 Body_part denotes colon http://purl.obolibrary.org/obo/UBERON_0001155
T89 803-818 Body_part denotes small intestine http://purl.obolibrary.org/obo/UBERON_0002108
T90 809-818 Body_part denotes intestine http://purl.obolibrary.org/obo/UBERON_0000160
T91 820-824 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T92 826-831 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955
T93 927-938 Body_part denotes endothelium http://purl.obolibrary.org/obo/UBERON_0001986
T94 1138-1151 Body_part denotes renal tubules http://purl.obolibrary.org/obo/UBERON_0009773
T95 1153-1157 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T96 3906-3911 Body_part denotes serum http://purl.obolibrary.org/obo/UBERON_0001977
T97 4117-4122 Body_part denotes serum http://purl.obolibrary.org/obo/UBERON_0001977
T98 4624-4629 Body_part denotes serum http://purl.obolibrary.org/obo/UBERON_0001977
T99 4836-4839 Body_part denotes RAS http://purl.obolibrary.org/obo/UBERON_0018229
T100 4934-4940 Body_part denotes kidney http://purl.obolibrary.org/obo/UBERON_0002113
T101 6218-6221 Body_part denotes RAS http://purl.obolibrary.org/obo/UBERON_0018229
T102 7330-7335 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T103 7543-7561 Body_part denotes pulmonary arterial http://purl.obolibrary.org/obo/UBERON_0002012
T104 9070-9074 Body_part denotes hand http://purl.obolibrary.org/obo/UBERON_0002398
T105 9549-9554 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T106 10382-10387 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T107 10397-10402 Body_part denotes serum http://purl.obolibrary.org/obo/UBERON_0001977
T108 10498-10502 Body_part denotes hand http://purl.obolibrary.org/obo/UBERON_0002398
T109 10706-10718 Body_part denotes blood plasma http://purl.obolibrary.org/obo/UBERON_0001969
T110 10706-10711 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T111 11662-11667 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T112 12391-12395 Body_part denotes hand http://purl.obolibrary.org/obo/UBERON_0002398
T113 14236-14239 Body_part denotes RAS http://purl.obolibrary.org/obo/UBERON_0018229
T114 14255-14259 Body_part denotes hand http://purl.obolibrary.org/obo/UBERON_0002398
T115 14746-14751 Body_part denotes serum http://purl.obolibrary.org/obo/UBERON_0001977
T116 15037-15042 Body_part denotes liver http://purl.obolibrary.org/obo/UBERON_0002107
T117 15292-15310 Body_part denotes pulmonary arteries http://purl.obolibrary.org/obo/UBERON_0002012
T118 15568-15572 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T119 15623-15627 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T120 16353-16358 Body_part denotes shell http://purl.obolibrary.org/obo/UBERON_0006612
T121 17352-17356 Body_part denotes hand http://purl.obolibrary.org/obo/UBERON_0002398
T122 20798-20803 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T123 20938-20943 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T124 21297-21302 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T125 21423-21435 Body_part denotes baroreceptor http://purl.obolibrary.org/obo/UBERON_0004019
T126 22177-22181 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T127 23313-23318 Body_part denotes heart http://purl.obolibrary.org/obo/UBERON_0000948
T128 23320-23324 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T129 23326-23331 Body_part denotes liver http://purl.obolibrary.org/obo/UBERON_0002107
T130 23333-23338 Body_part denotes colon http://purl.obolibrary.org/obo/UBERON_0001155
T131 23356-23362 Body_part denotes organs http://purl.obolibrary.org/obo/UBERON_0000062
T132 23387-23392 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T133 25317-25322 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T134 27550-27553 Body_part denotes RAS http://purl.obolibrary.org/obo/UBERON_0018229
T135 28121-28133 Body_part denotes renal artery http://purl.obolibrary.org/obo/UBERON_0001184
T136 28127-28133 Body_part denotes artery http://purl.obolibrary.org/obo/UBERON_0001637
T137 28484-28487 Body_part denotes RAS http://purl.obolibrary.org/obo/UBERON_0018229
T138 28563-28566 Body_part denotes RAS http://purl.obolibrary.org/obo/UBERON_0018229

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
1471 95-99 Gene denotes ACE2 Gene:59272
1472 105-108 Gene denotes ACE Gene:59272
1473 110-123 Disease denotes Hyperactivity MESH:D006948
1488 156-160 Gene denotes ACE2 Gene:59272
1489 165-168 Gene denotes ACE Gene:59272
1490 252-256 Gene denotes ACE2 Gene:59272
1491 352-355 Gene denotes ACE Gene:59272
1492 443-447 Gene denotes ACE2 Gene:59272
1493 596-606 Gene denotes bradykinin Gene:3827
1494 896-900 Gene denotes ACE2 Gene:59272
1495 1077-1081 Gene denotes ACE2 Gene:59272
1496 1229-1237 Gene denotes Ang (1–7 Gene:284
1497 1271-1275 Gene denotes MasR Gene:116511
1498 404-413 Chemical denotes dipeptide MESH:D004151
1499 498-505 Chemical denotes proline MESH:D011392
1500 725-736 Disease denotes hypotensive MESH:D007022
1501 1335-1346 Disease denotes hypotension MESH:D007022
1576 1374-1378 Gene denotes ACE2 Gene:59272
1577 1391-1394 Gene denotes ACE Gene:59272
1578 1817-1820 Gene denotes ACE Gene:59272
1579 1825-1829 Gene denotes ACE2 Gene:59272
1580 1858-1866 Gene denotes Ang (1–9 Gene:284
1581 1883-1889 Gene denotes Ang II Gene:24179
1582 1902-1906 Gene denotes ACE2 Gene:59272
1583 1950-1954 Gene denotes ACE2 Gene:59272
1584 2736-2740 Gene denotes ACE2 Gene:59272
1585 4410-4413 Gene denotes ACE Gene:59272
1586 4418-4422 Gene denotes ACE2 Gene:59272
1587 4624-4637 Gene denotes serum albumin Gene:213
1588 5115-5119 Gene denotes ACE2 Gene:59272
1589 5359-5363 Gene denotes ACE2 Gene:59272
1590 2453-2460 Gene denotes albumin Gene:213
1591 5774-5781 Gene denotes albumin Gene:213
1592 5672-5679 Gene denotes albumin Gene:213
1593 5269-5276 Gene denotes albumin Gene:213
1594 4784-4791 Gene denotes albumin Gene:213
1595 4269-4276 Gene denotes albumin Gene:213
1596 3423-3430 Gene denotes albumin Gene:213
1597 3219-3226 Gene denotes albumin Gene:213
1598 3037-3044 Gene denotes albumin Gene:213
1599 2917-2924 Gene denotes albumin Gene:213
1600 2869-2876 Gene denotes albumin Gene:213
1601 2810-2817 Gene denotes albumin Gene:213
1602 2055-2063 Species denotes patients Tax:9606
1603 2257-2265 Species denotes patients Tax:9606
1604 2534-2544 Species denotes SARS-CoV-2 Tax:2697049
1605 3193-3201 Species denotes patients Tax:9606
1606 3375-3383 Species denotes patients Tax:9606
1607 4507-4515 Species denotes patients Tax:9606
1608 4913-4921 Species denotes patients Tax:9606
1609 4949-4957 Species denotes patients Tax:9606
1610 5210-5218 Species denotes patients Tax:9606
1611 5594-5602 Species denotes patients Tax:9606
1612 5706-5714 Species denotes patients Tax:9606
1613 5761-5769 Species denotes patients Tax:9606
1614 3900-3905 Species denotes human Tax:9606
1615 1847-1853 Gene denotes Ang II Gene:24179
1616 3723-3730 Gene denotes albumin Gene:213
1617 1462-1466 Chemical denotes EDTA MESH:D004492
1618 1507-1515 Chemical denotes chloride MESH:D002712
1619 1519-1527 Chemical denotes fluoride MESH:D005459
1620 1586-1594 Chemical denotes chloride MESH:D002712
1621 1775-1783 Chemical denotes chloride MESH:D002712
1622 1924-1932 Chemical denotes chloride MESH:D002712
1623 2065-2073 Chemical denotes chloride MESH:D002712
1624 4156-4161 Chemical denotes metal MESH:D008670
1625 4175-4179 Chemical denotes iron MESH:D007501
1626 4543-4554 Chemical denotes Ang peptide
1627 5458-5462 Chemical denotes Zn2+
1628 5556-5560 Chemical denotes Zn2+
1629 2046-2054 Disease denotes COVID–19 MESH:C000657245
1630 2248-2256 Disease denotes COVID-19 MESH:C000657245
1631 2563-2598 Disease denotes adult respiratory distress syndrome MESH:D012128
1632 2600-2604 Disease denotes ARDS MESH:D012128
1633 2608-2616 Disease denotes COVID-19 MESH:C000657245
1634 2678-2704 Disease denotes inflammatory bowel disease MESH:D015212
1635 2706-2709 Disease denotes IBD MESH:D015212
1636 3188-3192 Disease denotes ARDS MESH:D012128
1637 3296-3312 Disease denotes hypoalbuminaemia
1638 3370-3374 Disease denotes ARDS MESH:D012128
1639 4502-4506 Disease denotes ARDS MESH:D012128
1640 4598-4602 Disease denotes ARDS MESH:D012128
1641 4648-4656 Disease denotes COVID-19 MESH:C000657245
1642 4886-4912 Disease denotes asthmatic/allergic disease MESH:D004342
1643 4926-4948 Disease denotes chronic kidney disease MESH:D051436
1644 4979-5001 Disease denotes cardiovascular disease MESH:D002318
1645 5039-5047 Disease denotes COVID-19 MESH:C000657245
1646 5188-5209 Disease denotes chronic renal disease MESH:D051436
1647 5376-5398 Disease denotes chronic renal diseases MESH:D051436
1648 5587-5593 Disease denotes asthma MESH:D001249
1649 5699-5705 Disease denotes asthma MESH:D001249
1699 6061-6065 Gene denotes ACE2 Gene:59272
1700 6070-6073 Gene denotes ACE Gene:59272
1701 6689-6694 Gene denotes IL-1β Gene:3552
1702 6696-6700 Gene denotes IL-6 Gene:3569
1703 6702-6706 Gene denotes IL-8 Gene:3576
1704 6711-6716 Gene denotes TNF-α Gene:7124
1705 6820-6825 Gene denotes TNF-α Gene:7124
1706 6854-6858 Gene denotes IL-6 Gene:3569
1707 6863-6867 Gene denotes IL-8 Gene:3576
1708 7456-7461 Gene denotes IL-1β Gene:3552
1709 7463-7467 Gene denotes IL-6 Gene:3569
1710 7469-7473 Gene denotes IL-8 Gene:3576
1711 7475-7480 Gene denotes TNF-α Gene:7124
1712 7516-7521 Gene denotes IL-10 Gene:3586
1713 7647-7652 Gene denotes IL-1β Gene:3552
1714 7654-7658 Gene denotes IL-2 Gene:3558
1715 7660-7664 Gene denotes IL-4 Gene:3565
1716 7666-7670 Gene denotes IL-6 Gene:3569
1717 7672-7676 Gene denotes IL-8 Gene:3576
1718 7678-7683 Gene denotes IL-10 Gene:3586
1719 7695-7700 Gene denotes TNF-α Gene:7124
1720 6276-6284 Species denotes patients Tax:9606
1721 6793-6801 Species denotes patients Tax:9606
1722 7592-7600 Species denotes SARS-CoV Tax:694009
1723 5853-5858 Chemical denotes ZnCl2 MESH:C016837
1724 5859-5879 Chemical denotes ZnO/hexachloroethane
1725 6122-6130 Chemical denotes chloride MESH:D002712
1726 6299-6304 Chemical denotes metal MESH:D008670
1727 6554-6564 Chemical denotes metal fume
1728 8173-8178 Chemical denotes ZnCl2 MESH:C016837
1729 5966-5970 Disease denotes ARDS MESH:D012128
1730 6026-6034 Disease denotes COVID-19 MESH:C000657245
1731 6225-6229 Disease denotes ARDS MESH:D012128
1732 6267-6275 Disease denotes COVID-19 MESH:C000657245
1733 6310-6315 Disease denotes fever MESH:D005334
1734 6317-6336 Disease denotes a flu-like syndrome MESH:D007251
1735 6442-6462 Disease denotes respiratory symptoms MESH:D012818
1736 6493-6502 Disease denotes pneumonia MESH:D011014
1737 6565-6570 Disease denotes fever MESH:D005334
1738 6597-6602 Disease denotes fever MESH:D005334
1739 6604-6611 Disease denotes fatigue MESH:D005221
1740 6613-6624 Disease denotes muscle ache MESH:D063806
1741 6626-6631 Disease denotes cough MESH:D003371
1742 6633-6640 Disease denotes dyspnea MESH:D004417
1743 6784-6792 Disease denotes COVID-19 MESH:C000657245
1744 7219-7227 Disease denotes COVID-19 MESH:C000657245
1745 7543-7574 Disease denotes pulmonary arterial hypertension MESH:D000081029
1746 7823-7827 Disease denotes ARDS MESH:D012128
1747 7837-7856 Disease denotes SARS-CoV infections MESH:C000657245
1771 8418-8443 Gene denotes Zrt- and Irt-like protein Gene:84619
1772 8445-8448 Gene denotes ZIP Gene:84619
1773 9787-9792 Gene denotes B0AT1 Gene:340024
1774 9832-9836 Gene denotes ACE2 Gene:59272
1775 9928-9935 Gene denotes insulin Gene:3630
1776 10057-10061 Gene denotes ACE2 Gene:59272
1777 10097-10101 Gene denotes ACE2 Gene:59272
1778 8908-8912 Species denotes rice Tax:4530
1779 9755-9760 Species denotes human Tax:9606
1780 8470-8474 Chemical denotes Zn2+
1781 8485-8489 Chemical denotes Cu2+
1782 8494-8498 Chemical denotes Fe2+
1783 8705-8715 Chemical denotes zinc oxide MESH:D015034
1784 8746-8764 Chemical denotes zinc chloride salt
1785 8936-8946 Chemical denotes folic acid MESH:D005492
1786 9076-9080 Chemical denotes Zn2+
1787 9190-9194 Chemical denotes Zn2+
1788 9223-9228 Chemical denotes amine MESH:D000588
1789 9240-9251 Chemical denotes carboxylate
1790 9357-9367 Chemical denotes ZnCl2 salt
1791 9371-9376 Chemical denotes Zn-AA
1792 9715-9722 Chemical denotes zinc-AA
1793 9868-9875 Chemical denotes zinc-AA
1800 10397-10410 Gene denotes serum albumin Gene:213
1801 10374-10378 Chemical denotes Zn2+
1802 10525-10529 Chemical denotes Zn2+
1803 10570-10574 Chemical denotes Zn2+
1804 10750-10754 Chemical denotes Zn2+
1805 10895-10899 Chemical denotes Zn2+
1875 11150-11153 Gene denotes ZIP Gene:84619
1876 12360-12363 Gene denotes ZIP Gene:84619
1877 12519-12522 Gene denotes ZIP Gene:84619
1878 12752-12759 Gene denotes albumin Gene:213
1879 13258-13265 Gene denotes albumin Gene:213
1880 13841-13851 Gene denotes fibrinogen Gene:2244
1881 14294-14301 Gene denotes albumin Gene:213
1882 13648-13655 Gene denotes albumin Gene:213
1883 13558-13565 Gene denotes albumin Gene:213
1884 13196-13203 Gene denotes albumin Gene:213
1885 12923-12930 Gene denotes albumin Gene:213
1886 12173-12181 Species denotes patients Tax:9606
1887 14709-14716 Species denotes patient Tax:9606
1888 15745-15753 Species denotes patients Tax:9606
1889 10970-10975 Chemical denotes metal MESH:D008670
1890 11131-11135 Chemical denotes Zn2+
1891 12215-12219 Chemical denotes Zn2+
1892 12262-12266 Chemical denotes Fe2+
1893 12271-12275 Chemical denotes Cu2+
1894 12331-12336 Chemical denotes metal MESH:D008670
1895 12478-12482 Chemical denotes Fe2+
1896 12510-12514 Chemical denotes Zn2+
1897 12608-12618 Chemical denotes EDTA metal
1898 12797-12802 Chemical denotes metal MESH:D008670
1899 12855-12870 Chemical denotes free fatty acid MESH:D005230
1900 12872-12875 Chemical denotes FFA MESH:D005230
1901 12964-12969 Chemical denotes metal MESH:D008670
1902 13237-13243 Chemical denotes carbon MESH:D002244
1903 13288-13292 Chemical denotes Zn2+
1904 13687-13691 Chemical denotes Zn2+
1905 13776-13780 Chemical denotes Zn2+
1906 13867-13874 Chemical denotes heparin MESH:D006493
1907 14470-14475 Chemical denotes ZnCl2 MESH:C016837
1908 14476-14479 Chemical denotes ZnO MESH:D015034
1909 14480-14496 Chemical denotes hexachloroethane MESH:C010182
1910 11662-11679 Disease denotes blood coagulation MESH:D001778
1911 11765-11788 Disease denotes cardiovascular diseases MESH:D002318
1912 11790-11808 Disease denotes metabolic syndrome MESH:D024821
1913 11810-11822 Disease denotes inflammation MESH:D007249
1914 11836-11842 Disease denotes stress MESH:D000079225
1915 11844-11852 Disease denotes diabetes MESH:D003920
1916 11857-11867 Disease denotes thrombosis MESH:D013927
1917 11984-12003 Disease denotes Alzheimer’s disease MESH:D000544
1918 12008-12027 Disease denotes cardiac dysfunction MESH:D006331
1919 12127-12136 Disease denotes Alzheimer MESH:D000544
1920 12147-12172 Disease denotes neurodegenerative disease MESH:D019636
1921 12442-12450 Disease denotes COVID-19 MESH:C000657245
1922 12671-12676 Disease denotes death MESH:D003643
1923 12698-12724 Disease denotes neurodegenerative diseases MESH:D019636
1924 13329-13341 Disease denotes dyslipidemia MESH:D050171
1925 13441-13447 Disease denotes stress MESH:D000079225
1926 13750-13769 Disease denotes Alzheimer’s disease MESH:D000544
1927 13990-14000 Disease denotes thrombotic MESH:D013927
1928 14311-14314 Disease denotes IBD MESH:D015212
1929 14316-14320 Disease denotes ARDS MESH:D012128
1930 14325-14333 Disease denotes COVID-19 MESH:C000657245
1931 14425-14429 Disease denotes ARDS MESH:D012128
1932 14676-14680 Disease denotes ARDS MESH:D012128
1933 14775-14779 Disease denotes ARDS MESH:D012128
1934 14794-14799 Disease denotes death MESH:D003643
1935 14805-14823 Disease denotes multiorgan failure MESH:D009102
1936 14851-14866 Disease denotes hepatic failure MESH:D017093
1937 15078-15083 Disease denotes death MESH:D003643
1938 15095-15114 Disease denotes respiratory failure MESH:D012131
1939 15348-15376 Disease denotes acute pulmonary hypertension MESH:D006976
1940 15423-15431 Disease denotes fibrosis MESH:D005355
1941 15520-15528 Disease denotes coughing MESH:D003371
1942 15533-15540 Disease denotes dyspnea MESH:D004417
1943 15736-15744 Disease denotes COVID-19 MESH:C000657245
1946 15811-15815 Gene denotes ACE2 Gene:59272
1947 15793-15800 Chemical denotes MLN4760 MESH:C486469
1977 15868-15872 Gene denotes ACE2 Gene:59272
1978 16062-16066 Gene denotes ACE2 Gene:59272
1979 16365-16369 Gene denotes ACE2 Gene:59272
1980 16491-16495 Gene denotes ACE2 Gene:59272
1981 16731-16735 Gene denotes ACE2 Gene:59272
1982 16785-16789 Gene denotes ACE2 Gene:59272
1983 16816-16820 Gene denotes ACE2 Gene:59272
1984 16849-16853 Gene denotes ACE2 Gene:59272
1985 16945-16949 Gene denotes ACE2 Gene:59272
1986 17047-17051 Gene denotes ACE2 Gene:59272
1987 17109-17113 Gene denotes ACE2 Gene:59272
1988 17192-17196 Gene denotes ACE2 Gene:59272
1989 17227-17231 Gene denotes ACE2 Gene:59272
1990 17245-17249 Gene denotes ACE2 Gene:59272
1991 17303-17307 Gene denotes ACE2 Gene:59272
1992 17406-17410 Gene denotes ACE2 Gene:59272
1993 17625-17629 Gene denotes ACE2 Gene:59272
1994 17714-17718 Gene denotes ACE2 Gene:59272
1995 17261-17266 Gene denotes spike Gene:43740568
1996 17086-17091 Gene denotes spike Gene:43740568
1997 16993-16998 Gene denotes spike Gene:43740568
1998 16919-16924 Gene denotes spike Gene:43740568
1999 16810-16815 Gene denotes spike Gene:43740568
2000 17650-17653 Gene denotes MLN Gene:4295
2001 16725-16730 Species denotes human Tax:9606
2002 16843-16848 Species denotes human Tax:9606
2003 17789-17794 Gene denotes spike Gene:43740568
2004 17543-17548 Gene denotes spike Gene:43740568
2005 17774-17779 Chemical denotes sACE2
2046 17850-17854 Gene denotes ACE2 Gene:59272
2047 17903-17907 Gene denotes ACE2 Gene:59272
2048 18249-18252 Gene denotes ACE Gene:59272
2049 18788-18792 Gene denotes ACE2 Gene:59272
2050 18986-18990 Gene denotes CD34 Gene:947
2051 19034-19038 Gene denotes ACE2 Gene:59272
2052 19956-19960 Gene denotes ACE2 Gene:59272
2053 20132-20136 Gene denotes ACE2 Gene:59272
2054 20186-20190 Gene denotes ACE2 Gene:59272
2055 20239-20243 Gene denotes ACE2 Gene:59272
2056 20318-20322 Gene denotes ACE2 Gene:59272
2057 19667-19675 Gene denotes Ang (1–7 Gene:284
2058 19504-19507 Gene denotes MLN Gene:4295
2059 19181-19184 Gene denotes MLN Gene:4295
2060 18129-18132 Gene denotes MLN Gene:4295
2061 18921-18926 Gene denotes mACE2 Gene:70008
2062 18807-18812 Gene denotes mACE2 Gene:70008
2063 17844-17849 Species denotes human Tax:9606
2064 17897-17902 Species denotes human Tax:9606
2065 18239-18244 Species denotes human Tax:9606
2066 20264-20269 Species denotes human Tax:9606
2067 19643-19649 Gene denotes Ang II Gene:24179
2068 17810-17817 Chemical denotes MLN4760 MESH:C486469
2069 18256-18262 Chemical denotes rhACE2
2070 18361-18366 Chemical denotes rhACE
2071 18453-18458 Chemical denotes rhACE
2072 18522-18528 Chemical denotes rhACE2
2073 18598-18604 Chemical denotes rhACE2
2074 18631-18637 Chemical denotes rhACE2
2075 18645-18650 Chemical denotes rhACE
2076 19050-19055 Chemical denotes Dx600
2077 19194-19199 Chemical denotes DX600
2078 19246-19255 Chemical denotes disulfide MESH:D004220
2079 19370-19376 Chemical denotes rhACE2
2080 19565-19571 Chemical denotes rhACE2
2081 19629-19635 Chemical denotes rhACE2
2082 19686-19691 Chemical denotes DX600
2083 19735-19741 Chemical denotes rhACE2
2084 19979-19984 Chemical denotes Dx600
2085 19454-19474 Disease denotes hypercapnic acidosis MESH:D000138
2117 20385-20389 Gene denotes ACE2 Gene:59272
2118 20558-20562 Gene denotes ACE2 Gene:59272
2119 20654-20658 Gene denotes ACE2 Gene:59272
2120 20765-20772 Gene denotes Ang 1–7 Gene:284
2121 20823-20827 Gene denotes ACE2 Gene:70008
2122 21200-21204 Gene denotes ACE2 Gene:302668
2123 21474-21478 Gene denotes ACE2 Gene:302668
2124 21561-21565 Gene denotes ACE2 Gene:70008
2125 21599-21602 Gene denotes ACE Gene:70008
2126 20738-20744 Gene denotes Ang II Gene:24179
2127 21571-21574 Gene denotes MLN Gene:69563
2128 20898-20901 Gene denotes MLN Gene:69563
2129 20468-20471 Gene denotes MLN Gene:4295
2130 20346-20349 Gene denotes MLN Gene:4295
