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PMC:7408073 / 24825-27628 JSONTXT

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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T172 66-70 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T173 199-203 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T174 537-541 Body_part denotes mRNA http://purl.org/sig/ont/fma/fma67122
T175 556-570 Body_part denotes left ventricle http://purl.org/sig/ont/fma/fma7101
T176 713-729 Body_part denotes cardiac myocytes http://purl.org/sig/ont/fma/fma14067
T177 793-797 Body_part denotes mRNA http://purl.org/sig/ont/fma/fma67122
T178 978-994 Body_part denotes cardiac myocytes http://purl.org/sig/ont/fma/fma14067
T179 1010-1038 Body_part denotes vascular smooth muscle cells http://purl.org/sig/ont/fma/fma284560
T180 1033-1038 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T181 1098-1102 Body_part denotes mRNA http://purl.org/sig/ont/fma/fma67122
T182 1593-1600 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T183 2628-2641 Body_part denotes cell membrane http://purl.org/sig/ont/fma/fma63841
T184 2628-2632 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T55 1760-1763 Body_part denotes RAS http://purl.obolibrary.org/obo/UBERON_0018229
T56 2345-2348 Body_part denotes RAS http://purl.obolibrary.org/obo/UBERON_0018229

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
1013 85-88 Gene denotes ACE Gene:59272
1014 101-105 Gene denotes ACE2 Gene:59272
1015 378-381 Gene denotes ACE Gene:302668
1016 382-386 Gene denotes ACE2 Gene:302668
1017 423-426 Gene denotes ACE Gene:302668
1018 532-536 Gene denotes ACE2 Gene:302668
1019 667-673 Gene denotes Ang II Gene:24179
1020 788-792 Gene denotes ACE2 Gene:302668
1021 878-882 Gene denotes ACE2 Gene:302668
1022 914-918 Gene denotes AT1R Gene:24180
1023 1040-1048 Gene denotes Ang (1–7 Gene:305843
1024 1093-1097 Gene denotes ACE2 Gene:302668
1025 1209-1217 Gene denotes Ang (1–7 Gene:305843
1026 1240-1244 Gene denotes AT1R Gene:24180
1027 1326-1334 Gene denotes Ang (1–7 Gene:305843
1028 1376-1382 Gene denotes Ang II Gene:24179
1029 1392-1396 Gene denotes ACE2 Gene:302668
1030 1481-1485 Gene denotes ACE2 Gene:302668
1031 1534-1542 Gene denotes Ang (1–7 Gene:305843
1032 1564-1568 Gene denotes ACE2 Gene:302668
1033 1808-1811 Gene denotes ACE Gene:302668
1034 1812-1816 Gene denotes ACE2 Gene:302668
1035 1934-1938 Gene denotes ACE2 Gene:302668
1036 1973-1977 Gene denotes MasR Gene:116511
1037 2227-2231 Gene denotes AT1R Gene:185
1038 2261-2265 Gene denotes MasR Gene:116511
1039 2522-2526 Gene denotes ACE2 Gene:59272
1040 2546-2554 Gene denotes Ang (1–7 Gene:284
1041 2623-2627 Gene denotes ACE2 Gene:59272
1042 2711-2715 Gene denotes ACE2 Gene:59272
1043 1161-1169 Gene denotes Ang-(1–7 Gene:305843
1044 2407-2415 Gene denotes Ang (1–7 Gene:284
1045 2251-2259 Gene denotes Ang (1–7 Gene:284
1046 1963-1971 Gene denotes Ang (1–7 Gene:305843
1047 654-662 Gene denotes Ang (1–7 Gene:305843
1048 2739-2744 Gene denotes spike Gene:43740568
1049 2571-2575 Gene denotes MasR Gene:116511
1050 1266-1270 Gene denotes MasR Gene:116511
1051 1137-1141 Gene denotes MasR Gene:116511
1052 127-132 Species denotes human Tax:9606
1053 580-584 Species denotes rats Tax:10116
1054 753-757 Species denotes rats Tax:10116
1055 999-1002 Species denotes rat Tax:10116
1056 2385-2395 Species denotes SARS-CoV-2 Tax:2697049
1057 2745-2755 Species denotes SARS-CoV-2 Tax:2697049
1058 2417-2423 Gene denotes Ang II Gene:24179
1059 2220-2226 Gene denotes Ang II Gene:24179
1060 1456-1462 Gene denotes Ang II Gene:24179
1061 1233-1239 Gene denotes Ang II Gene:24179
1062 1064-1070 Gene denotes Ang II Gene:24179
1063 857-863 Gene denotes Ang II Gene:24179
1064 759-765 Gene denotes Ang II Gene:24179
1065 13-31 Disease denotes hypoxic conditions MESH:D000071069
1066 319-326 Disease denotes hypoxia MESH:D000860
1067 2109-2116 Disease denotes hypoxia MESH:D000860
1068 2117-2137 Disease denotes SARS-CoV-2 infection MESH:C000657245
1069 2309-2327 Disease denotes hypoxic conditions MESH:D000071069

