PMC:7408073 / 36437-36815 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T218","span":{"begin":90,"end":95},"obj":"Body_part"}],"attributes":[{"id":"A218","pred":"fma_id","subj":"T218","obj":"http://purl.org/sig/ont/fma/fma9670"}],"text":"In mice studies a MasR blocker (A779) administered alone was not associated with systolic blood pressure alterations, and the hypotensive effect produced by rACE2 co-infused with Ang II was unaffected by A779 co-administration, indicating that the hypotensive activity of rACE2 mainly depended on Ang II degradation rather than on increase of Ang (1–7) and MasR activation [82]."}

{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T79","span":{"begin":90,"end":95},"obj":"Body_part"}],"attributes":[{"id":"A79","pred":"uberon_id","subj":"T79","obj":"http://purl.obolibrary.org/obo/UBERON_0000178"}],"text":"In mice studies a MasR blocker (A779) administered alone was not associated with systolic blood pressure alterations, and the hypotensive effect produced by rACE2 co-infused with Ang II was unaffected by A779 co-administration, indicating that the hypotensive activity of rACE2 mainly depended on Ang II degradation rather than on increase of Ang (1–7) and MasR activation [82]."}

{"project":"LitCovid-PubTator","denotations":[{"id":"1429","span":{"begin":157,"end":162},"obj":"Gene"},{"id":"1430","span":{"begin":343,"end":351},"obj":"Gene"},{"id":"1431","span":{"begin":357,"end":361},"obj":"Gene"},{"id":"1439","span":{"begin":18,"end":22},"obj":"Gene"},{"id":"1444","span":{"begin":272,"end":277},"obj":"Gene"},{"id":"1447","span":{"begin":3,"end":7},"obj":"Species"},{"id":"1458","span":{"begin":297,"end":303},"obj":"Gene"},{"id":"1459","span":{"begin":179,"end":185},"obj":"Gene"},{"id":"1461","span":{"begin":126,"end":137},"obj":"Disease"},{"id":"1462","span":{"begin":248,"end":259},"obj":"Disease"}],"attributes":[{"id":"A1429","pred":"tao:has_database_id","subj":"1429","obj":"Gene:302668"},{"id":"A1430","pred":"tao:has_database_id","subj":"1430","obj":"Gene:11727"},{"id":"A1431","pred":"tao:has_database_id","subj":"1431","obj":"Gene:116511"},{"id":"A1439","pred":"tao:has_database_id","subj":"1439","obj":"Gene:116511"},{"id":"A1444","pred":"tao:has_database_id","subj":"1444","obj":"Gene:302668"},{"id":"A1447","pred":"tao:has_database_id","subj":"1447","obj":"Tax:10090"},{"id":"A1458","pred":"tao:has_database_id","subj":"1458","obj":"Gene:24179"},{"id":"A1459","pred":"tao:has_database_id","subj":"1459","obj":"Gene:24179"},{"id":"A1461","pred":"tao:has_database_id","subj":"1461","obj":"MESH:D007022"},{"id":"A1462","pred":"tao:has_database_id","subj":"1462","obj":"MESH:D007022"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"In mice studies a MasR blocker (A779) administered alone was not associated with systolic blood pressure alterations, and the hypotensive effect produced by rACE2 co-infused with Ang II was unaffected by A779 co-administration, indicating that the hypotensive activity of rACE2 mainly depended on Ang II degradation rather than on increase of Ang (1–7) and MasR activation [82]."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T425","span":{"begin":16,"end":17},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T426","span":{"begin":90,"end":95},"obj":"http://purl.obolibrary.org/obo/UBERON_0000178"},{"id":"T427","span":{"begin":90,"end":95},"obj":"http://www.ebi.ac.uk/efo/EFO_0000296"},{"id":"T428","span":{"begin":260,"end":268},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T429","span":{"begin":362,"end":372},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"}],"text":"In mice studies a MasR blocker (A779) administered alone was not associated with systolic blood pressure alterations, and the hypotensive effect produced by rACE2 co-infused with Ang II was unaffected by A779 co-administration, indicating that the hypotensive activity of rACE2 mainly depended on Ang II degradation rather than on increase of Ang (1–7) and MasR activation [82]."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T330","span":{"begin":179,"end":182},"obj":"Chemical"},{"id":"T331","span":{"begin":183,"end":185},"obj":"Chemical"},{"id":"T332","span":{"begin":297,"end":300},"obj":"Chemical"},{"id":"T333","span":{"begin":301,"end":303},"obj":"Chemical"},{"id":"T334","span":{"begin":343,"end":346},"obj":"Chemical"}],"attributes":[{"id":"A330","pred":"chebi_id","subj":"T330","obj":"http://purl.obolibrary.org/obo/CHEBI_48433"},{"id":"A331","pred":"chebi_id","subj":"T331","obj":"http://purl.obolibrary.org/obo/CHEBI_74067"},{"id":"A332","pred":"chebi_id","subj":"T332","obj":"http://purl.obolibrary.org/obo/CHEBI_48433"},{"id":"A333","pred":"chebi_id","subj":"T333","obj":"http://purl.obolibrary.org/obo/CHEBI_74067"},{"id":"A334","pred":"chebi_id","subj":"T334","obj":"http://purl.obolibrary.org/obo/CHEBI_48433"}],"text":"In mice studies a MasR blocker (A779) administered alone was not associated with systolic blood pressure alterations, and the hypotensive effect produced by rACE2 co-infused with Ang II was unaffected by A779 co-administration, indicating that the hypotensive activity of rACE2 mainly depended on Ang II degradation rather than on increase of Ang (1–7) and MasR activation [82]."}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T68","span":{"begin":304,"end":315},"obj":"http://purl.obolibrary.org/obo/GO_0009056"}],"text":"In mice studies a MasR blocker (A779) administered alone was not associated with systolic blood pressure alterations, and the hypotensive effect produced by rACE2 co-infused with Ang II was unaffected by A779 co-administration, indicating that the hypotensive activity of rACE2 mainly depended on Ang II degradation rather than on increase of Ang (1–7) and MasR activation [82]."}

{"project":"LitCovid-sentences","denotations":[{"id":"T171","span":{"begin":0,"end":378},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"In mice studies a MasR blocker (A779) administered alone was not associated with systolic blood pressure alterations, and the hypotensive effect produced by rACE2 co-infused with Ang II was unaffected by A779 co-administration, indicating that the hypotensive activity of rACE2 mainly depended on Ang II degradation rather than on increase of Ang (1–7) and MasR activation [82]."}

{"project":"2_test","denotations":[{"id":"32708755-19948988-20678752","span":{"begin":374,"end":376},"obj":"19948988"}],"text":"In mice studies a MasR blocker (A779) administered alone was not associated with systolic blood pressure alterations, and the hypotensive effect produced by rACE2 co-infused with Ang II was unaffected by A779 co-administration, indicating that the hypotensive activity of rACE2 mainly depended on Ang II degradation rather than on increase of Ang (1–7) and MasR activation [82]."}