2131 21015-21019 Species denotes mice Tax:10090
2132 21072-21076 Species denotes rats Tax:10116
2133 21446-21450 Species denotes rats Tax:10116
2134 21673-21677 Species denotes mice Tax:10090
2135 21048-21058 Species denotes transgenic Tax:10090
2136 20996-21001 Chemical denotes water MESH:D014867
2137 21351-21358 Chemical denotes MLN4760 MESH:C486469
2138 21641-21655 Chemical denotes streptozotocin MESH:D013311
2139 20861-20873 Disease denotes hypertensive MESH:D006973
2140 21059-21071 Disease denotes hypertensive MESH:D006973
2141 21166-21178 Disease denotes hypertensive MESH:D006973
2142 21284-21296 Disease denotes hypertensive MESH:D006973
2143 21503-21514 Disease denotes bradycardia MESH:D001919
2144 21604-21615 Disease denotes albuminuria MESH:D000419
2145 21620-21637 Disease denotes glomerular injury MESH:D007674
2146 21664-21672 Disease denotes diabetic MESH:D003920
2147 21738-21746 Disease denotes diabetic MESH:D003920
2177 21843-21847 Gene denotes ACE2 Gene:59272
2178 22301-22306 Gene denotes rACE2 Gene:302668
2179 22364-22368 Gene denotes ACE2 Gene:59272
2180 23088-23092 Gene denotes ACE2 Gene:302668
2181 23282-23286 Gene denotes ACE2 Gene:302668
2182 23374-23378 Gene denotes ACE2 Gene:302668
2183 23599-23602 Gene denotes ACE Gene:70008
2184 23603-23607 Gene denotes ACE2 Gene:70008
2185 23451-23454 Gene denotes MLN Gene:69563
2186 23146-23149 Gene denotes MLN Gene:100126231
2187 22736-22739 Gene denotes MLN Gene:100126231
2188 22569-22572 Gene denotes MLN Gene:4295
2189 22251-22254 Gene denotes MLN Gene:69563
2190 22010-22014 Species denotes mice Tax:10090
2191 22144-22149 Species denotes mouse Tax:10090
2192 22295-22300 Species denotes human Tax:9606
2193 22542-22547 Species denotes human Tax:9606
2194 22698-22717 Species denotes Sprague-Dawley rats Tax:10116
2195 23514-23519 Species denotes mouse Tax:10090
2196 21817-21822 Chemical denotes DX600
2197 22851-22856 Chemical denotes water MESH:D014867
2198 23431-23437 Chemical denotes GL1001 MESH:C486469
2199 22177-22194 Disease denotes lung inflammation MESH:D011014
2200 22425-22434 Disease denotes mortality MESH:D003643
2201 22664-22685 Disease denotes myocardial infarction MESH:D009203
2202 22926-22935 Disease denotes pressures MESH:D006973
2203 23112-23133 Disease denotes myocardial infarction MESH:D009203
2204 23185-23193 Disease denotes COVID-19 MESH:C000657245
2205 23529-23536 Disease denotes colitis MESH:D003092
2229 23707-23711 Gene denotes ACE2 Gene:59272
2230 23771-23775 Gene denotes ACE2 Gene:59272
2231 23781-23784 Gene denotes ACE Gene:59272
2232 23900-23904 Gene denotes ACE2 Gene:59272
2233 23910-23913 Gene denotes ACE Gene:59272
2234 23994-23998 Gene denotes ACE2 Gene:59272
2235 24296-24307 Gene denotes transferrin Gene:7018
2236 25141-25148 Species denotes patient Tax:9606
2237 23932-23936 Chemical denotes EDTA MESH:D004492
2238 24027-24031 Chemical denotes EDTA MESH:D004492
2239 24080-24084 Chemical denotes Zn2+
2240 24093-24097 Chemical denotes Ca2+ MESH:D000069285
2241 24102-24106 Chemical denotes Fe2+
2242 24148-24152 Chemical denotes Ca2+ MESH:D000069285
2243 24228-24232 Chemical denotes Zn2+
2244 24269-24273 Chemical denotes iron MESH:D007501
2245 24331-24335 Chemical denotes iron MESH:D007501
2246 24442-24447 Chemical denotes metal MESH:D008670
2247 24504-24508 Chemical denotes EDTA MESH:D004492
2248 24522-24526 Chemical denotes Zn2+
2249 24614-24623 Chemical denotes CaNa2EDTA
2250 25095-25104 Chemical denotes CaNa2EDTA
2251 24910-24925 Disease denotes zinc deficiency MESH:C564286
2267 25662-25665 Gene denotes ACE Gene:59272
2268 25669-25673 Gene denotes ACE2 Gene:59272
2269 25809-25812 Gene denotes ACE Gene:59272
2270 25817-25821 Gene denotes ACE2 Gene:59272
2271 25881-25884 Gene denotes ACE Gene:59272
2272 25889-25893 Gene denotes ACE2 Gene:59272
2273 26116-26120 Gene denotes ACE2 Gene:59272
2274 26121-26124 Gene denotes ACE Gene:59272
2275 26225-26229 Gene denotes ACE2 Gene:59272
2276 26464-26468 Gene denotes ACE2 Gene:59272
2277 26435-26438 Gene denotes MLN Gene:4295
2278 25253-25262 Chemical denotes CaNa2EDTA
2279 25400-25404 Chemical denotes iron MESH:D007501
2280 25588-25593 Chemical denotes metal MESH:D008670
2281 26013-26018 Chemical denotes metal MESH:D008670
2295 26808-26818 Gene denotes fibrinogen Gene:2244
2296 26682-26690 Species denotes patients Tax:9606
2297 27271-27279 Species denotes patients Tax:9606
2298 26505-26516 Chemical denotes chloroquine MESH:D002738
2299 26765-26769 Chemical denotes Zn2+
2300 26844-26855 Chemical denotes chloroquine MESH:D002738
2301 27004-27008 Chemical denotes Zn2+
2302 27184-27188 Chemical denotes Zn2+
2303 27316-27327 Chemical denotes chloroquine MESH:D002738
2304 26673-26681 Disease denotes COVID-19 MESH:C000657245
2305 26887-26897 Disease denotes thrombotic MESH:D013927
2306 27233-27243 Disease denotes thrombotic MESH:D013927
2307 27262-27270 Disease denotes COVID-19 MESH:C000657245
2329 28307-28314 Species denotes patient Tax:9606
2330 27649-27654 Chemical denotes metal MESH:D008670
2331 28074-28078 Chemical denotes EDTA MESH:D004492
2332 28270-28275 Chemical denotes metal MESH:D008670
2333 27473-27481 Disease denotes COVID-19 MESH:C000657245
2334 27482-27491 Disease denotes infection MESH:D007239
2335 27524-27531 Disease denotes hypoxia MESH:D000860
2336 27733-27765 Disease denotes fatal renal toxicity and failure MESH:D051437
2337 27767-27795 Disease denotes hepatic toxicity and failure MESH:D056486
2338 27797-27825 Disease denotes gastrointestinal haemorrhage MESH:D006471
2339 27827-27838 Disease denotes arrhythmias MESH:D001145
2340 27840-27846 Disease denotes tetany MESH:D013746
2341 27848-27861 Disease denotes hypocalcaemia
2342 27863-27874 Disease denotes hypotension MESH:D007022
2343 27876-27887 Disease denotes convulsions MESH:D012640
2344 27889-27907 Disease denotes respiratory arrest MESH:D012131
2345 27913-27928 Disease denotes agranulocytosis MESH:D000380
2346 27954-27964 Disease denotes infections MESH:D007239
2347 27969-27974 Disease denotes death MESH:D003643
2348 28020-28034 Disease denotes renal toxicity MESH:D007674
2349 28121-28142 Disease denotes renal artery diseases MESH:D007674
2388 28630-28634 Gene denotes ACE2 Gene:59272
2389 28647-28650 Gene denotes ACE Gene:59272
2390 28812-28816 Gene denotes ACE2 Gene:59272
2391 28927-28931 Gene denotes ACE2 Gene:59272
2392 29187-29191 Gene denotes ACE2 Gene:59272
2393 29210-29213 Gene denotes ACE Gene:59272
2394 29229-29233 Gene denotes ACE2 Gene:59272
2395 29278-29281 Gene denotes ACE Gene:59272
2396 29286-29290 Gene denotes ACE2 Gene:59272
2397 29359-29363 Gene denotes ACE2 Gene:59272
2398 29399-29402 Gene denotes ACE Gene:59272
2399 29563-29567 Gene denotes ACE2 Gene:59272
2400 29616-29620 Gene denotes ACE2 Gene:59272
2401 29719-29723 Gene denotes ACE2 Gene:59272
2402 29839-29843 Gene denotes ACE2 Gene:59272
2403 29867-29871 Gene denotes ACE2 Gene:59272
2404 29996-30000 Gene denotes ACE2 Gene:59272
2405 30123-30127 Gene denotes ACE2 Gene:59272
2406 30468-30476 Gene denotes Ang (1–9 Gene:284
2407 30520-30524 Gene denotes ACE2 Gene:59272
2408 30459-30463 Gene denotes MasR Gene:116511
2409 30449-30457 Gene denotes Ang (1–7 Gene:284
2410 29891-29896 Gene denotes spike Gene:43740568
2411 30069-30072 Gene denotes MLN Gene:4295
2412 29908-29916 Species denotes SARS-CoV Tax:694009
2413 29802-29810 Species denotes SARS-CoV Tax:694009
2414 29477-29493 Chemical denotes basic amino acid MESH:D024361
2415 29633-29641 Chemical denotes agmatine MESH:D000376
2416 29658-29666 Chemical denotes arginine MESH:D001120
2417 29735-29739 Chemical denotes NAAE
2418 29747-29751 Chemical denotes NAAE
2419 29939-29943 Chemical denotes NAAE
2420 29981-29985 Chemical denotes NAAE
2421 30091-30099 Chemical denotes agmatine MESH:D000376
2422 30559-30567 Chemical denotes agmatine MESH:D000376
2423 30656-30664 Chemical denotes agmatine MESH:D000376
2424 30751-30767 Chemical denotes agmatine sulfate
2425 30717-30733 Disease denotes neuropathic pain MESH:D009437
2442 31265-31269 Gene denotes ACE2 Gene:59272
2443 31274-31277 Gene denotes ACE Gene:59272
2444 31084-31091 Species denotes soybean Tax:3847
2445 31753-31758 Species denotes human Tax:9606
2446 31926-31931 Species denotes human Tax:9606
2447 30831-30836 Chemical denotes metal MESH:D008670
2448 30855-30863 Chemical denotes phytates MESH:D010833
2449 30868-30878 Chemical denotes folic acid MESH:D005492
2450 31039-31052 Chemical denotes nicotianamine MESH:C082893
2451 31119-31124 Chemical denotes metal MESH:D008670
2452 31166-31171 Chemical denotes metal MESH:D008670
2453 31181-31194 Chemical denotes Nicotianamine MESH:C082893
2454 31298-31306 Chemical denotes zeolites MESH:D017641
2455 31391-31406 Chemical denotes aluminosilicate MESH:C049037
2456 31622-31627 Chemical denotes water MESH:D014867
2457 31792-31806 Chemical denotes clinoptilolite MESH:C083175
2473 32009-32013 Gene denotes ACE2 Gene:59272
2474 32220-32224 Gene denotes ACE2 Gene:59272
2475 32327-32331 Gene denotes ACE2 Gene:59272
2476 32466-32470 Gene denotes ACE2 Gene:59272
2477 32594-32599 Gene denotes hACE2 Gene:59272
2478 32177-32187 Species denotes SARS-CoV-2 Tax:2697049
2479 32321-32326 Species denotes human Tax:9606
2480 32687-32695 Species denotes patients Tax:9606
2481 32725-32731 Chemical denotes rhACE2
2482 32057-32075 Disease denotes SARS-CoV infection MESH:C000657245
2483 32254-32269 Disease denotes viral infection MESH:D001102
2484 32362-32370 Disease denotes COVID-19 MESH:C000657245
2485 32384-32388 Disease denotes ARDS MESH:D012128
2486 32678-32686 Disease denotes COVID-19 MESH:C000657245
2487 32735-32739 Disease denotes ARDS MESH:D012128

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T233 1335-1346 Disease denotes hypotension http://purl.obolibrary.org/obo/MONDO_0005468
T234 2046-2054 Disease denotes COVID–19 http://purl.obolibrary.org/obo/MONDO_0100096
T235 2248-2256 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T236 2534-2542 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T237 2534-2538 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T238 2563-2598 Disease denotes adult respiratory distress syndrome http://purl.obolibrary.org/obo/MONDO_0006502
T239 2569-2598 Disease denotes respiratory distress syndrome http://purl.obolibrary.org/obo/MONDO_0009971
T240 2600-2604 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T241 2608-2616 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T242 2678-2704 Disease denotes inflammatory bowel disease http://purl.obolibrary.org/obo/MONDO_0005265
T243 2706-2709 Disease denotes IBD http://purl.obolibrary.org/obo/MONDO_0005052|http://purl.obolibrary.org/obo/MONDO_0005265
T245 3188-3192 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T246 3370-3374 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T247 4502-4506 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T248 4598-4602 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T249 4648-4656 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T250 4896-4912 Disease denotes allergic disease http://purl.obolibrary.org/obo/MONDO_0005271
T251 4896-4904 Disease denotes allergic http://purl.obolibrary.org/obo/MONDO_0004980
T252 4926-4948 Disease denotes chronic kidney disease http://purl.obolibrary.org/obo/MONDO_0005300
T253 4934-4948 Disease denotes kidney disease http://purl.obolibrary.org/obo/MONDO_0001343|http://purl.obolibrary.org/obo/MONDO_0005240
T255 4979-5001 Disease denotes cardiovascular disease http://purl.obolibrary.org/obo/MONDO_0004995
T256 5039-5047 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T257 5188-5209 Disease denotes chronic renal disease http://purl.obolibrary.org/obo/MONDO_0005300
T258 5196-5209 Disease denotes renal disease http://purl.obolibrary.org/obo/MONDO_0002118|http://purl.obolibrary.org/obo/MONDO_0005240
T260 5376-5398 Disease denotes chronic renal diseases http://purl.obolibrary.org/obo/MONDO_0005300
T261 5420-5424 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T262 5587-5593 Disease denotes asthma http://purl.obolibrary.org/obo/MONDO_0004979
T263 5699-5705 Disease denotes asthma http://purl.obolibrary.org/obo/MONDO_0004979
T264 5966-5970 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T265 6026-6034 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T266 6225-6229 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T267 6267-6275 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T268 6319-6322 Disease denotes flu http://purl.obolibrary.org/obo/MONDO_0005812
T269 6493-6502 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T270 6784-6792 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T271 7219-7227 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T272 7543-7574 Disease denotes pulmonary arterial hypertension http://purl.obolibrary.org/obo/MONDO_0015924|http://purl.obolibrary.org/obo/MONDO_0024533
T274 7562-7574 Disease denotes hypertension http://purl.obolibrary.org/obo/MONDO_0005044
T275 7576-7579 Disease denotes PAH http://purl.obolibrary.org/obo/MONDO_0015924
T276 7592-7600 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T277 7592-7596 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T278 7823-7827 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T279 7829-7832 Disease denotes PAH http://purl.obolibrary.org/obo/MONDO_0015924
T280 7837-7845 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T281 7837-7841 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T282 7846-7856 Disease denotes infections http://purl.obolibrary.org/obo/MONDO_0005550
T283 11765-11788 Disease denotes cardiovascular diseases http://purl.obolibrary.org/obo/MONDO_0004995
T284 11790-11808 Disease denotes metabolic syndrome http://purl.obolibrary.org/obo/MONDO_0004955
T285 11810-11822 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T286 11844-11852 Disease denotes diabetes http://purl.obolibrary.org/obo/MONDO_0005015
T287 11857-11867 Disease denotes thrombosis http://purl.obolibrary.org/obo/MONDO_0000831
T288 11943-11950 Disease denotes amyloid http://purl.obolibrary.org/obo/MONDO_0019065
T289 11984-12003 Disease denotes Alzheimer’s disease http://purl.obolibrary.org/obo/MONDO_0004975
T290 12147-12172 Disease denotes neurodegenerative disease http://purl.obolibrary.org/obo/MONDO_0005559
T291 12442-12450 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T292 12698-12724 Disease denotes neurodegenerative diseases http://purl.obolibrary.org/obo/MONDO_0005559
T293 12872-12875 Disease denotes FFA http://purl.obolibrary.org/obo/MONDO_0016776
T294 13172-13175 Disease denotes FFA http://purl.obolibrary.org/obo/MONDO_0016776
T295 13329-13341 Disease denotes dyslipidemia http://purl.obolibrary.org/obo/MONDO_0002525
T296 13697-13704 Disease denotes amyloid http://purl.obolibrary.org/obo/MONDO_0019065
T297 13750-13769 Disease denotes Alzheimer’s disease http://purl.obolibrary.org/obo/MONDO_0004975
T298 14311-14314 Disease denotes IBD http://purl.obolibrary.org/obo/MONDO_0005052|http://purl.obolibrary.org/obo/MONDO_0005265
T300 14316-14320 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T301 14325-14333 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T302 14425-14429 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T303 14676-14680 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T304 14775-14779 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T305 14805-14823 Disease denotes multiorgan failure http://purl.obolibrary.org/obo/MONDO_0043726
T306 15095-15114 Disease denotes respiratory failure http://purl.obolibrary.org/obo/MONDO_0021113
T307 15237-15243 Disease denotes injury http://purl.obolibrary.org/obo/MONDO_0021178
T308 15354-15376 Disease denotes pulmonary hypertension http://purl.obolibrary.org/obo/MONDO_0005149
T309 15364-15376 Disease denotes hypertension http://purl.obolibrary.org/obo/MONDO_0005044
T310 15736-15744 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T311 16348-16352 Disease denotes clam http://purl.obolibrary.org/obo/MONDO_0011948
T312 19466-19474 Disease denotes acidosis http://purl.obolibrary.org/obo/MONDO_0006022
T313 19498-19502 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T314 20786-20812 Disease denotes increase of blood pressure http://purl.obolibrary.org/obo/MONDO_0005044
T315 21631-21637 Disease denotes injury http://purl.obolibrary.org/obo/MONDO_0021178
T316 22182-22194 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T317 22664-22685 Disease denotes myocardial infarction http://purl.obolibrary.org/obo/MONDO_0005068
T318 23112-23133 Disease denotes myocardial infarction http://purl.obolibrary.org/obo/MONDO_0005068
T319 23185-23193 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T320 23529-23536 Disease denotes colitis http://purl.obolibrary.org/obo/MONDO_0005292
T321 26673-26681 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T322 27262-27270 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T323 27473-27481 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T324 27482-27491 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T325 27827-27838 Disease denotes arrhythmias http://purl.obolibrary.org/obo/MONDO_0007263
T326 27863-27874 Disease denotes hypotension http://purl.obolibrary.org/obo/MONDO_0005468
T327 27913-27928 Disease denotes agranulocytosis http://purl.obolibrary.org/obo/MONDO_0001609
T328 27954-27964 Disease denotes infections http://purl.obolibrary.org/obo/MONDO_0005550
T329 28121-28142 Disease denotes renal artery diseases http://purl.obolibrary.org/obo/MONDO_0002286
T330 29802-29810 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T331 29802-29806 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T332 29908-29916 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T333 29908-29912 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T334 32057-32075 Disease denotes SARS-CoV infection http://purl.obolibrary.org/obo/MONDO_0005091
T335 32057-32061 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T336 32066-32075 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T337 32177-32185 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T338 32177-32181 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T339 32254-32269 Disease denotes viral infection http://purl.obolibrary.org/obo/MONDO_0005108
T340 32260-32269 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T341 32362-32370 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T342 32384-32388 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T343 32393-32396 Disease denotes PAH http://purl.obolibrary.org/obo/MONDO_0015924
T344 32678-32686 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T345 32735-32739 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T346 32744-32747 Disease denotes PAH http://purl.obolibrary.org/obo/MONDO_0015924

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T452 131-132 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T453 260-261 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T454 292-293 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T455 359-360 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T456 391-392 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T457 448-451 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T458 452-453 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T459 510-511 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T460 607-615 http://purl.obolibrary.org/obo/PR_000018263 denotes peptides
T461 680-688 http://purl.obolibrary.org/obo/PR_000018263 denotes peptides
T462 773-778 http://purl.obolibrary.org/obo/UBERON_0000948 denotes heart
T463 773-778 http://purl.obolibrary.org/obo/UBERON_0007100 denotes heart
T464 773-778 http://purl.obolibrary.org/obo/UBERON_0015228 denotes heart
T465 773-778 http://www.ebi.ac.uk/efo/EFO_0000815 denotes heart
T466 780-787 http://purl.obolibrary.org/obo/UBERON_0002113 denotes kidneys
T467 780-787 http://www.ebi.ac.uk/efo/EFO_0000927 denotes kidneys
T468 780-787 http://www.ebi.ac.uk/efo/EFO_0000929 denotes kidneys