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T169 1878-1881 Disease denotes AT1 http://purl.obolibrary.org/obo/MONDO_0008840
T170 2021-2024 Disease denotes AT1 http://purl.obolibrary.org/obo/MONDO_0008840
T171 2117-2125 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T172 2117-2121 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T173 2128-2137 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T174 2385-2393 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T175 2385-2389 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T176 2745-2753 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T177 2745-2749 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T315 33-34 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T316 66-70 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T317 127-132 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T318 176-177 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T319 199-203 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T320 333-334 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T321 713-729 http://purl.obolibrary.org/obo/CL_0000746 denotes cardiac myocytes
T322 806-814 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T323 894-902 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T324 978-994 http://purl.obolibrary.org/obo/CL_0000746 denotes cardiac myocytes
T325 1003-1009 http://www.ebi.ac.uk/efo/EFO_0000265 denotes aortic
T326 1019-1038 http://purl.obolibrary.org/obo/CL_0000192 denotes smooth muscle cells
T327 1125-1126 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T328 1245-1255 http://purl.obolibrary.org/obo/SO_0000418 denotes signalling
T329 1264-1265 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T330 1427-1434 http://purl.obolibrary.org/obo/PR_000018263 denotes peptide
T331 1584-1592 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T332 1649-1657 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T333 1698-1699 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T334 1748-1752 http://www.ebi.ac.uk/efo/EFO_0001410 denotes arms
T335 1900-1901 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T336 1920-1926 http://purl.obolibrary.org/obo/SO_0000418 denotes signal
T337 1950-1958 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T338 1987-1988 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T339 2007-2013 http://purl.obolibrary.org/obo/SO_0000418 denotes signal
T340 2034-2042 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T341 2333-2337 http://www.ebi.ac.uk/efo/EFO_0001410 denotes arms
T342 2536-2544 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T343 2576-2586 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T344 2628-2632 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T345 2633-2641 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T346 2778-2779 http://purl.obolibrary.org/obo/CLO_0001020 denotes a

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T196 278-281 Chemical denotes Ang http://purl.obolibrary.org/obo/CHEBI_48433
T197 288-291 Chemical denotes Ang http://purl.obolibrary.org/obo/CHEBI_48433
T198 292-294 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T199 423-437 Chemical denotes ACE inhibitors http://purl.obolibrary.org/obo/CHEBI_35457
T200 427-437 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T201 439-444 Chemical denotes ACEIs http://purl.obolibrary.org/obo/CHEBI_35457
T202 452-455 Chemical denotes Ang http://purl.obolibrary.org/obo/CHEBI_48433
T203 456-458 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T204 654-657 Chemical denotes Ang http://purl.obolibrary.org/obo/CHEBI_48433
T205 667-670 Chemical denotes Ang http://purl.obolibrary.org/obo/CHEBI_48433
T206 671-673 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T207 759-762 Chemical denotes Ang http://purl.obolibrary.org/obo/CHEBI_48433
T208 763-765 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T209 857-860 Chemical denotes Ang http://purl.obolibrary.org/obo/CHEBI_48433
T210 861-863 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T211 1040-1043 Chemical denotes Ang http://purl.obolibrary.org/obo/CHEBI_48433
T212 1064-1067 Chemical denotes Ang http://purl.obolibrary.org/obo/CHEBI_48433
T213 1068-1070 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T214 1142-1152 Chemical denotes antagonist http://purl.obolibrary.org/obo/CHEBI_48706
T215 1161-1164 Chemical denotes Ang http://purl.obolibrary.org/obo/CHEBI_48433
T216 1209-1212 Chemical denotes Ang http://purl.obolibrary.org/obo/CHEBI_48433
T217 1233-1236 Chemical denotes Ang http://purl.obolibrary.org/obo/CHEBI_48433
T218 1237-1239 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T219 1326-1329 Chemical denotes Ang http://purl.obolibrary.org/obo/CHEBI_48433
T220 1348-1353 Chemical denotes ACEIs http://purl.obolibrary.org/obo/CHEBI_35457
T221 1376-1379 Chemical denotes Ang http://purl.obolibrary.org/obo/CHEBI_48433
T222 1380-1382 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T223 1423-1426 Chemical denotes Ang http://purl.obolibrary.org/obo/CHEBI_48433
T224 1427-1434 Chemical denotes peptide http://purl.obolibrary.org/obo/CHEBI_16670
T225 1456-1459 Chemical denotes Ang http://purl.obolibrary.org/obo/CHEBI_48433
T226 1460-1462 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T227 1534-1537 Chemical denotes Ang http://purl.obolibrary.org/obo/CHEBI_48433
T228 1593-1600 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T229 1760-1763 Chemical denotes RAS http://purl.obolibrary.org/obo/CHEBI_63620
T230 1871-1874 Chemical denotes Ang http://purl.obolibrary.org/obo/CHEBI_48433
T231 1875-1877 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T232 1963-1966 Chemical denotes Ang http://purl.obolibrary.org/obo/CHEBI_48433
T233 2220-2223 Chemical denotes Ang http://purl.obolibrary.org/obo/CHEBI_48433
T234 2224-2226 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T235 2240-2250 Chemical denotes antagonist http://purl.obolibrary.org/obo/CHEBI_48706
T236 2251-2254 Chemical denotes Ang http://purl.obolibrary.org/obo/CHEBI_48433
T237 2345-2348 Chemical denotes RAS http://purl.obolibrary.org/obo/CHEBI_63620
T238 2407-2410 Chemical denotes Ang http://purl.obolibrary.org/obo/CHEBI_48433
T239 2417-2420 Chemical denotes Ang http://purl.obolibrary.org/obo/CHEBI_48433
T240 2421-2423 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T241 2546-2549 Chemical denotes Ang http://purl.obolibrary.org/obo/CHEBI_48433

