PMC:7408073 / 33076-33463 JSONTXT

{"project":"LitCovid-PubTator","denotations":[{"id":"1307","span":{"begin":120,"end":128},"obj":"Gene"},{"id":"1308","span":{"begin":171,"end":182},"obj":"Gene"},{"id":"1309","span":{"begin":215,"end":219},"obj":"Gene"},{"id":"1310","span":{"begin":249,"end":259},"obj":"Gene"},{"id":"1311","span":{"begin":272,"end":282},"obj":"Gene"},{"id":"1312","span":{"begin":298,"end":302},"obj":"Gene"},{"id":"1314","span":{"begin":98,"end":106},"obj":"Gene"},{"id":"1318","span":{"begin":109,"end":115},"obj":"Gene"},{"id":"1319","span":{"begin":238,"end":245},"obj":"Chemical"},{"id":"1320","span":{"begin":340,"end":352},"obj":"Chemical"},{"id":"1323","span":{"begin":62,"end":70},"obj":"Disease"}],"attributes":[{"id":"A1307","pred":"tao:has_database_id","subj":"1307","obj":"Gene:284"},{"id":"A1308","pred":"tao:has_database_id","subj":"1308","obj":"Gene:623"},{"id":"A1309","pred":"tao:has_database_id","subj":"1309","obj":"Gene:59272"},{"id":"A1310","pred":"tao:has_database_id","subj":"1310","obj":"Gene:3827"},{"id":"A1311","pred":"tao:has_database_id","subj":"1311","obj":"Gene:3827"},{"id":"A1312","pred":"tao:has_database_id","subj":"1312","obj":"Gene:59272"},{"id":"A1314","pred":"tao:has_database_id","subj":"1314","obj":"Gene:284"},{"id":"A1318","pred":"tao:has_database_id","subj":"1318","obj":"Gene:24179"},{"id":"A1323","pred":"tao:has_database_id","subj":"1323","obj":"MESH:C000657245"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Although in the present work I have supposed that most of the COVID-19 symptoms might derive from Ang (1–7), Ang II and Ang (1–9) peptide upregulation, the involvement of B1 receptor pathway suppression mediated by ACE2 metabolisation of des-Arg(9)-bradykinin to inactive bradykinin (1–7) or other ACE2-downstream peptides such as apelins, casomorphins and dynorphins cannot be rule out."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T224","span":{"begin":62,"end":70},"obj":"Disease"}],"attributes":[{"id":"A224","pred":"mondo_id","subj":"T224","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"}],"text":"Although in the present work I have supposed that most of the COVID-19 symptoms might derive from Ang (1–7), Ang II and Ang (1–9) peptide upregulation, the involvement of B1 receptor pathway suppression mediated by ACE2 metabolisation of des-Arg(9)-bradykinin to inactive bradykinin (1–7) or other ACE2-downstream peptides such as apelins, casomorphins and dynorphins cannot be rule out."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T400","span":{"begin":130,"end":137},"obj":"http://purl.obolibrary.org/obo/PR_000018263"},{"id":"T401","span":{"begin":314,"end":322},"obj":"http://purl.obolibrary.org/obo/PR_000018263"}],"text":"Although in the present work I have supposed that most of the COVID-19 symptoms might derive from Ang (1–7), Ang II and Ang (1–9) peptide upregulation, the involvement of B1 receptor pathway suppression mediated by ACE2 metabolisation of des-Arg(9)-bradykinin to inactive bradykinin (1–7) or other ACE2-downstream peptides such as apelins, casomorphins and dynorphins cannot be rule out."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T290","span":{"begin":98,"end":101},"obj":"Chemical"},{"id":"T291","span":{"begin":109,"end":112},"obj":"Chemical"},{"id":"T292","span":{"begin":113,"end":115},"obj":"Chemical"},{"id":"T293","span":{"begin":120,"end":123},"obj":"Chemical"},{"id":"T294","span":{"begin":130,"end":137},"obj":"Chemical"},{"id":"T295","span":{"begin":242,"end":245},"obj":"Chemical"},{"id":"T297","span":{"begin":249,"end":259},"obj":"Chemical"},{"id":"T298","span":{"begin":272,"end":282},"obj":"Chemical"},{"id":"T299","span":{"begin":314,"end":322},"obj":"Chemical"}],"attributes":[{"id":"A290","pred":"chebi_id","subj":"T290","obj":"http://purl.obolibrary.org/obo/CHEBI_48433"},{"id":"A291","pred":"chebi_id","subj":"T291","obj":"http://purl.obolibrary.org/obo/CHEBI_48433"},{"id":"A292","pred":"chebi_id","subj":"T292","obj":"http://purl.obolibrary.org/obo/CHEBI_74067"},{"id":"A293","pred":"chebi_id","subj":"T293","obj":"http://purl.obolibrary.org/obo/CHEBI_48433"},{"id":"A294","pred":"chebi_id","subj":"T294","obj":"http://purl.obolibrary.org/obo/CHEBI_16670"},{"id":"A295","pred":"chebi_id","subj":"T295","obj":"http://purl.obolibrary.org/obo/CHEBI_16467"},{"id":"A296","pred":"chebi_id","subj":"T295","obj":"http://purl.obolibrary.org/obo/CHEBI_29952"},{"id":"A297","pred":"chebi_id","subj":"T297","obj":"http://purl.obolibrary.org/obo/CHEBI_3165"},{"id":"A298","pred":"chebi_id","subj":"T298","obj":"http://purl.obolibrary.org/obo/CHEBI_3165"},{"id":"A299","pred":"chebi_id","subj":"T299","obj":"http://purl.obolibrary.org/obo/CHEBI_16670"}],"text":"Although in the present work I have supposed that most of the COVID-19 symptoms might derive from Ang (1–7), Ang II and Ang (1–9) peptide upregulation, the involvement of B1 receptor pathway suppression mediated by ACE2 metabolisation of des-Arg(9)-bradykinin to inactive bradykinin (1–7) or other ACE2-downstream peptides such as apelins, casomorphins and dynorphins cannot be rule out."}

{"project":"LitCovid-sentences","denotations":[{"id":"T155","span":{"begin":0,"end":387},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Although in the present work I have supposed that most of the COVID-19 symptoms might derive from Ang (1–7), Ang II and Ang (1–9) peptide upregulation, the involvement of B1 receptor pathway suppression mediated by ACE2 metabolisation of des-Arg(9)-bradykinin to inactive bradykinin (1–7) or other ACE2-downstream peptides such as apelins, casomorphins and dynorphins cannot be rule out."}