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PMC:7408073 / 27710-32113 JSONTXT

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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T185 198-205 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T186 809-821 Body_part denotes glycoprotein http://purl.org/sig/ont/fma/fma62925
T187 982-986 Body_part denotes IL-1 http://purl.org/sig/ont/fma/fma86583
T188 1106-1111 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T189 1172-1188 Body_part denotes epithelial cells http://purl.org/sig/ont/fma/fma66768
T190 1183-1188 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T191 1215-1224 Body_part denotes cytokines http://purl.org/sig/ont/fma/fma84050
T192 1242-1246 Body_part denotes IL-1 http://purl.org/sig/ont/fma/fma86583
T193 1368-1372 Body_part denotes IL-1 http://purl.org/sig/ont/fma/fma86583
T194 1447-1456 Body_part denotes cytokines http://purl.org/sig/ont/fma/fma84050
T195 1475-1479 Body_part denotes IL-1 http://purl.org/sig/ont/fma/fma86583
T196 1873-1884 Body_part denotes cytoplasmic http://purl.org/sig/ont/fma/fma66835
T197 2134-2141 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T198 2280-2284 Body_part denotes IL-1 http://purl.org/sig/ont/fma/fma86583
T199 2430-2434 Body_part denotes hand http://purl.org/sig/ont/fma/fma9712
T200 2484-2488 Body_part denotes hand http://purl.org/sig/ont/fma/fma9712
T201 3316-3320 Body_part denotes hand http://purl.org/sig/ont/fma/fma9712
T202 3370-3374 Body_part denotes hand http://purl.org/sig/ont/fma/fma9712
T203 3383-3396 Body_part denotes immune system http://purl.org/sig/ont/fma/fma9825
T204 3935-3939 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T58 1885-1889 Body_part denotes tail http://purl.obolibrary.org/obo/UBERON_0002415
T59 2430-2434 Body_part denotes hand http://purl.obolibrary.org/obo/UBERON_0002398
T60 2484-2488 Body_part denotes hand http://purl.obolibrary.org/obo/UBERON_0002398
T61 2680-2704 Body_part denotes renin–angiotensin system http://purl.obolibrary.org/obo/UBERON_0018229
T62 3316-3320 Body_part denotes hand http://purl.obolibrary.org/obo/UBERON_0002398
T63 3370-3374 Body_part denotes hand http://purl.obolibrary.org/obo/UBERON_0002398
T64 3383-3396 Body_part denotes immune system http://purl.obolibrary.org/obo/UBERON_0002405
T65 3935-3939 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T66 4041-4044 Body_part denotes RAS http://purl.obolibrary.org/obo/UBERON_0018229
T67 4399-4402 Body_part denotes RAS http://purl.obolibrary.org/obo/UBERON_0018229

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
1078 2280-2285 Gene denotes IL-1β Gene:3552
1079 2290-2295 Gene denotes TNF-α Gene:7124
1080 2367-2371 Gene denotes ACE2 Gene:59272
1081 2408-2412 Gene denotes ACE2 Gene:59272
1082 2260-2268 Species denotes SARS-CoV Tax:694009
1083 2450-2465 Disease denotes viral infection MESH:D001102
1097 2717-2722 Gene denotes renin Gene:5972
1098 2724-2727 Gene denotes ACE Gene:59272
1099 2732-2736 Gene denotes ACE2 Gene:59272
1100 2807-2815 Gene denotes Ang (1–9 Gene:284
1101 2818-2826 Gene denotes Ang (1–5 Gene:284
1102 2856-2866 Gene denotes bradykinin Gene:3827
1103 2898-2902 Gene denotes ACE2 Gene:59272
1104 2796-2804 Gene denotes Ang (1–7 Gene:284
1105 2935-2945 Species denotes SARS-CoV-2 Tax:2697049
1106 2680-2685 Gene denotes renin Gene:5972
1107 2788-2794 Gene denotes Ang II Gene:24179
1108 2585-2592 Disease denotes Hypoxia MESH:D000860
1109 2620-2631 Disease denotes hypercapnia MESH:D006935
1119 2957-2961 Gene denotes ACE2 Gene:59272
1120 3069-3072 Gene denotes ACE Gene:59272
1121 3112-3118 Gene denotes Ang II Gene:24179
1122 3125-3129 Gene denotes ACE2 Gene:59272
1123 3152-3160 Gene denotes Ang (1–7 Gene:284
1124 3059-3064 Gene denotes renin Gene:5972
1125 3011-3017 Gene denotes Ang II Gene:24179
1126 2988-2999 Disease denotes hypotensive MESH:D007022
