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PMC:7408073 / 27630-38007 JSONTXT

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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T185 278-285 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T186 889-901 Body_part denotes glycoprotein http://purl.org/sig/ont/fma/fma62925
T187 1062-1066 Body_part denotes IL-1 http://purl.org/sig/ont/fma/fma86583
T188 1186-1191 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T189 1252-1268 Body_part denotes epithelial cells http://purl.org/sig/ont/fma/fma66768
T190 1263-1268 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T191 1295-1304 Body_part denotes cytokines http://purl.org/sig/ont/fma/fma84050
T192 1322-1326 Body_part denotes IL-1 http://purl.org/sig/ont/fma/fma86583
T193 1448-1452 Body_part denotes IL-1 http://purl.org/sig/ont/fma/fma86583
T194 1527-1536 Body_part denotes cytokines http://purl.org/sig/ont/fma/fma84050
T195 1555-1559 Body_part denotes IL-1 http://purl.org/sig/ont/fma/fma86583
T196 1953-1964 Body_part denotes cytoplasmic http://purl.org/sig/ont/fma/fma66835
T197 2214-2221 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T198 2360-2364 Body_part denotes IL-1 http://purl.org/sig/ont/fma/fma86583
T199 2510-2514 Body_part denotes hand http://purl.org/sig/ont/fma/fma9712
T200 2564-2568 Body_part denotes hand http://purl.org/sig/ont/fma/fma9712
T201 3396-3400 Body_part denotes hand http://purl.org/sig/ont/fma/fma9712
T202 3450-3454 Body_part denotes hand http://purl.org/sig/ont/fma/fma9712
T203 3463-3476 Body_part denotes immune system http://purl.org/sig/ont/fma/fma9825
T204 4015-4019 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T205 4595-4600 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670
T206 4810-4815 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T207 4843-4847 Body_part denotes hand http://purl.org/sig/ont/fma/fma9712
T208 5029-5034 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T209 5049-5053 Body_part denotes hand http://purl.org/sig/ont/fma/fma9712
T210 5084-5098 Body_part denotes cell membranes http://purl.org/sig/ont/fma/fma63841
T211 5084-5088 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T212 5160-5164 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T213 6526-6532 Body_part denotes serine http://purl.org/sig/ont/fma/fma82764
T214 7378-7382 Body_part denotes mRNA http://purl.org/sig/ont/fma/fma67122
T215 8235-8240 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T216 8632-8651 Body_part denotes smooth muscle cells http://purl.org/sig/ont/fma/fma14072
T217 8646-8651 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T218 8897-8902 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670
T219 9329-9334 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670
T220 9356-9363 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T221 9491-9502 Body_part denotes macrophages http://purl.org/sig/ont/fma/fma63261
T222 9509-9514 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T223 9763-9768 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670
T224 9785-9790 Body_part denotes heart http://purl.org/sig/ont/fma/fma7088
T225 10240-10251 Body_part denotes vasculature http://purl.org/sig/ont/fma/fma69050

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T57 23-26 Body_part denotes RAS http://purl.obolibrary.org/obo/UBERON_0018229
T58 1965-1969 Body_part denotes tail http://purl.obolibrary.org/obo/UBERON_0002415
T59 2510-2514 Body_part denotes hand http://purl.obolibrary.org/obo/UBERON_0002398
T60 2564-2568 Body_part denotes hand http://purl.obolibrary.org/obo/UBERON_0002398
T61 2760-2784 Body_part denotes renin–angiotensin system http://purl.obolibrary.org/obo/UBERON_0018229
T62 3396-3400 Body_part denotes hand http://purl.obolibrary.org/obo/UBERON_0002398
T63 3450-3454 Body_part denotes hand http://purl.obolibrary.org/obo/UBERON_0002398
T64 3463-3476 Body_part denotes immune system http://purl.obolibrary.org/obo/UBERON_0002405
T65 4015-4019 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T66 4121-4124 Body_part denotes RAS http://purl.obolibrary.org/obo/UBERON_0018229
T67 4479-4482 Body_part denotes RAS http://purl.obolibrary.org/obo/UBERON_0018229
T68 4595-4600 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T69 4843-4847 Body_part denotes hand http://purl.obolibrary.org/obo/UBERON_0002398
T70 5049-5053 Body_part denotes hand http://purl.obolibrary.org/obo/UBERON_0002398
T71 5160-5164 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T72 5394-5400 Body_part denotes organs http://purl.obolibrary.org/obo/UBERON_0000062
T73 5889-5892 Body_part denotes RAS http://purl.obolibrary.org/obo/UBERON_0018229
T74 6138-6141 Body_part denotes RAS http://purl.obolibrary.org/obo/UBERON_0018229
T75 6279-6282 Body_part denotes RAS http://purl.obolibrary.org/obo/UBERON_0018229
T76 7085-7088 Body_part denotes RAS http://purl.obolibrary.org/obo/UBERON_0018229
T77 7565-7568 Body_part denotes RAS http://purl.obolibrary.org/obo/UBERON_0018229
T78 7598-7601 Body_part denotes RAS http://purl.obolibrary.org/obo/UBERON_0018229
T79 8897-8902 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T80 9329-9334 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T81 9763-9768 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T82 9785-9790 Body_part denotes heart http://purl.obolibrary.org/obo/UBERON_0000948
T83 10240-10251 Body_part denotes vasculature http://purl.obolibrary.org/obo/UBERON_0002049

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
1071 3-11 Disease denotes COVID-19 MESH:C000657245
1078 2360-2365 Gene denotes IL-1β Gene:3552
1079 2370-2375 Gene denotes TNF-α Gene:7124
1080 2447-2451 Gene denotes ACE2 Gene:59272
1081 2488-2492 Gene denotes ACE2 Gene:59272
1082 2340-2348 Species denotes SARS-CoV Tax:694009
1083 2530-2545 Disease denotes viral infection MESH:D001102
1097 2797-2802 Gene denotes renin Gene:5972
1098 2804-2807 Gene denotes ACE Gene:59272
1099 2812-2816 Gene denotes ACE2 Gene:59272
1100 2887-2895 Gene denotes Ang (1–9 Gene:284
1101 2898-2906 Gene denotes Ang (1–5 Gene:284
