PMC:7408073 / 18307-18657 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T117","span":{"begin":39,"end":46},"obj":"Body_part"},{"id":"T118","span":{"begin":72,"end":76},"obj":"Body_part"},{"id":"T119","span":{"begin":78,"end":85},"obj":"Body_part"},{"id":"T120","span":{"begin":144,"end":148},"obj":"Body_part"},{"id":"T121","span":{"begin":203,"end":208},"obj":"Body_part"},{"id":"T122","span":{"begin":215,"end":226},"obj":"Body_part"},{"id":"T123","span":{"begin":221,"end":226},"obj":"Body_part"}],"attributes":[{"id":"A117","pred":"fma_id","subj":"T117","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A118","pred":"fma_id","subj":"T118","obj":"http://purl.org/sig/ont/fma/fma67122"},{"id":"A119","pred":"fma_id","subj":"T119","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A120","pred":"fma_id","subj":"T120","obj":"http://purl.org/sig/ont/fma/fma86583"},{"id":"A121","pred":"fma_id","subj":"T121","obj":"http://purl.org/sig/ont/fma/fma9670"},{"id":"A122","pred":"fma_id","subj":"T122","obj":"http://purl.org/sig/ont/fma/fma0326120"},{"id":"A123","pred":"fma_id","subj":"T123","obj":"http://purl.org/sig/ont/fma/fma68646"}],"text":"in hypoxic conditions upregulated ACE2 protein expression [55] and ACE2 mRNA, protein and activity were increased in response to hypoxia and by IL-1β [56]. In line with these observations, in peripheral blood human CD34+ cells, MasR expression and ACE2 expression, activity and shedding (of sACE2 catalytically active forms) were increased under hypo"}

{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T35","span":{"begin":203,"end":208},"obj":"Body_part"}],"attributes":[{"id":"A35","pred":"uberon_id","subj":"T35","obj":"http://purl.obolibrary.org/obo/UBERON_0000178"}],"text":"in hypoxic conditions upregulated ACE2 protein expression [55] and ACE2 mRNA, protein and activity were increased in response to hypoxia and by IL-1β [56]. In line with these observations, in peripheral blood human CD34+ cells, MasR expression and ACE2 expression, activity and shedding (of sACE2 catalytically active forms) were increased under hypo"}