1127 3030-3041 Disease denotes Hypotension MESH:D007022
1136 3178-3186 Gene denotes Ang (1–7 Gene:284
1137 3254-3259 Gene denotes IL-10 Gene:3586
1138 3547-3552 Gene denotes IL-10 Gene:3586
1139 3490-3498 Gene denotes Ang (1–7 Gene:284
1140 3273-3302 Disease denotes eosinopaenia and lymphopaenia
1141 3416-3431 Disease denotes virus infection MESH:D001102
1142 3478-3488 Disease denotes infections MESH:D007239
1143 3632-3652 Disease denotes SARS-CoV-2 infection MESH:C000657245
1152 3658-3666 Gene denotes Ang (1–7 Gene:284
1153 3668-3672 Gene denotes MasR Gene:116511
1154 3693-3697 Gene denotes ACE2 Gene:59272
1155 3809-3813 Gene denotes AT1R Gene:185
1156 3842-3846 Gene denotes ACE2 Gene:59272
1157 3802-3808 Gene denotes Ang II Gene:24179
1158 3759-3765 Gene denotes Ang II Gene:24179
1159 3778-3785 Disease denotes hypoxia MESH:D000860
1164 3876-3884 Gene denotes Ang (1–7 Gene:284
1165 3886-3890 Gene denotes MasR Gene:116511
1166 3911-3930 Disease denotes cardiac dysfunction MESH:D006331
1167 3971-3978 Disease denotes hypoxia MESH:D000860
1175 4063-4067 Gene denotes ACE2 Gene:59272
1176 4175-4179 Gene denotes ACE2 Gene:59272
1177 4227-4235 Gene denotes Ang (1–9 Gene:284
1178 4254-4257 Gene denotes AT2 Gene:186
1179 4128-4134 Gene denotes Ang II Gene:24179
1180 4306-4316 Disease denotes thrombosis MESH:D013927
1181 4327-4345 Disease denotes hypoxic conditions MESH:D000071069
1231 38-42 Gene denotes ACE2 Gene:59272
1232 142-146 Gene denotes ACE2 Gene:59272
1233 210-214 Gene denotes ACE2 Gene:59272
1234 402-406 Gene denotes ACE2 Gene:59272
1235 601-607 Gene denotes ADAM17 Gene:6868
1236 608-612 Gene denotes TACE Gene:6868
1237 627-631 Gene denotes ACE2 Gene:59272
1238 645-650 Gene denotes TNF-α Gene:7124
1239 709-713 Gene denotes ACE2 Gene:59272
1240 972-977 Gene denotes TNF-α Gene:7124
1241 982-987 Gene denotes IL-1β Gene:3552
1242 1069-1073 Gene denotes ACE2 Gene:59272
1243 1146-1150 Gene denotes ACE2 Gene:59272
1244 1232-1237 Gene denotes TNF-α Gene:7124
1245 1242-1247 Gene denotes IL-1β Gene:3552
1246 1305-1309 Gene denotes ACE2 Gene:59272
1247 1368-1373 Gene denotes IL-1β Gene:3552
1248 1465-1470 Gene denotes TNF-α Gene:7124
1249 1475-1480 Gene denotes IL-1β Gene:3552
1250 1564-1570 Gene denotes ADAM17 Gene:6868
1251 1659-1664 Gene denotes TNF-α Gene:7124
1252 1736-1741 Gene denotes TNF-α Gene:7124
1253 1808-1814 Gene denotes ADAM17 Gene:6868
1254 1815-1819 Gene denotes TACE Gene:6868
1255 1868-1872 Gene denotes ACE2 Gene:59272
1256 1915-1921 Gene denotes ADAM17 Gene:6868
1257 1922-1926 Gene denotes TACE Gene:6868
1258 2099-2103 Gene denotes ACE2 Gene:59272
1259 2108-2113 Gene denotes TNF-α Gene:7124
1260 2153-2157 Gene denotes ACE2 Gene:59272
1261 192-197 Gene denotes spike Gene:43740568
1262 46-56 Species denotes SARS-CoV-2 Tax:2697049
1263 158-166 Species denotes SARS-CoV Tax:694009
1264 287-295 Species denotes SARS-CoV Tax:694009
1265 348-351 Species denotes CoV Tax:11118
1266 567-575 Species denotes SARS-CoV Tax:694009
1267 582-585 Species denotes CoV Tax:11118
1268 825-835 Species denotes SARS-CoV-2 Tax:2697049
1269 847-855 Species denotes SARS-CoV Tax:694009
1270 1025-1035 Species denotes SARS-CoV-2 Tax:2697049
1271 1607-1615 Species denotes SARS-CoV Tax:694009
1272 2003-2011 Species denotes SARS-CoV Tax:694009
1273 343-347 Species denotes NL63 Tax:277944
1274 577-581 Species denotes NL63 Tax:277944
1275 868-873 Gene denotes furin Gene:5045
1276 2128-2133 Gene denotes spike Gene:43740568
1277 317-337 Disease denotes respiratory symptoms MESH:D012818
1278 1644-1653 Disease denotes infection MESH:D007239
1279 1701-1719 Disease denotes SARS-CoV infection MESH:C000657245

