PMC:7408073 / 20087-20582 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T139","span":{"begin":106,"end":111},"obj":"Body_part"},{"id":"T140","span":{"begin":469,"end":473},"obj":"Body_part"}],"attributes":[{"id":"A139","pred":"fma_id","subj":"T139","obj":"http://purl.org/sig/ont/fma/fma68877"},{"id":"A140","pred":"fma_id","subj":"T140","obj":"http://purl.org/sig/ont/fma/fma7195"}],"text":"Moreover, hypercapnic acidosis (pH 6.8/6.9, a condition that could occur in SARS) induced in isolated rat lungs has been shown to induce a (compensatory) venular dilatation mediated by cyclooxygenase activation (inhibited by indomethacin) [63], an enzyme that has been shown to be induced downstream of Ang (1–7)/MasR pathway in isolated rat hearts (again inhibited by indomethacin) [64], suggesting the involvement of ACE2/Ang (1–7) pathway in mediating CO2-dependent lung venular vasodilation."}

{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T43","span":{"begin":469,"end":473},"obj":"Body_part"}],"attributes":[{"id":"A43","pred":"uberon_id","subj":"T43","obj":"http://purl.obolibrary.org/obo/UBERON_0002048"}],"text":"Moreover, hypercapnic acidosis (pH 6.8/6.9, a condition that could occur in SARS) induced in isolated rat lungs has been shown to induce a (compensatory) venular dilatation mediated by cyclooxygenase activation (inhibited by indomethacin) [63], an enzyme that has been shown to be induced downstream of Ang (1–7)/MasR pathway in isolated rat hearts (again inhibited by indomethacin) [64], suggesting the involvement of ACE2/Ang (1–7) pathway in mediating CO2-dependent lung venular vasodilation."}

{"project":"LitCovid-PubTator","denotations":[{"id":"782","span":{"begin":313,"end":317},"obj":"Gene"},{"id":"783","span":{"begin":419,"end":423},"obj":"Gene"},{"id":"784","span":{"begin":424,"end":432},"obj":"Gene"},{"id":"837","span":{"begin":303,"end":311},"obj":"Gene"},{"id":"860","span":{"begin":102,"end":105},"obj":"Species"},{"id":"861","span":{"begin":338,"end":341},"obj":"Species"},{"id":"936","span":{"begin":10,"end":30},"obj":"Disease"}],"attributes":[{"id":"A782","pred":"tao:has_database_id","subj":"782","obj":"Gene:116511"},{"id":"A783","pred":"tao:has_database_id","subj":"783","obj":"Gene:302668"},{"id":"A784","pred":"tao:has_database_id","subj":"784","obj":"Gene:305843"},{"id":"A837","pred":"tao:has_database_id","subj":"837","obj":"Gene:305843"},{"id":"A860","pred":"tao:has_database_id","subj":"860","obj":"Tax:10116"},{"id":"A861","pred":"tao:has_database_id","subj":"861","obj":"Tax:10116"},{"id":"A936","pred":"tao:has_database_id","subj":"936","obj":"MESH:D000138"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Moreover, hypercapnic acidosis (pH 6.8/6.9, a condition that could occur in SARS) induced in isolated rat lungs has been shown to induce a (compensatory) venular dilatation mediated by cyclooxygenase activation (inhibited by indomethacin) [63], an enzyme that has been shown to be induced downstream of Ang (1–7)/MasR pathway in isolated rat hearts (again inhibited by indomethacin) [64], suggesting the involvement of ACE2/Ang (1–7) pathway in mediating CO2-dependent lung venular vasodilation."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T148","span":{"begin":22,"end":30},"obj":"Disease"},{"id":"T149","span":{"begin":76,"end":80},"obj":"Disease"}],"attributes":[{"id":"A148","pred":"mondo_id","subj":"T148","obj":"http://purl.obolibrary.org/obo/MONDO_0006022"},{"id":"A149","pred":"mondo_id","subj":"T149","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"}],"text":"Moreover, hypercapnic acidosis (pH 6.8/6.9, a condition that could occur in SARS) induced in isolated rat lungs has been shown to induce a (compensatory) venular dilatation mediated by cyclooxygenase activation (inhibited by indomethacin) [63], an enzyme that has been shown to be induced downstream of Ang (1–7)/MasR pathway in isolated rat hearts (again inhibited by indomethacin) [64], suggesting the involvement of ACE2/Ang (1–7) pathway in mediating CO2-dependent lung venular vasodilation."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T238","span":{"begin":44,"end":45},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T239","span":{"begin":106,"end":111},"obj":"http://www.ebi.ac.uk/efo/EFO_0000934"},{"id":"T240","span":{"begin":112,"end":115},"obj":"http://purl.obolibrary.org/obo/CLO_0051582"},{"id":"T241","span":{"begin":137,"end":138},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T242","span":{"begin":200,"end":210},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T243","span":{"begin":260,"end":263},"obj":"http://purl.obolibrary.org/obo/CLO_0051582"},{"id":"T244","span":{"begin":342,"end":348},"obj":"http://purl.obolibrary.org/obo/UBERON_0000948"},{"id":"T245","span":{"begin":342,"end":348},"obj":"http://purl.obolibrary.org/obo/UBERON_0007100"},{"id":"T246","span":{"begin":342,"end":348},"obj":"http://purl.obolibrary.org/obo/UBERON_0015228"},{"id":"T247","span":{"begin":342,"end":348},"obj":"http://www.ebi.ac.uk/efo/EFO_0000815"},{"id":"T248","span":{"begin":469,"end":473},"obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"id":"T249","span":{"begin":469,"end":473},"obj":"http://www.ebi.ac.uk/efo/EFO_0000934"}],"text":"Moreover, hypercapnic acidosis (pH 6.8/6.9, a condition that could occur in SARS) induced in isolated rat lungs has been shown to induce a (compensatory) venular dilatation mediated by cyclooxygenase activation (inhibited by indomethacin) [63], an enzyme that has been shown to be induced downstream of Ang (1–7)/MasR pathway in isolated rat hearts (again inhibited by indomethacin) [64], suggesting the involvement of ACE2/Ang (1–7) pathway in mediating CO2-dependent lung venular vasodilation."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T133","span":{"begin":303,"end":306},"obj":"Chemical"},{"id":"T134","span":{"begin":424,"end":427},"obj":"Chemical"},{"id":"T135","span":{"begin":455,"end":458},"obj":"Chemical"}],"attributes":[{"id":"A133","pred":"chebi_id","subj":"T133","obj":"http://purl.obolibrary.org/obo/CHEBI_48433"},{"id":"A134","pred":"chebi_id","subj":"T134","obj":"http://purl.obolibrary.org/obo/CHEBI_48433"},{"id":"A135","pred":"chebi_id","subj":"T135","obj":"http://purl.obolibrary.org/obo/CHEBI_16526"}],"text":"Moreover, hypercapnic acidosis (pH 6.8/6.9, a condition that could occur in SARS) induced in isolated rat lungs has been shown to induce a (compensatory) venular dilatation mediated by cyclooxygenase activation (inhibited by indomethacin) [63], an enzyme that has been shown to be induced downstream of Ang (1–7)/MasR pathway in isolated rat hearts (again inhibited by indomethacin) [64], suggesting the involvement of ACE2/Ang (1–7) pathway in mediating CO2-dependent lung venular vasodilation."}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T29","span":{"begin":482,"end":494},"obj":"http://purl.obolibrary.org/obo/GO_0042311"}],"text":"Moreover, hypercapnic acidosis (pH 6.8/6.9, a condition that could occur in SARS) induced in isolated rat lungs has been shown to induce a (compensatory) venular dilatation mediated by cyclooxygenase activation (inhibited by indomethacin) [63], an enzyme that has been shown to be induced downstream of Ang (1–7)/MasR pathway in isolated rat hearts (again inhibited by indomethacin) [64], suggesting the involvement of ACE2/Ang (1–7) pathway in mediating CO2-dependent lung venular vasodilation."}