1102 2936-2946 Gene denotes bradykinin Gene:3827
1103 2978-2982 Gene denotes ACE2 Gene:59272
1104 2876-2884 Gene denotes Ang (1–7 Gene:284
1105 3015-3025 Species denotes SARS-CoV-2 Tax:2697049
1106 2760-2765 Gene denotes renin Gene:5972
1107 2868-2874 Gene denotes Ang II Gene:24179
1108 2665-2672 Disease denotes Hypoxia MESH:D000860
1109 2700-2711 Disease denotes hypercapnia MESH:D006935
1119 3037-3041 Gene denotes ACE2 Gene:59272
1120 3149-3152 Gene denotes ACE Gene:59272
1121 3192-3198 Gene denotes Ang II Gene:24179
1122 3205-3209 Gene denotes ACE2 Gene:59272
1123 3232-3240 Gene denotes Ang (1–7 Gene:284
1124 3139-3144 Gene denotes renin Gene:5972
1125 3091-3097 Gene denotes Ang II Gene:24179
1126 3068-3079 Disease denotes hypotensive MESH:D007022
1127 3110-3121 Disease denotes Hypotension MESH:D007022
1136 3258-3266 Gene denotes Ang (1–7 Gene:284
1137 3334-3339 Gene denotes IL-10 Gene:3586
1138 3627-3632 Gene denotes IL-10 Gene:3586
1139 3570-3578 Gene denotes Ang (1–7 Gene:284
1140 3353-3382 Disease denotes eosinopaenia and lymphopaenia
1141 3496-3511 Disease denotes virus infection MESH:D001102
1142 3558-3568 Disease denotes infections MESH:D007239
1143 3712-3732 Disease denotes SARS-CoV-2 infection MESH:C000657245
1152 3738-3746 Gene denotes Ang (1–7 Gene:284
1153 3748-3752 Gene denotes MasR Gene:116511
1154 3773-3777 Gene denotes ACE2 Gene:59272
1155 3889-3893 Gene denotes AT1R Gene:185
1156 3922-3926 Gene denotes ACE2 Gene:59272
1157 3882-3888 Gene denotes Ang II Gene:24179
1158 3839-3845 Gene denotes Ang II Gene:24179
1159 3858-3865 Disease denotes hypoxia MESH:D000860
1164 3956-3964 Gene denotes Ang (1–7 Gene:284
1165 3966-3970 Gene denotes MasR Gene:116511
1166 3991-4010 Disease denotes cardiac dysfunction MESH:D006331
1167 4051-4058 Disease denotes hypoxia MESH:D000860
1175 4143-4147 Gene denotes ACE2 Gene:59272
1176 4255-4259 Gene denotes ACE2 Gene:59272
1177 4307-4315 Gene denotes Ang (1–9 Gene:284
1178 4334-4337 Gene denotes AT2 Gene:186
1179 4208-4214 Gene denotes Ang II Gene:24179
1180 4386-4396 Disease denotes thrombosis MESH:D013927
1181 4407-4425 Disease denotes hypoxic conditions MESH:D000071069
1231 118-122 Gene denotes ACE2 Gene:59272
1232 222-226 Gene denotes ACE2 Gene:59272
1233 290-294 Gene denotes ACE2 Gene:59272
1234 482-486 Gene denotes ACE2 Gene:59272
1235 681-687 Gene denotes ADAM17 Gene:6868
1236 688-692 Gene denotes TACE Gene:6868
1237 707-711 Gene denotes ACE2 Gene:59272
1238 725-730 Gene denotes TNF-α Gene:7124
1239 789-793 Gene denotes ACE2 Gene:59272
1240 1052-1057 Gene denotes TNF-α Gene:7124
1241 1062-1067 Gene denotes IL-1β Gene:3552
1242 1149-1153 Gene denotes ACE2 Gene:59272
1243 1226-1230 Gene denotes ACE2 Gene:59272
1244 1312-1317 Gene denotes TNF-α Gene:7124
1245 1322-1327 Gene denotes IL-1β Gene:3552
1246 1385-1389 Gene denotes ACE2 Gene:59272
1247 1448-1453 Gene denotes IL-1β Gene:3552
1248 1545-1550 Gene denotes TNF-α Gene:7124
1249 1555-1560 Gene denotes IL-1β Gene:3552
1250 1644-1650 Gene denotes ADAM17 Gene:6868
1251 1739-1744 Gene denotes TNF-α Gene:7124
1252 1816-1821 Gene denotes TNF-α Gene:7124
1253 1888-1894 Gene denotes ADAM17 Gene:6868
1254 1895-1899 Gene denotes TACE Gene:6868
1255 1948-1952 Gene denotes ACE2 Gene:59272
1256 1995-2001 Gene denotes ADAM17 Gene:6868
1257 2002-2006 Gene denotes TACE Gene:6868
1258 2179-2183 Gene denotes ACE2 Gene:59272
1259 2188-2193 Gene denotes TNF-α Gene:7124
1260 2233-2237 Gene denotes ACE2 Gene:59272
1261 272-277 Gene denotes spike Gene:43740568
1262 126-136 Species denotes SARS-CoV-2 Tax:2697049
1263 238-246 Species denotes SARS-CoV Tax:694009
1264 367-375 Species denotes SARS-CoV Tax:694009
1265 428-431 Species denotes CoV Tax:11118
1266 647-655 Species denotes SARS-CoV Tax:694009
1267 662-665 Species denotes CoV Tax:11118
1268 905-915 Species denotes SARS-CoV-2 Tax:2697049
1269 927-935 Species denotes SARS-CoV Tax:694009
1270 1105-1115 Species denotes SARS-CoV-2 Tax:2697049
1271 1687-1695 Species denotes SARS-CoV Tax:694009
1272 2083-2091 Species denotes SARS-CoV Tax:694009
1273 423-427 Species denotes NL63 Tax:277944
1274 657-661 Species denotes NL63 Tax:277944
1275 948-953 Gene denotes furin Gene:5045
1276 2208-2213 Gene denotes spike Gene:43740568
1277 397-417 Disease denotes respiratory symptoms MESH:D012818
1278 1724-1733 Disease denotes infection MESH:D007239
1279 1781-1799 Disease denotes SARS-CoV infection MESH:C000657245
1302 4493-4497 Gene denotes ACE2 Gene:59272
1303 4531-4535 Gene denotes ACE2 Gene:59272
1304 4849-4853 Gene denotes ACE2 Gene:59272
1305 4912-4916 Gene denotes ACE2 Gene:59272
1306 5070-5074 Gene denotes ACE2 Gene:59272
1307 5566-5574 Gene denotes Ang (1–9 Gene:284
1308 5617-5628 Gene denotes B1 receptor Gene:623
1309 5661-5665 Gene denotes ACE2 Gene:59272
1310 5695-5705 Gene denotes bradykinin Gene:3827
1311 5718-5728 Gene denotes bradykinin Gene:3827
1312 5744-5748 Gene denotes ACE2 Gene:59272
1313 5012-5017 Gene denotes mACE2 Gene:70008
1314 5544-5552 Gene denotes Ang (1–7 Gene:284
1315 4505-4515 Species denotes SARS-CoV-2 Tax:2697049
1316 4972-4982 Species denotes SARS-CoV-2 Tax:2697049
1317 5314-5324 Species denotes SARS-CoV-2 Tax:2697049
1318 5555-5561 Gene denotes Ang II Gene:24179
1319 5684-5691 Chemical denotes des-Arg
1320 5786-5798 Chemical denotes casomorphins
1321 4937-4944 Disease denotes hypoxia MESH:D000860
1322 4945-4956 Disease denotes hypotension MESH:D007022
1323 5508-5516 Disease denotes COVID-19 MESH:C000657245
1329 6251-6258 Gene denotes TMPRSS2 Gene:7113
1330 6263-6269 Gene denotes ADAM17 Gene:6868
1331 6300-6305 Gene denotes renin Gene:5972
1332 6307-6310 Gene denotes ACE Gene:59272
1333 6315-6319 Gene denotes ACE2 Gene:59272
1346 6463-6470 Gene denotes TMPRSS2 Gene:7113
1347 6475-6481 Gene denotes ADAM17 Gene:6868
1348 6542-6549 Gene denotes TMPRSS2 Gene:7113
1349 6703-6709 Gene denotes ADAM17 Gene:6868
1350 6826-6832 Gene denotes ADAM17 Gene:6868
1351 6842-6846 Gene denotes ACE2 Gene:59272
1352 6889-6893 Gene denotes ACE2 Gene:59272
1353 7015-7019 Gene denotes ACE2 Gene:59272