T469 789-794 http://purl.obolibrary.org/obo/UBERON_0002107 denotes liver
T470 789-794 http://www.ebi.ac.uk/efo/EFO_0000887 denotes liver
T471 796-801 http://purl.obolibrary.org/obo/UBERON_0001155 denotes colon
T472 803-818 http://purl.obolibrary.org/obo/UBERON_0002108 denotes small intestine
T473 820-824 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T474 820-824 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T475 826-831 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
T476 826-831 http://www.ebi.ac.uk/efo/EFO_0000302 denotes brain
T477 836-842 http://purl.obolibrary.org/obo/UBERON_0000473 denotes testes
T478 911-925 http://purl.obolibrary.org/obo/CL_0000746 denotes cardiomyocytes
T479 927-938 http://purl.obolibrary.org/obo/UBERON_0001986 denotes endothelium
T480 957-962 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T481 973-979 http://purl.obolibrary.org/obo/UBERON_0001005 denotes airway
T482 980-985 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T483 996-1015 http://purl.obolibrary.org/obo/CL_0000192 denotes smooth muscle cells
T484 1031-1043 http://purl.obolibrary.org/obo/CL_0000178 denotes Leydig cells
T485 1118-1128 http://purl.obolibrary.org/obo/CL_0000066 denotes epithelial
T486 1129-1134 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T487 1138-1151 http://purl.obolibrary.org/obo/UBERON_0009773 denotes renal tubules
T488 1153-1157 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T489 1153-1157 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T490 1205-1210 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T491 1257-1267 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T492 1399-1400 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T493 1471-1480 http://purl.obolibrary.org/obo/CLO_0001658 denotes activated
T494 1699-1709 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T495 1985-1991 http://purl.obolibrary.org/obo/CLO_0001658 denotes active
T496 2028-2034 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T497 2218-2224 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T498 2304-2314 http://purl.obolibrary.org/obo/CLO_0001658 denotes activities
T499 2443-2449 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T500 2467-2468 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T501 2606-2607 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T502 2711-2712 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T503 2741-2749 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T504 2785-2791 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T505 2839-2845 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T506 3030-3036 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T507 3069-3075 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T508 3122-3128 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T509 3155-3156 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T510 3346-3352 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T511 3658-3664 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T512 3746-3747 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T513 3825-3826 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T514 3900-3905 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T515 3998-4005 http://purl.obolibrary.org/obo/UBERON_0003100 denotes females
T516 4038-4043 http://purl.obolibrary.org/obo/UBERON_0003101 denotes males
T517 4038-4043 http://www.ebi.ac.uk/efo/EFO_0000970 denotes males
T518 4219-4225 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T519 4309-4314 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T520 4442-4450 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T521 4547-4554 http://purl.obolibrary.org/obo/PR_000018263 denotes peptide
T522 4573-4579 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T523 4753-4754 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T524 4809-4815 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T525 4840-4848 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T526 4934-4940 http://purl.obolibrary.org/obo/UBERON_0002113 denotes kidney
T527 4934-4940 http://www.ebi.ac.uk/efo/EFO_0000927 denotes kidney
T528 4934-4940 http://www.ebi.ac.uk/efo/EFO_0000929 denotes kidney
T529 4966-4967 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T530 5056-5057 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T531 5120-5128 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T532 5364-5372 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T533 5444-5445 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T534 5480-5481 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T535 5512-5513 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T536 5665-5671 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T537 5940-5946 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T538 6086-6095 http://purl.obolibrary.org/obo/CLO_0001658 denotes activated
T539 6187-6197 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T540 6206-6210 http://www.ebi.ac.uk/efo/EFO_0001410 denotes arms
T541 6317-6318 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T542 6407-6408 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T543 6571-6574 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T544 6613-6619 http://purl.obolibrary.org/obo/UBERON_0001630 denotes muscle
T545 6613-6619 http://purl.obolibrary.org/obo/UBERON_0005090 denotes muscle
T546 6613-6619 http://www.ebi.ac.uk/efo/EFO_0000801 denotes muscle
T547 6613-6619 http://www.ebi.ac.uk/efo/EFO_0001949 denotes muscle
T548 6702-6706 http://purl.obolibrary.org/obo/CLO_0053704 denotes IL-8
T549 6863-6867 http://purl.obolibrary.org/obo/CLO_0053704 denotes IL-8
T550 6896-6897 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T551 7108-7117 http://purl.obolibrary.org/obo/CL_0000576 denotes monocytes
T552 7136-7142 http://purl.obolibrary.org/obo/CL_0000084 denotes T cell
T553 7159-7162 http://purl.obolibrary.org/obo/CLO_0054060 denotes 102
T554 7192-7195 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T555 7306-7309 http://purl.obolibrary.org/obo/CLO_0054060 denotes 102
T556 7330-7341 http://www.ebi.ac.uk/efo/EFO_0000296 denotes blood cells
T557 7382-7383 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T558 7469-7473 http://purl.obolibrary.org/obo/CLO_0053704 denotes IL-8
T559 7543-7561 http://purl.obolibrary.org/obo/UBERON_0002012 denotes pulmonary arterial
T560 7543-7561 http://www.ebi.ac.uk/efo/EFO_0001399 denotes pulmonary arterial
T561 7607-7611 http://www.ebi.ac.uk/efo/EFO_0001410 denotes arms
T562 7654-7658 http://purl.obolibrary.org/obo/PR_000001379 denotes IL-2
T563 7672-7676 http://purl.obolibrary.org/obo/CLO_0053704 denotes IL-8
T564 7762-7763 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T565 7791-7801 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T566 7957-7958 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T567 8350-8372 http://purl.obolibrary.org/obo/UBERON_0005409 denotes gastrointestinal tract
T568 8792-8802 http://purl.obolibrary.org/obo/UBERON_0000160 denotes intestinal
T569 8792-8802 http://www.ebi.ac.uk/efo/EFO_0000834 denotes intestinal
T570 9131-9133 http://purl.obolibrary.org/obo/CLO_0001627 denotes AA
T571 9271-9272 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T572 9374-9376 http://purl.obolibrary.org/obo/CLO_0001627 denotes AA
T573 9477-9485 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T574 9506-9516 http://purl.obolibrary.org/obo/UBERON_0000160 denotes intestinal
T575 9506-9516 http://www.ebi.ac.uk/efo/EFO_0000834 denotes intestinal
T576 9549-9554 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T577 9549-9554 http://www.ebi.ac.uk/efo/EFO_0000296 denotes blood
T578 9619-9621 http://purl.obolibrary.org/obo/CLO_0001627 denotes AA
T579 9720-9722 http://purl.obolibrary.org/obo/CLO_0001627 denotes AA
T580 9736-9738 http://purl.obolibrary.org/obo/CLO_0001627 denotes AA
T581 9755-9760 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T582 9801-9803 http://purl.obolibrary.org/obo/CLO_0001627 denotes AA
T583 9873-9875 http://purl.obolibrary.org/obo/CLO_0001627 denotes AA
T584 9884-9885 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T585 9928-9935 http://purl.obolibrary.org/obo/PR_000009054 denotes insulin
T586 9975-9980 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T587 9996-9997 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T588 10042-10050 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T589 10140-10146 http://purl.obolibrary.org/obo/UBERON_0001969 denotes Plasma
T590 10194-10195 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T591 10212-10222 http://purl.obolibrary.org/obo/UBERON_0000160 denotes intestinal
T592 10212-10222 http://www.ebi.ac.uk/efo/EFO_0000834 denotes intestinal
T593 10382-10387 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T594 10382-10387 http://www.ebi.ac.uk/efo/EFO_0000296 denotes blood
T595 10477-10483 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T596 10557-10559 http://purl.obolibrary.org/obo/CLO_0001627 denotes AA
T597 10666-10676 http://purl.obolibrary.org/obo/CLO_0001658 denotes activities
T598 10706-10718 http://purl.obolibrary.org/obo/UBERON_0001969 denotes blood plasma
T599 10786-10803 http://purl.obolibrary.org/obo/CL_0000115 denotes endothelial cells
T600 10835-10852 http://purl.obolibrary.org/obo/CL_0000115 denotes endothelial cells
T601 10905-10911 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T602 10948-10949 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T603 11088-11098 http://purl.obolibrary.org/obo/CL_0000000 denotes cell types
T604 11109-11115 http://purl.obolibrary.org/obo/UBERON_0001969 denotes Plasma
T605 11174-11178 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T606 11195-11200 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T607 11217-11223 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T608 11242-11247 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T609 11249-11266 http://purl.obolibrary.org/obo/CL_0000115 denotes endothelial cells
T610 11280-11294 http://purl.obolibrary.org/obo/CL_0000746 denotes cardiomyocytes
T611 11520-11530 http://purl.obolibrary.org/obo/CLO_0001658 denotes activities
T612 11558-11573 http://purl.obolibrary.org/obo/CL_0000786 denotes plasma to cells
T613 11662-11667 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T614 11662-11667 http://www.ebi.ac.uk/efo/EFO_0000296 denotes blood
T615 11690-11700 http://purl.obolibrary.org/obo/SO_0000418 denotes signalling
T616 11706-11707 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T617 11906-11909 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T618 11943-11963 http://purl.obolibrary.org/obo/PR_000036193 denotes amyloid beta-peptide
T619 12104-12107 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T620 12294-12295 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T621 12407-12413 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T622 12628-12631 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T623 12666-12670 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T624 12688-12694 http://purl.obolibrary.org/obo/UBERON_0000473 denotes tested
T625 12726-12729 http://purl.obolibrary.org/obo/CLO_0054060 denotes 102
T626 12745-12751 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T627 12768-12769 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T628 12946-12947 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T629 13225-13228 http://purl.obolibrary.org/obo/CLO_0050884 denotes ten
T630 13305-13306 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T631 13408-13414 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T632 13452-13462 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T633 13597-13603 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T634 13638-13639 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T635 13697-13718 http://purl.obolibrary.org/obo/PR_000036193 denotes amyloid beta-peptides
T636 13781-13784 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T637 13875-13883 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T638 13907-13910 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T639 13921-13922 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T640 14075-14081 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T641 14145-14151 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T642 14218-14228 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T643 14287-14293 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T644 14356-14362 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T645 14707-14708 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T646 14884-14885 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T647 14939-14940 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T648 14965-14971 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T649 15037-15042 http://purl.obolibrary.org/obo/UBERON_0002107 denotes liver
T650 15037-15042 http://www.ebi.ac.uk/efo/EFO_0000887 denotes liver
T651 15220-15236 http://purl.obolibrary.org/obo/CL_0000115 denotes endothelial cell
T652 15292-15310 http://purl.obolibrary.org/obo/UBERON_0002012 denotes pulmonary arteries
T653 15292-15310 http://www.ebi.ac.uk/efo/EFO_0001399 denotes pulmonary arteries
T654 15568-15572 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T655 15568-15572 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T656 15623-15627 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T657 15623-15627 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T658 15637-15642 http://purl.obolibrary.org/obo/UBERON_0000473 denotes tests
T659 15915-15923 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T660 15949-15957 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T661 16124-16125 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T662 16138-16145 http://purl.obolibrary.org/obo/CLO_0001927 denotes bending
T663 16162-16170 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T664 16222-16230 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T665 16346-16347 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T666 16514-16515 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T667 16531-16539 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T668 16638-16646 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T669 16725-16730 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T670 16843-16848 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T671 16870-16874 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T672 16886-16887 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T673 17065-17071 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T674 17072-17080 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T675 17148-17156 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T676 17318-17326 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T677 17390-17398 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T678 17660-17663 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T679 17821-17822 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T680 17844-17849 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T681 17897-17902 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T682 17934-17935 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T683 18008-18009 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T684 18018-18019 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T685 18054-18055 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T686 18115-18118 http://purl.obolibrary.org/obo/CLO_0053001 denotes 114
T687 18121-18128 http://purl.obolibrary.org/obo/UBERON_0000473 denotes Testing
T688 18187-18188 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T689 18239-18244 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T690 18246-18248 http://purl.obolibrary.org/obo/CLO_0008812 denotes rh
T691 18263-18273 http://purl.obolibrary.org/obo/CLO_0001658 denotes activities
T692 18301-18304 http://purl.obolibrary.org/obo/CLO_0053001 denotes 114
T693 18318-18319 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T694 18429-18430 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T695 18582-18583 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T696 18652-18655 http://purl.obolibrary.org/obo/CLO_0053001 denotes 114
T697 18697-18698 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T698 18731-18739 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T699 18761-18769 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T700 18852-18853 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T701 18915-18916 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T702 18964-18981 http://purl.obolibrary.org/obo/CL_0000842 denotes mononuclear cells
T703 19019-19022 http://purl.obolibrary.org/obo/CLO_0053001 denotes 114
T704 19025-19026 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T705 19116-19117 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T706 19119-19122 http://purl.obolibrary.org/obo/CLO_0053001 denotes 114
T707 19164-19172 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T708 19356-19357 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T709 19409-19417 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T710 19427-19428 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T711 19572-19580 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T712 19810-19814 http://purl.obolibrary.org/obo/CLO_0050171 denotes M–10
T713 19904-19905 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T714 19973-19974 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T715 20101-20109 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T716 20137-20145 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T717 20157-20165 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T718 20215-20223 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T719 20264-20269 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T720 20270-20276 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T721 20334-20337 http://purl.obolibrary.org/obo/CLO_0001046 denotes 116
T722 20448-20453 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T723 20659-20667 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T724 20696-20697 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T725 20798-20803 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T726 20798-20803 http://www.ebi.ac.uk/efo/EFO_0000296 denotes blood
T727 20911-20914 http://purl.obolibrary.org/obo/CLO_0053799 denotes 4-5
T728 20938-20943 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T729 20938-20943 http://www.ebi.ac.uk/efo/EFO_0000296 denotes blood
T730 21033-21037 http://purl.obolibrary.org/obo/UBERON_0003101 denotes male
T731 21033-21037 http://www.ebi.ac.uk/efo/EFO_0000970 denotes male
T732 21045-21047 http://purl.obolibrary.org/obo/CLO_0050509 denotes 27
T733 21179-21187 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T734 21297-21302 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T735 21297-21302 http://www.ebi.ac.uk/efo/EFO_0000296 denotes blood
T736 21394-21397 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T737 21463-21464 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T738 21494-21495 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T739 21690-21691 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T740 21736-21737 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T741 21824-21825 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T742 21835-21842 http://purl.obolibrary.org/obo/PR_000018263 denotes peptide
T743 21873-21874 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T744 22050-22051 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T745 22142-22143 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T746 22144-22149 http://purl.obolibrary.org/obo/CLO_0007836 denotes mouse
T747 22177-22181 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T748 22177-22181 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T749 22196-22199 http://purl.obolibrary.org/obo/CLO_0001053 denotes 121