{"project":"LitCovid-PubTator","denotations":[{"id":"757","span":{"begin":34,"end":38},"obj":"Gene"},{"id":"758","span":{"begin":67,"end":71},"obj":"Gene"},{"id":"759","span":{"begin":144,"end":149},"obj":"Gene"},{"id":"760","span":{"begin":215,"end":219},"obj":"Gene"},{"id":"761","span":{"begin":228,"end":232},"obj":"Gene"},{"id":"762","span":{"begin":248,"end":252},"obj":"Gene"},{"id":"853","span":{"begin":209,"end":214},"obj":"Species"},{"id":"922","span":{"begin":3,"end":21},"obj":"Disease"},{"id":"923","span":{"begin":129,"end":136},"obj":"Disease"}],"attributes":[{"id":"A757","pred":"tao:has_database_id","subj":"757","obj":"Gene:59272"},{"id":"A758","pred":"tao:has_database_id","subj":"758","obj":"Gene:59272"},{"id":"A759","pred":"tao:has_database_id","subj":"759","obj":"Gene:3552"},{"id":"A760","pred":"tao:has_database_id","subj":"760","obj":"Gene:947"},{"id":"A761","pred":"tao:has_database_id","subj":"761","obj":"Gene:116511"},{"id":"A762","pred":"tao:has_database_id","subj":"762","obj":"Gene:59272"},{"id":"A853","pred":"tao:has_database_id","subj":"853","obj":"Tax:9606"},{"id":"A922","pred":"tao:has_database_id","subj":"922","obj":"MESH:D000071069"},{"id":"A923","pred":"tao:has_database_id","subj":"923","obj":"MESH:D000860"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"in hypoxic conditions upregulated ACE2 protein expression [55] and ACE2 mRNA, protein and activity were increased in response to hypoxia and by IL-1β [56]. In line with these observations, in peripheral blood human CD34+ cells, MasR expression and ACE2 expression, activity and shedding (of sACE2 catalytically active forms) were increased under hypo"}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T203","span":{"begin":90,"end":98},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T204","span":{"begin":203,"end":208},"obj":"http://purl.obolibrary.org/obo/UBERON_0000178"},{"id":"T205","span":{"begin":203,"end":208},"obj":"http://www.ebi.ac.uk/efo/EFO_0000296"},{"id":"T206","span":{"begin":209,"end":214},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9606"},{"id":"T207","span":{"begin":221,"end":226},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T208","span":{"begin":265,"end":273},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T209","span":{"begin":311,"end":317},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"}],"text":"in hypoxic conditions upregulated ACE2 protein expression [55] and ACE2 mRNA, protein and activity were increased in response to hypoxia and by IL-1β [56]. In line with these observations, in peripheral blood human CD34+ cells, MasR expression and ACE2 expression, activity and shedding (of sACE2 catalytically active forms) were increased under hypo"}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T118","span":{"begin":39,"end":46},"obj":"Chemical"},{"id":"T119","span":{"begin":78,"end":85},"obj":"Chemical"},{"id":"T120","span":{"begin":144,"end":146},"obj":"Chemical"}],"attributes":[{"id":"A118","pred":"chebi_id","subj":"T118","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A119","pred":"chebi_id","subj":"T119","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A120","pred":"chebi_id","subj":"T120","obj":"http://purl.obolibrary.org/obo/CHEBI_63895"},{"id":"A121","pred":"chebi_id","subj":"T120","obj":"http://purl.obolibrary.org/obo/CHEBI_74072"}],"text":"in hypoxic conditions upregulated ACE2 protein expression [55] and ACE2 mRNA, protein and activity were increased in response to hypoxia and by IL-1β [56]. In line with these observations, in peripheral blood human CD34+ cells, MasR expression and ACE2 expression, activity and shedding (of sACE2 catalytically active forms) were increased under hypo"}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T26","span":{"begin":117,"end":136},"obj":"http://purl.obolibrary.org/obo/GO_0001666"}],"text":"in hypoxic conditions upregulated ACE2 protein expression [55] and ACE2 mRNA, protein and activity were increased in response to hypoxia and by IL-1β [56]. In line with these observations, in peripheral blood human CD34+ cells, MasR expression and ACE2 expression, activity and shedding (of sACE2 catalytically active forms) were increased under hypo"}

{"project":"LitCovid-PD-HP","denotations":[{"id":"T31","span":{"begin":129,"end":136},"obj":"Phenotype"}],"attributes":[{"id":"A31","pred":"hp_id","subj":"T31","obj":"http://purl.obolibrary.org/obo/HP_0012418"}],"text":"in hypoxic conditions upregulated ACE2 protein expression [55] and ACE2 mRNA, protein and activity were increased in response to hypoxia and by IL-1β [56]. In line with these observations, in peripheral blood human CD34+ cells, MasR expression and ACE2 expression, activity and shedding (of sACE2 catalytically active forms) were increased under hypo"}

{"project":"2_test","denotations":[{"id":"32708755-16166274-20678709","span":{"begin":59,"end":61},"obj":"16166274"},{"id":"32708755-24147777-20678710","span":{"begin":151,"end":153},"obj":"24147777"}],"text":"in hypoxic conditions upregulated ACE2 protein expression [55] and ACE2 mRNA, protein and activity were increased in response to hypoxia and by IL-1β [56]. In line with these observations, in peripheral blood human CD34+ cells, MasR expression and ACE2 expression, activity and shedding (of sACE2 catalytically active forms) were increased under hypo"}