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PMC:7408073 / 32114-33463 JSONTXT

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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T205 111-116 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670
T206 326-331 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T207 359-363 Body_part denotes hand http://purl.org/sig/ont/fma/fma9712
T208 545-550 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T209 565-569 Body_part denotes hand http://purl.org/sig/ont/fma/fma9712
T210 600-614 Body_part denotes cell membranes http://purl.org/sig/ont/fma/fma63841
T211 600-604 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T212 676-680 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T68 111-116 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T69 359-363 Body_part denotes hand http://purl.obolibrary.org/obo/UBERON_0002398
T70 565-569 Body_part denotes hand http://purl.obolibrary.org/obo/UBERON_0002398
T71 676-680 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T72 910-916 Body_part denotes organs http://purl.obolibrary.org/obo/UBERON_0000062

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
1302 9-13 Gene denotes ACE2 Gene:59272
1303 47-51 Gene denotes ACE2 Gene:59272
1304 365-369 Gene denotes ACE2 Gene:59272
1305 428-432 Gene denotes ACE2 Gene:59272
1306 586-590 Gene denotes ACE2 Gene:59272
1307 1082-1090 Gene denotes Ang (1–9 Gene:284
1308 1133-1144 Gene denotes B1 receptor Gene:623
1309 1177-1181 Gene denotes ACE2 Gene:59272
1310 1211-1221 Gene denotes bradykinin Gene:3827
1311 1234-1244 Gene denotes bradykinin Gene:3827
1312 1260-1264 Gene denotes ACE2 Gene:59272
1313 528-533 Gene denotes mACE2 Gene:70008
1314 1060-1068 Gene denotes Ang (1–7 Gene:284
1315 21-31 Species denotes SARS-CoV-2 Tax:2697049
1316 488-498 Species denotes SARS-CoV-2 Tax:2697049
1317 830-840 Species denotes SARS-CoV-2 Tax:2697049
1318 1071-1077 Gene denotes Ang II Gene:24179
1319 1200-1207 Chemical denotes des-Arg
1320 1302-1314 Chemical denotes casomorphins
1321 453-460 Disease denotes hypoxia MESH:D000860
1322 461-472 Disease denotes hypotension MESH:D007022
1323 1024-1032 Disease denotes COVID-19 MESH:C000657245

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T216 21-29 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T217 21-25 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T218 461-472 Disease denotes hypotension http://purl.obolibrary.org/obo/MONDO_0005468
T219 488-496 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T220 488-492 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T221 756-772 Disease denotes systemic disease http://purl.obolibrary.org/obo/MONDO_0015938
T222 830-838 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T223 830-834 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T224 1024-1032 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T386 44-46 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T387 111-116 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T388 111-116 http://www.ebi.ac.uk/efo/EFO_0000296 denotes blood
T389 209-217 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T390 326-331 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T391 416-424 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T392 545-550 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T393 600-604 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T394 605-614 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membranes
T395 634-642 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T396 676-680 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T397 676-680 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T398 854-855 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T399 910-919 http://purl.obolibrary.org/obo/UBERON_0003103 denotes organs in
T400 1092-1099 http://purl.obolibrary.org/obo/PR_000018263 denotes peptide
T401 1276-1284 http://purl.obolibrary.org/obo/PR_000018263 denotes peptides

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T290 1060-1063 Chemical denotes Ang http://purl.obolibrary.org/obo/CHEBI_48433
T291 1071-1074 Chemical denotes Ang http://purl.obolibrary.org/obo/CHEBI_48433
T292 1075-1077 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T293 1082-1085 Chemical denotes Ang http://purl.obolibrary.org/obo/CHEBI_48433
T294 1092-1099 Chemical denotes peptide http://purl.obolibrary.org/obo/CHEBI_16670
T295 1204-1207 Chemical denotes Arg http://purl.obolibrary.org/obo/CHEBI_16467|http://purl.obolibrary.org/obo/CHEBI_29952
T297 1211-1221 Chemical denotes bradykinin http://purl.obolibrary.org/obo/CHEBI_3165
T298 1234-1244 Chemical denotes bradykinin http://purl.obolibrary.org/obo/CHEBI_3165
T299 1276-1284 Chemical denotes peptides http://purl.obolibrary.org/obo/CHEBI_16670

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T60 96-107 http://purl.obolibrary.org/obo/GO_0009056 denotes degradation
T61 141-150 http://purl.obolibrary.org/obo/GO_0007588 denotes excretion
T62 773-785 http://purl.obolibrary.org/obo/GO_0009405 denotes pathogenesis

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T151 0-347 Sentence denotes Finally, ACE2-loaded SARS-CoV-2 virions and S1-ACE2 complexes may impair both sACE2 proteolytic degradation by blood proteases and its renal excretion, therefore blunting the removal of its systemic enzymatic activity and indicating that circulating viral particles are dangerous even when they are not able to entry into the cells (see Figure 2).
T152 348-551 Sentence denotes On the one hand, ACE2 hypertranscription and consequent increase of membrane (m)ACE2 exposure induced by hypoxia/hypotension may facilitate SARS-CoV-2 entry and its lifecycle into mACE2 expressing cells.
T153 552-786 Sentence denotes On the other hand, the release of ACE2 from the cell membranes and its subsequent activity in the bloodstream and in local (lung/cardiac) extracellular fluids are likely critical steps in contributing to systemic disease pathogenesis.
T154 787-961 Sentence denotes Nevertheless, the same aetiological agent, SARS-CoV-2, can produce a variety of clinical syndromes, which involves several organs in relation to the subject’s predisposition.
T155 962-1349 Sentence denotes Although in the present work I have supposed that most of the COVID-19 symptoms might derive from Ang (1–7), Ang II and Ang (1–9) peptide upregulation, the involvement of B1 receptor pathway suppression mediated by ACE2 metabolisation of des-Arg(9)-bradykinin to inactive bradykinin (1–7) or other ACE2-downstream peptides such as apelins, casomorphins and dynorphins cannot be rule out.

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T58 453-460 Phenotype denotes hypoxia http://purl.obolibrary.org/obo/HP_0012418
T59 461-472 Phenotype denotes hypotension http://purl.obolibrary.org/obo/HP_0002615