T750 22295-22300 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T751 22451-22458 http://purl.obolibrary.org/obo/NCBITaxon_33208 denotes animals
T752 22542-22547 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T753 22628-22629 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T754 22693-22697 http://purl.obolibrary.org/obo/UBERON_0003101 denotes male
T755 22693-22697 http://www.ebi.ac.uk/efo/EFO_0000970 denotes male
T756 22758-22761 http://purl.obolibrary.org/obo/CLO_0002096 denotes C16
T757 22815-22816 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T758 22917-22925 http://purl.obolibrary.org/obo/UBERON_0001637 denotes arterial
T759 22917-22925 http://www.ebi.ac.uk/efo/EFO_0000814 denotes arterial
T760 23042-23044 http://purl.obolibrary.org/obo/CLO_0001407 denotes 52
T761 23058-23059 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T762 23287-23295 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T763 23313-23318 http://purl.obolibrary.org/obo/UBERON_0000948 denotes heart
T764 23313-23318 http://purl.obolibrary.org/obo/UBERON_0007100 denotes heart
T765 23313-23318 http://purl.obolibrary.org/obo/UBERON_0015228 denotes heart
T766 23313-23318 http://www.ebi.ac.uk/efo/EFO_0000815 denotes heart
T767 23320-23324 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T768 23320-23324 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T769 23326-23331 http://purl.obolibrary.org/obo/UBERON_0002107 denotes liver
T770 23326-23331 http://www.ebi.ac.uk/efo/EFO_0000887 denotes liver
T771 23333-23338 http://purl.obolibrary.org/obo/UBERON_0001155 denotes colon
T772 23356-23362 http://purl.obolibrary.org/obo/UBERON_0003103 denotes organs
T773 23387-23392 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T774 23387-23392 http://www.ebi.ac.uk/efo/EFO_0000296 denotes blood
T775 23397-23414 http://purl.obolibrary.org/obo/CL_0000115 denotes endothelial cells
T776 23500-23508 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T777 23512-23513 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T778 23514-23519 http://purl.obolibrary.org/obo/CLO_0007836 denotes mouse
T779 23938-23939 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T780 23957-23960 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T781 23999-24007 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T782 24052-24055 http://purl.obolibrary.org/obo/CLO_0054060 denotes 102
T783 24135-24141 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T784 24277-24283 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T785 24312-24313 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T786 24353-24359 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T787 24468-24477 http://purl.obolibrary.org/obo/OBI_0100026 denotes organisms
T788 24468-24477 http://purl.obolibrary.org/obo/UBERON_0000468 denotes organisms
T789 24821-24831 http://purl.obolibrary.org/obo/CLO_0001658 denotes activities
T790 24856-24859 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T791 24926-24929 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T792 25054-25057 http://purl.obolibrary.org/obo/CLO_0054060 denotes 102
T793 25113-25114 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T794 25317-25322 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T795 25317-25322 http://www.ebi.ac.uk/efo/EFO_0000296 denotes blood
T796 25335-25336 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T797 25627-25632 http://purl.obolibrary.org/obo/GO_0005623 denotes Cells
T798 25759-25765 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T799 25822-25832 http://purl.obolibrary.org/obo/CLO_0001658 denotes activities
T800 26082-26087 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T801 26175-26181 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T802 26182-26190 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T803 26282-26287 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T804 26517-26520 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T805 26610-26619 http://purl.obolibrary.org/obo/GO_0005764 denotes lysosomes
T806 26856-26859 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T807 26898-26906 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T808 26930-26940 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T809 26978-26988 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T810 27026-27044 http://purl.obolibrary.org/obo/GO_0030141 denotes secretory granules
T811 27045-27048 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T812 27096-27104 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T813 27281-27282 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T814 27538-27542 http://www.ebi.ac.uk/efo/EFO_0001410 denotes arms
T815 27571-27572 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T816 27678-27679 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T817 28079-28082 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T818 28127-28133 http://purl.obolibrary.org/obo/UBERON_0001637 denotes artery
T819 28127-28133 http://www.ebi.ac.uk/efo/EFO_0000814 denotes artery
T820 28244-28245 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T821 28348-28353 http://purl.obolibrary.org/obo/UBERON_0000473 denotes tests
T822 28600-28601 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T823 28652-28655 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T33721 28673-28679 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T825 28689-28692 http://purl.obolibrary.org/obo/CLO_0001046 denotes 116
T826 28731-28732 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T827 28767-28768 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T828 28828-28834 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T829 28842-28845 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T830 28870-28871 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T831 28878-28880 http://purl.obolibrary.org/obo/CLO_0001627 denotes AA
T832 28884-28885 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T833 28898-28905 http://purl.obolibrary.org/obo/PR_000018263 denotes peptide
T834 28944-28947 http://purl.obolibrary.org/obo/CLO_0001046 denotes 116
T835 28980-28982 http://purl.obolibrary.org/obo/CLO_0001627 denotes AA
T836 29088-29089 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T837 29096-29098 http://purl.obolibrary.org/obo/CLO_0001627 denotes AA
T838 29102-29103 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T839 29116-29123 http://purl.obolibrary.org/obo/PR_000018263 denotes peptide
T840 29234-29242 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T841 29466-29467 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T842 29668-29671 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T843 29672-29673 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T844 29755-29756 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T845 29811-29819 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T846 29854-29862 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T847 29944-29947 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T848 29989-29990 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T849 30036-30037 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T850 30139-30147 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T851 30275-30278 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T852 30408-30411 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T853 30525-30533 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T854 30568-30571 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T855 30572-30573 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T856 30584-30590 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T857 30665-30668 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T858 30790-30791 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T859 30943-30953 http://purl.obolibrary.org/obo/UBERON_0000160 denotes intestinal
T860 30943-30953 http://www.ebi.ac.uk/efo/EFO_0000834 denotes intestinal
T861 31096-31097 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T862 31195-31198 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T863 31225-31233 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T864 31380-31381 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T865 31532-31540 http://purl.obolibrary.org/obo/UBERON_0002553 denotes cavities
T866 31581-31582 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T867 31711-31714 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T868 31753-31758 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T869 31830-31833 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T870 31926-31931 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T871 32274-32275 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T872 32299-32300 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T873 32321-32326 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T874 32332-32335 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T875 32451-32457 http://purl.obolibrary.org/obo/CLO_0001658 denotes active
T876 32559-32560 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T877 32608-32611 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T878 32768-32772 http://purl.obolibrary.org/obo/CLO_0001185 denotes 2018

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T343 16-22 Chemical denotes Action http://purl.obolibrary.org/obo/CHEBI_5133
T344 51-54 Chemical denotes RAS http://purl.obolibrary.org/obo/CHEBI_63620
T345 55-62 Chemical denotes Pathway http://purl.obolibrary.org/obo/CHEBI_34922
T346 177-181 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T348 312-322 Chemical denotes amino acid http://purl.obolibrary.org/obo/CHEBI_33709
T349 312-317 Chemical denotes amino http://purl.obolibrary.org/obo/CHEBI_46882
T350 318-322 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T351 404-413 Chemical denotes dipeptide http://purl.obolibrary.org/obo/CHEBI_46761
T352 498-505 Chemical denotes proline http://purl.obolibrary.org/obo/CHEBI_17203|http://purl.obolibrary.org/obo/CHEBI_26271
T354 533-551 Chemical denotes C-terminal residue http://purl.obolibrary.org/obo/CHEBI_33711
T355 588-591 Chemical denotes RAS http://purl.obolibrary.org/obo/CHEBI_63620
T356 596-606 Chemical denotes bradykinin http://purl.obolibrary.org/obo/CHEBI_3165
T357 607-615 Chemical denotes peptides http://purl.obolibrary.org/obo/CHEBI_16670
T358 680-688 Chemical denotes peptides http://purl.obolibrary.org/obo/CHEBI_16670
T359 715-724 Chemical denotes Apelin-13 http://purl.obolibrary.org/obo/CHEBI_80131
T360 954-956 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T361 1229-1232 Chemical denotes Ang http://purl.obolibrary.org/obo/CHEBI_48433
T362 1401-1405 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T364 1447-1451 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T366 1462-1466 Chemical denotes EDTA http://purl.obolibrary.org/obo/CHEBI_42191|http://purl.obolibrary.org/obo/CHEBI_64755
T368 1507-1515 Chemical denotes chloride http://purl.obolibrary.org/obo/CHEBI_17996
T369 1519-1527 Chemical denotes fluoride http://purl.obolibrary.org/obo/CHEBI_17051
T370 1528-1534 Chemical denotes anions http://purl.obolibrary.org/obo/CHEBI_22563
T371 1539-1550 Chemical denotes zinc cation http://purl.obolibrary.org/obo/CHEBI_29105|http://purl.obolibrary.org/obo/CHEBI_63056
T373 1539-1543 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T375 1544-1550 Chemical denotes cation http://purl.obolibrary.org/obo/CHEBI_36916
T376 1586-1594 Chemical denotes chloride http://purl.obolibrary.org/obo/CHEBI_17996
T377 1600-1604 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T379 1684-1689 Chemical denotes anion http://purl.obolibrary.org/obo/CHEBI_22563
T380 1694-1698 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T382 1775-1783 Chemical denotes chloride http://purl.obolibrary.org/obo/CHEBI_17996
T383 1784-1788 Chemical denotes ions http://purl.obolibrary.org/obo/CHEBI_24870
T384 1799-1802 Chemical denotes Ang http://purl.obolibrary.org/obo/CHEBI_48433
T385 1847-1850 Chemical denotes Ang http://purl.obolibrary.org/obo/CHEBI_48433
T386 1851-1853 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T387 1858-1861 Chemical denotes Ang http://purl.obolibrary.org/obo/CHEBI_48433
T388 1883-1886 Chemical denotes Ang http://purl.obolibrary.org/obo/CHEBI_48433
T389 1887-1889 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T390 1924-1932 Chemical denotes chloride http://purl.obolibrary.org/obo/CHEBI_17996
T391 2065-2073 Chemical denotes chloride http://purl.obolibrary.org/obo/CHEBI_17996
T392 2225-2229 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T394 2435-2439 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T396 2469-2476 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T397 2777-2781 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T399 2846-2850 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T401 2940-2944 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T403 3091-3095 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T405 3129-3133 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T407 3278-3282 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T409 3331-3335 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T411 3414-3418 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T413 3472-3476 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T415 3499-3503 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T417 3551-3555 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T419 3665-3669 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T421 3718-3722 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T423 3773-3777 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T425 3878-3882 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T427 3966-3970 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T429 4065-4069 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T431 4141-4145 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T433 4162-4166 Chemical denotes ions http://purl.obolibrary.org/obo/CHEBI_24870
T434 4175-4179 Chemical denotes iron http://purl.obolibrary.org/obo/CHEBI_18248
T435 4226-4230 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T437 4292-4296 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T439 4382-4386 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T441 4543-4546 Chemical denotes Ang http://purl.obolibrary.org/obo/CHEBI_48433
T442 4547-4554 Chemical denotes peptide http://purl.obolibrary.org/obo/CHEBI_16670
T443 4836-4839 Chemical denotes RAS http://purl.obolibrary.org/obo/CHEBI_63620
T444 5099-5103 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T446 5228-5232 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T448 5296-5300 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T450 5458-5461 Chemical denotes Zn2 http://purl.obolibrary.org/obo/CHEBI_37256
T451 5556-5559 Chemical denotes Zn2 http://purl.obolibrary.org/obo/CHEBI_37256
T452 5853-5858 Chemical denotes ZnCl2 http://purl.obolibrary.org/obo/CHEBI_49976
T453 5859-5862 Chemical denotes ZnO http://purl.obolibrary.org/obo/CHEBI_36560
T454 5863-5879 Chemical denotes hexachloroethane http://purl.obolibrary.org/obo/CHEBI_39227
T455 5957-5961 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T457 6122-6130 Chemical denotes chloride http://purl.obolibrary.org/obo/CHEBI_17996
T458 6135-6144 Chemical denotes zinc ions http://purl.obolibrary.org/obo/CHEBI_27365
T459 6135-6139 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T461 6140-6144 Chemical denotes ions http://purl.obolibrary.org/obo/CHEBI_24870
T462 6218-6221 Chemical denotes RAS http://purl.obolibrary.org/obo/CHEBI_63620
T463 6394-6398 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T465 6689-6691 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T467 6696-6698 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T469 6702-6704 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T471 6854-6856 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T473 6863-6865 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T475 7026-7030 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T477 7456-7458 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T479 7463-7465 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T481 7469-7471 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T483 7516-7518 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T485 7576-7579 Chemical denotes PAH http://purl.obolibrary.org/obo/CHEBI_104011|http://purl.obolibrary.org/obo/CHEBI_31204|http://purl.obolibrary.org/obo/CHEBI_33848|http://purl.obolibrary.org/obo/CHEBI_53305
T489 7647-7649 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T491 7654-7656 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T493 7660-7662 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T495 7666-7668 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T497 7672-7674 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T499 7678-7680 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T501 7685-7687 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T503 7829-7832 Chemical denotes PAH http://purl.obolibrary.org/obo/CHEBI_104011|http://purl.obolibrary.org/obo/CHEBI_31204|http://purl.obolibrary.org/obo/CHEBI_33848|http://purl.obolibrary.org/obo/CHEBI_53305
T507 7892-7896 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T509 7986-7990 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T511 8057-8061 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T513 8138-8142 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T515 8173-8178 Chemical denotes ZnCl2 http://purl.obolibrary.org/obo/CHEBI_49976
T516 8225-8229 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T518 8306-8310 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T520 8393-8397 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T522 8436-8443 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T523 8470-8473 Chemical denotes Zn2 http://purl.obolibrary.org/obo/CHEBI_37256
T524 8499-8503 Chemical denotes ions http://purl.obolibrary.org/obo/CHEBI_24870
T525 8531-8535 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T527 8577-8581 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T529 8638-8642 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T531 8705-8715 Chemical denotes zinc oxide http://purl.obolibrary.org/obo/CHEBI_36560
T532 8705-8709 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T534 8710-8715 Chemical denotes oxide http://purl.obolibrary.org/obo/CHEBI_25741|http://purl.obolibrary.org/obo/CHEBI_29356
T536 8746-8759 Chemical denotes zinc chloride http://purl.obolibrary.org/obo/CHEBI_49976
T537 8746-8750 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T539 8751-8759 Chemical denotes chloride http://purl.obolibrary.org/obo/CHEBI_17996
T540 8760-8764 Chemical denotes salt http://purl.obolibrary.org/obo/CHEBI_24866|http://purl.obolibrary.org/obo/CHEBI_26710
T542 8829-8844 Chemical denotes food components http://purl.obolibrary.org/obo/CHEBI_78295
T543 8936-8946 Chemical denotes folic acid http://purl.obolibrary.org/obo/CHEBI_27470
T544 8942-8946 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T545 8981-8985 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T547 9000-9004 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T549 9035-9039 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T551 9076-9079 Chemical denotes Zn2 http://purl.obolibrary.org/obo/CHEBI_37256
T552 9118-9129 Chemical denotes amino acids http://purl.obolibrary.org/obo/CHEBI_33709
T553 9118-9123 Chemical denotes amino http://purl.obolibrary.org/obo/CHEBI_46882
T554 9124-9129 Chemical denotes acids http://purl.obolibrary.org/obo/CHEBI_37527
T555 9131-9133 Chemical denotes AA http://purl.obolibrary.org/obo/CHEBI_15843|http://purl.obolibrary.org/obo/CHEBI_72816|http://purl.obolibrary.org/obo/CHEBI_33709