1354 7264-7268 Gene denotes ACE2 Gene:59272
1355 6565-6575 Species denotes SARS-CoV-2 Tax:2697049
1356 6526-6532 Chemical denotes serine MESH:D012694
1357 7149-7157 Disease denotes COVID-19 MESH:C000657245
1367 7663-7667 Gene denotes ACE2 Gene:59272
1368 7713-7716 Gene denotes ACE Gene:59272
1369 7754-7758 Gene denotes MasR Gene:116511
1370 7782-7786 Gene denotes ACE2 Gene:59272
1371 7788-7791 Gene denotes ACE Gene:59272
1372 7796-7801 Gene denotes renin Gene:5972
1373 7941-7945 Gene denotes MasR Gene:116511
1374 7703-7708 Gene denotes renin Gene:5972
1375 7848-7857 Species denotes SARS-CoVs Tax:694009
1422 8185-8193 Gene denotes Ang-(1–7 Gene:284
1423 8404-8412 Gene denotes Ang-(1–7 Gene:284
1424 8492-8496 Gene denotes ACE2 Gene:59272
1425 8596-8600 Gene denotes ACE2 Gene:59272
1426 8705-8709 Gene denotes iNOS Gene:4843
1427 8742-8748 Gene denotes Ang II Gene:24179
1428 8773-8781 Gene denotes Ang (1–7 Gene:284
1429 8964-8969 Gene denotes rACE2 Gene:302668
1430 9150-9158 Gene denotes Ang (1–7 Gene:11727
1431 9164-9168 Gene denotes MasR Gene:116511
1432 10317-10321 Gene denotes ACE2 Gene:59272
1433 8125-8133 Gene denotes Ang-(1–7 Gene:284
1434 8104-8112 Gene denotes Ang-(1–7 Gene:284
1435 8430-8438 Gene denotes Ang (1–5 Gene:284
1436 10276-10280 Gene denotes MasR Gene:116511
1437 10219-10223 Gene denotes MasR Gene:116511
1438 10036-10040 Gene denotes MasR Gene:116511
1439 8825-8829 Gene denotes MasR Gene:116511
1440 8519-8523 Gene denotes MasR Gene:116511
1441 8346-8350 Gene denotes MasR Gene:116511
1442 8267-8271 Gene denotes MasR Gene:116511
1443 8152-8156 Gene denotes MasR Gene:116511
1444 9079-9084 Gene denotes rACE2 Gene:302668
1445 8229-8234 Species denotes human Tax:9606
1446 8619-8624 Species denotes human Tax:9606
1447 8810-8814 Species denotes mice Tax:10090
1448 9232-9236 Species denotes rats Tax:10116
1449 9815-9818 Species denotes rat Tax:10116
1450 10128-10132 Species denotes mice Tax:10090
1451 10136-10140 Species denotes rats Tax:10116
1452 10181-10187 Species denotes humans Tax:9606
1453 10368-10376 Species denotes patients Tax:9606
1454 8053-8065 Gene denotes Mas receptor Gene:116511
1455 7995-8007 Gene denotes Mas receptor Gene:116511
1456 9576-9582 Gene denotes Ang II Gene:24179
1457 9437-9443 Gene denotes Ang II Gene:24179
1458 9104-9110 Gene denotes Ang II Gene:24179
1459 8986-8992 Gene denotes Ang II Gene:24179
1460 8601-8614 Disease denotes hyperactivity MESH:D006948
1461 8933-8944 Disease denotes hypotensive MESH:D007022
1462 9055-9066 Disease denotes hypotensive MESH:D007022
1463 9219-9231 Disease denotes hypertensive MESH:D006973
1464 9445-9457 Disease denotes renal injury MESH:D007674
1465 9828-9846 Disease denotes cardiac arrhythmia MESH:D001145
1466 9936-9946 Disease denotes arrhythmic MESH:D001145
1467 10359-10367 Disease denotes COVID-19 MESH:C000657245

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T178 3-11 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T179 126-134 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T180 126-130 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T181 238-246 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T182 238-242 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T183 367-375 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T184 367-371 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T185 531-535 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T186 647-655 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T187 647-651 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T188 905-913 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T189 905-909 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T190 927-935 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T191 927-931 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T192 1105-1113 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T193 1105-1109 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T194 1687-1695 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T195 1687-1691 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T196 1724-1733 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T197 1781-1799 Disease denotes SARS-CoV infection http://purl.obolibrary.org/obo/MONDO_0005091
T198 1781-1785 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T199 1790-1799 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T200 2083-2091 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T201 2083-2087 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T202 2340-2348 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T203 2340-2344 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T204 2530-2545 Disease denotes viral infection http://purl.obolibrary.org/obo/MONDO_0005108
T205 2536-2545 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T206 3015-3023 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T207 3015-3019 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T208 3110-3121 Disease denotes Hypotension http://purl.obolibrary.org/obo/MONDO_0005468
T209 3496-3511 Disease denotes virus infection http://purl.obolibrary.org/obo/MONDO_0005108
T210 3502-3511 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T211 3558-3568 Disease denotes infections http://purl.obolibrary.org/obo/MONDO_0005550
T212 3712-3720 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T213 3712-3716 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T214 3723-3732 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T215 4386-4396 Disease denotes thrombosis http://purl.obolibrary.org/obo/MONDO_0000831
T216 4505-4513 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T217 4505-4509 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T218 4945-4956 Disease denotes hypotension http://purl.obolibrary.org/obo/MONDO_0005468
T219 4972-4980 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T220 4972-4976 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T221 5240-5256 Disease denotes systemic disease http://purl.obolibrary.org/obo/MONDO_0015938
