PMC:7408073 / 343-620 JSONTXT

{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T4","span":{"begin":46,"end":49},"obj":"Body_part"}],"attributes":[{"id":"A4","pred":"uberon_id","subj":"T4","obj":"http://purl.obolibrary.org/obo/UBERON_0018229"}],"text":"Based purely on experimental studies in which RAS pathway inhibitors were administered in vivo to humans/rodents, a reasonable hypothesis of using inhibitors that block both ACE and ACE2 zinc metalloproteases and their downstream pathways in COVID-19 patients will be proposed."}

{"project":"LitCovid-PubTator","denotations":[{"id":"21","span":{"begin":174,"end":177},"obj":"Gene"},{"id":"22","span":{"begin":182,"end":186},"obj":"Gene"},{"id":"27","span":{"begin":98,"end":104},"obj":"Species"},{"id":"28","span":{"begin":251,"end":259},"obj":"Species"},{"id":"32","span":{"begin":242,"end":250},"obj":"Disease"}],"attributes":[{"id":"A21","pred":"tao:has_database_id","subj":"21","obj":"Gene:59272"},{"id":"A22","pred":"tao:has_database_id","subj":"22","obj":"Gene:59272"},{"id":"A27","pred":"tao:has_database_id","subj":"27","obj":"Tax:9606"},{"id":"A28","pred":"tao:has_database_id","subj":"28","obj":"Tax:9606"},{"id":"A32","pred":"tao:has_database_id","subj":"32","obj":"MESH:C000657245"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Based purely on experimental studies in which RAS pathway inhibitors were administered in vivo to humans/rodents, a reasonable hypothesis of using inhibitors that block both ACE and ACE2 zinc metalloproteases and their downstream pathways in COVID-19 patients will be proposed."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T4","span":{"begin":242,"end":250},"obj":"Disease"}],"attributes":[{"id":"A4","pred":"mondo_id","subj":"T4","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"}],"text":"Based purely on experimental studies in which RAS pathway inhibitors were administered in vivo to humans/rodents, a reasonable hypothesis of using inhibitors that block both ACE and ACE2 zinc metalloproteases and their downstream pathways in COVID-19 patients will be proposed."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T1177","span":{"begin":98,"end":104},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9606"},{"id":"T48692","span":{"begin":114,"end":115},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"}],"text":"Based purely on experimental studies in which RAS pathway inhibitors were administered in vivo to humans/rodents, a reasonable hypothesis of using inhibitors that block both ACE and ACE2 zinc metalloproteases and their downstream pathways in COVID-19 patients will be proposed."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T4","span":{"begin":46,"end":49},"obj":"Chemical"},{"id":"T5","span":{"begin":50,"end":68},"obj":"Chemical"},{"id":"T6","span":{"begin":58,"end":68},"obj":"Chemical"},{"id":"T7","span":{"begin":147,"end":157},"obj":"Chemical"},{"id":"T8","span":{"begin":187,"end":191},"obj":"Chemical"}],"attributes":[{"id":"A4","pred":"chebi_id","subj":"T4","obj":"http://purl.obolibrary.org/obo/CHEBI_63620"},{"id":"A5","pred":"chebi_id","subj":"T5","obj":"http://purl.obolibrary.org/obo/CHEBI_76932"},{"id":"A6","pred":"chebi_id","subj":"T6","obj":"http://purl.obolibrary.org/obo/CHEBI_35222"},{"id":"A7","pred":"chebi_id","subj":"T7","obj":"http://purl.obolibrary.org/obo/CHEBI_35222"},{"id":"A8","pred":"chebi_id","subj":"T8","obj":"http://purl.obolibrary.org/obo/CHEBI_27363"},{"id":"A9","pred":"chebi_id","subj":"T8","obj":"http://purl.obolibrary.org/obo/CHEBI_30185"}],"text":"Based purely on experimental studies in which RAS pathway inhibitors were administered in vivo to humans/rodents, a reasonable hypothesis of using inhibitors that block both ACE and ACE2 zinc metalloproteases and their downstream pathways in COVID-19 patients will be proposed."}

{"project":"LitCovid-sentences","denotations":[{"id":"T5","span":{"begin":0,"end":277},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Based purely on experimental studies in which RAS pathway inhibitors were administered in vivo to humans/rodents, a reasonable hypothesis of using inhibitors that block both ACE and ACE2 zinc metalloproteases and their downstream pathways in COVID-19 patients will be proposed."}