T558 9175-9183 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T559 9190-9193 Chemical denotes Zn2 http://purl.obolibrary.org/obo/CHEBI_37256
T560 9223-9235 Chemical denotes amine groups http://purl.obolibrary.org/obo/CHEBI_51142
T561 9223-9228 Chemical denotes amine http://purl.obolibrary.org/obo/CHEBI_32952
T562 9252-9258 Chemical denotes anions http://purl.obolibrary.org/obo/CHEBI_22563
T563 9357-9362 Chemical denotes ZnCl2 http://purl.obolibrary.org/obo/CHEBI_49976
T564 9363-9367 Chemical denotes salt http://purl.obolibrary.org/obo/CHEBI_24866|http://purl.obolibrary.org/obo/CHEBI_26710
T566 9371-9373 Chemical denotes Zn http://purl.obolibrary.org/obo/CHEBI_27363
T567 9374-9376 Chemical denotes AA http://purl.obolibrary.org/obo/CHEBI_15843|http://purl.obolibrary.org/obo/CHEBI_72816|http://purl.obolibrary.org/obo/CHEBI_33709
T570 9420-9424 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T572 9602-9606 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T574 9619-9621 Chemical denotes AA http://purl.obolibrary.org/obo/CHEBI_15843|http://purl.obolibrary.org/obo/CHEBI_72816|http://purl.obolibrary.org/obo/CHEBI_33709
T577 9634-9638 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T579 9639-9644 Chemical denotes salts http://purl.obolibrary.org/obo/CHEBI_24866
T580 9695-9699 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T582 9715-9719 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T584 9720-9722 Chemical denotes AA http://purl.obolibrary.org/obo/CHEBI_15843|http://purl.obolibrary.org/obo/CHEBI_72816|http://purl.obolibrary.org/obo/CHEBI_33709
T587 9736-9738 Chemical denotes AA http://purl.obolibrary.org/obo/CHEBI_15843|http://purl.obolibrary.org/obo/CHEBI_72816|http://purl.obolibrary.org/obo/CHEBI_33709
T590 9801-9803 Chemical denotes AA http://purl.obolibrary.org/obo/CHEBI_15843|http://purl.obolibrary.org/obo/CHEBI_72816|http://purl.obolibrary.org/obo/CHEBI_33709
T593 9868-9872 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T595 9873-9875 Chemical denotes AA http://purl.obolibrary.org/obo/CHEBI_15843|http://purl.obolibrary.org/obo/CHEBI_72816|http://purl.obolibrary.org/obo/CHEBI_33709
T598 9928-9935 Chemical denotes insulin http://purl.obolibrary.org/obo/CHEBI_145810
T599 10011-10015 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T601 10147-10151 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T603 10302-10314 Chemical denotes dietary zinc http://purl.obolibrary.org/obo/CHEBI_29105
T604 10310-10314 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T606 10374-10377 Chemical denotes Zn2 http://purl.obolibrary.org/obo/CHEBI_37256
T607 10439-10443 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T609 10466-10473 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T610 10525-10528 Chemical denotes Zn2 http://purl.obolibrary.org/obo/CHEBI_37256
T611 10557-10559 Chemical denotes AA http://purl.obolibrary.org/obo/CHEBI_15843|http://purl.obolibrary.org/obo/CHEBI_72816|http://purl.obolibrary.org/obo/CHEBI_33709
T614 10570-10573 Chemical denotes Zn2 http://purl.obolibrary.org/obo/CHEBI_37256
T615 10615-10619 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T617 10698-10702 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T619 10750-10753 Chemical denotes Zn2 http://purl.obolibrary.org/obo/CHEBI_37256
T620 10808-10812 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T622 10895-10898 Chemical denotes Zn2 http://purl.obolibrary.org/obo/CHEBI_37256
T42913 11040-11044 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T61190 11131-11134 Chemical denotes Zn2 http://purl.obolibrary.org/obo/CHEBI_37256
T14672 11334-11338 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T35422 11357-11361 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T6498 11451-11455 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T46147 11548-11552 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T80373 11685-11689 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T99687 11894-11898 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T73526 11943-11955 Chemical denotes amyloid beta http://purl.obolibrary.org/obo/CHEBI_64645
T25126 11951-11955 Chemical denotes beta http://purl.obolibrary.org/obo/CHEBI_10545
T81124 11956-11963 Chemical denotes peptide http://purl.obolibrary.org/obo/CHEBI_16670
T69400 12050-12058 Chemical denotes zinc ion http://purl.obolibrary.org/obo/CHEBI_27365
T43909 12050-12054 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T90698 12055-12058 Chemical denotes ion http://purl.obolibrary.org/obo/CHEBI_24870
T23 12215-12218 Chemical denotes Zn2 http://purl.obolibrary.org/obo/CHEBI_37256
T11305 12247-12253 Chemical denotes metals http://purl.obolibrary.org/obo/CHEBI_33521
T25 12337-12341 Chemical denotes ions http://purl.obolibrary.org/obo/CHEBI_24870
T8552 12510-12513 Chemical denotes Zn2 http://purl.obolibrary.org/obo/CHEBI_37256
T27 12565-12569 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T46411 12608-12612 Chemical denotes EDTA http://purl.obolibrary.org/obo/CHEBI_42191|http://purl.obolibrary.org/obo/CHEBI_64755
T9001 12619-12627 Chemical denotes chelator http://purl.obolibrary.org/obo/CHEBI_38161
T72606 12780-12787 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T34459 12803-12807 Chemical denotes ions http://purl.obolibrary.org/obo/CHEBI_24870
T8109 12816-12820 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T36 12837-12846 Chemical denotes molecules http://purl.obolibrary.org/obo/CHEBI_25367
T35424 12860-12870 Chemical denotes fatty acid http://purl.obolibrary.org/obo/CHEBI_35366
T51103 12866-12870 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T4450 12872-12875 Chemical denotes FFA http://purl.obolibrary.org/obo/CHEBI_42638|http://purl.obolibrary.org/obo/CHEBI_35366
T26241 12953-12960 Chemical denotes carrier http://purl.obolibrary.org/obo/CHEBI_78059
T16974 12970-12974 Chemical denotes ions http://purl.obolibrary.org/obo/CHEBI_24870
T80700 12991-13000 Chemical denotes molecules http://purl.obolibrary.org/obo/CHEBI_25367
T93666 13036-13045 Chemical denotes molecules http://purl.obolibrary.org/obo/CHEBI_25367
T47509 13172-13175 Chemical denotes FFA http://purl.obolibrary.org/obo/CHEBI_42638|http://purl.obolibrary.org/obo/CHEBI_35366
T36449 13180-13184 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T66182 13237-13243 Chemical denotes carbon http://purl.obolibrary.org/obo/CHEBI_27594|http://purl.obolibrary.org/obo/CHEBI_33415
T10714 13244-13249 Chemical denotes atoms http://purl.obolibrary.org/obo/CHEBI_33250
T87033 13288-13291 Chemical denotes Zn2 http://purl.obolibrary.org/obo/CHEBI_37256
T84664 13400-13404 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T4649 13540-13544 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T68380 13687-13690 Chemical denotes Zn2 http://purl.obolibrary.org/obo/CHEBI_37256
T39438 13697-13709 Chemical denotes amyloid beta http://purl.obolibrary.org/obo/CHEBI_64645
T95341 13705-13709 Chemical denotes beta http://purl.obolibrary.org/obo/CHEBI_10545
T90891 13710-13718 Chemical denotes peptides http://purl.obolibrary.org/obo/CHEBI_16670
T79507 13776-13779 Chemical denotes Zn2 http://purl.obolibrary.org/obo/CHEBI_37256
T11769 13867-13874 Chemical denotes heparin http://purl.obolibrary.org/obo/CHEBI_28304
T88200 14166-14170 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T72355 14236-14239 Chemical denotes RAS http://purl.obolibrary.org/obo/CHEBI_63620
T765 14405-14409 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T83715 14470-14475 Chemical denotes ZnCl2 http://purl.obolibrary.org/obo/CHEBI_49976
T56869 14476-14479 Chemical denotes ZnO http://purl.obolibrary.org/obo/CHEBI_36560
T70147 14480-14496 Chemical denotes hexachloroethane http://purl.obolibrary.org/obo/CHEBI_39227
T4674 14752-14756 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T51227 14972-14976 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T75 16463-16473 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T47611 16593-16602 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T93730 16679-16687 Chemical denotes electron http://purl.obolibrary.org/obo/CHEBI_10545
T82543 16925-16932 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T74998 16999-17006 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T37661 17267-17275 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T59859 17364-17371 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T68655 17549-17557 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T22243 17639-17648 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T66791 17697-17706 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T85 17795-17803 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T26019 17850-17864 Chemical denotes ACE2 inhibitor http://purl.obolibrary.org/obo/CHEBI_147289
T54501 17855-17864 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T75789 17936-17951 Chemical denotes racemic mixture http://purl.obolibrary.org/obo/CHEBI_60911
T7082 17944-17951 Chemical denotes mixture http://purl.obolibrary.org/obo/CHEBI_60004
T14426 18138-18153 Chemical denotes racemic mixture http://purl.obolibrary.org/obo/CHEBI_60911
T52319 18146-18153 Chemical denotes mixture http://purl.obolibrary.org/obo/CHEBI_60004
T74419 18289-18299 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T93878 18406-18414 Chemical denotes racemate http://purl.obolibrary.org/obo/CHEBI_60911
T90533 18559-18567 Chemical denotes racemate http://purl.obolibrary.org/obo/CHEBI_60911
T46386 18678-18688 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T96 18892-18900 Chemical denotes racemate http://purl.obolibrary.org/obo/CHEBI_60911
T36982 19034-19048 Chemical denotes ACE2 inhibitor http://purl.obolibrary.org/obo/CHEBI_147289
T92521 19039-19048 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T41578 19246-19255 Chemical denotes disulfide http://purl.obolibrary.org/obo/CHEBI_48343
T100 19280-19290 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T22298 19647-19649 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T60880 19881-19889 Chemical denotes racemate http://purl.obolibrary.org/obo/CHEBI_60911
T91051 20003-20013 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T32362 20318-20332 Chemical denotes ACE2 inhibitor http://purl.obolibrary.org/obo/CHEBI_147289
T91312 20323-20332 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T3770 20355-20364 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T42358 20742-20744 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T84420 20996-21001 Chemical denotes water http://purl.obolibrary.org/obo/CHEBI_15377
T69860 21033-21037 Chemical denotes male http://purl.obolibrary.org/obo/CHEBI_30780
T80273 21368-21375 Chemical denotes nucleus http://purl.obolibrary.org/obo/CHEBI_33252
T43819 21723-21732 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T58470 21835-21842 Chemical denotes peptide http://purl.obolibrary.org/obo/CHEBI_16670
T85380 21843-21857 Chemical denotes ACE2 inhibitor http://purl.obolibrary.org/obo/CHEBI_147289
T2332 21848-21857 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T27493 21982-21991 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T56128 22216-22225 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T23596 22364-22379 Chemical denotes ACE2 inhibitors http://purl.obolibrary.org/obo/CHEBI_147289
T10113 22369-22379 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T6036 22693-22697 Chemical denotes male http://purl.obolibrary.org/obo/CHEBI_30780
T60127 22758-22761 Chemical denotes C16 http://purl.obolibrary.org/obo/CHEBI_15756
T121 22817-22825 Chemical denotes solution http://purl.obolibrary.org/obo/CHEBI_75958
T93537 22851-22856 Chemical denotes water http://purl.obolibrary.org/obo/CHEBI_15377
T27633 23008-23013 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T73784 23816-23822 Chemical denotes cation http://purl.obolibrary.org/obo/CHEBI_36916
T52408 23823-23828 Chemical denotes anion http://purl.obolibrary.org/obo/CHEBI_22563
T48403 23879-23883 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T22224 23932-23936 Chemical denotes EDTA http://purl.obolibrary.org/obo/CHEBI_42191|http://purl.obolibrary.org/obo/CHEBI_64755
T5627 23940-23946 Chemical denotes cation http://purl.obolibrary.org/obo/CHEBI_36916
T70245 23947-23955 Chemical denotes chelator http://purl.obolibrary.org/obo/CHEBI_38161
T22254 24027-24031 Chemical denotes EDTA http://purl.obolibrary.org/obo/CHEBI_42191|http://purl.obolibrary.org/obo/CHEBI_64755
T68253 24080-24083 Chemical denotes Zn2 http://purl.obolibrary.org/obo/CHEBI_37256
T95886 24228-24231 Chemical denotes Zn2 http://purl.obolibrary.org/obo/CHEBI_37256
T85661 24269-24273 Chemical denotes iron http://purl.obolibrary.org/obo/CHEBI_18248
T94180 24331-24335 Chemical denotes iron http://purl.obolibrary.org/obo/CHEBI_18248
T30043 24448-24452 Chemical denotes ions http://purl.obolibrary.org/obo/CHEBI_24870
T94269 24504-24508 Chemical denotes EDTA http://purl.obolibrary.org/obo/CHEBI_42191|http://purl.obolibrary.org/obo/CHEBI_64755
T6513 24522-24525 Chemical denotes Zn2 http://purl.obolibrary.org/obo/CHEBI_37256
T20754 24644-24648 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T40517 24718-24722 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T43428 24752-24756 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T36225 24851-24855 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T30838 24910-24914 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T53337 25400-25421 Chemical denotes iron chelating agents http://purl.obolibrary.org/obo/CHEBI_38157
T25372 25400-25404 Chemical denotes iron http://purl.obolibrary.org/obo/CHEBI_18248
T27100 25405-25421 Chemical denotes chelating agents http://purl.obolibrary.org/obo/CHEBI_38161
T154 25453-25461 Chemical denotes zinc ion http://purl.obolibrary.org/obo/CHEBI_27365
T155 25453-25457 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T83733 25458-25461 Chemical denotes ion http://purl.obolibrary.org/obo/CHEBI_24870
T158 25559-25575 Chemical denotes chelating agents http://purl.obolibrary.org/obo/CHEBI_38161
T43731 25594-25598 Chemical denotes ions http://purl.obolibrary.org/obo/CHEBI_24870
T75520 25607-25611 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T86735 25719-25723 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T55396 25781-25785 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T79616 25957-25961 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T58337 26019-26035 Chemical denotes chelating agents http://purl.obolibrary.org/obo/CHEBI_38161
T33902 26074-26078 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T76669 26329-26333 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T173 26348-26357 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T19266 26402-26406 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T6825 26505-26516 Chemical denotes chloroquine http://purl.obolibrary.org/obo/CHEBI_3638
T177 26556-26560 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T70735 26703-26707 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T181 26722-26726 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T183 26765-26768 Chemical denotes Zn2 http://purl.obolibrary.org/obo/CHEBI_37256
T41696 26844-26855 Chemical denotes chloroquine http://purl.obolibrary.org/obo/CHEBI_3638
T185 27004-27007 Chemical denotes Zn2 http://purl.obolibrary.org/obo/CHEBI_37256
T99734 27184-27187 Chemical denotes Zn2 http://purl.obolibrary.org/obo/CHEBI_37256
T86289 27316-27327 Chemical denotes chloroquine http://purl.obolibrary.org/obo/CHEBI_3638
T188 27359-27365 Chemical denotes cation http://purl.obolibrary.org/obo/CHEBI_36916
T41096 27366-27382 Chemical denotes chelating agents http://purl.obolibrary.org/obo/CHEBI_38161
T99407 27550-27553 Chemical denotes RAS http://purl.obolibrary.org/obo/CHEBI_63620
T191 27655-27671 Chemical denotes chelating agents http://purl.obolibrary.org/obo/CHEBI_38161
T97596 28058-28062 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T61973 28074-28078 Chemical denotes EDTA http://purl.obolibrary.org/obo/CHEBI_42191|http://purl.obolibrary.org/obo/CHEBI_64755
T73647 28192-28196 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T92153 28276-28292 Chemical denotes chelating agents http://purl.obolibrary.org/obo/CHEBI_38161
T53011 28484-28487 Chemical denotes RAS http://purl.obolibrary.org/obo/CHEBI_63620
T9812 28563-28566 Chemical denotes RAS http://purl.obolibrary.org/obo/CHEBI_63620
T87402 28617-28626 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T44967 28710-28719 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T3727 28817-28824 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T14121 28878-28880 Chemical denotes AA http://purl.obolibrary.org/obo/CHEBI_15843|http://purl.obolibrary.org/obo/CHEBI_72816
T84458 28898-28905 Chemical denotes peptide http://purl.obolibrary.org/obo/CHEBI_16670
T69057 28980-28982 Chemical denotes AA http://purl.obolibrary.org/obo/CHEBI_15843|http://purl.obolibrary.org/obo/CHEBI_72816
T91071 28995-28999 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T19503 29015-29019 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T46424 29033-29044 Chemical denotes amino acids http://purl.obolibrary.org/obo/CHEBI_33709
T65597 29033-29038 Chemical denotes amino http://purl.obolibrary.org/obo/CHEBI_46882
T8159 29039-29044 Chemical denotes acids http://purl.obolibrary.org/obo/CHEBI_37527
T14330 29096-29098 Chemical denotes AA http://purl.obolibrary.org/obo/CHEBI_15843|http://purl.obolibrary.org/obo/CHEBI_72816
T85515 29116-29123 Chemical denotes peptide http://purl.obolibrary.org/obo/CHEBI_16670
T32788 29483-29493 Chemical denotes amino acid http://purl.obolibrary.org/obo/CHEBI_33709
T79856 29483-29488 Chemical denotes amino http://purl.obolibrary.org/obo/CHEBI_46882
T15688 29489-29493 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T92075 29497-29505 Chemical denotes molecule http://purl.obolibrary.org/obo/CHEBI_25367
T25025 29580-29584 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T1810 29616-29631 Chemical denotes ACE2 inhibitors http://purl.obolibrary.org/obo/CHEBI_147289
T34831 29621-29631 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T28604 29633-29641 Chemical denotes agmatine http://purl.obolibrary.org/obo/CHEBI_17431|http://purl.obolibrary.org/obo/CHEBI_58145
T22491 29658-29666 Chemical denotes arginine http://purl.obolibrary.org/obo/CHEBI_16467|http://purl.obolibrary.org/obo/CHEBI_29016|http://purl.obolibrary.org/obo/CHEBI_32696
T28753 29719-29733 Chemical denotes ACE2 inhibitor http://purl.obolibrary.org/obo/CHEBI_147289
T2369 29724-29733 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T78716 29763-29771 Chemical denotes molecule http://purl.obolibrary.org/obo/CHEBI_25367
T50950 29897-29904 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T79228 29996-30010 Chemical denotes ACE2 inhibitor http://purl.obolibrary.org/obo/CHEBI_147289
T7622 30001-30010 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T71996 30091-30099 Chemical denotes agmatine http://purl.obolibrary.org/obo/CHEBI_17431|http://purl.obolibrary.org/obo/CHEBI_58145
T88126 30559-30567 Chemical denotes agmatine http://purl.obolibrary.org/obo/CHEBI_17431|http://purl.obolibrary.org/obo/CHEBI_58145
T22869 30656-30664 Chemical denotes agmatine http://purl.obolibrary.org/obo/CHEBI_17431|http://purl.obolibrary.org/obo/CHEBI_58145
T85420 30751-30759 Chemical denotes agmatine http://purl.obolibrary.org/obo/CHEBI_17431|http://purl.obolibrary.org/obo/CHEBI_58145
T82274 30760-30767 Chemical denotes sulfate http://purl.obolibrary.org/obo/CHEBI_16189
T71277 30837-30853 Chemical denotes chelating agents http://purl.obolibrary.org/obo/CHEBI_38161
T50847 30868-30878 Chemical denotes folic acid http://purl.obolibrary.org/obo/CHEBI_27470
T11602 30874-30878 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T248 30887-30903 Chemical denotes chelating agents http://purl.obolibrary.org/obo/CHEBI_38161