T222 5314-5322 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T223 5314-5318 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T224 5508-5516 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T225 6565-6573 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T226 6565-6569 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T227 7149-7157 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T228 7278-7296 Disease denotes immune suppression http://purl.obolibrary.org/obo/MONDO_0007816
T229 7848-7852 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T230 9451-9457 Disease denotes injury http://purl.obolibrary.org/obo/MONDO_0021178
T231 9836-9846 Disease denotes arrhythmia http://purl.obolibrary.org/obo/MONDO_0007263
T232 10359-10367 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T347 152-155 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T348 295-298 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T349 819-821 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T350 822-824 http://purl.obolibrary.org/obo/CLO_0008922 denotes S2
T351 822-824 http://purl.obolibrary.org/obo/CLO_0050052 denotes S2
T352 946-947 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T353 980-982 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T354 983-985 http://purl.obolibrary.org/obo/CLO_0008922 denotes S2
T355 983-985 http://purl.obolibrary.org/obo/CLO_0050052 denotes S2
T356 1114-1118 http://purl.obolibrary.org/obo/CLO_0050507 denotes 2 [2
T357 1168-1178 http://purl.obolibrary.org/obo/CL_0000066 denotes epithelial
T358 1179-1185 http://purl.obolibrary.org/obo/UBERON_0001005 denotes airway
T359 1186-1191 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T360 1252-1262 http://purl.obolibrary.org/obo/CL_0000066 denotes epithelial
T361 1263-1268 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T362 1611-1619 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T363 1630-1640 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T364 1965-1969 http://purl.obolibrary.org/obo/UBERON_0002415 denotes tail
T365 2007-2017 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T366 2103-2104 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T367 2258-2268 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T368 2438-2446 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T369 2601-2607 http://purl.obolibrary.org/obo/CLO_0001658 denotes active
T370 2649-2659 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T371 2731-2739 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T372 2748-2752 http://www.ebi.ac.uk/efo/EFO_0001410 denotes arms
T373 2963-2971 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T374 3203-3204 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T375 3463-3476 http://purl.obolibrary.org/obo/UBERON_0002405 denotes immune system
T376 3496-3501 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T377 3538-3546 http://purl.obolibrary.org/obo/OBI_0100026 denotes organism
T378 3538-3546 http://purl.obolibrary.org/obo/UBERON_0000468 denotes organism
T379 3598-3606 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T380 3927-3935 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T381 4015-4019 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T382 4015-4019 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T383 4092-4100 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T384 4109-4113 http://www.ebi.ac.uk/efo/EFO_0001410 denotes arms
T385 4467-4471 http://www.ebi.ac.uk/efo/EFO_0001410 denotes arms
T386 4528-4530 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T387 4595-4600 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T388 4595-4600 http://www.ebi.ac.uk/efo/EFO_0000296 denotes blood
T389 4693-4701 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T390 4810-4815 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T391 4900-4908 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T392 5029-5034 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T393 5084-5088 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T394 5089-5098 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membranes
T395 5118-5126 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T396 5160-5164 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T397 5160-5164 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T398 5338-5339 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T399 5394-5403 http://purl.obolibrary.org/obo/UBERON_0003103 denotes organs in
T400 5576-5583 http://purl.obolibrary.org/obo/PR_000018263 denotes peptide
T401 5760-5768 http://purl.obolibrary.org/obo/PR_000018263 denotes peptides
T402 6330-6338 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T403 6498-6506 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T404 6586-6587 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T405 6625-6628 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T406 6720-6728 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T407 6729-6732 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T408 6761-6764 http://purl.obolibrary.org/obo/CLO_0050884 denotes ten
T409 6880-6888 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T410 7032-7040 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T411 7376-7377 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T412 7553-7557 http://www.ebi.ac.uk/efo/EFO_0001410 denotes arms
T413 7678-7686 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T414 7727-7735 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T415 7812-7822 http://purl.obolibrary.org/obo/CLO_0001658 denotes activities
T416 7918-7919 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T417 8215-8225 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T418 8229-8240 http://purl.obolibrary.org/obo/CLO_0053065 denotes human cells
T419 8281-8284 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T420 8619-8624 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T421 8625-8631 http://www.ebi.ac.uk/efo/EFO_0000265 denotes aortic
T422 8632-8651 http://purl.obolibrary.org/obo/CL_0000192 denotes smooth muscle cells