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T179 46-54 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T180 46-50 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T181 158-166 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T182 158-162 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T183 287-295 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T184 287-291 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T185 451-455 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T186 567-575 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T187 567-571 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T188 825-833 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T189 825-829 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T190 847-855 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T191 847-851 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T192 1025-1033 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T193 1025-1029 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T194 1607-1615 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T195 1607-1611 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T196 1644-1653 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T197 1701-1719 Disease denotes SARS-CoV infection http://purl.obolibrary.org/obo/MONDO_0005091
T198 1701-1705 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T199 1710-1719 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T200 2003-2011 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T201 2003-2007 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T202 2260-2268 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T203 2260-2264 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T204 2450-2465 Disease denotes viral infection http://purl.obolibrary.org/obo/MONDO_0005108
T205 2456-2465 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T206 2935-2943 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T207 2935-2939 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T208 3030-3041 Disease denotes Hypotension http://purl.obolibrary.org/obo/MONDO_0005468
T209 3416-3431 Disease denotes virus infection http://purl.obolibrary.org/obo/MONDO_0005108
T210 3422-3431 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T211 3478-3488 Disease denotes infections http://purl.obolibrary.org/obo/MONDO_0005550
T212 3632-3640 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T213 3632-3636 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T214 3643-3652 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T215 4306-4316 Disease denotes thrombosis http://purl.obolibrary.org/obo/MONDO_0000831

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T347 72-75 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T348 215-218 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T349 739-741 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T350 742-744 http://purl.obolibrary.org/obo/CLO_0008922 denotes S2
T351 742-744 http://purl.obolibrary.org/obo/CLO_0050052 denotes S2
T352 866-867 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T353 900-902 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T354 903-905 http://purl.obolibrary.org/obo/CLO_0008922 denotes S2
T355 903-905 http://purl.obolibrary.org/obo/CLO_0050052 denotes S2
T356 1034-1038 http://purl.obolibrary.org/obo/CLO_0050507 denotes 2 [2
T357 1088-1098 http://purl.obolibrary.org/obo/CL_0000066 denotes epithelial
T358 1099-1105 http://purl.obolibrary.org/obo/UBERON_0001005 denotes airway
T359 1106-1111 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T360 1172-1182 http://purl.obolibrary.org/obo/CL_0000066 denotes epithelial
T361 1183-1188 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T362 1531-1539 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T363 1550-1560 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T364 1885-1889 http://purl.obolibrary.org/obo/UBERON_0002415 denotes tail