T86761 30938-30942 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T13737 31039-31052 Chemical denotes nicotianamine http://purl.obolibrary.org/obo/CHEBI_25520|http://purl.obolibrary.org/obo/CHEBI_58249
T39108 31125-31133 Chemical denotes chelator http://purl.obolibrary.org/obo/CHEBI_38161
T254 31166-31179 Chemical denotes metal cations http://purl.obolibrary.org/obo/CHEBI_25213
T55642 31172-31179 Chemical denotes cations http://purl.obolibrary.org/obo/CHEBI_36916
T80399 31181-31194 Chemical denotes Nicotianamine http://purl.obolibrary.org/obo/CHEBI_17721
T257 31242-31246 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T41173 31348-31352 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T99158 31382-31387 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T63352 31407-31415 Chemical denotes minerals http://purl.obolibrary.org/obo/CHEBI_46662
T15395 31622-31627 Chemical denotes water http://purl.obolibrary.org/obo/CHEBI_15377
T62193 31635-31641 Chemical denotes metals http://purl.obolibrary.org/obo/CHEBI_33521
T31321 31643-31650 Chemical denotes cations http://purl.obolibrary.org/obo/CHEBI_36916
T24234 31660-31666 Chemical denotes toxins http://purl.obolibrary.org/obo/CHEBI_27026
T54933 31759-31767 Chemical denotes medicine http://purl.obolibrary.org/obo/CHEBI_23888
T45243 32043-32053 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T93394 32393-32396 Chemical denotes PAH http://purl.obolibrary.org/obo/CHEBI_104011|http://purl.obolibrary.org/obo/CHEBI_31204|http://purl.obolibrary.org/obo/CHEBI_33848|http://purl.obolibrary.org/obo/CHEBI_53305
T26208 32600-32607 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T274 32744-32747 Chemical denotes PAH http://purl.obolibrary.org/obo/CHEBI_104011|http://purl.obolibrary.org/obo/CHEBI_31204|http://purl.obolibrary.org/obo/CHEBI_33848|http://purl.obolibrary.org/obo/CHEBI_53305

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T70 1305-1317 http://purl.obolibrary.org/obo/GO_0042311 denotes vasodilation
T71 2410-2421 http://purl.obolibrary.org/obo/GO_0006810 denotes transporter
T72 4292-4303 http://purl.obolibrary.org/obo/GO_0071578 denotes zinc import
T73 5301-5310 http://purl.obolibrary.org/obo/GO_0007588 denotes excretion
T74 5469-5478 http://purl.obolibrary.org/obo/GO_0007588 denotes excretion
T75 7086-7104 http://purl.obolibrary.org/obo/GO_0001816 denotes cytokine secretion
T76 7095-7104 http://purl.obolibrary.org/obo/GO_0046903 denotes secretion
T77 7284-7299 http://purl.obolibrary.org/obo/GO_0006955 denotes immune response
T78 8057-8073 http://purl.obolibrary.org/obo/GO_0055069 denotes zinc homeostasis
T79 8057-8073 http://purl.obolibrary.org/obo/GO_0006882 denotes zinc homeostasis
T80 8062-8073 http://purl.obolibrary.org/obo/GO_0042592 denotes homeostasis
T81 8225-8241 http://purl.obolibrary.org/obo/GO_0055069 denotes zinc homeostasis
T82 8225-8241 http://purl.obolibrary.org/obo/GO_0006882 denotes zinc homeostasis
T83 8230-8241 http://purl.obolibrary.org/obo/GO_0042592 denotes homeostasis
T84 8393-8410 http://purl.obolibrary.org/obo/GO_0006829 denotes zinc transporters
T85 9040-9049 http://purl.obolibrary.org/obo/GO_0007588 denotes excretion
T86 9506-9527 http://purl.obolibrary.org/obo/GO_0050892 denotes intestinal absorption
T87 9685-9691 http://purl.obolibrary.org/obo/GO_0098739 denotes uptake
T88 9685-9691 http://purl.obolibrary.org/obo/GO_0098657 denotes uptake
T89 9705-9711 http://purl.obolibrary.org/obo/GO_0098739 denotes uptake
T90 9705-9711 http://purl.obolibrary.org/obo/GO_0098657 denotes uptake
T91 9804-9815 http://purl.obolibrary.org/obo/GO_0006810 denotes transporter
T92 9876-9882 http://purl.obolibrary.org/obo/GO_0098739 denotes uptake
T93 9876-9882 http://purl.obolibrary.org/obo/GO_0098657 denotes uptake
T94 9936-9948 http://purl.obolibrary.org/obo/GO_0009058 denotes biosynthesis
T95 9949-9958 http://purl.obolibrary.org/obo/GO_0046903 denotes secretion
T96 10102-10111 http://purl.obolibrary.org/obo/GO_0009058 denotes synthesis
T97 10212-10233 http://purl.obolibrary.org/obo/GO_0050892 denotes intestinal absorption
T98 10244-10253 http://purl.obolibrary.org/obo/GO_0007588 denotes excretion
T99 10439-10455 http://purl.obolibrary.org/obo/GO_0006829 denotes zinc transporter
T100 10808-10819 http://purl.obolibrary.org/obo/GO_0071578 denotes zinc uptake
T101 10813-10819 http://purl.obolibrary.org/obo/GO_0098739 denotes uptake
T102 10813-10819 http://purl.obolibrary.org/obo/GO_0098657 denotes uptake
T103 11065-11074 http://purl.obolibrary.org/obo/GO_0097194 denotes apoptosis
T104 11065-11074 http://purl.obolibrary.org/obo/GO_0006915 denotes apoptosis
T105 11650-11660 http://purl.obolibrary.org/obo/GO_0008152 denotes metabolism
T106 11662-11679 http://purl.obolibrary.org/obo/GO_0007596 denotes blood coagulation
T107 11668-11679 http://purl.obolibrary.org/obo/GO_0050817 denotes coagulation
T108 11690-11700 http://purl.obolibrary.org/obo/GO_0023052 denotes signalling
T109 11810-11822 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T110 11971-11980 http://purl.obolibrary.org/obo/GO_0009058 denotes formation
T111 12565-12576 http://purl.obolibrary.org/obo/GO_0071578 denotes zinc uptake
T112 12570-12576 http://purl.obolibrary.org/obo/GO_0098739 denotes uptake
T113 12570-12576 http://purl.obolibrary.org/obo/GO_0098657 denotes uptake
T114 12666-12676 http://purl.obolibrary.org/obo/GO_0008219 denotes cell death
T115 12770-12779 http://purl.obolibrary.org/obo/GO_0006810 denotes transport
T116 13585-13591 http://purl.obolibrary.org/obo/GO_0140352 denotes efflux
T117 13585-13591 http://purl.obolibrary.org/obo/GO_0140115 denotes efflux
T118 13737-13746 http://purl.obolibrary.org/obo/GO_0009058 denotes formation
T119 17915-17924 http://purl.obolibrary.org/obo/GO_0009058 denotes synthesis
T120 19377-19388 http://purl.obolibrary.org/obo/GO_0006508 denotes proteolysis
T121 19650-19661 http://purl.obolibrary.org/obo/GO_0009056 denotes degradation
T122 21436-21442 http://purl.obolibrary.org/obo/GO_0060004 denotes reflex
T123 21496-21502 http://purl.obolibrary.org/obo/GO_0060004 denotes reflex
T124 22182-22194 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T125 24958-24964 http://purl.obolibrary.org/obo/GO_0040007 denotes growth
T126 24966-24986 http://purl.obolibrary.org/obo/GO_0048666 denotes neuronal development
T127 25848-25866 http://purl.obolibrary.org/obo/GO_0044249 denotes cellular synthesis
T128 25857-25866 http://purl.obolibrary.org/obo/GO_0009058 denotes synthesis
T129 25894-25903 http://purl.obolibrary.org/obo/GO_0009058 denotes synthesis
T130 26125-26134 http://purl.obolibrary.org/obo/GO_0009058 denotes synthesis
T131 26556-26567 http://purl.obolibrary.org/obo/GO_0071578 denotes zinc uptake
T132 26561-26567 http://purl.obolibrary.org/obo/GO_0098739 denotes uptake
T133 26561-26567 http://purl.obolibrary.org/obo/GO_0098657 denotes uptake
T134 26921-26940 http://purl.obolibrary.org/obo/GO_0030168 denotes platelet activation
T135 26969-26988 http://purl.obolibrary.org/obo/GO_0030168 denotes platelet activation
T136 27134-27143 http://purl.obolibrary.org/obo/GO_0009058 denotes formation
T137 28063-28072 http://purl.obolibrary.org/obo/GO_0007588 denotes excretion
T138 30305-30328 http://purl.obolibrary.org/obo/GO_0009889 denotes regulating NO synthesis
T139 30319-30328 http://purl.obolibrary.org/obo/GO_0009058 denotes synthesis
T140 30943-30964 http://purl.obolibrary.org/obo/GO_0050892 denotes intestinal absorption
T141 32254-32269 http://purl.obolibrary.org/obo/GO_0016032 denotes viral infection

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T177 0-2 Sentence denotes 5.
T178 3-88 Sentence denotes Mechanism of Action and Potential Risk of Using RAS Pathway Inhibitors Targeting ACE2
T179 90-94 Sentence denotes 5.1.
T180 95-124 Sentence denotes ACE2 (and ACE) Hyperactivity:
T181 125-155 Sentence denotes Is It a Matter of (Free) Zinc?
T182 156-251 Sentence denotes ACE2 and ACE are two zinc metalloprotease that function differently despite their similarities.
T183 252-442 Sentence denotes ACE2 is a monocarboxypeptidase (cleaves a C-terminal single amino acid from its substrate), whereas ACE is a dipeptidylpeptidase (releases a C-terminal dipeptide from its substrate) [86,87].
T184 443-749 Sentence denotes ACE2 has a substrate preference for hydrolysis between proline and a hydrophobic or basic C-terminal residue [79,86,87] and acts not only on the RAS and bradykinin peptides but also on the C-terminus of the apelin, casomorphin dynorphin peptides [79], possibly inhibiting Apelin-13 hypotensive action [44].
T185 750-866 Sentence denotes It is expressed in the heart, kidneys, liver, colon, small intestine, lung, brain and testes [39,44,45,46,76,77,87].
T186 867-1076 Sentence denotes Among the tissues expressing ACE2 there are cardiomyocytes, endothelium, alveolar type II cells, ciliated airway cells, vascular smooth muscle cells and testicular Leydig cells [14,39,44,45,46,76,77,87,88,89].
T187 1077-1373 Sentence denotes ACE2 is present on the apical surface of epithelial cells of renal tubules, lung alveoli and vascular endothelia, in these last cells the production of Ang (1–7) induces autocrine activation of MasR axis leading to NOS-mediated vasodilation and consequently hypotension [14,44,45,46,86,87,88,89].
T188 1374-1559 Sentence denotes ACE2, as well as ACE, is a zinc metalloprotease that can be inhibited by zinc chelating EDTA and activated by high concentrations of chloride or fluoride anions and zinc cation [79,90].
T189 1560-1624 Sentence denotes Indeed, both enzymes have chloride- and zinc-binding sites [90].
T190 1625-1749 Sentence denotes It is conceivable that these sites are responsible for the anion and zinc activation effect in both homologous enzymes [90].
T191 1750-2008 Sentence denotes However, the presence of chloride ions increases Ang I cleavage by ACE and ACE2 (increasing both Ang II and Ang (1–9)) and decreases Ang II cleavage by ACE2, suggesting that chloride induces specific ACE2 conformational changes in its active site (see [44]).
T192 2009-2179 Sentence denotes To this regard, in plasma samples of COVID–19 patients, chloride range is usually normal or slightly higher (99.6–107.0 mmol/L) than normal values (96.–106.0 mmol/L) [5].
T193 2180-2266 Sentence denotes Unfortunately, I was not able to find plasma zinc concentrations in COVID-19 patients.
T194 2267-2386 Sentence denotes Zinc is involved in several cellular activities and its systemic concentration is tightly regulated by several factors.
T195 2387-2987 Sentence denotes Of interest, the major transporter/reservoir of zinc in plasma is albumin [91], a protein that was detected at significantly low concentrations in SARS-CoV-2 as well as severe adult respiratory distress syndrome (ARDS, a COVID-19-like disease) (usually < 3.5 g/dL, normal range 3.5–5.4) and inflammatory bowel disease (IBD, a disease with increased ACE2 activity) [6,8,66,92] Since most of zinc in plasma is sequestered by albumin, the total amount of plasma zinc mostly depends on albumin concentration and even small changes in albumin’s capacity for zinc binding may have significant consequences.
T196 2988-3210 Sentence denotes To this regard, reduced concentrations of plasma albumin is believed to increase plasma levels of free zinc, while reducing the total plasma zinc concentrations [91], a condition that was observed in ARDS patients [93,94].
T197 3211-3353 Sentence denotes Indeed, albumin can potentially deplete free bioavailable forms of zinc; vice versa, hypoalbuminaemia may increase free zinc levels in plasma.
T198 3354-3489 Sentence denotes Therefore, some ARDS patients with low levels of both total zinc and albumin might have rather higher than lower free zinc levels [93].
T199 3490-3704 Sentence denotes The free zinc concentration, which describes the fraction of zinc that is loosely bound and easily exchangeable, represents the highly bioavailable (and toxic) part of plasma zinc but it is not clinically detected.
T200 3705-3785 Sentence denotes To that end, zinc/albumin ratio might be a surrogate marker of free zinc levels.
T201 3786-3925 Sentence denotes Indeed, only recently it was described a fluorescence-based method for determining the free zinc concentration in human serum samples [95].
T202 3926-4049 Sentence denotes With this method it was shown that free zinc concentration in sera from females was significantly lower than in males [95].
T203 4050-4199 Sentence denotes Moreover, free zinc concentration did correlate neither with total serum concentrations of zinc (or other metal ions such as iron) nor with age [95].
T204 4200-4423 Sentence denotes Notably, increased plasma zinc bioavailability consequent to reduced albumin levels induces zinc import into cells and likely increases the cellular functions associated to cellular zinc concentrations such as ACE and ACE2.
T205 4424-4610 Sentence denotes Indeed, enzymatic activity of both enzymes seems significantly upregulated in ARDS patients as detected by analysis of Ang peptide concentrations in plasma (see Box later in ARDS topic).
T206 4611-4849 Sentence denotes In addition, serum albumin levels in COVID-19 were usually very low (in severe forms is usually < 3.1 g/dL) [6,8], raising the possibility of a negative correlation between albumin concentration in plasma and increase of the RAS activity.
T207 4850-5172 Sentence denotes In line with these hypotheses, both asthmatic/allergic disease patients and chronic kidney disease patients without a history of cardiovascular disease, which are protected from developing COVID-19, showed a significant decrease in both circulating zinc levels and ACE2 activity as compared to normal values [96,97,98,99].
T208 5173-5479 Sentence denotes Interestingly, chronic renal disease patients with low zinc levels had normal concentrations of albumin but higher urinary zinc excretion than healthy controls [97], suggesting that low ACE2 activity in chronic renal diseases (and protection from SARS) might derive from a higher free Zn2+ renal excretion.
T209 5480-5617 Sentence denotes A similar mechanism mediated by a reduction of extracellular levels of free Zn2+ might be hypothesised for asthma patients, as well [98].
T210 5618-5815 Sentence denotes Unfortunately, I could not find information on plasma albumin concentrations for asthma patients; nevertheless, we might suppose that in these patients the albumin concentration is in normal range.
T211 5816-6049 Sentence denotes Intriguingly, inhalation exposure to ZnCl2/ZnO/hexachloroethane (the main ingredients in smoke bombs) induces both elevated plasma levels of zinc and ARDS with clinical pictures that strongly resemble those of COVID-19 [100,101,102].
T212 6050-6285 Sentence denotes Since both ACE2 and ACE enzymes are activated by high concentrations of chloride and zinc ions [79,90], it is possible to hypothesise an activation of both arms of the RAS in ARDS induced by smoke bombs as well as in COVID-19 patients.
T213 6286-6537 Sentence denotes In addition, metal fume fever, a flu-like syndrome caused by inhalation of welding fumes (mainly containing zinc) can be a predictor for the development of respiratory symptoms and welders have an increased pneumonia and cardiovascular risk [103,104].
T214 6538-6810 Sentence denotes In this regard, metal fume fever has been shown to produce fever, fatigue, muscle ache, cough, dyspnea, and an increase of several cytokines including IL-1β, IL-6, IL-8 and TNF-α [103], symptoms and cytokines that have already been described for COVID-19 patients [2,8,9].
T215 6811-6996 Sentence denotes Notably, TNF-α was upregulated early while IL-6 and IL-8 increased later, suggesting a subsequent involvement of these latter cytokines in response to inhalation of welding fumes [103].
T216 6997-7165 Sentence denotes Moreover, elevated levels of zinc have been shown not only to stimulate pro-inflammatory cytokine secretion by monocytes, but also inhibit T cell functions (see [102]).
T217 7166-7528 Sentence denotes Zinc supplementation that has also been proposed for COVID-19 treatment [105,106,107], is able to suppress allogeneic immune response (see [102]) and incubation of blood cells with welding fume particles resulted in a considerable increase not only of pro-inflammatory cytokines (including IL-1β, IL-6, IL-8, TNF-α) but also the tolerogenic cytokine IL-10 [104].
T218 7529-7857 Sentence denotes Similarly, in pulmonary arterial hypertension (PAH) as well as SARS-CoV, both arms of the inflammatory system (namely IL-1β, IL-2, IL-4, IL-6, IL-8, IL-10, IL-12 and TNF-α) have been shown to be upregulated [108,109,110], suggesting a common systemic pathway of activation in welding syndrome, ARDS, PAH and SARS-CoV infections.
T219 7858-8027 Sentence denotes Finally, the correlations between zinc exposure (metal fume) and cytokine storm [103,104] suggests a possible link between free zinc increase and these type of diseases.
T220 8028-8208 Sentence denotes More information on systemic zinc homeostasis and multiorgan effects of elevated levels of extracellular free zinc (such as in subjects inhaling ZnCl2 smoke) is available in Box 4.
T221 8209-8311 Sentence denotes Box 4 Systemic zinc homeostasis and multiorgan effects of elevated levels of extracellular free zinc.
T222 8312-8553 Sentence denotes Zinc absorption occurs throughout the gastrointestinal tract into enterocytes by zinc transporters of the Zrt- and Irt-like protein (ZIP) family that take up Zn2+, but also Cu2+ and Fe2+ ions, both of which can inhibit zinc absorption [111].
T223 8554-8851 Sentence denotes The bioavailability of zinc is affected by several factors among them the amount of zinc in food, its chemical form (from very low availability, e.g., zinc oxide, to comparatively high, e.g., zinc chloride salt) and its binding to other (intestinal absorbed or non-absorbed) food components [111].
T224 8852-9056 Sentence denotes For example, phytates (components present in foods like rice, cereals and corn) and folic acid can form insoluble complexes with zinc that decrease zinc absorption and increase fecal zinc excretion [111].
T225 9057-9293 Sentence denotes On the other hand, Zn2+ can form complexes with most natural amino acids (AA) that for example can come from digested proteins; each Zn2+ can be coordinated with the amine groups and carboxylate anions of two AAs (a molar ratio of 1:2).
T226 9294-9568 Sentence denotes Interestingly, in an in vitro model, the formulation of either ZnCl2 salt or Zn-AA complexes were absorbed by enterocytes and zinc was released on the opposite side of the enterocyte membrane, thus mimicking the intestinal absorption and release into the blood stream [111].
T227 9569-9700 Sentence denotes It is therefore conceivable that zinc chelates of AA, as well as zinc salts, may participate in bioavailability and uptake of zinc.
T228 9701-9987 Sentence denotes The uptake of zinc-AA complexes by AA transporters of human enterocytes suggests that B0AT1 neutral AA transporter associated with ACE2 [28] might also be involved in zinc-AA uptake (a similar mechanism might be supposable for insulin biosynthesis/secretion in pancreatic β cells [91]).
T229 9988-10139 Sentence denotes Indeed, a recycling of zinc-AAs, possibly supplied by membrane bound ACE2 monocarboxypeptidase cleavage, for ACE2 synthesis could be also hypothesised.
T230 10140-10357 Sentence denotes Plasma zinc concentration is mainly regulated through a balance between intestinal absorption and renal excretion involving specific mechanisms sensitive to both dietary zinc availability and its cellular utilization.
T231 10358-10484 Sentence denotes The majority of Zn2+ in blood binds to serum albumin, which represents the major zinc transporter/reservoir protein in plasma.
T232 10485-10744 Sentence denotes On the other hand, labile-bound pool of Zn2+ labile complexes (e.g., of AA) and free Zn2+ are the biologically available forms of zinc for cellular internalization and/or enzymatic activities (0.1–1% of the total zinc in blood plasma under normal conditions).