T423 8702-8704 http://purl.obolibrary.org/obo/CLO_0007074 denotes kB
T424 8702-8704 http://purl.obolibrary.org/obo/CLO_0051988 denotes kB
T425 8823-8824 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T426 8897-8902 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T427 8897-8902 http://www.ebi.ac.uk/efo/EFO_0000296 denotes blood
T428 9067-9075 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T429 9169-9179 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T430 9258-9259 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T431 9274-9275 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T432 9329-9334 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T433 9329-9334 http://www.ebi.ac.uk/efo/EFO_0000296 denotes blood
T434 9411-9412 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T435 9507-9514 http://purl.obolibrary.org/obo/CL_0000084 denotes T cells
T436 9601-9602 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T437 9615-9616 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T438 9692-9693 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T439 9731-9732 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T440 9763-9768 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T441 9763-9768 http://www.ebi.ac.uk/efo/EFO_0000296 denotes blood
T442 9785-9790 http://purl.obolibrary.org/obo/UBERON_0000948 denotes heart
T443 9785-9790 http://purl.obolibrary.org/obo/UBERON_0007100 denotes heart
T444 9785-9790 http://purl.obolibrary.org/obo/UBERON_0015228 denotes heart
T445 9785-9790 http://www.ebi.ac.uk/efo/EFO_0000815 denotes heart
T446 9813-9814 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T447 9866-9867 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T448 9971-9972 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T449 10053-10056 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T450 10181-10187 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes humans
T451 10322-10330 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T242 23-26 Chemical denotes RAS http://purl.obolibrary.org/obo/CHEBI_63620
T243 278-285 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T244 822-824 Chemical denotes S2 http://purl.obolibrary.org/obo/CHEBI_29387
T245 889-901 Chemical denotes glycoprotein http://purl.obolibrary.org/obo/CHEBI_17089
T246 983-985 Chemical denotes S2 http://purl.obolibrary.org/obo/CHEBI_29387
T247 1062-1064 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T249 1322-1324 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T251 1448-1450 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T253 1555-1557 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T255 2214-2221 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T256 2360-2362 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T258 2766-2777 Chemical denotes angiotensin http://purl.obolibrary.org/obo/CHEBI_48433
T259 2861-2864 Chemical denotes Ang http://purl.obolibrary.org/obo/CHEBI_48433
T260 2868-2871 Chemical denotes Ang http://purl.obolibrary.org/obo/CHEBI_48433
T261 2872-2874 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T262 2876-2879 Chemical denotes Ang http://purl.obolibrary.org/obo/CHEBI_48433
T263 2887-2890 Chemical denotes Ang http://purl.obolibrary.org/obo/CHEBI_48433
T264 2898-2901 Chemical denotes Ang http://purl.obolibrary.org/obo/CHEBI_48433
T265 2925-2935 Chemical denotes metabolite http://purl.obolibrary.org/obo/CHEBI_25212
T266 2936-2946 Chemical denotes bradykinin http://purl.obolibrary.org/obo/CHEBI_3165
T267 3091-3094 Chemical denotes Ang http://purl.obolibrary.org/obo/CHEBI_48433
T268 3095-3097 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T269 3192-3195 Chemical denotes Ang http://purl.obolibrary.org/obo/CHEBI_48433
T270 3196-3198 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T271 3232-3235 Chemical denotes Ang http://purl.obolibrary.org/obo/CHEBI_48433
T272 3258-3261 Chemical denotes Ang http://purl.obolibrary.org/obo/CHEBI_48433
T273 3334-3336 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T275 3570-3573 Chemical denotes Ang http://purl.obolibrary.org/obo/CHEBI_48433
T276 3627-3629 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T278 3738-3741 Chemical denotes Ang http://purl.obolibrary.org/obo/CHEBI_48433
T279 3839-3842 Chemical denotes Ang http://purl.obolibrary.org/obo/CHEBI_48433
T280 3843-3845 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T281 3882-3885 Chemical denotes Ang http://purl.obolibrary.org/obo/CHEBI_48433
T282 3886-3888 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T283 3956-3959 Chemical denotes Ang http://purl.obolibrary.org/obo/CHEBI_48433
T284 4121-4124 Chemical denotes RAS http://purl.obolibrary.org/obo/CHEBI_63620
T285 4192-4195 Chemical denotes Ang http://purl.obolibrary.org/obo/CHEBI_48433
T286 4208-4211 Chemical denotes Ang http://purl.obolibrary.org/obo/CHEBI_48433
T287 4212-4214 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T288 4307-4310 Chemical denotes Ang http://purl.obolibrary.org/obo/CHEBI_48433
T289 4479-4482 Chemical denotes RAS http://purl.obolibrary.org/obo/CHEBI_63620
T290 5544-5547 Chemical denotes Ang http://purl.obolibrary.org/obo/CHEBI_48433
T291 5555-5558 Chemical denotes Ang http://purl.obolibrary.org/obo/CHEBI_48433
T292 5559-5561 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T293 5566-5569 Chemical denotes Ang http://purl.obolibrary.org/obo/CHEBI_48433
T294 5576-5583 Chemical denotes peptide http://purl.obolibrary.org/obo/CHEBI_16670
T295 5688-5691 Chemical denotes Arg http://purl.obolibrary.org/obo/CHEBI_16467|http://purl.obolibrary.org/obo/CHEBI_29952
T297 5695-5705 Chemical denotes bradykinin http://purl.obolibrary.org/obo/CHEBI_3165
T298 5718-5728 Chemical denotes bradykinin http://purl.obolibrary.org/obo/CHEBI_3165
T299 5760-5768 Chemical denotes peptides http://purl.obolibrary.org/obo/CHEBI_16670
T300 5889-5892 Chemical denotes RAS http://purl.obolibrary.org/obo/CHEBI_63620
T301 6138-6141 Chemical denotes RAS http://purl.obolibrary.org/obo/CHEBI_63620
T302 6279-6282 Chemical denotes RAS http://purl.obolibrary.org/obo/CHEBI_63620