T365 1927-1937 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T366 2023-2024 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T367 2178-2188 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T368 2358-2366 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T369 2521-2527 http://purl.obolibrary.org/obo/CLO_0001658 denotes active
T370 2569-2579 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T371 2651-2659 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T372 2668-2672 http://www.ebi.ac.uk/efo/EFO_0001410 denotes arms
T373 2883-2891 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T374 3123-3124 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T375 3383-3396 http://purl.obolibrary.org/obo/UBERON_0002405 denotes immune system
T376 3416-3421 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T377 3458-3466 http://purl.obolibrary.org/obo/OBI_0100026 denotes organism
T378 3458-3466 http://purl.obolibrary.org/obo/UBERON_0000468 denotes organism
T379 3518-3526 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T380 3847-3855 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T381 3935-3939 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T382 3935-3939 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T383 4012-4020 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T384 4029-4033 http://www.ebi.ac.uk/efo/EFO_0001410 denotes arms
T385 4387-4391 http://www.ebi.ac.uk/efo/EFO_0001410 denotes arms

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T243 198-205 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T244 742-744 Chemical denotes S2 http://purl.obolibrary.org/obo/CHEBI_29387
T245 809-821 Chemical denotes glycoprotein http://purl.obolibrary.org/obo/CHEBI_17089
T246 903-905 Chemical denotes S2 http://purl.obolibrary.org/obo/CHEBI_29387
T247 982-984 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T249 1242-1244 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T251 1368-1370 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T253 1475-1477 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T255 2134-2141 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T256 2280-2282 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T258 2686-2697 Chemical denotes angiotensin http://purl.obolibrary.org/obo/CHEBI_48433
T259 2781-2784 Chemical denotes Ang http://purl.obolibrary.org/obo/CHEBI_48433
T260 2788-2791 Chemical denotes Ang http://purl.obolibrary.org/obo/CHEBI_48433
T261 2792-2794 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T262 2796-2799 Chemical denotes Ang http://purl.obolibrary.org/obo/CHEBI_48433
T263 2807-2810 Chemical denotes Ang http://purl.obolibrary.org/obo/CHEBI_48433
T264 2818-2821 Chemical denotes Ang http://purl.obolibrary.org/obo/CHEBI_48433
T265 2845-2855 Chemical denotes metabolite http://purl.obolibrary.org/obo/CHEBI_25212
T266 2856-2866 Chemical denotes bradykinin http://purl.obolibrary.org/obo/CHEBI_3165
T267 3011-3014 Chemical denotes Ang http://purl.obolibrary.org/obo/CHEBI_48433
T268 3015-3017 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T269 3112-3115 Chemical denotes Ang http://purl.obolibrary.org/obo/CHEBI_48433
T270 3116-3118 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T271 3152-3155 Chemical denotes Ang http://purl.obolibrary.org/obo/CHEBI_48433
T272 3178-3181 Chemical denotes Ang http://purl.obolibrary.org/obo/CHEBI_48433
T273 3254-3256 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T275 3490-3493 Chemical denotes Ang http://purl.obolibrary.org/obo/CHEBI_48433
T276 3547-3549 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T278 3658-3661 Chemical denotes Ang http://purl.obolibrary.org/obo/CHEBI_48433
T279 3759-3762 Chemical denotes Ang http://purl.obolibrary.org/obo/CHEBI_48433
T280 3763-3765 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T281 3802-3805 Chemical denotes Ang http://purl.obolibrary.org/obo/CHEBI_48433
