PMC:7408073 / 29899-30214 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T198","span":{"begin":91,"end":95},"obj":"Body_part"},{"id":"T199","span":{"begin":241,"end":245},"obj":"Body_part"},{"id":"T200","span":{"begin":295,"end":299},"obj":"Body_part"}],"attributes":[{"id":"A198","pred":"fma_id","subj":"T198","obj":"http://purl.org/sig/ont/fma/fma86583"},{"id":"A199","pred":"fma_id","subj":"T199","obj":"http://purl.org/sig/ont/fma/fma9712"},{"id":"A200","pred":"fma_id","subj":"T200","obj":"http://purl.org/sig/ont/fma/fma9712"}],"text":"can sustain positive feedback loops at different levels (Figure 2):(1) SARS-CoV can induce IL-1β and TNF-α systemic secretion that can mediate viral-independent surface membrane ACE2 upregulation and shedding. Of note, ACE2 shedding, on one hand, protects from viral infection but, on the other hand, increases circ"}

{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T59","span":{"begin":241,"end":245},"obj":"Body_part"},{"id":"T60","span":{"begin":295,"end":299},"obj":"Body_part"}],"attributes":[{"id":"A59","pred":"uberon_id","subj":"T59","obj":"http://purl.obolibrary.org/obo/UBERON_0002398"},{"id":"A60","pred":"uberon_id","subj":"T60","obj":"http://purl.obolibrary.org/obo/UBERON_0002398"}],"text":"can sustain positive feedback loops at different levels (Figure 2):(1) SARS-CoV can induce IL-1β and TNF-α systemic secretion that can mediate viral-independent surface membrane ACE2 upregulation and shedding. Of note, ACE2 shedding, on one hand, protects from viral infection but, on the other hand, increases circ"}

{"project":"LitCovid-PubTator","denotations":[{"id":"1078","span":{"begin":91,"end":96},"obj":"Gene"},{"id":"1079","span":{"begin":101,"end":106},"obj":"Gene"},{"id":"1080","span":{"begin":178,"end":182},"obj":"Gene"},{"id":"1081","span":{"begin":219,"end":223},"obj":"Gene"},{"id":"1082","span":{"begin":71,"end":79},"obj":"Species"},{"id":"1083","span":{"begin":261,"end":276},"obj":"Disease"}],"attributes":[{"id":"A1078","pred":"tao:has_database_id","subj":"1078","obj":"Gene:3552"},{"id":"A1079","pred":"tao:has_database_id","subj":"1079","obj":"Gene:7124"},{"id":"A1080","pred":"tao:has_database_id","subj":"1080","obj":"Gene:59272"},{"id":"A1081","pred":"tao:has_database_id","subj":"1081","obj":"Gene:59272"},{"id":"A1082","pred":"tao:has_database_id","subj":"1082","obj":"Tax:694009"},{"id":"A1083","pred":"tao:has_database_id","subj":"1083","obj":"MESH:D001102"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"can sustain positive feedback loops at different levels (Figure 2):(1) SARS-CoV can induce IL-1β and TNF-α systemic secretion that can mediate viral-independent surface membrane ACE2 upregulation and shedding. Of note, ACE2 shedding, on one hand, protects from viral infection but, on the other hand, increases circ"}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T202","span":{"begin":71,"end":79},"obj":"Disease"},{"id":"T203","span":{"begin":71,"end":75},"obj":"Disease"},{"id":"T204","span":{"begin":261,"end":276},"obj":"Disease"},{"id":"T205","span":{"begin":267,"end":276},"obj":"Disease"}],"attributes":[{"id":"A202","pred":"mondo_id","subj":"T202","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A203","pred":"mondo_id","subj":"T203","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A204","pred":"mondo_id","subj":"T204","obj":"http://purl.obolibrary.org/obo/MONDO_0005108"},{"id":"A205","pred":"mondo_id","subj":"T205","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"}],"text":"can sustain positive feedback loops at different levels (Figure 2):(1) SARS-CoV can induce IL-1β and TNF-α systemic secretion that can mediate viral-independent surface membrane ACE2 upregulation and shedding. Of note, ACE2 shedding, on one hand, protects from viral infection but, on the other hand, increases circ"}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T368","span":{"begin":169,"end":177},"obj":"http://purl.obolibrary.org/obo/UBERON_0000158"}],"text":"can sustain positive feedback loops at different levels (Figure 2):(1) SARS-CoV can induce IL-1β and TNF-α systemic secretion that can mediate viral-independent surface membrane ACE2 upregulation and shedding. Of note, ACE2 shedding, on one hand, protects from viral infection but, on the other hand, increases circ"}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T256","span":{"begin":91,"end":93},"obj":"Chemical"}],"attributes":[{"id":"A256","pred":"chebi_id","subj":"T256","obj":"http://purl.obolibrary.org/obo/CHEBI_63895"},{"id":"A257","pred":"chebi_id","subj":"T256","obj":"http://purl.obolibrary.org/obo/CHEBI_74072"}],"text":"can sustain positive feedback loops at different levels (Figure 2):(1) SARS-CoV can induce IL-1β and TNF-α systemic secretion that can mediate viral-independent surface membrane ACE2 upregulation and shedding. Of note, ACE2 shedding, on one hand, protects from viral infection but, on the other hand, increases circ"}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T53","span":{"begin":116,"end":125},"obj":"http://purl.obolibrary.org/obo/GO_0046903"},{"id":"T54","span":{"begin":261,"end":276},"obj":"http://purl.obolibrary.org/obo/GO_0016032"}],"text":"can sustain positive feedback loops at different levels (Figure 2):(1) SARS-CoV can induce IL-1β and TNF-α systemic secretion that can mediate viral-independent surface membrane ACE2 upregulation and shedding. Of note, ACE2 shedding, on one hand, protects from viral infection but, on the other hand, increases circ"}