T303 6526-6532 Chemical denotes serine http://purl.obolibrary.org/obo/CHEBI_17822
T304 6606-6624 Chemical denotes protease inhibitor http://purl.obolibrary.org/obo/CHEBI_37670|http://purl.obolibrary.org/obo/CHEBI_60258
T306 6615-6624 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T307 7085-7088 Chemical denotes RAS http://purl.obolibrary.org/obo/CHEBI_63620
T308 7361-7375 Chemical denotes apolipoprotein http://purl.obolibrary.org/obo/CHEBI_39015
T309 7409-7420 Chemical denotes polypeptide http://purl.obolibrary.org/obo/CHEBI_15841
T310 7565-7568 Chemical denotes RAS http://purl.obolibrary.org/obo/CHEBI_63620
T311 7580-7590 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T312 7598-7601 Chemical denotes RAS http://purl.obolibrary.org/obo/CHEBI_63620
T313 8066-8076 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T314 8104-8107 Chemical denotes Ang http://purl.obolibrary.org/obo/CHEBI_48433
T315 8125-8128 Chemical denotes Ang http://purl.obolibrary.org/obo/CHEBI_48433
T316 8157-8168 Chemical denotes antagonists http://purl.obolibrary.org/obo/CHEBI_48706
T317 8185-8188 Chemical denotes Ang http://purl.obolibrary.org/obo/CHEBI_48433
T318 8404-8407 Chemical denotes Ang http://purl.obolibrary.org/obo/CHEBI_48433
T319 8430-8433 Chemical denotes Ang http://purl.obolibrary.org/obo/CHEBI_48433
T320 8507-8517 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T321 8524-8535 Chemical denotes antagonists http://purl.obolibrary.org/obo/CHEBI_48706
T322 8685-8690 Chemical denotes NADPH http://purl.obolibrary.org/obo/CHEBI_16474|http://purl.obolibrary.org/obo/CHEBI_57783
T324 8699-8701 Chemical denotes NF http://purl.obolibrary.org/obo/CHEBI_141424|http://purl.obolibrary.org/obo/CHEBI_25573|http://purl.obolibrary.org/obo/CHEBI_1224
T327 8742-8745 Chemical denotes Ang http://purl.obolibrary.org/obo/CHEBI_48433
T328 8746-8748 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T329 8773-8776 Chemical denotes Ang http://purl.obolibrary.org/obo/CHEBI_48433
T330 8986-8989 Chemical denotes Ang http://purl.obolibrary.org/obo/CHEBI_48433
T331 8990-8992 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T332 9104-9107 Chemical denotes Ang http://purl.obolibrary.org/obo/CHEBI_48433
T333 9108-9110 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T334 9150-9153 Chemical denotes Ang http://purl.obolibrary.org/obo/CHEBI_48433
T335 9356-9363 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T336 9437-9440 Chemical denotes Ang http://purl.obolibrary.org/obo/CHEBI_48433
T337 9441-9443 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T338 9576-9579 Chemical denotes Ang http://purl.obolibrary.org/obo/CHEBI_48433
T339 9580-9582 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T340 9621-9625 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T341 10041-10052 Chemical denotes antagonists http://purl.obolibrary.org/obo/CHEBI_48706
T342 10281-10292 Chemical denotes antagonists http://purl.obolibrary.org/obo/CHEBI_48706

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T50 731-740 http://purl.obolibrary.org/obo/GO_0046903 denotes secretion
T51 1745-1754 http://purl.obolibrary.org/obo/GO_0046903 denotes secretion
T52 1822-1831 http://purl.obolibrary.org/obo/GO_0046903 denotes secretion
T53 2385-2394 http://purl.obolibrary.org/obo/GO_0046903 denotes secretion
T54 2530-2545 http://purl.obolibrary.org/obo/GO_0016032 denotes viral infection
T55 2817-2826 http://purl.obolibrary.org/obo/GO_0009058 denotes synthesis
T56 3053-3067 http://purl.obolibrary.org/obo/GO_0042311 denotes vasodilatative
T57 3098-3108 http://purl.obolibrary.org/obo/GO_0009056 denotes catabolism
T58 3409-3431 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammatory responses
T59 3778-3787 http://purl.obolibrary.org/obo/GO_0009058 denotes synthesis
T60 4580-4591 http://purl.obolibrary.org/obo/GO_0009056 denotes degradation
T61 4625-4634 http://purl.obolibrary.org/obo/GO_0007588 denotes excretion
T62 5257-5269 http://purl.obolibrary.org/obo/GO_0009405 denotes pathogenesis
T63 6482-6506 http://purl.obolibrary.org/obo/GO_0008237 denotes metalloprotease activity
T64 7232-7248 http://purl.obolibrary.org/obo/GO_0006955 denotes immune responses
T65 7323-7348 http://purl.obolibrary.org/obo/GO_0002250 denotes adaptive immune responses
T66 7361-7375 http://purl.obolibrary.org/obo/GO_0005319 denotes apolipoprotein
T67 7378-7390 http://purl.obolibrary.org/obo/GO_0016556 denotes mRNA editing
T68 9111-9122 http://purl.obolibrary.org/obo/GO_0009056 denotes degradation
T69 9364-9373 http://purl.obolibrary.org/obo/GO_0007588 denotes excretion

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T128 0-2 Sentence denotes 4.
T129 3-79 Sentence denotes COVID-19 Can Induce RAS-mediated Positive Feedback Loops at Different Levels
T130 80-255 Sentence denotes Intriguingly, the binding affinity of ACE2 to SARS-CoV-2 binding domain has been reported to be either equal to or 10- to 20-fold higher than ACE2 binding to SARS-CoV [27,32].
T131 256-357 Sentence denotes The affinity of spike protein for ACE2 has been shown to correlate with the severity of disease [24].
T132 358-631 Sentence denotes Although SARS-CoV produces more severe respiratory symptoms than NL63-CoV does, both viral receptor binding domains bind to ACE2 with similar affinity [78], indicating that SARS development is not related to the strength of binding affinity and depends on other mechanisms.
T133 632-870 Sentence denotes In contrast to SARS-CoV, NL63-CoV did not induce ADAM17/TACE-mediated both ACE2 shedding and TNF-α secretion [17], suggesting that increased cleavability of ACE2 receptor and possibly of S1-S2 boundary may be crucial for disease severity.
T134 871-1042 Sentence denotes Indeed, the spike glycoprotein of SARS-CoV-2 but not of SARS-CoV, contains a furin-like cleavage site at the S1-S2 boundary which indicates an increased cleavability [13].
T135 1043-1197 Sentence denotes Of note, TNF-α and IL-1β were shown to both be upregulated in SARS-CoV-2 [2] and induce viral-independent ACE2 shedding from epithelial airway cells [16].
