PMC:7408073 / 31368-31581 JSONTXT

{"project":"LitCovid-PubTator","denotations":[{"id":"1152","span":{"begin":0,"end":8},"obj":"Gene"},{"id":"1153","span":{"begin":10,"end":14},"obj":"Gene"},{"id":"1154","span":{"begin":35,"end":39},"obj":"Gene"},{"id":"1155","span":{"begin":151,"end":155},"obj":"Gene"},{"id":"1156","span":{"begin":184,"end":188},"obj":"Gene"},{"id":"1157","span":{"begin":144,"end":150},"obj":"Gene"},{"id":"1158","span":{"begin":101,"end":107},"obj":"Gene"},{"id":"1159","span":{"begin":120,"end":127},"obj":"Disease"}],"attributes":[{"id":"A1152","pred":"tao:has_database_id","subj":"1152","obj":"Gene:284"},{"id":"A1153","pred":"tao:has_database_id","subj":"1153","obj":"Gene:116511"},{"id":"A1154","pred":"tao:has_database_id","subj":"1154","obj":"Gene:59272"},{"id":"A1155","pred":"tao:has_database_id","subj":"1155","obj":"Gene:185"},{"id":"A1156","pred":"tao:has_database_id","subj":"1156","obj":"Gene:59272"},{"id":"A1157","pred":"tao:has_database_id","subj":"1157","obj":"Gene:24179"},{"id":"A1158","pred":"tao:has_database_id","subj":"1158","obj":"Gene:24179"},{"id":"A1159","pred":"tao:has_database_id","subj":"1159","obj":"MESH:D000860"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Ang (1–7)/MasR pathway can sustain ACE2 synthesis even in the presence of elevated concentrations of Ang II (such as in hypoxia), by inhibiting Ang II/AT1R-mediated down-modulation of ACE2 activity (see Figure 1)."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T380","span":{"begin":189,"end":197},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"}],"text":"Ang (1–7)/MasR pathway can sustain ACE2 synthesis even in the presence of elevated concentrations of Ang II (such as in hypoxia), by inhibiting Ang II/AT1R-mediated down-modulation of ACE2 activity (see Figure 1)."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T278","span":{"begin":0,"end":3},"obj":"Chemical"},{"id":"T279","span":{"begin":101,"end":104},"obj":"Chemical"},{"id":"T280","span":{"begin":105,"end":107},"obj":"Chemical"},{"id":"T281","span":{"begin":144,"end":147},"obj":"Chemical"},{"id":"T282","span":{"begin":148,"end":150},"obj":"Chemical"}],"attributes":[{"id":"A278","pred":"chebi_id","subj":"T278","obj":"http://purl.obolibrary.org/obo/CHEBI_48433"},{"id":"A279","pred":"chebi_id","subj":"T279","obj":"http://purl.obolibrary.org/obo/CHEBI_48433"},{"id":"A280","pred":"chebi_id","subj":"T280","obj":"http://purl.obolibrary.org/obo/CHEBI_74067"},{"id":"A281","pred":"chebi_id","subj":"T281","obj":"http://purl.obolibrary.org/obo/CHEBI_48433"},{"id":"A282","pred":"chebi_id","subj":"T282","obj":"http://purl.obolibrary.org/obo/CHEBI_74067"}],"text":"Ang (1–7)/MasR pathway can sustain ACE2 synthesis even in the presence of elevated concentrations of Ang II (such as in hypoxia), by inhibiting Ang II/AT1R-mediated down-modulation of ACE2 activity (see Figure 1)."}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T59","span":{"begin":40,"end":49},"obj":"http://purl.obolibrary.org/obo/GO_0009058"}],"text":"Ang (1–7)/MasR pathway can sustain ACE2 synthesis even in the presence of elevated concentrations of Ang II (such as in hypoxia), by inhibiting Ang II/AT1R-mediated down-modulation of ACE2 activity (see Figure 1)."}

{"project":"LitCovid-PD-HP","denotations":[{"id":"T56","span":{"begin":120,"end":127},"obj":"Phenotype"}],"attributes":[{"id":"A56","pred":"hp_id","subj":"T56","obj":"http://purl.obolibrary.org/obo/HP_0012418"}],"text":"Ang (1–7)/MasR pathway can sustain ACE2 synthesis even in the presence of elevated concentrations of Ang II (such as in hypoxia), by inhibiting Ang II/AT1R-mediated down-modulation of ACE2 activity (see Figure 1)."}