PMC:7408073 / 25519-25784 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T176","span":{"begin":19,"end":35},"obj":"Body_part"},{"id":"T177","span":{"begin":99,"end":103},"obj":"Body_part"}],"attributes":[{"id":"A176","pred":"fma_id","subj":"T176","obj":"http://purl.org/sig/ont/fma/fma14067"},{"id":"A177","pred":"fma_id","subj":"T177","obj":"http://purl.org/sig/ont/fma/fma67122"}],"text":"In this regard, in cardiac myocytes isolated from neonatal rats, Ang II significantly reduced ACE2 mRNA and its activity, effects blocked by ARBs, indicating that Ang II downregulates ACE2 expression/activity through an AT1R-dependent mechanism [76] (see Figure 1)."}

{"project":"LitCovid-PubTator","denotations":[{"id":"1020","span":{"begin":94,"end":98},"obj":"Gene"},{"id":"1021","span":{"begin":184,"end":188},"obj":"Gene"},{"id":"1022","span":{"begin":220,"end":224},"obj":"Gene"},{"id":"1054","span":{"begin":59,"end":63},"obj":"Species"},{"id":"1063","span":{"begin":163,"end":169},"obj":"Gene"},{"id":"1064","span":{"begin":65,"end":71},"obj":"Gene"}],"attributes":[{"id":"A1020","pred":"tao:has_database_id","subj":"1020","obj":"Gene:302668"},{"id":"A1021","pred":"tao:has_database_id","subj":"1021","obj":"Gene:302668"},{"id":"A1022","pred":"tao:has_database_id","subj":"1022","obj":"Gene:24180"},{"id":"A1054","pred":"tao:has_database_id","subj":"1054","obj":"Tax:10116"},{"id":"A1063","pred":"tao:has_database_id","subj":"1063","obj":"Gene:24179"},{"id":"A1064","pred":"tao:has_database_id","subj":"1064","obj":"Gene:24179"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"In this regard, in cardiac myocytes isolated from neonatal rats, Ang II significantly reduced ACE2 mRNA and its activity, effects blocked by ARBs, indicating that Ang II downregulates ACE2 expression/activity through an AT1R-dependent mechanism [76] (see Figure 1)."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T321","span":{"begin":19,"end":35},"obj":"http://purl.obolibrary.org/obo/CL_0000746"},{"id":"T322","span":{"begin":112,"end":120},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T323","span":{"begin":200,"end":208},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"}],"text":"In this regard, in cardiac myocytes isolated from neonatal rats, Ang II significantly reduced ACE2 mRNA and its activity, effects blocked by ARBs, indicating that Ang II downregulates ACE2 expression/activity through an AT1R-dependent mechanism [76] (see Figure 1)."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T207","span":{"begin":65,"end":68},"obj":"Chemical"},{"id":"T208","span":{"begin":69,"end":71},"obj":"Chemical"},{"id":"T209","span":{"begin":163,"end":166},"obj":"Chemical"},{"id":"T210","span":{"begin":167,"end":169},"obj":"Chemical"}],"attributes":[{"id":"A207","pred":"chebi_id","subj":"T207","obj":"http://purl.obolibrary.org/obo/CHEBI_48433"},{"id":"A208","pred":"chebi_id","subj":"T208","obj":"http://purl.obolibrary.org/obo/CHEBI_74067"},{"id":"A209","pred":"chebi_id","subj":"T209","obj":"http://purl.obolibrary.org/obo/CHEBI_48433"},{"id":"A210","pred":"chebi_id","subj":"T210","obj":"http://purl.obolibrary.org/obo/CHEBI_74067"}],"text":"In this regard, in cardiac myocytes isolated from neonatal rats, Ang II significantly reduced ACE2 mRNA and its activity, effects blocked by ARBs, indicating that Ang II downregulates ACE2 expression/activity through an AT1R-dependent mechanism [76] (see Figure 1)."}

{"project":"LitCovid-sentences","denotations":[{"id":"T120","span":{"begin":0,"end":265},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"In this regard, in cardiac myocytes isolated from neonatal rats, Ang II significantly reduced ACE2 mRNA and its activity, effects blocked by ARBs, indicating that Ang II downregulates ACE2 expression/activity through an AT1R-dependent mechanism [76] (see Figure 1)."}

{"project":"2_test","denotations":[{"id":"32708755-18849338-20678735","span":{"begin":246,"end":248},"obj":"18849338"}],"text":"In this regard, in cardiac myocytes isolated from neonatal rats, Ang II significantly reduced ACE2 mRNA and its activity, effects blocked by ARBs, indicating that Ang II downregulates ACE2 expression/activity through an AT1R-dependent mechanism [76] (see Figure 1)."}