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T44 66-81 http://purl.obolibrary.org/obo/GO_0010467 denotes gene expression
T45 204-217 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T46 1245-1255 http://purl.obolibrary.org/obo/GO_0023052 denotes signalling
T47 1569-1582 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T48 1721-1731 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T49 2025-2042 http://purl.obolibrary.org/obo/GO_0038024 denotes receptor activity

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T118 0-332 Sentence denotes Similarly to hypoxic conditions, a strong correlation between the gene expression of ACE and that of ACE2 was also observed in human renal cortical biopsy specimen, suggesting a link between the two gene transcription, possibly related to the amount/excess of their substrates (Ang I and Ang II) and not exclusively to hypoxia [74].
T119 333-693 Sentence denotes A link that tends to maintain the balance of ACE/ACE2 ratio, but that may be disrupted by ACE inhibitors (ACEIs) or by Ang II type 1 receptor blockers (ARBs) which both have been shown to upregulate ACE2 mRNA expression in left ventricle of Lewis rats, possibly through two different mechanisms involving upregulation of Ang (1–7) or Ang II, respectively [75].
T120 694-959 Sentence denotes In this regard, in cardiac myocytes isolated from neonatal rats, Ang II significantly reduced ACE2 mRNA and its activity, effects blocked by ARBs, indicating that Ang II downregulates ACE2 expression/activity through an AT1R-dependent mechanism [76] (see Figure 1).
T121 960-1314 Sentence denotes Moreover, in both cardiac myocytes and rat aortic vascular smooth muscle cells, Ang (1–7) prevented the Ang II-mediated reduction in ACE2 mRNA, an effect blocked by a selective MasR antagonist, D-Ala7-Ang-(1–7) (also known as A779), indicating that Ang (1–7) downregulates Ang II/AT1R signalling through a MasR-dependent mechanism [76,77] (see Figure 1).
T122 1315-1658 Sentence denotes Therefore, Ang (1–7) (as well as ACEIs and ARBs), preventing Ang II-mediated ACE2 downregulation, shift the Ang peptide balance in favour of Ang II metabolisation by ACE2, which, in turn, leads to further production of Ang (1–7), finally sustaining ACE2 transcription, membrane protein expression and eventually shedding and systemic activity.
T123 1659-1870 Sentence denotes Altogether these observations indicate a complex interplay of regulation between the two arms of the RAS in which feedback mechanisms of reciprocal (ACE/ACE2) pathway inhibition are involved at different levels:
T124 1871-2058 Sentence denotes Ang II/AT1 receptor mediates a negative feedback signal on the ACE2 expression/activity and Ang (1–7)/MasR mediated a negative feedback signal on the AT1 receptor activity (see Figure 1).
T125 2059-2289 Sentence denotes These reciprocal inhibitions in some cases (e.g., hypoxia/SARS-CoV-2 infection) can give rise to positive feedback loops that markedly shift the balance between Ang II/AT1R and the antagonist Ang (1–7)/MasR pathway (see Figure 1).
T126 2290-2587 Sentence denotes For example, under hypoxic conditions both arms of the RAS are upregulated and the presence of SARS-CoV-2 can affect Ang (1–7)/Ang II balance (which might be further influenced by ACEI/ARBs) by shifting it in favour of an increased ACE2 systemic activity, Ang (1–7) production and MasR activation.
T127 2588-2803 Sentence denotes This, in turn, can lead to further ACE2 cell membrane expression (increasing the probability of viral entry), which, after ACE2 shedding by binding to spike-SARS-CoV-2, ultimately establish a positive feedback loop.

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T51 319-326 Phenotype denotes hypoxia http://purl.obolibrary.org/obo/HP_0012418
T52 2109-2116 Phenotype denotes hypoxia http://purl.obolibrary.org/obo/HP_0012418

2_test

Id Subject Object Predicate Lexical cue
32708755-17303661-20678733 328-330 17303661 denotes 74
32708755-15897343-20678734 689-691 15897343 denotes 75
32708755-18849338-20678735 940-942 18849338 denotes 76
32708755-18849338-20678736 1292-1294 18849338 denotes 76
32708755-18768926-20678737 1295-1297 18768926 denotes 77