T282 3806-3808 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T283 3876-3879 Chemical denotes Ang http://purl.obolibrary.org/obo/CHEBI_48433
T284 4041-4044 Chemical denotes RAS http://purl.obolibrary.org/obo/CHEBI_63620
T285 4112-4115 Chemical denotes Ang http://purl.obolibrary.org/obo/CHEBI_48433
T286 4128-4131 Chemical denotes Ang http://purl.obolibrary.org/obo/CHEBI_48433
T287 4132-4134 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T288 4227-4230 Chemical denotes Ang http://purl.obolibrary.org/obo/CHEBI_48433
T289 4399-4402 Chemical denotes RAS http://purl.obolibrary.org/obo/CHEBI_63620

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T50 651-660 http://purl.obolibrary.org/obo/GO_0046903 denotes secretion
T51 1665-1674 http://purl.obolibrary.org/obo/GO_0046903 denotes secretion
T52 1742-1751 http://purl.obolibrary.org/obo/GO_0046903 denotes secretion
T53 2305-2314 http://purl.obolibrary.org/obo/GO_0046903 denotes secretion
T54 2450-2465 http://purl.obolibrary.org/obo/GO_0016032 denotes viral infection
T55 2737-2746 http://purl.obolibrary.org/obo/GO_0009058 denotes synthesis
T56 2973-2987 http://purl.obolibrary.org/obo/GO_0042311 denotes vasodilatative
T57 3018-3028 http://purl.obolibrary.org/obo/GO_0009056 denotes catabolism
T58 3329-3351 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammatory responses
T59 3698-3707 http://purl.obolibrary.org/obo/GO_0009058 denotes synthesis

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T130 0-175 Sentence denotes Intriguingly, the binding affinity of ACE2 to SARS-CoV-2 binding domain has been reported to be either equal to or 10- to 20-fold higher than ACE2 binding to SARS-CoV [27,32].
T131 176-277 Sentence denotes The affinity of spike protein for ACE2 has been shown to correlate with the severity of disease [24].
T132 278-551 Sentence denotes Although SARS-CoV produces more severe respiratory symptoms than NL63-CoV does, both viral receptor binding domains bind to ACE2 with similar affinity [78], indicating that SARS development is not related to the strength of binding affinity and depends on other mechanisms.
T133 552-790 Sentence denotes In contrast to SARS-CoV, NL63-CoV did not induce ADAM17/TACE-mediated both ACE2 shedding and TNF-α secretion [17], suggesting that increased cleavability of ACE2 receptor and possibly of S1-S2 boundary may be crucial for disease severity.
T134 791-962 Sentence denotes Indeed, the spike glycoprotein of SARS-CoV-2 but not of SARS-CoV, contains a furin-like cleavage site at the S1-S2 boundary which indicates an increased cleavability [13].
T135 963-1117 Sentence denotes Of note, TNF-α and IL-1β were shown to both be upregulated in SARS-CoV-2 [2] and induce viral-independent ACE2 shedding from epithelial airway cells [16].
T136 1118-1391 Sentence denotes Moreover, viral-independent ACE2 surface release from epithelial cells was not only inducible by cytokines (e.g., TNF-α and IL-1β) but also constitutively and spontaneously produced when ACE2 surface expression was upregulated [16], for example upon IL-1β stimulation [56].
T137 1392-1540 Sentence denotes This suggests that systemic release of proinflammatory cytokines such as TNF-α and IL-1β can mediate an increase of sACE2 and its systemic activity.
T138 1541-1681 Sentence denotes Of note, activation of ADAM17/TACE metalloprotease was induced by SARS-CoV and necessary for efficient infection (and TNF-α secretion) [17].
T139 1682-1943 Sentence denotes Intriguingly, both SARS-CoV infection and concomitant TNF-α secretion were significantly attenuated not only by knock-down of ADAM17/TACE expression by siRNA but also by deletion of the ACE2 cytoplasmic tail which is responsible for ADAM17/TACE activation [17].
T140 1944-2114 Sentence denotes Altogether these observations suggest the possibility that SARS-CoV may induce a positive feedback loop leading to surface expression and shedding of both ACE2 and TNF-α.