{"project":"LitCovid-sentences","denotations":[{"id":"T98","span":{"begin":0,"end":495},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Moreover, hypercapnic acidosis (pH 6.8/6.9, a condition that could occur in SARS) induced in isolated rat lungs has been shown to induce a (compensatory) venular dilatation mediated by cyclooxygenase activation (inhibited by indomethacin) [63], an enzyme that has been shown to be induced downstream of Ang (1–7)/MasR pathway in isolated rat hearts (again inhibited by indomethacin) [64], suggesting the involvement of ACE2/Ang (1–7) pathway in mediating CO2-dependent lung venular vasodilation."}

{"project":"LitCovid-PD-HP","denotations":[{"id":"T39","span":{"begin":22,"end":30},"obj":"Phenotype"}],"attributes":[{"id":"A39","pred":"hp_id","subj":"T39","obj":"http://purl.obolibrary.org/obo/HP_0001941"}],"text":"Moreover, hypercapnic acidosis (pH 6.8/6.9, a condition that could occur in SARS) induced in isolated rat lungs has been shown to induce a (compensatory) venular dilatation mediated by cyclooxygenase activation (inhibited by indomethacin) [63], an enzyme that has been shown to be induced downstream of Ang (1–7)/MasR pathway in isolated rat hearts (again inhibited by indomethacin) [64], suggesting the involvement of ACE2/Ang (1–7) pathway in mediating CO2-dependent lung venular vasodilation."}

{"project":"2_test","denotations":[{"id":"32708755-9546381-20678714","span":{"begin":240,"end":242},"obj":"9546381"},{"id":"32708755-21874245-20678715","span":{"begin":384,"end":386},"obj":"21874245"}],"text":"Moreover, hypercapnic acidosis (pH 6.8/6.9, a condition that could occur in SARS) induced in isolated rat lungs has been shown to induce a (compensatory) venular dilatation mediated by cyclooxygenase activation (inhibited by indomethacin) [63], an enzyme that has been shown to be induced downstream of Ang (1–7)/MasR pathway in isolated rat hearts (again inhibited by indomethacin) [64], suggesting the involvement of ACE2/Ang (1–7) pathway in mediating CO2-dependent lung venular vasodilation."}