T233 10745-10928 Sentence denotes Free Zn2+ is subsequently accumulated by endothelial cells and zinc uptake and release by endothelial cells is the crucial step for redistribution of Zn2+ from plasma to tissues [91].
T234 10929-11108 Sentence denotes Zinc is considered a relatively nontoxic metal; however, several data report that excessive free extracellular zinc is toxic and induce apoptosis in different cell types [91,102].
T235 11109-11442 Sentence denotes Plasma excess of free Zn2+ is uptaken by ZIP transporters on the cell surface of each cells in contact with plasma (including immune cells, endothelial cells, neurons and cardiomyocytes), leading to increase of intracellular zinc that can modulate zinc associated cellular functions in both physiological and pathological conditions.
T236 11443-11873 Sentence denotes Indeed, zinc is an important mediator/messenger involved in several cellular activities and the shift of zinc from plasma to cells may be significant for both normal physiological processes including energy metabolism, blood coagulation, and zinc signalling, and a range of disease states, including neurodegenerative and cardiovascular diseases, metabolic syndrome, inflammation, endothelial stress, diabetes and thrombosis [91].
T237 11874-12100 Sentence denotes For example, excess zinc intake has been shown to contribute to both amyloid beta-peptide plaque formation in Alzheimer’s disease and cardiac dysfunction, indicating that free zinc ion may be much more toxic than thought [91].
T238 12101-12377 Sentence denotes It has been reported that Alzheimer and other neurodegenerative disease patients show elevated levels not only of Zn2+ but also of other divalent metals such as Fe2+ and Cu2+ [112], suggesting a possible link between the increase metal ions and saturation of ZIP transporters.
T239 12378-12591 Sentence denotes On the other hand, increased plasma ferritin levels (such as in COVID-19 [2,3,6]) might reduce free Fe2+ and its “competition” with Zn2+ for ZIP transporters, finally increasing cellular zinc uptake and functions.
T240 12592-12731 Sentence denotes To this regard, EDTA metal chelator has been shown to protect from neural cell death and it was tested in neurodegenerative diseases [102].
T241 12732-12914 Sentence denotes Of interest, plasma albumin acts as a transport protein for both metal ions such as zinc and hydrophobic molecules such as free fatty acid (FFA) to allow their systemic distribution.
T242 12915-13096 Sentence denotes Indeed, albumin is well beyond a mere carrier of metal ions and hydrophobic molecules, and by binding of these different molecules mediates their crosstalk and bioavailability [91].
T243 13097-13209 Sentence denotes To this regard, one particularly intriguing allosteric link exists between FFA and zinc binding to albumin [91].
T244 13210-13415 Sentence denotes When FFAs with ten or more carbon atoms bind to albumin causes the release of Zn2+, suggesting a possible link between dyslipidemia and toxic effects mediated by consequent increase of free zinc in plasma.
T245 13416-13604 Sentence denotes For example, endothelial stress and activation and pro-inflammatory action of FFAs may be mediated by their effects on free zinc release from albumin and its consequent efflux from plasma.
T246 13605-13775 Sentence denotes Different studies have suggested a role of albumin to inhibit interaction of free Zn2+ with amyloid beta-peptides and combat plaque formation in Alzheimer’s disease [91].
T247 13776-13889 Sentence denotes Zn2+ has also been shown to promote clot stability by binding to fibrinogen and inhibiting heparin activity [91].
T248 13890-14011 Sentence denotes An evidence that has suggested a possible positive correlation between increased levels of FFAs and thrombotic risk [91].
T249 14012-14241 Sentence denotes In addition, physiological conditions associated with elevated plasma FFAs, such as physical exercise, can also produce an increased plasma level of free zinc and its downstream physiological events (e.g., activation of the RAS).
T250 14242-14410 Sentence denotes On the other hand, reduced concentrations of plasma albumin (such as IBD, ARDS and COVID-19) will induce elevated plasma levels of both free FFAs and bioavailable zinc.
T251 14411-14573 Sentence denotes Intriguingly, ARDS is induced after inhalation exposure to ZnCl2/ZnO/hexachloroethane, the main ingredients in smoke bombs used for crowd dispersal [100,101,102].
T252 14574-14691 Sentence denotes To this regard, soldiers that breathed smoke-bomb fumes have been shown to quickly or slowly develope ARDS [100,101].
T253 14692-14874 Sentence denotes Interestingly, a patient who had the highest level of serum zinc rapidly developed ARDS that leads to death from multiorgan failure (including respiratory and hepatic failure) [100].
T254 14875-15162 Sentence denotes Instead, a slow progressive clinical course was associated with a significant increase of plasma zinc concentration that negatively correlated with pulmonary and liver function [100], finally leading to death for severe respiratory failure three to five weeks after inhalation [100,101].
T255 15163-15263 Sentence denotes At autopsy diffuse microvascular obliteration and marked endothelial cell injury was apparent [101].
T256 15264-15456 Sentence denotes Widespread occlusion of the pulmonary arteries may contribute to the development of acute pulmonary hypertension and extensive interstitial and intra-alveolar fibrosis was also observed [101].
T257 15457-15669 Sentence denotes Other soldiers wearing gas masks, immediately developed severe coughing and dyspnea, and slowly improved their lung function (only twelve months after exposure their lung function tests were nearly normal) [101].
T258 15670-15754 Sentence denotes All clinical conditions that strongly resemble those described in COVID-19 patients.
T259 15756-15760 Sentence denotes 5.2.
T260 15761-15827 Sentence denotes Safety and Efficacy Concerns of MLN4760 and Dx600 ACE2 Inhibitors.
T261 15828-15967 Sentence denotes It is known that the catalytic cleft of ACE2 consists of two peptidase subdomains: one membrane-distal and the other one membrane-proximal.
T262 15968-16088 Sentence denotes Their weak interactions are consistent with the ability to transition from open to the closed ACE2 conformation [28,90].
T263 16089-16364 Sentence denotes Indeed, the two subdomains undergo a large hinge-bending motion in which membrane-proximal subdomain remains almost unchanged, while membrane-distal subdomain moves to close the distance between the two subdomains, mimicking the opening/closing movement of a clam shell [90].
T264 16365-16655 Sentence denotes ACE2 open conformation likely reflects free state of the enzyme available to catch substrates (or inhibitors), then, when the ACE2 receptor binds to a substrate, the membrane-distal subdomain closes around the substrate (or the inhibitor), finally performing the enzymatic activity [24,90].
T265 16656-16836 Sentence denotes Interestingly, in cryo–electron microscopy structures of full-length human ACE2, only the closed/substrate-bound conformation of ACE2 was observed in the spike-ACE2 complexes [28].
T266 16837-17081 Sentence denotes Since human ACE2 is assembled on cell surface as a homodimer [28], binding of the spike protein trimer onto ACE2 dimer suggests simultaneous binding of two spike protein trimers to substrate-bound conformer of ACE2 homodimer on plasma membrane.
T267 17082-17338 Sentence denotes The spike binding sites on ACE2 homodimer are localized above the membrane-distal peptidase subdomain of each ACE2 monomer, nevertheless neither ACE2 shedding nor ACE2 binding to spike proteins have been shown to inhibit ACE2 enzymatic activity [16,17,24].
T268 17339-17606 Sentence denotes On the other hand, the S-protein-binding region of membrane-distal ACE2 subdomain is not significantly perturbed by the receptor conformational changes and maintains the ability to associate with soluble spike proteins independently on open/closed conformations [24].
T269 17607-17809 Sentence denotes Interestingly, an ACE2 specific inhibitor (MLN-4760) has been shown to induce the closed (inhibitor-bound) ACE2 structure [90] and to retain its inhibitory effects on sACE2 bound to spike proteins [24].
T270 17810-18010 Sentence denotes MLN4760 is a potent and selective human ACE2 inhibitor (IC50 = 0.44 nM against soluble human ACE2) whose synthesis produces a racemic mixture of two diastereomers that showed 75:25 ratio for Isomer A:
T271 18011-18120 Sentence denotes Isomer B [113,114] and the purified isomer B is the isomer commercially available from Merck Millipore [114].
T272 18121-18306 Sentence denotes Testing MLN-4760 racemic mixture and its isomers, it was observed a concentration-dependent inhibition of recombinant human (rh)ACE or rhACE2 activities with all three inhibitors [114].
T273 18307-18657 Sentence denotes The isomer B was less selective (near minimal-maximal rhACE inhibition range 10−6M-10−4M) than the racemate or the isomer A (near minimal-maximal rhACE inhibition range 10−6M-10−2M) and less effective (near maximal rhACE2 inhibition at 10−7M) than the racemate or the isomer A (near maximal rhACE2 inhibition at 10−8 M) for rhACE2 versus rhACE [114].
T274 18658-19024 Sentence denotes Moreover, all three inhibitors exerted a significantly higher inhibitory activity against soluble than membrane-bound forms of (m)ACE2 (near maximal mACE2 inhibition at 10−6M), being the isomer B more selective and effective than the racemate or the isomer A for mACE2 vs. mACE expressed on the surface of mononuclear cells (or CD34 hematopoietic progenitors) [114].
T275 19025-19124 Sentence denotes A second ACE2 inhibitor, Dx600, produced similar results to those obtained with the isomer B [114].
T276 19125-19291 Sentence denotes Another study evaluated the inhibitory activity of both MLN-4760 and DX600 (either the linear conformational form or the disulfide bridged cyclic variant) inhibitors.
T277 19292-19503 Sentence denotes In this report, the experiments were performed at pH 6.5 [115], a pH at which rhACE2 proteolysis operates at maximal activity [79] and a condition that resembles hypercapnic acidosis which may occur during SARS.
T278 19504-19840 Sentence denotes MLN-4760 was still able to strongly and specifically inhibit rhACE2 activity (near maximal inhibition at 10−8 M), preventing rhACE2-driven Ang II degradation into Ang (1–7), whereas DX600 (either linear or cyclic variant) inhibits rhACE2 at relatively higher concentration (near maximal inhibition at 10−6 M–10−7 M, respectively) [115].
T279 19841-19985 Sentence denotes Altogether these data indicate that the racemate or the isomer A are more effective in inhibiting soluble forms of ACE2 than isomer B and Dx600.
T280 19986-20339 Sentence denotes Therefore, these inhibitors at opportune (low) concentrations are expected to preferentially reduce systemic sACE2 activity, while preserving the ACE2 activity of (local) membrane-associated forms of ACE2, knowing that catalytic activity of circulating ACE2 was undetectable in human plasma of healthy subjects due to an endogenous ACE2 inhibitor [116].
T281 20340-20695 Sentence denotes Since MLN-4760 inhibitor promotes the closed ACE2 conformation [90] which is the preferential conformer for virus binding [28], MLN-4760 is expected to not prevent viral entry; nevertheless, its inhibitory function on ACE2 pathway might work on the positive feedback loops (above described) that ultimately favour ACE2 membrane expression and viral entry.
T282 20696-20813 Sentence denotes A potential risk factor of inhibiting the Ang II metabolization into Ang 1–7 could be the increase of blood pressure.
T283 20814-21323 Sentence denotes Although ACE2 pathway inhibition might lead to hypertensive effects, treatment with MLN-4760 for 4-5 weeks had no effect on blood pressure when administered 10 mg/kg/day in drinking water in wild type mice [117] nor in male (mRen2)27 transgenic hypertensive rats (administered 30 mg/kg/day subcutaneously via mini-osmotic pumps) [118], suggesting that hypertensive activity mediated by ACE2 inhibition is promptly balanced by compensatory mechanisms either in normal or hypertensive blood pressure conditions.
T284 21324-21529 Sentence denotes In addition, injections of MLN4760 into the nucleus tractus solitarii has been shown to reduce the baroreceptor reflex in rats, suggesting a role for ACE2 in controlling a reflex bradycardia (see [39,44]).
T285 21530-21764 Sentence denotes Finally, chronic inhibition of ACE2 with MLN-4760 led to increase of ACE, albuminuria and glomerular injury in streptozotocin-induced diabetic mice, indicating a possible adverse effect of the inhibitor in a diabetic background [119].
T286 21765-21938 Sentence denotes Extensive experiments have been also performed with DX600, a specific peptide ACE2 inhibitor that exhibited a mixed competitive and non-competitive type of inhibition [120].
T287 21939-22036 Sentence denotes Actually, several reports describing Dx600 inhibitor administration in mice suggest its safe use.
T288 22037-22317 Sentence denotes Of interest, a report described its (safe) use alone (1 mg/kg per day) by nasal inhalation for 3 days in a mouse model of endotoxin-induced lung inflammation [121]; however, this inhibitor is less efficacious than MLN-4760 in inhibiting the soluble forms of human rACE2 [114,115].
T289 22318-22514 Sentence denotes Altogether these reports on administration of ACE2 inhibitors do not reveal significant adverse impacts or mortality in experimental animals, which suggests their safety in chronic administration.
T290 22515-22614 Sentence denotes This was also confirmed in human clinical trials with MLN-4760 (clinical name: ORE1001, see later).
T291 22615-23134 Sentence denotes Of interest, a report showed that on day 28 post-myocardial infarction, adult male Sprague-Dawley rats that had received MLN-4760 (also called C16) 25 mg/mL/day by daily intraperitoneal injection (as a solution of 42 mg/mL in distilled water) tended to have lower left ventricular pulse pressure, mean arterial pressures and left ventricular relaxation time constant-Tau compared to untreated group (see table 2 of the paper) [52], suggesting a possible protective role of ACE2 inhibition in post-myocardial infarction.
T292 23135-23415 Sentence denotes Therefore, MLN-4760 might be helpful not only for COVID-19 but also in targeted therapies for pathologies correlated with an excessive increase of ACE2 activity that may involve heart, lung, liver, colon or other tissues/organs expressing ACE2 such as blood and endothelial cells.
T293 23416-23642 Sentence denotes As an example, GL1001 (old name of MLN-4760) showed to produce an anti-inflammatory activity in a mouse model of colitis [122], highlighting the importance of the yin-yang balance of ACE/ACE2 pathways (“in medio stat virtus”).
T294 23644-23648 Sentence denotes 5.3.
T295 23649-23697 Sentence denotes Safety and Efficacy Concerns of Chelating Agents
T296 23698-23915 Sentence denotes Based on ACE2 mechanism of action, there are alternative ways to inhibit ACE2 (and ACE), for example concentration of cation/anion might also targets of intervention to inhibit the zinc metalloprotease ACE2 (and ACE).
T297 23916-24013 Sentence denotes In this regard, EDTA, a cation chelator, has been shown to be able to inhibit ACE2 activity [79].
T298 24014-24308 Sentence denotes Of interest, EDTA binds with 106- and 102-fold higher affinity to Zn2+ than to Ca2+ and Fe2+, respectively [123], and in plasma, free Ca2+ concentration (1.05–1.30 mmol/L) is “only” about 103-fold higher than free Zn2+ (0.1–2.0 µmol/L), while majority of iron in plasma is bound to transferrin.
T299 24309-24421 Sentence denotes As a consequence, the iron concentration in plasma of healthy subjects is very low on the order of 10−18M [112].
T300 24422-24729 Sentence denotes Among the essential metal ions present in the organisms, the specific affinity of EDTA for systemic Zn2+ in physiologic conditions is highlighted by the evidence that prolonged treatment with CaNa2EDTA results in specific zinc depletion that is believed to mediate the teratogenic effects of the drug [123].
T301 24730-25059 Sentence denotes As already mentioned, zinc is an important mediator/messenger involved in several cellular activities and excess of free zinc has been shown to be toxic (see also Box 4); however, zinc deficiency has also detrimental effects on growth, neuronal development, and immunity, and in severe cases its consequences can be deadly [102].
T302 25060-25252 Sentence denotes For these reasons, treatments with CaNa2EDTA require a careful monitoring of the patient for the therapeutic effects as well as possible complications, so as to titrate the appropriate dosage.
T303 25253-25358 Sentence denotes CaNa2EDTA was approved by FDA in chelation therapy for lowering blood lead levels a long time ago (1953).
T304 25359-25492 Sentence denotes Then, different (commercially available) iron chelating agents, expected to work in chelating zinc ion as well, were approved by FDA.
T305 25493-25626 Sentence denotes Chelation therapy comprises intravenous or oral administration of chelating agents that remove metal ions such as zinc from the body.
T306 25627-25724 Sentence denotes Cells synthesising high amounts of ACE or ACE2 needs of high amounts of bioavailable (free) zinc.
T307 25725-25867 Sentence denotes Therefore, it is conceivable that plasma levels of free zinc may influence not only ACE and ACE2 activities but also their cellular synthesis.
T308 25868-25999 Sentence denotes Indeed, both ACE and ACE2 synthesis might be particularly sensitive to reduction of free zinc levels in case of their upregulation.
T309 26000-26192 Sentence denotes In addition, metal chelating agents, by limiting the availability of free zinc to cells, might have effects on both ACE2/ACE synthesis and conformation (when assembled on the plasma membrane).
T310 26193-26490 Sentence denotes Indeed, the closed conformer of ACE2 homodimer that is the preferential conformation for virus binding [28], needs the presence of both zinc and substrate/inhibitor in the catalytic site [90], suggesting that zinc chelation (differently from MLN-4760) might also inhibit ACE2-mediated viral entry.
T311 26491-26737 Sentence denotes Intriguingly, chloroquine has been shown to specifically enhance zinc uptake and its accumulation/sequestration in the lysosomes [124], raising the possibility that it might work on COVID-19 patients by reducing zinc recycling and zinc functions.
T312 26738-26947 Sentence denotes As already mentioned, free Zn2+ promotes clot stability by binding to fibrinogen (see Box 4 and [91]) and chloroquine has been shown to have an anti-thrombotic activity by inhibiting platelet activation [125].
T313 26948-27328 Sentence denotes To this regard, upon platelet activation the release of Zn2+ store from their secretory granules has been shown to participate to the pro-coagulant activity in platelet-dependent fibrin formation [126], suggesting that an elevated free Zn2+ concentration might occur and contribute to thrombotic predisposition in COVID-19 patients, a phenomenon possibly countered by chloroquine.
T314 27329-27570 Sentence denotes For all of the above reasons, cation chelating agents, administered alone or in combination with other therapies, might be effective to counter COVID-19 infection, in particular when, induced by hypoxia, both arms of the RAS are upregulated.
T315 27571-27618 Sentence denotes A scenario that would deserve an investigation.
T316 27619-27981 Sentence denotes However, some formulations of metal chelating agents carry a black box warning because they may cause serious and fatal renal toxicity and failure, hepatic toxicity and failure, gastrointestinal haemorrhage, arrhythmias, tetany, hypocalcaemia, hypotension, convulsions, respiratory arrest, and agranulocytosis that can lead to serious infections and death [123].
T317 27982-28149 Sentence denotes For the sake of completeness, besides renal toxicity linked to the route of drug excretion, EDTA has been shown to be effective in chronic renal artery diseases [123].
T318 28150-28240 Sentence denotes Finally, for its teratogenic effects, the drug is also contraindicated in pregnancy [123].
T319 28241-28463 Sentence denotes As a result, treatments with metal chelating agents require close patient monitoring, including laboratory tests of renal and hepatic function, and absolute neutrophil count should be monitored before and during treatment.
T320 28464-28535 Sentence denotes Alternative ways of RAS pathway inhibition are also described in Box 5.
T321 28536-28586 Sentence denotes Box 5 Alternative ways of RAS pathway inhibition.
T322 28587-28694 Sentence denotes Of interest, a small cationic inhibitor of ACE2 (but not of ACE) has been detected in plasma samples [116].