T136 1198-1471 Sentence denotes Moreover, viral-independent ACE2 surface release from epithelial cells was not only inducible by cytokines (e.g., TNF-α and IL-1β) but also constitutively and spontaneously produced when ACE2 surface expression was upregulated [16], for example upon IL-1β stimulation [56].
T137 1472-1620 Sentence denotes This suggests that systemic release of proinflammatory cytokines such as TNF-α and IL-1β can mediate an increase of sACE2 and its systemic activity.
T138 1621-1761 Sentence denotes Of note, activation of ADAM17/TACE metalloprotease was induced by SARS-CoV and necessary for efficient infection (and TNF-α secretion) [17].
T139 1762-2023 Sentence denotes Intriguingly, both SARS-CoV infection and concomitant TNF-α secretion were significantly attenuated not only by knock-down of ADAM17/TACE expression by siRNA but also by deletion of the ACE2 cytoplasmic tail which is responsible for ADAM17/TACE activation [17].
T140 2024-2194 Sentence denotes Altogether these observations suggest the possibility that SARS-CoV may induce a positive feedback loop leading to surface expression and shedding of both ACE2 and TNF-α.
T141 2195-2478 Sentence denotes Indeed, upon spike protein binding to ACE2, downstream pathway activation can sustain positive feedback loops at different levels (Figure 2):(1) SARS-CoV can induce IL-1β and TNF-α systemic secretion that can mediate viral-independent surface membrane ACE2 upregulation and shedding.
T142 2479-2660 Sentence denotes Of note, ACE2 shedding, on one hand, protects from viral infection but, on the other hand, increases circulating/systemic active sACE2, leading to its downstream pathway activation.
T143 2661-3032 Sentence denotes (2) Hypoxia in combination or not with hypercapnia can upregulate the activity of both arms of the renin–angiotensin system by inducing renin, ACE and ACE2 synthesis, which can increase expression of Ang I, Ang II, Ang (1–7), Ang (1–9), Ang (1–5) and the inactive metabolite bradykinin (1–7), but also membrane bound ACE2, finally giving more chances to SARS-CoV-2 entry.
T144 3033-3109 Sentence denotes (3) ACE2 can induce vasodilatative hypotensive effects by Ang II catabolism.
T145 3110-3253 Sentence denotes Hypotension can induce again renin and ACE upregulation finally providing further Ang II, as a ACE2 substrate for further Ang (1–7) production.
T146 3254-3569 Sentence denotes (4) Ang (1–7) antiproliferative and apoptotic effects, possibly in part through IL-10, may mediate eosinopaenia and lymphopaenia that, on one hand, reduce inflammatory responses but, on the other hand, impair immune system ability to counter virus infection, finally predisposing the organism to further infections.
T147 3570-3733 Sentence denotes Ang (1–7) immunosuppressive activity, mediated or not by IL-10, may also support the reduced ability to generate an effective immunization to SARS-CoV-2 infection.
T148 3734-3951 Sentence denotes (5) Ang (1–7)/MasR pathway can sustain ACE2 synthesis even in the presence of elevated concentrations of Ang II (such as in hypoxia), by inhibiting Ang II/AT1R-mediated down-modulation of ACE2 activity (see Figure 1).
T149 3952-4125 Sentence denotes (6) Ang (1–7)/MasR pathway can produce cardiac dysfunction and lung alteration leading to systemic hypoxia, which, in turn, upregulates the activity of both arms of the RAS.
T150 4126-4483 Sentence denotes (7) Although the ACE2 catalytic efficiency is 400-fold lower with Ang I than with Ang II [79], high concentration of circulating ACE2 may be able to produce significant increase of Ang (1–9) that, by binding AT2 receptors, can produce arteriolar microvascular thrombosis and local hypoxic conditions finally inducing local upregulation both arms of the RAS.
T151 4484-4831 Sentence denotes Finally, ACE2-loaded SARS-CoV-2 virions and S1-ACE2 complexes may impair both sACE2 proteolytic degradation by blood proteases and its renal excretion, therefore blunting the removal of its systemic enzymatic activity and indicating that circulating viral particles are dangerous even when they are not able to entry into the cells (see Figure 2).
T152 4832-5035 Sentence denotes On the one hand, ACE2 hypertranscription and consequent increase of membrane (m)ACE2 exposure induced by hypoxia/hypotension may facilitate SARS-CoV-2 entry and its lifecycle into mACE2 expressing cells.
T153 5036-5270 Sentence denotes On the other hand, the release of ACE2 from the cell membranes and its subsequent activity in the bloodstream and in local (lung/cardiac) extracellular fluids are likely critical steps in contributing to systemic disease pathogenesis.
T154 5271-5445 Sentence denotes Nevertheless, the same aetiological agent, SARS-CoV-2, can produce a variety of clinical syndromes, which involves several organs in relation to the subject’s predisposition.
T155 5446-5833 Sentence denotes Although in the present work I have supposed that most of the COVID-19 symptoms might derive from Ang (1–7), Ang II and Ang (1–9) peptide upregulation, the involvement of B1 receptor pathway suppression mediated by ACE2 metabolisation of des-Arg(9)-bradykinin to inactive bradykinin (1–7) or other ACE2-downstream peptides such as apelins, casomorphins and dynorphins cannot be rule out.
T156 5834-6016 Sentence denotes Based on the above observations, in order to block the RAS-induced positive feedback loops, different pharmacological targets can be hypothesized and pursued alone or in combination.
T157 6017-6070 Sentence denotes They will be discussed in the next section and Box 3.
T158 6071-6174 Sentence denotes Box 3 Possible targets of therapeutic intervention to inhibit the RAS-induced positive feedback loops.
T159 6175-6448 Sentence denotes Pharmacological inhibition of enzymes involved in both viral entry, such as TMPRSS2 and ADAM17, and the RAS function such as renin, ACE and ACE2 enzymatic activity or their downstream pathways are expected to stop positive feedback loops and their detrimental consequences.
T160 6449-6507 Sentence denotes Inhibition of TMPRSS2 and ADAM17 metalloprotease activity.
T161 6508-6803 Sentence denotes Inhibition of the serine protease TMPRSS2 (necessary for SARS-CoV-2 entry) by a clinically proven protease inhibitor has been recently suggested by Hoffmann and colleagues [13] and inhibition of ADAM17 enzymatic activity has been already proposed about ten years ago by Haga and colleagues [20].