T141 2115-2398 Sentence denotes Indeed, upon spike protein binding to ACE2, downstream pathway activation can sustain positive feedback loops at different levels (Figure 2):(1) SARS-CoV can induce IL-1β and TNF-α systemic secretion that can mediate viral-independent surface membrane ACE2 upregulation and shedding.
T142 2399-2580 Sentence denotes Of note, ACE2 shedding, on one hand, protects from viral infection but, on the other hand, increases circulating/systemic active sACE2, leading to its downstream pathway activation.
T143 2581-2952 Sentence denotes (2) Hypoxia in combination or not with hypercapnia can upregulate the activity of both arms of the renin–angiotensin system by inducing renin, ACE and ACE2 synthesis, which can increase expression of Ang I, Ang II, Ang (1–7), Ang (1–9), Ang (1–5) and the inactive metabolite bradykinin (1–7), but also membrane bound ACE2, finally giving more chances to SARS-CoV-2 entry.
T144 2953-3029 Sentence denotes (3) ACE2 can induce vasodilatative hypotensive effects by Ang II catabolism.
T145 3030-3173 Sentence denotes Hypotension can induce again renin and ACE upregulation finally providing further Ang II, as a ACE2 substrate for further Ang (1–7) production.
T146 3174-3489 Sentence denotes (4) Ang (1–7) antiproliferative and apoptotic effects, possibly in part through IL-10, may mediate eosinopaenia and lymphopaenia that, on one hand, reduce inflammatory responses but, on the other hand, impair immune system ability to counter virus infection, finally predisposing the organism to further infections.
T147 3490-3653 Sentence denotes Ang (1–7) immunosuppressive activity, mediated or not by IL-10, may also support the reduced ability to generate an effective immunization to SARS-CoV-2 infection.
T148 3654-3871 Sentence denotes (5) Ang (1–7)/MasR pathway can sustain ACE2 synthesis even in the presence of elevated concentrations of Ang II (such as in hypoxia), by inhibiting Ang II/AT1R-mediated down-modulation of ACE2 activity (see Figure 1).
T149 3872-4045 Sentence denotes (6) Ang (1–7)/MasR pathway can produce cardiac dysfunction and lung alteration leading to systemic hypoxia, which, in turn, upregulates the activity of both arms of the RAS.
T150 4046-4403 Sentence denotes (7) Although the ACE2 catalytic efficiency is 400-fold lower with Ang I than with Ang II [79], high concentration of circulating ACE2 may be able to produce significant increase of Ang (1–9) that, by binding AT2 receptors, can produce arteriolar microvascular thrombosis and local hypoxic conditions finally inducing local upregulation both arms of the RAS.

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T53 2585-2592 Phenotype denotes Hypoxia http://purl.obolibrary.org/obo/HP_0012418
T54 2620-2631 Phenotype denotes hypercapnia http://purl.obolibrary.org/obo/HP_0012416
T55 3030-3041 Phenotype denotes Hypotension http://purl.obolibrary.org/obo/HP_0002615
T56 3778-3785 Phenotype denotes hypoxia http://purl.obolibrary.org/obo/HP_0012418
T57 3971-3978 Phenotype denotes hypoxia http://purl.obolibrary.org/obo/HP_0012418

2_test

Id Subject Object Predicate Lexical cue
32708755-32075877-20678738 168-170 32075877 denotes 27
32708755-32065055-20678739 171-173 32065055 denotes 32
32708755-15791205-20678740 273-275 15791205 denotes 24
32708755-19901337-20678741 430-432 19901337 denotes 78
32708755-18490652-20678742 662-664 18490652 denotes 17
32708755-32142651-20678743 958-960 32142651 denotes 13
32708755-32161940-20678744 1037-1038 32161940 denotes 2
32708755-24147777-20678745 1387-1389 24147777 denotes 56
32708755-18490652-20678746 1677-1679 18490652 denotes 17
32708755-18490652-20678747 1939-1941 18490652 denotes 17