T323 28695-28949 Sentence denotes The endogenous inhibitor might play a compensatory fine-control (within a threshold limit) for normal fluctuation of ACE2 protein in plasma and it has been hypothesized to be a basic AA or a small basic peptide able to compete with ACE2 substrates [116].
T324 28950-29057 Sentence denotes I have already mentioned that AA can chelate zinc forming labile zinc complexes of amino acids (see Box 4).
T325 29058-29243 Sentence denotes It is therefore possible that a basic AA or a small basic peptide capable to specifically accommodate into the catalytic site of ACE2, but into that of ACE, could inhibit ACE2 activity.
T326 29244-29408 Sentence denotes Indeed, despite the similarities, ACE and ACE2 possess different substrate specificity that depends on the smaller ACE2 binding pocket compared to that of ACE [90].
T327 29409-29585 Sentence denotes This specific aspect might determine the specificity for a specific basic amino acid or molecule that is able to accommodate into the catalytic pocket of ACE2 and bind to zinc.
T328 29586-29746 Sentence denotes Among the possible endogenous ACE2 inhibitors, agmatine, decarboxylated arginine, has a chemical structure that resembles that of an ACE2 inhibitor, NAAE [127].
T329 29747-29923 Sentence denotes NAAE is a small molecule that had demonstrated an anti-SARS-CoV activity, by acting on both ACE2 catalytic activity and ACE2 binding domain for spike protein of SARS-CoV [127].
T330 29924-29972 Sentence denotes Unfortunately, NAAE has never been used in vivo.
T331 29973-30263 Sentence denotes Indeed, NAAE is a weak ACE2 inhibitor, it is in fact more than a thousand-fold less potent than MLN-4760; however, if agmatine will be proven to have ACE2 inhibitory activity, it might be helpful to prevent the trigger of the positive feedback loops in the first mild phases of the disease.
T332 30264-30386 Sentence denotes Indeed, it has an important role in down-regulating NO synthesis reducing NO overproduction by different mechanisms [128].
T333 30387-30548 Sentence denotes Of note, NOS pathway has been shown to be upregulated by both Ang (1–7)/MasR and Ang (1–9)/AT2 receptor pathways that are downstream ACE2 activity [38,39,41,43].
T334 30549-30740 Sentence denotes Moreover, agmatine has a regulated plasma concentration in the range of 20-80 ng/mL and the use of dietary agmatine has been shown to be safe and effective in reducing neuropathic pain [129].
T335 30741-30816 Sentence denotes Moreover, agmatine sulfate is regularly taken as a bodybuilding supplement.
T336 30817-31027 Sentence denotes Among natural metal-chelating agents, phytates and folic acid are two chelating agents from vegetables that might reduce zinc intestinal absorption and possibly its systemic concentration (see Box 4 and [111]).
T337 31028-31180 Sentence denotes Similarly, nicotianamine that is extracted from plants (soybean) is a low-molecular weight metal chelator with high affinity for divalent metal cations.
T338 31181-31284 Sentence denotes Nicotianamine has been shown to inhibit the activity of both zinc metalloproteases, ACE2 and ACE [130].
T339 31285-31366 Sentence denotes In addition, zeolites might also be effective in reducing free zinc availability.
T340 31367-31495 Sentence denotes Zeolites are a group of aluminosilicate minerals with crystalline microporous structure that are originated from volcanic rocks.
T341 31496-31667 Sentence denotes Their molecular structure generates cavities that allow high absorbency capacity for a wide range of charged elements such as water, heavy metals, cations and many toxins.
T342 31668-31768 Sentence denotes Clinoptilolite is one of the zeolites that has been widely studied in veterinary and human medicine.
T343 31769-31955 Sentence denotes The increased usage of clinoptilolite-based products in vivo has stimulated several investigations on its safety and its positive medical effects related to human health (see [131,132]).
T344 31956-32093 Sentence denotes Finally, soluble and catalytically inactive forms of ACE2 have been shown to be potent inhibitors of SARS-CoV infection products [19,21].
T345 32094-32194 Sentence denotes An approach that could be pursued (in combination with other therapies) to inhibit SARS-CoV-2 entry.
T346 32195-32411 Sentence denotes Indeed, soluble forms of ACE2 are expected to protect from viral infection and a similar strategy using a recombinant form of human ACE2 has been proposed not only in COVID-19, but also in ARDS and PAH [108,133,134].
T347 32412-32542 Sentence denotes However, it is possible that catalytic active form of ACE2 might favour adverse effects in these specific pathological conditions.
T348 32543-32853 Sentence denotes To this regard, a clinical trial using recombinant hACE2 protein has been recently started (ClinicalTrials.gov number, NCT04287686) in COVID-19 patients and pilot clinical trials of rhACE2 in ARDS and PAH started in 2017 and 2018, respectively [108,134]; unfortunately, no conclusive results are available yet.

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T62 110-123 Phenotype denotes Hyperactivity http://purl.obolibrary.org/obo/HP_0000752
T63 1335-1346 Phenotype denotes hypotension http://purl.obolibrary.org/obo/HP_0002615
T64 2569-2589 Phenotype denotes respiratory distress http://purl.obolibrary.org/obo/HP_0002098
T65 2678-2704 Phenotype denotes inflammatory bowel disease http://purl.obolibrary.org/obo/HP_0002037
T66 3296-3312 Phenotype denotes hypoalbuminaemia http://purl.obolibrary.org/obo/HP_0003073
T67 4926-4948 Phenotype denotes chronic kidney disease http://purl.obolibrary.org/obo/HP_0012622
T68 4979-5001 Phenotype denotes cardiovascular disease http://purl.obolibrary.org/obo/HP_0001626
T69 5587-5593 Phenotype denotes asthma http://purl.obolibrary.org/obo/HP_0002099
T70 5699-5705 Phenotype denotes asthma http://purl.obolibrary.org/obo/HP_0002099
T71 6310-6315 Phenotype denotes fever http://purl.obolibrary.org/obo/HP_0001945
T72 6493-6502 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T73 6565-6570 Phenotype denotes fever http://purl.obolibrary.org/obo/HP_0001945
T74 6597-6602 Phenotype denotes fever http://purl.obolibrary.org/obo/HP_0001945
T75 6604-6611 Phenotype denotes fatigue http://purl.obolibrary.org/obo/HP_0012378
T76 6613-6624 Phenotype denotes muscle ache http://purl.obolibrary.org/obo/HP_0003326
T77 6626-6631 Phenotype denotes cough http://purl.obolibrary.org/obo/HP_0012735
T78 6633-6640 Phenotype denotes dyspnea http://purl.obolibrary.org/obo/HP_0002094
T79 7543-7574 Phenotype denotes pulmonary arterial hypertension http://purl.obolibrary.org/obo/HP_0002092
T80 7923-7937 Phenotype denotes cytokine storm http://purl.obolibrary.org/obo/HP_0033041
T81 11765-11788 Phenotype denotes cardiovascular diseases http://purl.obolibrary.org/obo/HP_0001626
T82 11984-12003 Phenotype denotes Alzheimer’s disease http://purl.obolibrary.org/obo/HP_0002511
T83 12147-12172 Phenotype denotes neurodegenerative disease http://purl.obolibrary.org/obo/HP_0002180
T84 12397-12422 Phenotype denotes increased plasma ferritin http://purl.obolibrary.org/obo/HP_0003281
T85 12698-12724 Phenotype denotes neurodegenerative diseases http://purl.obolibrary.org/obo/HP_0002180
T86 13329-13341 Phenotype denotes dyslipidemia http://purl.obolibrary.org/obo/HP_0003119
T87 13750-13769 Phenotype denotes Alzheimer’s disease http://purl.obolibrary.org/obo/HP_0002511
T88 14851-14866 Phenotype denotes hepatic failure http://purl.obolibrary.org/obo/HP_0001399
T89 15095-15114 Phenotype denotes respiratory failure http://purl.obolibrary.org/obo/HP_0002878
T90 15364-15376 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822
T91 15520-15528 Phenotype denotes coughing http://purl.obolibrary.org/obo/HP_0012735
T92 15533-15540 Phenotype denotes dyspnea http://purl.obolibrary.org/obo/HP_0002094
T93 19466-19474 Phenotype denotes acidosis http://purl.obolibrary.org/obo/HP_0001941
T94 20786-20812 Phenotype denotes increase of blood pressure http://purl.obolibrary.org/obo/HP_0032263
T95 21503-21514 Phenotype denotes bradycardia http://purl.obolibrary.org/obo/HP_0001662
T96 21604-21615 Phenotype denotes albuminuria http://purl.obolibrary.org/obo/HP_0012592
T97 22664-22685 Phenotype denotes myocardial infarction http://purl.obolibrary.org/obo/HP_0001658
T98 23112-23133 Phenotype denotes myocardial infarction http://purl.obolibrary.org/obo/HP_0001658
T99 23529-23536 Phenotype denotes colitis http://purl.obolibrary.org/obo/HP_0002583
T100 27524-27531 Phenotype denotes hypoxia http://purl.obolibrary.org/obo/HP_0012418
T101 27797-27825 Phenotype denotes gastrointestinal haemorrhage http://purl.obolibrary.org/obo/HP_0002239
T102 27827-27838 Phenotype denotes arrhythmias http://purl.obolibrary.org/obo/HP_0011675
T103 27840-27846 Phenotype denotes tetany http://purl.obolibrary.org/obo/HP_0001281
T104 27848-27861 Phenotype denotes hypocalcaemia http://purl.obolibrary.org/obo/HP_0002901
T105 27863-27874 Phenotype denotes hypotension http://purl.obolibrary.org/obo/HP_0002615
T106 27889-27907 Phenotype denotes respiratory arrest http://purl.obolibrary.org/obo/HP_0005943
T107 27913-27928 Phenotype denotes agranulocytosis http://purl.obolibrary.org/obo/HP_0012234
T108 30729-30733 Phenotype denotes pain http://purl.obolibrary.org/obo/HP_0012531

2_test

Id Subject Object Predicate Lexical cue
32708755-10969042-20678757 435-437 10969042 denotes 86
32708755-10924499-20678758 438-440 10924499 denotes 87
32708755-10969042-20678759 556-558 10969042 denotes 86
32708755-10924499-20678760 559-561 10924499 denotes 87
32708755-20599443-20678761 745-747 20599443 denotes 44
32708755-20599443-20678762 847-849 20599443 denotes 44
32708755-23249272-20678763 850-852 23249272 denotes 45
32708755-18849338-20678764 856-858 18849338 denotes 76
32708755-18768926-20678765 859-861 18768926 denotes 77
32708755-10924499-20678766 862-864 10924499 denotes 87
32708755-16007097-20678767 1045-1047 16007097 denotes 14
32708755-20599443-20678768 1051-1053 20599443 denotes 44
32708755-23249272-20678769 1054-1056 23249272 denotes 45
32708755-18849338-20678770 1060-1062 18849338 denotes 76
32708755-18768926-20678771 1063-1065 18768926 denotes 77
32708755-10924499-20678772 1066-1068 10924499 denotes 87
32708755-18022664-20678773 1069-1071 18022664 denotes 88
32708755-16306622-20678774 1072-1074 16306622 denotes 89
32708755-16007097-20678775 1348-1350 16007097 denotes 14
32708755-20599443-20678776 1351-1353 20599443 denotes 44
32708755-23249272-20678777 1354-1356 23249272 denotes 45
32708755-10969042-20678778 1360-1362 10969042 denotes 86
32708755-10924499-20678779 1363-1365 10924499 denotes 87
32708755-18022664-20678780 1366-1368 18022664 denotes 88
32708755-16306622-20678781 1369-1371 16306622 denotes 89
32708755-20599443-20678782 2003-2005 20599443 denotes 44
32708755-32109013-20678783 2176-2177 32109013 denotes 5
32708755-30266430-20678784 2462-2464 30266430 denotes 91
32708755-32294485-20678785 2752-2753 32294485 denotes 6
32708755-31986264-20678786 2754-2755 31986264 denotes 8
32708755-24505094-20678787 2756-2758 24505094 denotes 66
32708755-30845246-20678788 2759-2761 30845246 denotes 92
32708755-30266430-20678789 3150-3152 30266430 denotes 91
32708755-21827444-20678790 3203-3205 21827444 denotes 93
32708755-28570269-20678791 3206-3208 28570269 denotes 94
32708755-21827444-20678792 3485-3487 21827444 denotes 93
32708755-31426452-20678793 3921-3923 31426452 denotes 95
32708755-31426452-20678794 4045-4047 31426452 denotes 95
32708755-31426452-20678795 4195-4197 31426452 denotes 95
32708755-32294485-20678796 4720-4721 32294485 denotes 6
32708755-31986264-20678797 4722-4723 31986264 denotes 8
32708755-25813276-20678798 5159-5161 25813276 denotes 96
32708755-28953660-20678799 6036-6039 28953660 denotes 100
32708755-20617034-20678800 6044-6047 20617034 denotes 102
32708755-32276440-20678801 6528-6531 32276440 denotes 103
32708755-30718726-20678802 6532-6535 30718726 denotes 104
32708755-32276440-20678803 6718-6721 32276440 denotes 103
32708755-32161940-20678804 6803-6804 32161940 denotes 2
32708755-31986264-20678805 6805-6806 31986264 denotes 8
32708755-32297671-20678806 6807-6808 32297671 denotes 9
32708755-32276440-20678807 6991-6994 32276440 denotes 103
32708755-20617034-20678808 7159-7162 20617034 denotes 102
32708755-32408070-20678809 7247-7250 32408070 denotes 107
32708755-20617034-20678810 7306-7309 20617034 denotes 102
32708755-30718726-20678811 7523-7526 30718726 denotes 104
32708755-29903860-20678812 7737-7740 29903860 denotes 108
32708755-20713898-20678813 7741-7744 20713898 denotes 109
32708755-18832706-20678814 7745-7748 18832706 denotes 110
32708755-32276440-20678815 7939-7942 32276440 denotes 103
32708755-30718726-20678816 7943-7946 30718726 denotes 104
32708755-28717982-20678817 8548-8551 28717982 denotes 111
32708755-28717982-20678818 8846-8849 28717982 denotes 111
32708755-28717982-20678819 9051-9054 28717982 denotes 111
32708755-28717982-20678820 9563-9566 28717982 denotes 111
32708755-32132184-20678821 9838-9840 32132184 denotes 28
32708755-30266430-20678822 9982-9984 30266430 denotes 91
32708755-30266430-20678823 10924-10926 30266430 denotes 91
32708755-30266430-20678824 11100-11102 30266430 denotes 91
32708755-20617034-20678825 11103-11106 20617034 denotes 102
32708755-30266430-20678826 11869-11871 30266430 denotes 91
32708755-30266430-20678827 12096-12098 30266430 denotes 91
32708755-32161940-20678828 12452-12453 32161940 denotes 2
32708755-32171076-20678829 12454-12455 32171076 denotes 3
32708755-32294485-20678830 12456-12457 32294485 denotes 6
32708755-20617034-20678831 12726-12729 20617034 denotes 102
32708755-30266430-20678832 13092-13094 30266430 denotes 91
32708755-30266430-20678833 13205-13207 30266430 denotes 91
32708755-30266430-20678834 13771-13773 30266430 denotes 91
32708755-30266430-20678835 13885-13887 30266430 denotes 91
32708755-30266430-20678836 14007-14009 30266430 denotes 91
32708755-28953660-20678837 14560-14563 28953660 denotes 100
32708755-20617034-20678838 14568-14571 20617034 denotes 102
32708755-28953660-20678839 14682-14685 28953660 denotes 100
32708755-28953660-20678840 14869-14872 28953660 denotes 100
32708755-28953660-20678841 15053-15056 28953660 denotes 100
32708755-28953660-20678842 15153-15156 28953660 denotes 100
32708755-32132184-20678843 16081-16083 32132184 denotes 28
32708755-15791205-20678844 16648-16650 15791205 denotes 24
32708755-32132184-20678845 16832-16834 32132184 denotes 28
32708755-32132184-20678846 16899-16901 32132184 denotes 28
32708755-18490652-20678847 17331-17333 18490652 denotes 17
32708755-15791205-20678848 17334-17336 15791205 denotes 24
32708755-15791205-20678849 17602-17604 15791205 denotes 24
32708755-15791205-20678850 17805-17807 15791205 denotes 24
32708755-12358520-20678851 18021-18024 12358520 denotes 113
32708755-26851370-20678852 18025-18028 26851370 denotes 114
32708755-26851370-20678853 18115-18118 26851370 denotes 114
32708755-26851370-20678854 18301-18304 26851370 denotes 114
32708755-26851370-20678855 18652-18655 26851370 denotes 114
32708755-26851370-20678856 19019-19022 26851370 denotes 114
32708755-26851370-20678857 19119-19122 26851370 denotes 114
32708755-22777933-20678858 19350-19353 22777933 denotes 115
32708755-22777933-20678859 19835-19838 22777933 denotes 115
32708755-18223027-20678860 20334-20337 18223027 denotes 116
32708755-32132184-20678861 20463-20465 32132184 denotes 28
32708755-18235039-20678862 21021-21024 18235039 denotes 117
32708755-20300067-20678863 21144-21147 20300067 denotes 118
32708755-20599443-20678864 21524-21526 20599443 denotes 44
32708755-17579661-20678865 21759-21762 17579661 denotes 119
32708755-26851370-20678866 22308-22311 26851370 denotes 114
32708755-22777933-20678867 22312-22315 22777933 denotes 115
32708755-20797602-20678868 23042-23044 20797602 denotes 52
32708755-19517214-20678869 23538-23541 19517214 denotes 122
32708755-20717537-20678870 24122-24125 20717537 denotes 123
32708755-20717537-20678871 24724-24727 20717537 denotes 123
32708755-20617034-20678872 25054-25057 20617034 denotes 102
32708755-32132184-20678873 26297-26299 32132184 denotes 28
32708755-25271834-20678874 26621-26624 25271834 denotes 124
32708755-30266430-20678875 26835-26837 30266430 denotes 91
32708755-30316994-20678876 26942-26945 30316994 denotes 125
32708755-31171812-20678877 27145-27148 31171812 denotes 126
32708755-20717537-20678878 27976-27979 20717537 denotes 123
32708755-20717537-20678879 28144-28147 20717537 denotes 123
32708755-20717537-20678880 28235-28238 20717537 denotes 123
32708755-18223027-20678881 28689-28692 18223027 denotes 116
32708755-18223027-20678882 28944-28947 18223027 denotes 116
32708755-15492138-20678883 29741-29744 15492138 denotes 127
32708755-15492138-20678884 29918-29921 15492138 denotes 127
32708755-23769988-20678885 30381-30384 23769988 denotes 128
32708755-27082314-20678886 30535-30537 27082314 denotes 38
32708755-30554115-20678887 30541-30543 30554115 denotes 41
32708755-28717982-20678888 31021-31024 28717982 denotes 111
32708755-26106051-20678889 31279-31282 26106051 denotes 130
32708755-29387012-20678890 31945-31948 29387012 denotes 131
32708755-15367630-20678891 32086-32088 15367630 denotes 19
32708755-16510163-20678892 32089-32091 16510163 denotes 21
32708755-29903860-20678893 32398-32401 29903860 denotes 108
32708755-32333836-20678894 32402-32405 32333836 denotes 133
32708755-28877748-20678895 32406-32409 28877748 denotes 134
32708755-29903860-20678896 32788-32791 29903860 denotes 108
32708755-28877748-20678897 32792-32795 28877748 denotes 134