T162 6804-7158 Sentence denotes Indeed, inhibition of ADAM17-mediated ACE2 shedding is expected to increase membrane ACE2 expression and therefore the probability of viral entry; nevertheless, in the early phases of the disease, inhibition of ACE2 circulating activity might be sufficient to inhibit the systemic RAS pathway upregulation and the development of severe forms of COVID-19.
T163 7159-7533 Sentence denotes It is, in fact, possible that maintenance/recovery of correct organismal immune responses, by preventing ACE2-mediated immune suppression, in concert with cellular adaptive immune responses mediated by apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like (APOBEC) systems [80] may anyway work to induce both an effective “immunization” and the viral eradication.
T164 7534-7569 Sentence denotes Inhibition of both arms of the RAS.
T165 7570-7767 Sentence denotes Among the inhibitors of the RAS pathways, different strategy can be pursued involving either ACE2 enzymatic activity or its upstream renin and ACE enzymatic activity or its downstream MasR pathway.
T166 7768-7994 Sentence denotes Inhibition of ACE2, ACE and renin enzymatic activities and their involvement in SARS-CoVs will be extensively discussed in the next sections, instead a brief description of MasR inhibition will be presented in the present Box.
T167 7995-8077 Sentence denotes Mas receptor pathway inhibition and side effects of using Mas receptor inhibitors.
T168 8078-8241 Sentence denotes A779 also known as D-Ala7-Ang-(1–7) and D-Pro7-Ang-(1–7) are two distinct MasR antagonists able to prevent Ang-(1–7)-mediated downstream activation in human cells.
T169 8242-8615 Sentence denotes The existence of several MasR subtypes has been suggested based on the differential capacity of the two MasR blockers to fully inhibit some biological actions of Ang-(1–7) [and perhaps of Ang (1–5), see Figure 1] [39,70]; therefore, differently from ACE2 enzymatic inhibitors, MasR antagonists should be administered in combinations, in order to inhibit ACE2 hyperactivity.
T170 8616-8806 Sentence denotes In human aortic smooth muscle cells, they have been shown to restore NADPH oxidase/NF-kB/iNOS inflammatory pathway induced by Ang II when it is inhibited by Ang (1–7) co-administration [81].
T171 8807-9185 Sentence denotes In mice studies a MasR blocker (A779) administered alone was not associated with systolic blood pressure alterations, and the hypotensive effect produced by rACE2 co-infused with Ang II was unaffected by A779 co-administration, indicating that the hypotensive activity of rACE2 mainly depended on Ang II degradation rather than on increase of Ang (1–7) and MasR activation [82].
T172 9186-9379 Sentence denotes In another report, spontaneously hypertensive rats (SHRs) that received A-779 alone for a total of two weeks did not significantly alter basal blood pressure and urinary protein excretion [83].
T173 9380-9652 Sentence denotes Moreover, in SHRs treated with A-779 in combination with Ang II, renal injury and interstitial infiltration of macrophages and T cells were surprisingly reduced as compared with SHRs treated with Ang II alone, suggesting a safe use of A-779 drug in in vivo infusions [83].
T174 9653-9809 Sentence denotes Another report showed that infusion of A-779 alone for 7 days did not produce a significant effect neither on blood pressure nor on heart rate in SHRs [84].
T175 9810-10026 Sentence denotes In a rat model of cardiac arrhythmia, administration of A-779 alone did not cause any significant alteration in the number of arrhythmic events, confirming that A-779 can be safely delivered to rodents in vivo. [85].
T176 10027-10377 Sentence denotes Although MasR antagonists has been shown to be safe in acute and chronic in vivo studies either with mice or rats, there are no data on administration in humans and the existence of different MasR subtypes in the vasculature require combinations of MasR antagonists to inhibit an excess of ACE2 activity as for example may occur in COVID-19 patients.

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T53 2665-2672 Phenotype denotes Hypoxia http://purl.obolibrary.org/obo/HP_0012418
T54 2700-2711 Phenotype denotes hypercapnia http://purl.obolibrary.org/obo/HP_0012416
T55 3110-3121 Phenotype denotes Hypotension http://purl.obolibrary.org/obo/HP_0002615
T56 3858-3865 Phenotype denotes hypoxia http://purl.obolibrary.org/obo/HP_0012418
T57 4051-4058 Phenotype denotes hypoxia http://purl.obolibrary.org/obo/HP_0012418
T58 4937-4944 Phenotype denotes hypoxia http://purl.obolibrary.org/obo/HP_0012418
T59 4945-4956 Phenotype denotes hypotension http://purl.obolibrary.org/obo/HP_0002615
T60 8601-8614 Phenotype denotes hyperactivity http://purl.obolibrary.org/obo/HP_0000752
T61 9828-9846 Phenotype denotes cardiac arrhythmia http://purl.obolibrary.org/obo/HP_0011675

2_test

Id Subject Object Predicate Lexical cue
32708755-32075877-20678738 248-250 32075877 denotes 27
32708755-32065055-20678739 251-253 32065055 denotes 32
32708755-15791205-20678740 353-355 15791205 denotes 24
32708755-19901337-20678741 510-512 19901337 denotes 78
32708755-18490652-20678742 742-744 18490652 denotes 17
32708755-32142651-20678743 1038-1040 32142651 denotes 13
32708755-32161940-20678744 1117-1118 32161940 denotes 2
32708755-24147777-20678745 1467-1469 24147777 denotes 56
32708755-18490652-20678746 1757-1759 18490652 denotes 17
32708755-18490652-20678747 2019-2021 18490652 denotes 17
32708755-32142651-20678748 6681-6683 32142651 denotes 13
32708755-19995578-20678749 6799-6801 19995578 denotes 20
32708755-23488800-20678750 8459-8461 23488800 denotes 70
32708755-28018220-20678751 8802-8804 28018220 denotes 81
32708755-19948988-20678752 9181-9183 19948988 denotes 82
32708755-20713916-20678753 9375-9377 20713916 denotes 83
32708755-20713916-20678754 9648-9650 20713916 denotes 83
32708755-30913349-20678755 9805-9807 30913349 denotes 84
32708755-27730696-20678756 10022-10024 27730696 denotes 85